Analysis of Trend of Studies on Microneedle Treatment System (MTS)

Chun Hea Sun,Song Ho-Seub 대한약침학회 2021 Journal of pharmacopuncture Vol.24 No.4

Objectives: The purpose of this study was to analyze the microneedle therapy system (MTS) and its research methods for the past 10 years in Korea. Methods: Data on microneedle therapy system were collected using NDSL, KISS, RISS, and OASIS electronic databases from January 2010 to August 2021. “microneedle,” “derma stamp,” “microneedle therapy system” were used as the keywords. The present study, however, excluded data that were 1) unrelated to the microneedle therapy system, 2) from review/meta/protocol studies, and 3) from overseas studies. Data selected through the primary screening process, animal studies, case reports, and clinical data were included in the analysis. However, information data not related to the microneedle therapy system were excluded from the study. Results: Among the MTS-related papers published from January 2010 to August 2021, 7 animal research, 2 clinical trials, and 10 case studies were published. Based on the research topics, there were 8 papers on skin improvement and skin diseases, 7 papers on hair growth and hair loss, 3 papers on stability, and 1 paper on peripheral facial paralysis. Conclusion: Most of the studies related to MTS focused on skin, hair, and stability. The effect of MTS on hair growth and skin improvement has been confirmed, and it has been proven to have significant effects on the treatment of acne, acne scars, and hair loss in clinical practice. No serious side effects were observed during the MTS treatment, and the safety assessment confirmed that it was safe for use.

Study of Latest Trend on Acupuncture for Obesity Treatment

Chun Hea Sun,Kim Dong-Hwan,Song Ho-Seub 대한약침학회 2021 Journal of pharmacopuncture Vol.24 No.4

Objectives: The aim of this review was to appraise Korean studies published between 2010 and 2021 which examined the role of acupuncture in the treatment of obesity. Methods: We performed a search of the NDSL, KISS, RISS, OASIS, PubMed, EMBASE electronic databases for relevant animal researches, case reports, and clinical trials, using the following search terms: ‘obesity’, ‘acupuncture’, ‘electroacupuncture’, and ‘pharmacopuncture’. We excluded previous reviews and meta-analyses, studies not related to obesity or acupuncture treatment, as well as studies conducted in countries other than Korea. We also excluded studies where relevant information on acupuncture treatment in obesity could not be obtained. Results: Most studies were conducted in animals, followed by case reports and clinical trials. In animal researches and case reports, pharmacopuncture was the most used intervention. In case studies, electroacupuncture, thread-embedding therapy, manual acupuncture, acupotomy, and auricular acupuncture were also used. In animal researches, pharmacopuncture treatment was associated with improvement in obesity indices. In the case of local obesity, specific acupuncture techniques such as thread-embedding therapy and pharmacopuncture were associated with significant improvements in local obesity, even when diet and exercise were not controlled for. Conclusion: Acupuncture treatment showed significant benefit in the treatment of obesity, with a local effect evident for certain approaches, such thread-embedding therapy and acupotomy.

A Review of Acupuncture Treatment for Infertility

Chun, Hea sun,Song, Ho-Sueb Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.4

The purpose of this study was to analyze acupuncture treatment methods and acupoint used to treat infertility in the last decade. The data were retrieved from 2010.1 to 2021.8. using national and international electronic databases (PubMed, EMBASE, OASIS, NDSL, and KISS). "Infertility," "sterility," "acupuncture," "electroacupuncture," "bloodletting," "pharmacopuncture," were used as search terms. All studies were mainly concerned with acupuncture treatment of infertility, but the studies which were not related included; (1) infertility or acupuncture treatment; (2) animal studies; (3) review/meta/protocol or clinical study; comparative studies and case reports which were excluded from this review. Only clinical trials for acupuncture treatment of infertility were included in this review (n = 18). For infertility treatment studies using acupuncture, polycystic ovarian syndrome was the main cause of infertility, the most common acupoint used was CV4, CV3, CV6, SP6, BL23, and the treatment effect significantly improved in the group receiving acupuncture treatment compared with the control group, or the group taking Western medicine alone. In some studies, the group using acupuncture treatment did not show side effects. Acupuncture is an effective treatment for infertility.

A Meta-Analysis of Treatment Effects on Viral Pneumonia Using TCM Injections Specified in the Clinical Guideline for COVID-19 in China

Chun, Hea Sun,Choi, Su Hyeon,Song, Ho Sueb KOREAN PHARMACOPUNCTURE INSTITUTE 2021 Journal of pharmacopuncture Vol.24 No.3

Objectives: The purpose of this study is to analyze the efficacy of traditional Chinese medicine (TCM) injections specified in the clinical guideline for COVID-19 by conducting a meta-analysis of viral pneumonia data. Methods: TCM injections data on viral pneumonia were collected until July 31, 2021. CNKI, PubMed, EMBASE, and the Cochrane electronic database were used to collect the clinical data. "COVID-19," "Viral pneumonia," "Tanreqing," "Xiyanping," "Reduning," "Xingnaojing," "Xuebijing," "Shenmai," "Shengmai," and "Shenfu" were used as keywords. All data collected were mainly about TCM injections and viral pneumonia. Furthermore, studies that included results such as the total effective rate, cough disappearance time, antipyretic time, lung rhomboid disappearance time, and adverse drug reaction were collected for the meta-analysis to identify the efficacy of TCM injections. However, data unrelated to TCM injections specified in the clinical guidelines for COVID-19 or viral pneumonia were excluded. The quality of included RCTs was assessed by the Cochrane Risk of Bias Tool, and Review Manager 5.3 software was used to conduct the meta-analysis. Results: A total of 18 studies with 1540 patients were included in this study. The results of the meta-analysis showed that the total effective rate OR = 4.61 (95% CI 2.92, 7.25, p = 1.00/ I² = 0%); the cough disappearance time: SMD -1.23 (-1.37, -1.09, p < 0.00001/ I² = 94%); the antipyretic time: SMD -1.26 (-1.40, -1.11, p < 0.00001/ I²=94%); lung rhomboid disappearance time: SMD -1.17 (-1.33, -1.02, p < 0.00001/ I² = 89%); and adverse drug reaction was OR 0.36 (95% CI 0.20, 0.64, p = 0.21/ I² = 30%). From the results, the treatment group (TCM injection) showed better efficacy than the control group (Western medication). Conclusion: Xiyanping, Reduning, and Tanreqing injections may yield benefits as COVID-19 treatments. However, clinical trials on TCM injections for the treatment of COVID-19 are still lacking. More high-quality clinical trials are still required.

Trends of Clinical Research on Facial Spasm in Korean Medicine: A Review of Case Studies

Hea Sun Chun,Ju Chul Kim 대한침구의학회 2023 대한침구의학회지 Vol.40 No.2

This review aimed to examine and analyze trends of clinical research using case studies on facial spasms in Korean medicine. Seven web databases were searched for case studies on facial spasms using Korean and English search terms. Case studies were selected using the exclusion and inclusion criteria. Overall, 13 case studies were selected, analyzed, and classified according to the publication year and journal, study participants, cause, treatment methods, pattern identification, evaluation methods, improvement, and side effects. Case studies reporting on various treatment methods in Korean medicine, including acupuncture and pharmacopuncture for facial spasms, have been published since 2000. In addition, studies on new treatment methods in Korean medicine for facial spasm have been published. Combination therapy is the most common method used in Korean medicine-based case studies; therefore, future studies on single treatment are necessary. Most of the case studies on Korean medicine reported improved symptoms and patient satisfaction with the Korean medicine treatment method. No side effects were reported, except for facial swelling and bruising, indicating that Korean medicine treatment methods for facial spasm were safe and effective. Therefore, the Korean medicine treatment methods for facial spasm can be actively used in clinical practice and future research.

朝鮮後期 王朝實錄에 수록된 服色禁制 論議에 관한 硏究-白色禁制와 代替色을 中心으로-

전혜숙(Chun Hea-Sook),홍선아(Hong Sun-A) 한복문화학회 2004 韓服文化 Vol.7 No.1

The late period of Chosun was the time when the principle of justification and social position system under the ruling idea of neo-Confucianism were still emphasized. or when an ideal society based on the thought was still sought. providing no solutions to better cope with rapid changes in society. Appointed at this circumstance. intellectuals turned to incantations and Taoism. k5 one of the disciplines of Taoism. the principle of the sun and the moon and the five elements provoked controversies over the prohibition of dress colors.<br/> For the purpose. this researcher analyzed implications of frequent discussions about dress colors. found in<br/> <Chronical Record of the Chosun Dynasty). especially white color and its substitute.<br/> In conclusion. controversies over the prohibition of dress colors in late Chosun was a reflection of that time when the vitalization of the dynasty and promotion of national fortunes and ultimately strengthening of the royal power were pursued based on the principle of the sun and the moon and the five elements under sinocentrism.<br/>

Aspirin 결정화 과정 중 특성변화의 NIR 인라인 모니터링 연구

이혜은 ( Hea Eun Lee ),왕인천 ( In Chun Wang ),이민정 ( Min Jeong Lee ),서다영 ( Da Young Seo ),신상문 ( Sang Mun Shin ),최용선 ( Yong Sun Choi ),최광진 ( Guang Jin Choi ) 한국화학공학회 2010 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.48 No.6

제약산업에서 최종의약품의 품질과 성능은 결정분말의 크기, 모양 및 다형체 등에 의해서 크게 달라지므로, 원료의 약품(API)의 결정화 공정은 매우 중요한 제약공정이다. 본 연구에서는 NIR 분광기와 광섬유 탐침을 이용하여, API 결정화 공정을 인라인 모니터링하여, 결정화 진행과정에서 핵성성, 결정성장, 다형체 등의 주요 특성을 실시간으로 감시하고 예측할 수 있는지를 탐구하였다. NIR 스펙트럼 분석에는 주요인분석법(PCA)을 적용하였고, 잘 알려진 aspirin를 대상 API로 하여 에탄올과 아세톤의 용매 혼합비율에 따른 결정특성 변화를 관찰하였다. 여러 특성분석 결과, 생성되는 aspirin 결정체의 다형은 용매 혼합비에는 무관하게 상온에서 가장 안정상인 form-I이었지만, 핵생성 개시점, 결정입도 및 결정의 형상은 용매의 혼합비에 따라 크게 달라진다는 것을 확인하였다. 이러한 결과는 NIR 스펙트럼의 PCA 해석결과와 매우 긴밀한 상관성을 보여주었다. 결론적으로, NIR 인라인 모니터링을 통해서, 약물의 결정화 과정에서 관심사가 되는 주요 결정특성을 실시간으로 관찰하고 예측할 수 있음이 실증되었다. Since the quality and performance of medicinal products are heavily dependent upon the size, shape and polymorphism of active pharmaceutical ingredients (APIs), their crystallization has been regarded as one of the most important pharmaceutical processes. In this study, NIR-based inline measurements were employed to monitor key attributes of API particles real-time during the crystallization process. Principal component analysis (PCA) method was selected to correlate inline NIR spectra while the well-known aspirin was studied as a model drug. According to our characterization results, the ratio of ethanol to acetone did not cause any change in polymorphism, but resulted in a significant difference in the nucleation time, crystal growth and crystal shape. These phenomenological changes were well correlated with the PCA`s implications. It turned out that the NIR-based inline monitoring technology can be employed well in observing and predicting key quality attributes such as crystal size during pharmaceutical crystallization processes.

A highly efficient synthesis of L-β-2´-deoxy-4´-thio-1´-purine nucleosides as potential antiviral agents

Kim, Hea Ok,Jeong, Lak Shin,Lee, Sun Nan,Yoo, Soo Jeong,Moon, Hyung Ryong,Kim, Kil Soo,Chun, Moon Woo 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9

L-β-2'-Deoxy-4'-thio-1'-purine nucleosides were synthesized efficiently utilizing the neighboring group effect of the 2-benzoy-4-thiosugar acetate.

GRDB 기반의 검보정 촬영계획 시뮬레이션

서두천(Doo-Chun Seo),정재헌(Jae-Heon Jung),최혜선(Hea-Sun Choi),서동춘(Dong-Chuon Seo),홍기병(Gi-Byeong Hong),이선구(Sun-Gu Lee) 대한공간정보학회 2012 한국공간정보학회 학술대회 Vol.2012 No.5

다목적실용위성2호 위치정확도 특성

서두천(Doo-Chun Seo),박지용(Ji-Yong Park),최혜선(Hea-Sun Choi),정재헌(Jae-heon Jung),홍기병(Ki-Byung Hong),이선구(Sun-Gu Lee) 한국항공우주연구원 2013 항공우주기술 Vol.12 No.1

다목적실용위성 2호(이하 KOMPSAT-2)는 고해상도 1.0m 흑백영상을 촬영할 수 있는 PAN 카메라와 4.0m 다중파장대의 칼라 영상을 수집할 수 있는 멀티스펙스럴 카메라를 탑재하고 있다. 이를 통하여 취득한 위성영상은 국토관리, 농업, 환경, 해양감시 및 GIS등의 광범위한 분야에 활용되고 있다. 본 연구는 KOMPSAT-2 자료를 이용하여 지상좌표를 해석하는 방법과 해석된 지상좌표의 위치정확도를 KOMPSAT-2 시스템 요구사항인 위치정확도를 만족시키기 위해 현재 적용되고 있는 위치정확도 보정계수 산출절차를 정의하는 것을 목적으로 한다. The Korea Multi-Purpose SATellite-2 (KOMPSAT-2) is to provide 1.0 m Ground Sample Distance (GSD) panchromatic image and 4.0 m GSD multi-spectral image data for various applications. The KOMPSAT-2 system performs mission applications in the field of earth observations, covering land, sea, coastal zones, and Geographic Information Systems (GIS). The purpose of this document is to compute ground coordinate using satellite position, velocity and attitude data in KOMPSAT-2 and document for work-flow of location accuracy correction in KOMPSAT-2.