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李守南,全厚根,全鍾暉 대한감염학회 1972 감염 Vol.4 No.1
1) In 1951~1953, the incidence of Epidemic Hemorrhagic Fever was high in those united nation's allied forces residing in the front line of korean conf lict. However, the incidence of the Hemorrhagic Fever was declined in the personneles of the allied forces since the armistice July 1953, and it has been gradually increased in korean army and the Hemorrhagic Fever becomes one of the military diseases of major concerns in Korea. Incidences of Hemorrhagic Fever have been reported even in the civilians living in the southern part far below the front-line since 1965. In 1971, the epidemic incidence of Hemorrhagic Fever in almost every area of south Korea has been reported in civilians and the incidence exceeded that of military personnels, which has brought about sociomedical concerns(Table 1, Fig. 1). 2) The incidence of Hemorrhagic Fever has been reported year around, although there seems to have two peaks in the incidence curve, namely late spring (may to june) and late fall (october to december). In the military personnel residing in highly infectious area, the main peak were reported to be located in the second peak of "the late fall". However, analysis on the incidence of the civilian group residing in less highly infectious area shows that there is only one peak (late fall) in the incidence curve which simulates the incidence curve observed in northern Manchuria and asian Russia. 3) It has been accepted that there is no sexual, age or racial difference in the susceptability of the disease. In those neighbouring areas of the front line (of cease-fire) considered to be highly infectious area, mainly consisting of farmers working vigorously together without sexual difference, the incidence of the disease was same among male and female. Hewever, in those areas far from the front line, less highly infectious area, the male to female ratio of the incidence was 2,6~4,2:1. The increased incidence in male was ascribed to the fact that the males had more chance to be exposed to the infectious agent from the view point of environmental ecology. It is analogous to the decreased incidence in patients of younger and older age group in whom physical activity is relatively limited and chances to be exposed to the infectious agent seem to be less (Table 6,7). 4) 70 to 80% of infected patients consisted of the age group in their vigorous activity ranging 20 to 50 year old age group. This was also ascribed to the increased chance of exposure to the infection. Fatality rate was also higher in this group of patients engaged in vigrous physical activity than those in younger or older age group.
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Definitive concurrent chemoradiotherapy in locally advanced pancreatic cancer
Kwak YK,Lee JH,Lee MA,Chun HG,Kim DG,You YK,Hong TH,Jang HS. 대한방사선종양학회 2014 Radiation Oncology Journal Vol.32 No.2
Purpose Survival outcome of locally advanced pancreatic cancer has been poor and little is known about prognostic factors of the disease, especially in locally advanced cases treated with concurrent chemoradiation. This study was to analyze overall survival and prognostic factors of patients treated with concurrent chemoradiotherapy (CCRT) in locally advanced pancreatic cancer. Materials and Methods Medical records of 34 patients diagnosed with unresectable pancreatic cancer and treated with definitive CCRT, from December 2003 to December 2012, were reviewed. Median prescribed radiation dose was 50.4 Gy (range, 41.4 to 55.8 Gy), once daily, five times per week, 1.8 to 3 Gy per fraction. Results With a mean follow-up of 10 months (range, 0 to 49 months), median overall survival was 9 months. The 1- and 2-year survival rates were 40% and 10%, respectively. Median and mean time to progression were 5 and 7 months, respectively. Prognostic parameters related to overall survival were post-CCRT CA19-9 (p = 0.02), the Eastern Cooperative Oncology Group (ECOG) status (p < 0.01), and radiation dose (p = 0.04) according to univariate analysis. In multivariate analysis, post-CCRT CA19-9 value below 180 U/mL and ECOG status 0 or 1 were statistically significant independent prognostic factors associated with improved overall survival (p < 0.01 and p = 0.02, respectively). Conclusion Overall treatment results in locally advanced pancreatic cancer are relatively poor and few improvements have been accomplished in the past decades. Post-treatment CA19-9 below 180 U/mL and ECOG performance status 0 and 1 were significantly associated with an improved overall survival.
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