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- 저자 : Chuan-Hui Shan (검색결과 2 건)
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Deep Leaky Single-peaked Triangle Neural Networks
Chuan-Hui Shan,Xi-Rong Guo,Jun Ou 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.10
Recently, Deep learning has made a great deal of success in processing images, audios, and natural languages and so on. The activation function is one of the key factors in Deep learning. In this paper, according to characteristics of biological neurons, an improved Leaky Single-Peaked Triangle Linear Unit (LSPTLU) activation function is presented for the right-hand response unbounded of Rectified Linear Unit (ReLU) and Leaky ReLU(LReLU). LSPTLU is more in line with the biological neuron essence and achieves the excellent performance of equivalent or beyond ReLU and LReLU on different datsets, e.g., MNIST, Fashion-MNIST, SVHN, IMAGENET, CALTECH101 and CIFAR10 datasets.
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Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro
Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8
Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.
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