장애아동의 생애초기 개입 서비스에서 가족중심 모형에 대한 문헌연구 : 생태학적 접근 An Ecological Approach)

윤종희 동덕여자대학교 2004 생활과학연구 Vol.9 No.-

The purpose of the study was to review the literature on family-based early intervention. This was accomplished in two ways: one through a theoretical investigation, the other through a literature review and a case study. As the theoretical background, Bronfenbrenner`s ecology of human development and the fitness theory were employed. The conceptual model for this study was proposed with specific ecological system factors. The model contained four of Bronfenbrenner`s ecological systems. To be specific, with handicapped child in the center, there were five microsystem factors, namely early intervention service coordinator who assessed individual family service plan(IFSP), daycare, family care, head start, and the public school. The same set of Microsystems, excluding service coordinator, were posited as ecosystem factors as well because those are community-based resources which would become the Microsystems of the handicapped child only if s/he chose to enroll at one of them. Several macrosystem factors were also cited in the model. In addition to the theoretical model, a case was reviewed which demonstrated the successful early intervention with family-based and home-based approaches. Implications were further discussed.

청소년의 직업 및 교육의 성취에 미치는 가족의 영향

尹鍾姬 同德女子大學校 1989 同大論叢 Vol.19 No.1

이 연구의 주목적은 청소년의 학문성취 및 직업성취에 영향을 미치는 제반요인들-즉, 가정환경, 청소년의 성격, 의미있는 타자, 청소년의 성취동기-을 분석하는 데 있다. 부차적인 목적은 청소년의 진로개발 과정을 생태학적인 관점에서 개념화보고자 하는데 있다. 즉 환경이 청소년의 진로개발에 미치는 상대적인 영향중 특히 장시간에 걸쳐 영향을 주는 가족시스템의 중요성에 대해 생태학적인 관점에서 진단을 시도하였다. 본 연구에서는 지위성취모델(Status-Attainment)에 기초한 경로분석모델을 사용하였다. 경로분석의 결과는 앞서 언급한 생태학적 요인들이 청소년의 진로개발에 공헌하는 직접, 간접적인 영향을 모두 입증하였다. 진로개발에 직접적으로 영향을 미치는 요인은 청소년의 성취동기와 그들의 교육수준이었고, 간접적으로 영향을 미치는 요인은 가정환경과 청소년의 성격요인이었다. 장기추적 조사를 통해 수집된 자료와 경로분석모델을 통계처리에 사용함으로써 흔히 간과되기 쉬웠던 가족시스템의 영향, 특히 장기간에 걸친 가족의 간접적인 영향력이 과학적 과정으로 측정됨으로써 청소년의 진로개발과정에서의 가족의 중요성이 재확인되었다.

가족관련 교과목 수강 여대생의 가족기능성 강화를 위한 교과내용의 제안

윤종희,김리진 생활과학연구소 2005 생활과학연구 Vol.10 No.-

The main purposes of the present study were twofolds: first, to assess and describe the level of family function of female college students and secondly, to propose curriculum contents designed to enhance family adaptability and cohesion for the college students. The proposition was made based on the analysis of family functioning level of these college students in relation to socio-demographic factors and their willingness to take family-related courses. The subjects were 169 undergraduate students attending a 4-year women's university, located in Seoul. The level of family functioning was assessed by Family Adaptability & Cohesion Evaluation Scale(FACES Ⅲ). FACES Ⅲ was originally developed by Olson and Wilson(1985) and adapted in Korea by Yoon, Chan Jung(1995). Data were analyzed by frequencies, means, ANOVA, and scheffe post-hoc test, using SPSS 10.0. The results were as follows: (1) the mean of family functioning level of the female college students was found to be relatively high, compared to the results of previous studies; (2) there was a significant difference in the mean level of family functioning in relation to parents' educational level, among other factors; (3) approximately seventy percents of the subjects said that they would like to take three or more of family-related courses, if given the opportunity. Based on these results, implication for curriculum contents for family-related college courses were further discussed.

Effect of p-Phenylenediamine Application to Rat Skin on the Liver Oxygen Free Radical Systems

윤종국,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2003 Journal of biomedical laboratory sciences Vol.9 No.2

To evaluate the influence of hepatic oxygen free radical systems on liver injury by topical p-phenylenediamine (PPD) application on rat skin. PPD (25mg/16.5㎠) was topically applied to the abdominal region 5 times every other day and sacrificed. By PPD treatment, increasing rate of liver weight/body weight(%), serum activities of alanine aminotransferase and aspartate aminotransferase and decreasing rate of microsomal glucose-6-phosphatase activity were higher in the rats fed tungstate supplemented diet than those fed a standard diet. These findings indicate that group fed tungstate supplemented diet have more severe liver injury compared with group fed standard diet on topical PPD application. However, the activities of oxygen free radical generating enzymes such as xanthine oxidase (XO) and cytochrome P450 dependent aniline hydroxylase and those of oxygen free radical scavenging enzymes were not found to be different between these two animal groups. In the present study, a novel monitoring method to detect the generating of oxygen free radicals in liver extract was devised. Throughout this method, the oxidized PPD produced by oxygen free radicals was determined colorimetrically. The increasing rate of PPD oxidation by liver homogenate was higher in tungstate fed animals than in standard diet fed ones. Among the fractionations of liver extract, the mitochondria1 and postmitochondrial fractions in the liver extract of tungstate fed animals led to a higher availability of PPD oxidation by PPD treatment compared with standard diet fed ones. In conclusion, these results suggest that an enhanced liver injury in tungstate fed animals treated with PPD may be due to oxygen free radicals produced in other systems except oxygen free radicals generating from cytosolic XO system. Especially, oxidative availability by PPD can be used for oxygen free radical detection in some tissue.

아동기 스트레스에 관한 문헌 고찰

윤종희,정원주 同德女子大學校 1997 同大論叢 Vol.27 No.1

The purpose of the present study is to review theresearch literature on children's stress and thier copying styles. This literature review is organized from an ecological point of view, in that child's own characteristics as well as children's microsystem such as family school, and community factors are included. Also children's stress is viewed as a continuing process over the time span in which in individual child goes through the pocess of experiencing stressful events, of using copying strategies and, of exhibiting stressful symptoms.

성북구 거주 거동 불편 여성노인의 생활만족도에 관한 연구

윤종희,김덕성,안령미 동덕여자대학교 한국여성연구소 2002 젠더연구 Vol.- No.6

The purpose of the study was to investigate relationships among life satisfaction of the elderly women in poor-health conditions, with their self-esteem, health and financial status, family relations, and social participation. A structured questionnaire was used to interview a sample of 168 elderly women who were randomly selected from Sungbuk-ku, Seoul. The statistical methods used were percentiles, means, standard deviations, Cronbach`s α, Pearson`s correlations and a multiple regression. The regression analysis showed that the most powerful predictor of satisfaction of the poor-health elderly women was their self esteem, followed by relationships with their adult children, perceived financial status, age, and the amount of allowances. These variables accounted for 41.7% of life satisfaction of the sample. Implications for the policy-makers and practitioners were further discussed.

機能性胃腸障碍 및 急性肝炎 患者에서 Clebopride에 依한 症狀의 好轉과 胃內容物排出 時間과의 關係

范熙承,金成烈,鞠敦杓,朴光淑,尹鍾晩,崔元,金文烈 최신의학사 1985 最新醫學 Vol.28 No.6

Valinomycin 단분자막의 물성 연구

박희윤,이종만 성신여자대학교 기초과학연구소 2001 基礎科學硏究誌 Vol.19 No.-

The surface pressure - mean molecular area isotherms for valinomycin, a cyclic dodecadepsipeptide ionophore antibiotic, at the air/water interface have been investigated under various subphases and temperatures using Langmuir - type Film Balance in order to obtain the physical properties of monolayer of horizontally oriented valinomycin which is one component of mitochondria membrane. Pure valinomycin apparently forms reasonably stable monolayer at various temperatures. These curves give the extrapolated mean molecular area which is 383.77Å2 at 33℃, monolayer compressibility which is 0.0264cm/dyne and collapse pressure which is 16.06mN/m at 33℃. As the KCl concentration in subphase was increased more than 1.0M, an inflection, phase transition in the valinomycin force-area curve occured at successively lower surface pressure and higher mean molecular area. In contrast, Li+, Na+ and Cs+ ions showed no phase transition. When valinomycin complexes a cation, K+ at the membrane/water interface, it undergoes a rearrangement that is evident from a decrease in mean molecular area of approximately 15∼ 20Å2. And also the surface pressure versus mean molecular area curves of the mixed monolayer of valinomycin with L-α-Dipentadecanoyl Phosphatidylcholine (DPPC) were obtained at various compositions. By addition of DPPC, it was observed that the mean molecular area of mixed monolayer becames somewhat smaller than the value to be calculated theoretically. An equimolar mixture of valinomycin and DPPC gave an isotherm contour that indicates considerable condensation.

Bromobenzene의 투여 횟수에 따른 간독성의 차이

이상희,전태원,윤종국 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.1

실험동물에 있어서 간조직의 손상 정도에 미치는 xenobiotics의 투여기간에 의한 영향을 검토할 목적으로 hepatotoxin의 일종인 bromobenzene의 투여 횟수에 의한 간손상 정도와 이의 기전을 구명 한 결과는 다음과 같다. 횐쥐에 1일 간격으로 bromobenzene (400 mg/kg)을 복강으로 1회, 3회 및 6회 투여 한 실험군을 대상으로 하여 실시한 실험에서 혈청 alanine aminotransferase (ALT)의 확성 및 체중 당 간 무게는 bromobenzene을 1회 투여 한 1일째에는 대조군과 별다른 변동을 볼 수 없었으나 3회 투여 한 3일째에는 유의하게 증가되었으며, 이후 6일째 6회 투여한 실험군에서는 체중 당 간 무게 및 혈청 ALT활성이 3일째 보다 현저히 감소되어 오히려 대조군과 유사하였다. 이와 같이 투여 횟수의 증가에 따른 간손상의 정도가 투여 횟수와 비례하지 않은 것이 어떠한 기전에 의해서 나타나는지를 구명하기 위해 bromobenzene 대사에 관여 하는 간조직 중 aniline hydroxylase 및 glutathione S-transferase 활성과 glutathione (GSH) 함량을 측정한 결과, 이들 대사효소 및 GSH이용률이 bromobenzene 6회 투여 군에서 1회 및 3회 투여군보다 높게 나타났다. 이상 실험 결과를 종합해 볼 때 어떤 독성물질이 생체에 계속 폭로 시 어느 시점에서 중독현상이 경감되는 것은 이 독성물질의 대사율을 증가시켜 해독하려는 생리적응현상이 일어 날 수 있다는 가설을 제시 할 수 있다. A Study on the Effect of Injection Frequency on the Liver Damage in Rats To investigate the effect of injection frequency of bromobenzene on the liver damage, bromobenzene (400 mg/kg, i.p.) was given daily to rats for six days. All experimental animals were sacrificed at 24 hours after the last injection. Morphological changes of the liver were observed under a light microscopic examination. Functional changes of the liver were evaluated by the measurement of alanine aminotransferase activity. To clarify the cause of discrepancy in liver damage, hepatic glutathione (GSH) content, glutathione S-transferase (GSI) and aniline hydroxylase (AH) activities were determined. In the experiments of daily bromobenzene treatments, the sacrificed animals at six day (6 time-injected animals) showed slighter liver damage than those sacrificed at 3 day (3 time-injected ones), based on the liver morphological or functional findings; the decreasing ratio of GSH content and increasing ratio of liver GST and AH activities in the 6 time-injected group were higher than those in the 3 time-injected one.

랫드에 있어서 Bromobenzene의 격일 투여 시, 매일 투여한 경우와 간손상 정도의 비교

이상희,윤종국,조현국 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.2

Bromobenzene의 투여 간격에 따라 간손상이 어떠한 차이를 나타내는지를 검토하기 위하여 흰쥐에 체중 1kg 당 400mg의 bromobenzene을 복강으로 2일 및 1일 간격으로 각각 3회 투여한 다음 간손상을 병리조직학적, 간기능적 측면에서 검토한 결과 2일 간격으로 투여한 실험군에서 간손상이 경미하게 나타났다. 그리고 간조직 중 cytochrome P450 함량은 2일 간격으로 투여한 실험군에서는 대조군 보다 증가되는 경향을 보였으나 1일 간격으로 투여한 경우에는 대조군 보다 오히려 유의한 (p<0.01) 감소를 보였다. 간조직 중 대조군에 대한 glutathione 감소율과 glutathione S-transferase 활성 증가율은 2일 간격으로 bromobenzene을 투여한 군이 1일 간격으로 투여한 실험군 보다 높게 나타났다. 이상 실험 결과는 동일한 양과 회수로서 bromobenzene을 격일로 투여한 실험동물에 있어서 매일 투여한 경우 보다 간손상이 경미하였으며, 이는 bromobenzene의 대사율이 증가됨으로서 나타난 결과로 생각된다. To evaluate the effect of intervals of bromobenzene treatment on the liver damage, the bromobenzene(400 mg/kg, i.p.) was given to rats at either one day or two days interval at three times. All the experimental animals were sacrificed at 24 hours after the last injection. Liver morphological changes were observed under a light microscopic examination and liver functional changes were determined by the measurement of alaine aminotransferase (ALT) activity and hepatic malondialdehyde (MDA) content. The experimental to examine the cause of liver damage were cytochrome P450, glutathione (GSH) content and glutathione S-transferase(GST) activities. The results are summarized as follows; Based on the liver morphological and functional findings, the daily bromobenzene-treated rats (ED) showed the more severe liver damage than every other day bromobenzene-treated rats (EOD). The hepatic cytochrome p450 content was higher in EOD group than that in ED group. And the increasing rate of hepatic GST activity and decreasing rate of GSH content to the control were higher in EOD group than that in ED group. In conclusion, the treatment of bromobenzene intermittently to the rats may lead to more reduced liver injury compared with the continuously treated animals when both cases are treated with the same dose and frequency, and it may be caused by the enhancement of bromobenzene metabolism.