大岩山의 植物相

閔雄基,張珍成,全正壹,金輝,崔道烈,鄭承洙 서울대학교 수목원 2000 서울大學校 樹木園 硏究報告 Vol.- No.20

This study was carried out to investigate the flora of Mts. Dae-am, Dae-woo, Baek-suk, and Sa-myung located on the east side of DMZ in province Yang-gu-gun, from July 1999 to August 2000. Although two hundred and fifty eight vascular plant taxa (70 families 167 genera) were recorded, this was only a part of representatives in this community because of the restrictin of collections within the military zone. The overall forest stand age of this area was 40 to 50 years, but occasionally ca 70 years old trees were found. We reported 11 taxa of the rare and endangered species proposed by the Ministry of Environment in this area. The Yong-neup, the only high altitude (alt. 1,200m) moore in south Korea, are located in the peak of Mt. Dae-am-san. Some species of this moore (Carex chordorrhiza Ehrh., Carex limosa L., and Gentiana jamesii Hemsl.) - were only found in south Korea. This moor would suffer vegetation change by natural moorland succession and human disturbances. The long-term monitoring of variation of annual vegetation, species distribution, numbers and distribution pattern of individuals of rare species are recommended for the wetland conservation.

피나무(Tilia amurensis), 뽕잎피나무(T. taquetii), 일본피나무(T. japonica)의 형질분석을 통한 분류학적 한계

尹準九,張珍成,金輝,張桂羨,李興洙 서울大學校農業生命科學大學附屬樹木園 2003 서울大學校 樹木園 硏究報告 Vol.- No.23

본 연구는 한국산 피나무속의 3종(T.amurensis, T. insularis, T. taquetii)과 일본피나무(T.japonica)를 대상으로 6개 정량 형질(잎의 길이와 폭, 털의 밀도, 화경의 길이, 열매의 길이와 폭)을 비교 검토하였다. T.amurensis(피나무)와 T. insularis(섬피나무) T. taquetii(뽕잎피나무)는 기존에 잎의 크기와 털의 정도가 주요 형질로 알려져 있지만 본 연구결과 모두 뚜렷한 구분이 없는 연속변이를 보였다. 또한, 일본피나무와 국내 자생 피나무와 비교한 결과 기존에 알려진 화경의 길이에서 차이를 보였는데 제한된 개체를 근간으로 조사한 결과 일본피나무가 다소 긴 것을 확인하였다. 국내 자생 피나무, 섬피나무, 뽕잎피나무의 경우 독립된 종이기보다는 모두 피나무의 지역적 변이체임을 확인함과 동시에 동일종으로 처리하는 것이 타당하다고 생각한다. 그러나, 일본피나무의 경우는 좀 더 많은 개체수를 확보하여 화경의 길이에 대해 보다 자세한 조사가 이루어져야 할 것으로 생각된다. The hair density and type of leaf and bract, size of leaf and absence/presence of staminodes are important to recognize many taxa of Tilia. The systematic relationships among T. amurensis, T. insularis, T. taquetii in Korea and T. japonica in Japan were confused and were not clarified yet. Flower and fruit specimens of 121 individuals were sampled to investigate patterns of intraspecific variation and to evaluate the species delimitation among Tilia amurensis, T. taquetii, T. insularis, and T. japonica using six characters. The morphological differentiation among T. amurensis, T. insularis, and T. taquetii was not sufficient to warrant recognition of either specific or varietal status and should be treated as conspecific under T. amurensis. Based on results of limited number of specimens, the morphological discontinuity between T. amurensis and T. japonica was found only in peduncle length. Further study on this reproductive character are required to conduct any taxonomic treatment on these taxa.

The effect of different colored light emitting diode illumination on egg laying performance, egg qualities, blood hormone levels and behavior patterns in Brown Tsaiya duck

Su, Chin-Hui,Cheng, Chih-Hsiang,Lin, Jung-Hsin,Liu, Hsiu-Chou,Yu, Yen-Ting,Lin, Chai-Ching,Chen, Wei-Jung Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.11

Objective: The objective of this experiment was to investigate the effects of different colors produced by light emitting diode (LED) on Brown Tsaiya ducks. Methods: A total of 144 female Brown Tsaiya ducks were randomly allocated into three individual cage rearing chambers with different LED illumination colors as treatments. Three different treatments were: i) white color, ii) blue color, and iii) red color. The experiment periods were from ducks 21 to 49 weeks of age, determined traits included i) egg laying performance, ii) feed intake, iii) egg shell breaking strength, iv) egg shell thickness, v) egg Haugh unit, vi) egg weight, vii) serum Estradiol and Progesterone concentration, and viii) behavior pattern. Results: The results indicated that when compared with white and blue color, red color could stimulate ducks sexual maturation and raised the egg laying performance. The red light group was also observed to have the highest feed intake among three treatments. The blue treatment had the lowest egg shell breaking strength and the highest egg weight among three treatments, nevertheless, no significant difference was observed among three treatments on egg shell thickness and egg Haugh unit. The red light group had higher serum estradiol concentration than the white and blue groups, but no significant difference among treatments on the serum Progesterone concentration was found. The results of behavior pattern indicated that red light group showed more feeding and less resting behavior compared to the blue light group. Conclusion: We found a potential of applying red light illumination in the indoor laying duck raising system with positive results on egg laying performance and acceptable egg weight, equivalent egg qualities compared to white and blue light.

Increase of Phosphatase and Tensin Homolog by Silymarin to Inhibit Human Pharynx Squamous Cancer

Chin-Hui Su,Li-Jen Chen,Jyh Fei Liao,Juei-Tang Cheng 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.9

Silymarin is an active principle from the seeds of the milk thistle plant and is widely used as a hepatoprotective gent due to its antioxidant-like activity. In the present study, we evaluated the potential efficacy of silymarin against oral cancer and investigated its possible mechanism of action. Cell viability assay and western blotting analyses were used to identify silymarin-induced apoptotic cell death in human pharynx squamous cell carcinoma (FaDu) cells. The short interfering RNA (siRNA) is used to confirm the role of phosphatase and tensin homolog (PTEN) in silymarin-induced apoptosis. Treatment of FaDu cells with silymarin resulted in a significant decrease in cell viability (up to 70%). Silymarin inhibited the phosphorylation of Akt (over 10-fold) with an increase in expression of PTEN (five to sixfold). Consequently, the level of Bcl-2 expression was decreased five to sixfold and caspase 3 activated to induce apoptosis. Treatment with siRNA specific to PTEN gene diminished the action of silymarin. The results suggest that silymarin inhibits the Akt signaling pathway by increasing PTEN expression in FaDu cells and directly affects Bcl-2 family members. Also, we demonstrated the inhibitory activity of silymarin for oral cancer is related to cell survival. These mechanisms may in part explain the actions of silymarin and provide a rationale for the development of silymarin as an anticancer agent.

CHARACTERIZING THE TIME-FREQUENCY PROPERTIES OF THE 4 Hz QUASI-PERIODIC OSCILLATION AROUND THE BLACK HOLE X-ray BINARY XTE J1550-564

SU, YI-HAO,CHOU, YI,HU, CHIN-PING,YANG, TING-CHANG,HSIEH, HUNG-EN,CHUANG, PO-SHENG,LIN, CHING-PING,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

We present the results from analysis of the Hilbert-Huang transform (HHT) for the 4 Hz quasi-periodic oscillations (QPO) around the black hole X-ray binary XTE J1550-564. The resultant Hilbert spectra demonstrate that the QPO is composed of a series of intermittent signals appearing occasionally. From the analysis of the HHT, we further found the distribution of the lifetimes for the intermittent oscillations and the distribution for the time intervals with no significant signal (the break time). The mean lifetime is 1.45 s and 90% of the oscillation segments have lifetimes less than 3.1 s whereas the mean break time is 0.42 s and 90% of break times are less than 0.73 s. We conclude that the intermittent feature of the QPO could be explained by the Lense-Thirring precession model and rules out interpretations of continual frequency modulation.

ON THE COMPLEX VARIABILITY OF THE SUPERORBITAL MODULATION PERIOD OF LMC X-4

HU, CHIN-PING,LIN, CHING-PING,CHOU, YI,YANG, TING-CHANG,SU, YI-HAO,HSIEH, HUNG-EN,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

LMC X-4 is an eclipsing high-mass X-ray binary exhibiting a superorbital modulation with a period of ~ 30:5 days. We present a detailed study of the variations of the superorbital modulation period with a time baseline of ~ 18 years. The period determined in the light curve collected by the Monitor of All-sky X-ray Image (MAXI) significantly deviates from that observed by the All Sky Monitor (ASM) onboard the Rossi X-ray Timing Explorer (RXTE). Using the data collected by RXTE/ASM, MAXI, and the Burst Alert Telescope (BAT) onboard Swift, we found a significant period derivative, $\dot{P}=(2.08{\pm}0.12){\times}10^{-5}$. Furthermore, the O{C residual shows complex short-term variations indicating that the superorbital modulation of LMC X-4 exhibits complicated unstable behaviors. In addition, we used archive data collected by the Proportional Counter Array (PCA) on RXTE to estimate the orbital and spin parameters. The detected pulse frequencies obtained in small time segments were fitted with a circular orbital Doppler shift model. In addition to orbital parameters and spin frequency for each observation, we found a spin frequency derivative of $\dot{v}=(6.482{\pm}0.011){\times}10^{-13}Hz{\cdot}s^{-1}$. More precise orbital and spin parameters will be evaluated by the pulse arrival time delay technique in the future.

APPLICATIONS OF THE HILBERT-HUANG TRANSFORM ON THE NON-STATIONARY ASTRONOMICAL TIME SERIES

HU, CHIN-PING,CHOU, YI,YANG, TING-CHANG,SU, YI-HAO,HSIEH, HUNG-EN,LIN, CHING-PING,CHUANG, PO-SHENG,LIAO, NAI-HUI The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2

The development of time-frequency analysis techniques allow astronomers to successfully deal with the non-stationary time series that originate from unstable physical mechanisms. We applied a recently developed time-frequency analysis method, the Hilbert-Huang transform (HHT), to two non-stationary phenomena: the superorbital modulation in the high-mass X-ray binary SMC X-1 and the quasi-periodic oscillation (QPO) of the AGN RE J1034+396. From the analysis of SMC X-1, we obtained a Hilbert spectrum that shows more detailed information in both the time and frequency domains. Then, a phase-resolved analysis of both the spectra and the orbital profiles was presented. From the spectral analysis, we noticed that the iron line production is dominated by different regions of this binary system in different superorbital phases. Furthermore, a pre-eclipse dip lying at orbital phase ~0:6-0:85 was discovered during the superorbital transition state. We further applied the HHT to analyze the QPO of RE J1034+396. From the Hilbert spectrum and the O-C analysis results, we suggest that it is better to divide the evolution of the QPO into three epochs according to their different periodicities. The correlations between the QPO periods and corresponding fluxes were also different in these three epochs. The change in periodicity and the relationships could be interpreted as the change in oscillation mode based on the diskoseismology model.

Structure-based Virtual Screening and Identification of a Novel Androgen Receptor Antagonist

Song, Chin-Hee,Yang, Su Hui,Park, Eunsook,Cho, Suk Hee,Gong, Eun-Yeung,Khadka, Daulat Bikram,Cho, Won-Jea,Lee, Keesook American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.36

Age-Related Changes in Sulfur Amino Acid Metabolism in Male C57BL/6 Mice

( Jang Su Jeon ),( Jeong-ja Oh ),( Hui Chan Kwak ),( Hwi-yeol Yun ),( Hyoung Chin Kim ),( Young-mi Kim ),( Soo Jin Oh ),( Sang Kyum Kim ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2

Alterations in sulfur amino acid metabolism are associated with an increased risk of a number of common late-life diseases, which raises the possibility that metabolism of sulfur amino acids may change with age. The present study was conducted to understand the age-related changes in hepatic metabolism of sulfur amino acids in 2-, 6-, 18- and 30-month-old male C57BL/6 mice. For this purpose, metabolite profiling of sulfur amino acids from methionine to taurine or glutathione (GSH) was performed. The levels of sulfur amino acids and their metabolites were not significantly different among 2-, 6- and 18-month-old mice, except for plasma GSH and hepatic homocysteine. Plasma total GSH and hepatic total homocysteine levels were significantly higher in 2-month-old mice than those in the other age groups. In contrast, 30-month-old mice exhibited increased hepatic methionine and cysteine, compared with all other groups, but decreased hepatic S-adenosylmethionine (SAM), S-adenosylhomocysteine and homocysteine, relative to 2-month-old mice. No differences in hepatic reduced GSH, GSH disulfide, or taurine were observed. The hepatic changes in homocysteine and cysteine may be attributed to upregulation of cystathionine β-synthase and down-regulation of γ-glutamylcysteine ligase in the aged mice. The elevation of hepatic cysteine levels may be involved in the maintenance of hepatic GSH levels. The opposite changes of methionine and SAM suggest that the regulatory role of SAM in hepatic sulfur amino acid metabolism may be impaired in 30-month-old mice.

SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer

Yang, Su Hui,Song, Chin-Hee,Van, Hue Thi My,Park, Eunsook,Khadka, Daulat Bikram,Gong, Eun-Yeung,Lee, Keesook,Cho, Won-Jea American Chemical Society 2013 Journal of medicinal chemistry Vol.56 No.8

<P>Molecular knowledge of pure antagonism and systematic SAR study offered a direction for structural optimization of DIMN to provide nicotinamides as a novel series of AR antagonists. Nicotinamides with extended linear scaffold bearing sterically bulky alkoxy groups on isoquinoline end were synthesized for H12 displacement. AR binding affinity and molecular basis of antiandrogenic effect establish the optimized derivatives, <B>7au</B> and <B>7bb</B>, as promising candidates of second generation AR antagonists for advanced prostate cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jmcmar/2013/jmcmar.2013.56.issue-8/jm3014103/production/images/medium/jm-2012-014103_0011.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jm3014103'>ACS Electronic Supporting Info</A></P>