Correction: Rewritable full-color computer-generated holograms based on color-selective diffractive optical components including phase-change materials

Hwang, Chi-Young,Kim, Gi Heon,Yang, Jong-Heon,Hwang, Chi-Sun,Cho, Seong M.,Lee, Won-Jae,Pi, Jae-Eun,Choi, Ji Hun,Choi, Kyunghee,Kim, Hee-Ok,Lee, Seung-Yeol,Kim, Yong-Hae The Royal Society of Chemistry 2018 Nanoscale Vol.10 No.47

<P>Correction for ‘Rewritable full-color computer-generated holograms based on color-selective diffractive optical components including phase-change materials’ by Chi-Young Hwang <I>et al.</I>, <I>Nanoscale</I>, 2018, DOI: 10.1039/c8nr04471f.</P>

한국판UCLA 고독척도

김교헌,김지환 충남대학교 1989 學生生活硏究 Vol.16 No.-

물-LiBr吸收式 冷凍사이클의 性能豫測에 關한 硏究

김문헌,권영필,신치웅 崇田大學校 1981 論文集 Vol.11 No.1

The objective of this paper is to simulate the performance of H₂O-LiBr absorption refrigerator. The thermodynamic cycle of the H₂O-LiBr simple effect absorption refrigeration is analyzed and the coefficient of performance is derived for an ideal cycle. Equation for thermodynamic properties of LiBr solution and water are obtained by the least square method from equilibrium charts. And a computer program is developed, which can calculate the circulation ratic and the coefficient of performance from the efficiency of the heat exchanger and temperatures of generator, condenser, evaporator and absorber. The simulation of the performance by the computer shows the following characteristics. When the efficiency of the heat exhcnanger increase, the COP volue increases and the operating range is reduced by recry stallization. When the generator temperature increase, the COP value increases at a high condensor temperature but decrease at a low condenser temperature. However the COP value always increases as the condenser temperature decreases. It is more effective for high COP value to decrease the condenser temperature than to increase the generator temperature.

제주지역 특성을 도입한 병원설계 사례에 대한 연구 : 제주대학병원 현상설계안을 중심으로

임성보,김치헌,박순희 한국의료복지시설학회 2003 의료·복지 건축 Vol.9 No.2

The recent project has been progressed from focusing on the establishment of an international sense and making a symbclic building in Cheju Island. Its purpose is to provide the best medical services to the inhabitants, and to reflect the local feelings and the entire design concept based upon the role of the health promotion. This study is to explain the process of a traditional architecture method of Cheju applied to the modern design element and re-composition into the layout plan, the composition diagram of the exterior. the elevations etc. of the drawings of the project.

알코올 의존과 후보 유전자들간의 연관성 연구

정인원,김헌,홍주봉,지경환,이규영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 알코올 대사와 중추신경계내의 알코올 작용부위와 관련한 일부 후보유전자들이 알코올 의존과 관련이 있는지를 확인하고자 하였다. 방 법 : DSM-IV로 진단된 알코올 의존 환자 128명과 정상 대조군 128명을 대상으로 후보 유전자들의 다형성을 중합효소 연쇄반응과 제한효소처리법을 이용하여 동정하였다. 여기서 분리된 대립유전자와 유전자형에 따른 빈도의 차이를 유전자별로 각각 비교하였으며, 알코올 의존에 작용하는 서로 다른 유전자들에 의한 영향력을 배제하기 위하여 logistic regression 분석을 적용하였다. 결 과 : 알코올 의존군에서는 ALDH_2 유전자의 NN(wild type)형이 정상대조군에 비하여 유의하게 많았다(chi-square test, p<0.001). logistic regression analysis를 통하여 다른 유전자들에 의한 영향을 보정한 상태에서 ALDH_2가 NN(wild type)인 경우 다른 아형에 비하여 알코올 의존에 대한 odds ratio는 130.312이며 그 신뢰구간은 (17.22, 986.43)이었다. 한편, ASA는 N-glycosylation 부위에 변이형 대립유전자를 갖고 있는 경우(AG or GG)는 wild type에 비하여 알코올 의존에 대한 위험도는 2.344배이며 그 95% 신뢰구간은 (1.128, 4.871)이었다. 결 론 : 알코올 의존과 ALDH_2 유전자간에는 밀접한 연관성이 확인되었다. 또한 다른 유전자들은 개별 연관분석에서 의미있는 연관성이 관찰되지는 않았지만 logistic regression analysis를 통하여 N-glycosylation 부위에 다형성이 있는 ASA 유전자가 알코올 의존과 관련이 있음을 시사하였다. Objectives : This study was to explore the association between alcohol dependence and five candidate genes related to the metabolism of alcohol and the enzymes of the suspected sites in CNS. Methods : The genotype and allele frequencies of five candidate genes in 128 male hospitalized patients who met DSM-IV criteria for alcohol dependence were compared with 128 age-matched healthy male control subjects using polymerase chain reaction and restriction fragment length polymorphism. A logistic regression analysis was applied in order to exclude the reciprocal interactions among five candidate genes. Results : The NN genotype frequency of the ALDH_2 gene was significantly higher in alcoholic patients than in control subjects(chi-square test, p<0.001). No difference in frequency was found in the other four genes. In a logistic regression analysis, the odds ratio for alcohol dependence in the NN genotype of the ALDH_2 gene and AG or GG genotypes of the N glycosylation site on the ASA gene were 130.312(95% confidence interval, 17.22-986.43) and 2.344(95% confidence interval. 1.128-4.871), respectively. Conclusion : The result reiterates the association of the ALDH_2 gene polyporphism and the alcohol dependence. Logistic regression analysis additionally suggested that the N-glycosylation site on the ASA gene was associated with alcohol dependence.

알코올 의존 환자의 Tryptophan Hydroxylase 유전자 다형성

홍주봉,이상익,신철진,김헌,지경환,정인원 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 알코올 의존 환자에서 세로토닌 합성 조절 효소인 tryptophan hydroxylase(TPH) 유전자 다형성 빈도를 정상 대조군과 비교함으로써 알코올 의존의 유전적 요인을 추적하고, 임상변인과 이 유전자 다형성과의 관련성을 알아보고자 하였다. 방 법 : DSM-IV진단기준에 부합되는 알코올 의존 환자 100명과 정상 대조군 100명을 대상으로 TPH유전자 다형성을 증합효소 연쇄반응과 제한효소 처리법을 이용하여 동정하였다. 여기서 분리된 대립 유전자와 유전자형에 따른 빈도의 차이를 서로 비교하였으며, 알코올 의존 환자군의 여러 임상 변인에 따른 차이를 비교하였다. 결 과 : 알코올 의존 환자군과 대조군 간에 TPH의 A216C 유전자형 및 대립유전자 빈도에서의 통계적으로 유의한 차이는 관찰되지 않았으나, 조기 발병한 환자의 경우는 유전자형의 빈도가 AA,AC,CC형이 0.57, 0.39, 0.04, 후기 발병한 환자의 경우 0.34, 0.45, -.21로, 조기 발병한 환자군에서 대조군과 비교하여 통계적으로 유의하게 A 대립 유전자의 빈도가 높은 것이 관찰되었다.(by chi-square test, p<0.05). 결 론 : 이는 조기 발병형 알코올 의존의 경우 TPH유전자 다형성과 관련이 있으며, 일부 알코올 의존 환자에서 유전적으로 세로토닌계의 이상이 있다는 사실을 시사한다. Objectives : This study was performed to explore the association of tryptophan hydroxylase (TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity of symptoms in Korean alcoholics. Methods : The genotype and allele frequencies of TPH in 100 male hospitalized patients who met DSM-IV criteria for alcohol dependence were investigated using polymerase chain reaction and restriction fragment length plymorphism and were compared with 100 age-matched healthy male control subjects. And the associations between gene polymorphisms and clinical characteristics in alcoholic patients were explored. Results : The distributions of TPH genotype and allele in alcohol dependent patients were not different from control subjects. However, the frequencies of TPH genotype in early-onset alcoholic patients, which were 0.57, 0.39, and 0.04(AA, AC and CC, respectively), were significantly different from those of late-onset alcoholics(0.34, 0.45, and 0.21, respectively). "A" allele was found more frequent in early-onset alcoholics. Conclusion : The result suggests that TPH gene polymorphism is associated with early-onset alcioholic patients possibly related with inherited abnormalities of serotonin system.

Experiences of Latent Tuberculosis Infection Treatment for the North Korean Refugees

Kim, Beong Ki,Kim, Hee Jin,Kim, Ho Jin,Cha, Jae Hyung,Lee, Jin Beom,Jeon, Jeonghe,Kim, Chi Young,Kim, Young,Kim, Je Hyeong,Shin, Chol,Lee, Seung Heon The Korean Academy of Tuberculosis and Respiratory 2019 Tuberculosis and Respiratory Diseases Vol.82 No.4

Background: Tuberculosis (TB) is increasing in immigrants. We aimed to investigate the current status of latent tuberculosis infection (LTBI) treatment for North Korean Refugees (NKR) compared to South Koreans Contacts (SKC). Methods: TB close contacts in a closed facility of SKC and NKR who underwent LTBI screening in a settlement support center for NKR were analyzed retrospectively. Results: Among tuberculin skin test (TST) ${\geq}10mm$ (n=298) reactors, the males accounted for 72.2% in SKC (n=126) and 19.5% in NKR (n=172) (p<0.01). The mean age was higher in South Korea ($42.8{\pm}9.9years$ vs. $35.4{\pm}10.0years$, p<0.01). Additionally, the mean TST size was significantly bigger in NKR ($17.39{\pm}3.9mm$ vs. $16.57{\pm}4.2mm$, p=0.03). The LTBI treatments were initiated for all screened NKR, and LTBI completion rate was only 68.0%. However, in NKR, LTBI treatment completion rate was significantly increased by shorter 4R regimen (odds ratio [OR], 9.296; 95% confidence interval [CI], 4.159-20.774; p<0.01) and male (OR, 3.447; 95% CI, 1.191-9.974; p=0.02). Conclusion: LTBI treatment compliance must be improved in NKR with a shorter regimen. In addition, a larger study regarding a focus on LTBI with easy access to related data for NKR should be conducted.

Increased Volume of Surgery for Lumbar Spinal Stenosis and Changes in Surgical Methods and Outcomes: A Nationwide Cohort Study with a 5-Year Follow-Up

Kim, Chi Heon,Chung, Chun Kee,Kim, Myo Jeong,Choi, Yunhee,Kim, Min-Jung,Shin, Sukyoun,Jung, Jong-Myung,Hwang, Sung Hwan,Yang, Seung Heon,Park, Sung Bae,Lee, Jun Ho Elsevier 2018 World neurosurgery Vol.119 No.-

<P><B>Objective</B></P> <P>Examining spine surgery patterns over time is crucial to provide insights into variations and changes in clinical decision making. Changes in the number of surgeries, surgical methods, reoperation rates, and cost-effectiveness were analyzed for all patients who underwent surgery for lumbar spinal stenosis without spondylolisthesis in 2003 (2003 cohort) and 2008 (2008 cohort).</P> <P><B>Methods</B></P> <P>The national health insurance database was used to create the 2003 cohort (n = 10,990) and 2008 cohort (n = 27,942). The surgical methods were classified into decompression and fusion surgery. The cumulative reoperation probability between those surgeries was calculated using the Kaplan-Meier method in the 2003 cohort and 2008 cohort. Comparison of the incremental cost-effectiveness ratios showed the additional direct cost of a 1% change in the reoperation probability.</P> <P><B>Results</B></P> <P>The surgical volume increased 2.54-fold in the 2008 cohort. The age-adjusted number of surgeries per 1 million people increased 2.6-fold (from 154 in the 2003 cohort to 399 in the 2008 cohort) in aged patients and 1.9-fold (from 154 in the 2003 cohort to 291 in the 2008 cohort) in patients 20–59 years old in the 2008 cohort. The proportion of fusion surgeries increased from 20.3% in the 2003 cohort to 37.0% in the 2008 cohort. In total, the 5-year reoperation probabilities increased from 8.1% in the 2003 cohort to 11.2% in the 2008 cohort. Fusion decreased the reoperation probability by 1% at the cost of 1,711 U.S. dollars.</P> <P><B>Conclusions</B></P> <P>The increased numbers of spinal surgeries, fusion surgeries, and surgeries in older patients in a recent cohort were noteworthy. However, the increased surgical volume and fusion surgeries did not reduce the reoperation rate.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Examining patterns of spine surgery over time is crucial. </LI> <LI> The national health insurance database was analyzed. </LI> <LI> Increased surgical volume and fusion surgeries failed to reduce the reoperation. </LI> </UL> </P>

Experiences of Latent Tuberculosis Infection Treatment for the North Korean Refugees

( Beong Ki Kim ),( Hee Jin Kim ),( Ho Jin Kim ),( Jae Hyung Cha ),( Jin Beom Lee ),( Jeonghe Jeon ),( Chi Young Kim ),( Young Kim ),( Je Hyeong Kim ),( Chol Shin ),( Seung Heon Lee ) 대한결핵 및 호흡기학회 2019 Tuberculosis and Respiratory Diseases Vol.82 No.4

Background: Tuberculosis (TB) is increasing in immigrants. We aimed to investigate the current status of latent tuberculosis infection (LTBI) treatment for North Korean Refugees (NKR) compared to South Koreans Contacts (SKC). Methods: TB close contacts in a closed facility of SKC and NKR who underwent LTBI screening in a settlement support center for NKR were analyzed retrospectively. Results: Among tuberculin skin test (TST) ≥10 mm (n=298) reactors, the males accounted for 72.2% in SKC (n=126) and 19.5% in NKR (n=172) (p<0.01). The mean age was higher in South Korea (42.8±9.9 years vs. 35.4±10.0 years, p<0.01). Additionally, the mean TST size was significantly bigger in NKR (17.39±3.9 mm vs. 16.57±4.2 mm, p=0.03). The LTBI treatments were initiated for all screened NKR, and LTBI completion rate was only 68.0%. However, in NKR, LTBI treatment completion rate was significantly increased by shorter 4R regimen (odds ratio [OR], 9.296; 95% confidence interval [CI], 4.159-20.774; p<0.01) and male (OR, 3.447; 95% CI, 1.191-9.974; p=0.02). Conclusion: LTBI treatment compliance must be improved in NKR with a shorter regimen. In addition, a larger study regarding a focus on LTBI with easy access to related data for NKR should be conducted.

Preoperative Weakness and Demyelination of the Corticospinal Tract in Meningioma Patients : Changes in Diffusion Parameters Using Diffusion Tensor Imaging

Kim, Myoung Soo,Chung, Chun Kee,Jung, Hee-Won,Park, Chul-Kee,Kim, Chi Heon,Kim, June Sic The Korean Neurosurgical Society 2014 Journal of Korean neurosurgical society Vol.55 No.5

Objective : Differentiation of demyelination in white matter from axonal damage can be determined using diffusion tensor imaging (DTI). In this study using meningioma patients an attempt was made to evaluate the relationship between preoperative weakness and the changes of diffusion parameters in the corticospinal tract (CST) using DTI. Methods : Twenty-six patients with meningioma were enrolled in this study. Eleven of them suffered from objective motor weakness and were classified as Group 1. The remaining 15 patients did not present motor weakness and were classified as Group 2. Fiber tractography and CST diffusion parameters were obtained using DTIStudio. The ratios (lesion side mean value/contralateral side mean value) of CST diffusion parameters were compared with 1.0 as a test value using a one-sample t-test. Results : In Group 1, fractional anisotropy (FA), tensor trace (TT), and radial diffusivity (RD, ${\lambda}2$ and ${\lambda}3$) of the CST were significantly different between two hemispheres, but axial diffusivity (AD, ${\lambda}1$) of the CST was not significantly different between two hemispheres. In Group 2, FA and ${\lambda}3$ of CST did not differ significantly between the hemispheres. In Group 2, TT, ${\lambda}1$, and ${\lambda}2$ of CST in the ipsilateral hemisphere were significantly higher than those of the unaffected hemisphere. However, the differences were small. Conclusion : Motor weakness was related to a low FA and high TT resulting from increased RD of the CST fibers. CST diffusion changes in patients with weakness are similar to those for demyelination.