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Zhou, Chao,Teng, Wen-Jing,Yang, Jing,Hu, Zhen-Bo,Wang, Cong-Cong,Qin, Bao-Ning,Lv, Qing-Liang,Liu, Ze-Wang,Sun, Chang-Gang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: Chronic myelocytic leukemia is a disease that threatens both adults and children. Great progress has been achieved in treatment but protein-protein interaction networks underlining chronic myelocytic leukemia are less known. Objective: To develop a protein-protein interaction network for chronic myelocytic leukemia based on gene expression and to predict biological pathways underlying molecular complexes in the network. Materials and Methods: Genes involved in chronic myelocytic leukemia were selected from OMIM database. Literature mining was performed by Agilent Literature Search plugin and a protein-protein interaction network of chronic myelocytic leukemia was established by Cytoscape. The molecular complexes in the network were detected by Clusterviz plugin and pathway enrichment of molecular complexes were performed by DAVID online. Results and Discussion: There are seventy-nine chronic myelocytic leukemia genes in the Mendelian Inheritance In Man Database. The protein-protein interaction network of chronic myelocytic leukemia contained 638 nodes, 1830 edges and perhaps 5 molecular complexes. Among them, complex 1 is involved in pathways that are related to cytokine secretion, cytokine-receptor binding, cytokine receptor signaling, while complex 3 is related to biological behavior of tumors which can provide the bioinformatic foundation for further understanding the mechanisms of chronic myelocytic leukemia.
The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia
Hsiung, Chao Agnes,Lan, Qing,Hong, Yun-Chul,Chen, Chien-Jen,Hosgood III, H. Dean,Chang, I-Shou,Chatterjee, Nilanjan,Brennan, Paul,Wu, Chen,Zheng, Wei,Chang, Gee-Chen,Wu, Tangchun,Park, Jae Yong,Hsiao, Public Library of Science 2010 PLoS genetics Vol.6 No.8
<▼1><P>Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide significance with p-values of 10<SUP>−7</SUP> or lower. These studies have been performed primarily in cigarette smokers, raising the possibility that the observed associations could be related to tobacco use, lung carcinogenesis, or both. Since most women in Asia do not smoke, we conducted a genome-wide association study of lung adenocarcinoma in never-smoking females (584 cases, 585 controls) among Han Chinese in Taiwan and found that the most significant association was for rs2736100 on chromosome 5p15.33 (p = 1.30×10<SUP>−11</SUP>). This finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls (p = 5.38×10<SUP>−11</SUP>). A pooled analysis achieved genome-wide significance for rs2736100. This SNP marker localizes to the <I>CLPTM1L</I>-<I>TERT</I> locus on chromosome 5p15.33 (p = 2.60×10<SUP>−20</SUP>, allelic risk = 1.54, 95% Confidence Interval (CI) 1.41–1.68). Risks for heterozygote and homozygote carriers of the minor allele were 1.62 (95% CI; 1.40–1.87), and 2.35 (95% CI: 1.95–2.83), respectively. In summary, our results show that genetic variation in the <I>CLPTM1L-TERT</I> locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.</P></▼1><▼2><P><B>Author Summary</B></P><P>Worldwide, approximately 15% of lung cancer cases occur among nonsmokers. Genome-wide association studies (GWAS) of lung cancer conducted in populations of European background have identified three regions on chromosomes 5, 6, and 15 that harbor genetic variants that confer risk for lung cancer. Prior studies were conducted primarily in cigarette smokers, raising the possibility that the associations could be related to tobacco use, lung carcinogenesis, or both. A GWAS of lung cancer among never-smokers is an optimal setting to discover effects that are independent of smoking. Since most women in Asia do not smoke, we conducted a GWAS of lung adenocarcinoma among never-smoking females (584 cases, 585 controls) in Taiwan, and observed a region on chromosome 5 significantly associated with risk for lung cancer in never-smoking women. The finding was independently replicated in seven studies from East Asia totaling 1,164 lung adenocarcinomas and 1,736 controls. To our knowledge, this study is the first reported GWAS of lung cancer in East Asian women, and together with the replication studies represents the largest genetic association study in this population. The findings provide insight into the genetic contribution of common variants to lung carcinogenesis.</P></▼2>
Numerical simulation of slit wall effect on the Taylor vortex flow with radial temperature gradient
Dong Liu,Chang-qing Chao,Fang-neng Zhu,Xi-qiang Han,Chengtang Liu 한국유체기계학회 2015 International journal of fluid machinery and syste Vol.8 No.4
Numerical simulation was applied to investigate the Taylor vortex flow inside the concentric cylinders with a constant radial temperature gradient. The reliability of numerical simulation method was verified by the experimental results of PIV. The radial velocity and temperature distribution in plain and 12-slit model at different axial locations were compared, and the heat flux distributions along the inner cylinder wall at different work conditions were obtained. In the plain model, the average surface heat flux of inner cylinder increased with the inner cylinder rotation speed. In slit model, the slit wall significantly changed the distribution of flow field and temperature in the annulus gap, and the radial flow was strengthen obviously , which promoted the heat transfer process at the same working condition.
Axial slit wall effect on the flow instability and heat transfer in rotating concentric cylinders
Dong Liu,Chang-qing Chao,Ying-ze Wang,Fang-neng Zhu,김형범 대한기계학회 2016 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.30 No.12
The slit wall effect on the flow instability and heat transfer characteristics in Taylor-Couette flow was numerically studied by changing the rotating Reynolds number and applying the negative temperature gradient. The concentric cylinders with slit wall are seen in many rotating machineries. Six different models with the slit number 0, 6, 9, 12, 15 and 18 were investigated in this study. The results show the axial slit wall enhances the Taylor vortex flow and suppresses the azimuthal variation of wavy Taylor vortex flow. When negative temperature gradient exists, the results show that the heat transfer augmentation appears from laminar Taylor vortex to turbulent Taylor flow regime. The heat transfer enhancement become stronger as increasing the Reynolds number and slit number. The larger slit number model also accelerates the flow transition regardless of the negative temperature gradient or isothermal condition.
Numerical simulation of slit wall effect on the Taylor vortex flow with radial temperature gradient
Liu, Dong,Chao, Chang-qing,Zhu, Fang-neng,Han, Xi-qiang,Tang, Cheng Korean Society for Fluid machinery 2015 International journal of fluid machinery and syste Vol.8 No.4
Numerical simulation was applied to investigate the Taylor vortex flow inside the concentric cylinders with a constant radial temperature gradient. The reliability of numerical simulation method was verified by the experimental results of PIV. The radial velocity and temperature distribution in plain and 12-slit model at different axial locations were compared, and the heat flux distributions along the inner cylinder wall at different work conditions were obtained. In the plain model, the average surface heat flux of inner cylinder increased with the inner cylinder rotation speed. In slit model, the slit wall significantly changed the distribution of flow field and temperature in the annulus gap, and the radial flow was strengthen obviously, which promoted the heat transfer process at the same working condition.
Study on the constitutive behavior and hot deformation characteristic of Mg-4Sm-2Zn-0.5Zr alloy
Zhong-Yi Cai,Chao-jie Che,Ruo-Han Chang,Li-Ren Cheng,Qing-Min Chen 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.20 No.3
Mg–4Sm–2Zn–0.5Zr alloy is a new type of heat-resistant magnesium alloy, it has the mechanical properties similar to EZ33 alloy but is much cheaper than EZ33 in cost since Samarium (Sm) rather than Nd was employed in the alloy. In this paper, based on isothermal compression tests in the temperature range of 350–450 °C and strain rate range of 0.001–1.0 s−1, the Arrhenius-type constitutive equations for this alloy were established, and the hot working flow behavior and the microstructures of the alloy were examined. To evaluate the hot deformation mechanisms and determine the optimal processing parameters, 3D processing maps under different deformation conditions were developed according to the dynamic material model and Muthy instability criterion. The hot extrusion experiments were carried out, and the results show the predictions of processing maps are in agreement with the experimental results.