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Eun-whaChoi,Chang-wooLee 한국임상수의학회 2003 한국임상수의학회지 Vol.20 No.4
The purpose of this study is to evaluate urine protein-to-creatinine ratio as a parameter for early detection of nephrotic syndrome and as a parameter for monitoring effectiveness in early course of treatment. Nine healthy dogs were sensitized by intravenous injection with 1mg of endotoxin and 5mg of native bovine serum albumin. After 1 week, 120mg of cationized bovine serum albumin was injected intravenously 5 times a week. Among nine dogs, five dogs were confirmed as having developed glomerulonephritis and nephrotic syndrome by increase of urine protein-to-creatinine ratio(>1.0), hypoalbuminemia (<1.5g/dl), hypercholesterolemia (>240mg/dl) and azotemia (BUN >40mg/dl). During the induction of glomerulonephritis and the progression to nephrotic syndrome, the increase of urine protein-to-creatinine ratio was firstly detected. 1 to 4 weeks later, hypoalbuminemia, hypercholesterolemia, and azotemia were detected. Prednisolone (2.2mg/kg, bid) was administered orally to the dogs with induced nephrotic syndrome. In early stage of treatment, the increase of serum albumin and decrease of serum cholesterol were detected. 1 to 4 weeks later, decrease of urine protein-to-creatinine ratio was detected. It was concluded that urine protein-to-creatinine ratio is a useful parameter for early detection of nephrotic syndrome, and serum albumin and cholesterol are useful parameters for the monitoring in early course of treatment in nephrotic syndrome.
Chronic Lymphocytic Leukemia in a Dog
Seong-WooJung,EulSooChoi,Jong-BokLee,Cheol-YoungHwang,Hwa-youngYoun,Chang-WooLee,Houng-RyulHan 한국임상수의학회 2002 한국임상수의학회지 Vol.19 No.4
Chronic lymphocytic leukemia is a general disease that evolves over a longer duration and is characterized by more mature and well-differentiated lymphocytes in blood and bone marrow than those seen in acute leukemia. This report presents a 2-year-old mix neutered male dog with seizure, ascites, and transmissible venereal tumor. Diagnostic works-up concluded chronic lymphocytic leukemia. Chemotherapy composed of chlorambucil and prednisolone has been applied to the patient until now. Remission of almost manifestations was achieved, and the quality of life improved.