항통풍성 약물류가 Milk Xanthine Oxidase 활성에 미치는 영향

마광진,이경태,권창호 한국분자생물학회 1994 분자생물학뉴스 Vol.22 No.-

유산균 발효에 의한 사물탕들부터 노다케네틴의 분리 및 함량분석

김동선 ( Dong Seon Kim ),노주환 ( Joo Hwan Roh ),조장원 ( Chang Won Cho ),마진열 ( Jin Yeul Ma ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.1

Objectives: The purpose of this study was to investigate the changes in the contents of constituents in Samultang and its fermentations with 10 species of lactic acid bacteria. Methods: Ten strains of lactic acid bacteria, Lactobacillus casei, L. acidophilus , L. casei, L. plantarum, L. amylophilus, L. curvatus, L. delbruekil subsp. lactis, L. casei , B. breve, and B. thermophilum, were used for the fermentation of Samultang. The increased and decreased constituents were identified using HPLC/DAD and various liquid chromatographic techniques, and the structure was elucidated using NMR and MS. These compounds were quantitatively analyzed using an HPLC/DAD system. Results: A remarkably increased component was identified to be nodakenetin and a decreased component was determined to be nodakenin. The fermentation of the ten lactic acid bacteria demonstrated that the decomposable rate of these two compounds in fermented Samultang were different. Samultang fermented by L. plantarum showed the most remarkable changes. Conclusion: Nodakenetin was identified as bioconversion component after fermentation and L. plantarum was discovered the best bacteria to increase the component.

도농간 교육격차 해소를 위한 농촌지역 유형별 교육혁신 추진과제 탐색

나승일,정철영,구자억,박행모,장호순,김진구,마상진,조단비,문세연 한국농업교육학회 2007 농업교육과 인적자원개발 Vol.39 No.1

이 연구는 교육혁신에 대한 이론적 고찰을 토대로 농촌지역 교육혁신 성공요소를 도출하고, 농촌의 지역특성을 고려하여 도농간 교육격차 해소를 위한 농촌지역 유형별 추진과제를 제시하는 데 목적이 있었다. 연구목적 달성을 위해 문헌고찰 및 사례연구를 실시하였고, 연구결과의 타당성 확보를 위해 전문가협의회를 실시하였다. 농촌지역 교육혁신 성공요소는 마을공부방 운영 등 26개가 최종적으로 도출되었다. 또한 농촌지역 교육혁신모형을 개발하여 목표와 전략을 수립하고, 이를 기초로 농촌지역 유형별 추진과제를 제시하였다. 농촌지역 교육혁신의 비전은 "도농간 교육격차 해소를 위한 교육혁신 실현으로 살고 싶은 농촌지역 구현" 으로 설정하고, 이를 달성하기 위한 목표는 도시수준의 교육기회 제공, 농촌형 수월성 교육 추구, 지역 인적자원개발로 설정하였다. 농촌지역 유형별 중점적으로 추진해야 할 과제는 발전 농촌지역은 마을 공부방 운영 및 학습도우미 지원, 중간수준 농촌지역은 교육환경 개선, 장학금 지원 및 다양한 교육기회 제공, 저개발 농촌지역은 기존 지원 유지, 적극적 학습 지원 및 교원의 근무여건 개선, 도농복합 농촌지역에서는 교통편의 제공, 학습기회 개선 및 학부모의 교육참여 유도 등이 선정되었다. 그리고 농촌지역 유형별 중점 추진과제에 대한 단계별 로드맵과 이를 적용하기 위한 정책적 제언을 제시하였다. The purpose of this research was to derive success factors and explore actions plan for the education innovation of rural areas for releasing education gaps between urban and rural areas. For the purpose, the researcher carried out literature reviews and case analysis were conducted, and experts council were executed. As a result, 26 success factors for the education innovation of rural area were derived. And, this study suggested the education innovation model of rural area including goals and strategies to identify action plan for the education innovation by types of rural areas. The vision of the education innovation model was making the place pleasant to live in by doing education innovation for releasing education gaps between urban and rural areas. The goals of the education innovation model were to provide urban-level educational opportunities, to pursue rural-customized education for excellency and to develope local human resources. This study identified several core tasks corresponding to each rural area: additional establishment and operation of village study-rooms and support for learning assistant system for highly-developed rural areas; improvement of educational condition and provision of scholarship and various educational opportunities for middle-developed rural areas; maintenance of existing support, active learning-support and improvement of teachers' working conditions for lowly-developed rural areas; provision of traffic convenience, improvement of learning opportunities and promotion of parents' educational participation for urban-rural complex areas. Moreover, this study suggested roadmap according to action plan divided by types of rural areas, and political proposal for effective actualization of that.

An Experimental Estimation of Two Detection Limit Models

Chang-Jin Ma(Chang-Jin Ma),Susumu Tohno(Susumu Tohno),Mikio Kasahara(Mikio Kasahara),Gong-Unn Kang(Gong-Unn Kang) 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.E1

In environmental studies, decisions are often made on the analytical data indicating certain contaminants as being "detected" or "non-detectible." Since detection limits are analytical method specific, one has to first review the concepts and definitions associated with analytical method systems and specifications. In this study, the experimental analytical values for a series of low level standards (for an ionic species) were used as an example to estimate two different method detection limits (MDL). The scores of EPA's MOL and Pallesen's MDL determined by real analytical scores are 0.0575 and 0.0561 mg/L, respectively for our nitrate data. These scores determined by two different MDL models are roughly similar, while there are apparent differences between two methods with respect to statistical and systematical procedure. However, detennination of MDL for one's laboratory provides some practical applications which helps to assure one's regulating authorities that one's measured scores are accurate.

Characteristics of Gas- and Particle-phase Acids and NH₃at Urban and Rural Sites in Korea

Chang-Jin Ma(Chang-Jin Ma),Hui-Kang Kim(Hui-Kang Kim),Gong-Unn Kang(Gong-Unn Kang),Susumu Tohno(Susumu Tohno),Mikio Kasahara(Mikio Kasahara) 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.E1

To study the characteristics of ammonia and the related compounds, atmospheric aerosols and gases were collected using a triple filter pack sampler, a low volume air sampler, and a three-stage Andersen air sampler in Seoul and Kangwha Island, Korea from Dec. 1996 to Oct. 1997. Ammonia concentrations showed approximately two times higher in summer than in winter at both sites. The highest HNO₃ levels were generally observed in summertime at two sampling sites. The average mass concentration of PM_2.5 in heavily industrialized Seoul was about three times higher than that of Kangwha. In winter, the sum of NH₄^+ and its counter ions (such as CI^-, NO₃^-, and S0₄²^-) comprised 30-41% of PM_2.5 mass concentration at each sampling site. Temperature dependence of particulate nitrate was examined at the urban sampling site. The formation of the nitrate in the fine mode was dependent not only on the amount of precursors but also on the variation of temperature. (NH₄)S0₄and NH₄HS0₄coexisted with NH₄NO₃and NH₄Cl at each site. According to the summertime backward trajectory analysis. NO₃- showed higher level with air parcels transported from northeast Asian continent. On the other hand, the concentration of SO₄²- showed significantly higher level when air masses originated from Pacific Ocean, southern part of Japan. and Korea.

A Novel Herbal Medicine KIOM-MA Exerts an Anti-Inflammatory Effect in LPS-Stimulated RAW 264.7 Macrophage Cells

Oh, You-Chang,Cho, Won-Kyung,Jeong, Yun Hee,Im, Ga Young,Kim, Aeyung,Hwang, Youn-Hwan,Kim, Taesoo,Song, Kwang Hoon,Ma, Jin Yeul Hindawi Publishing Corporation 2012 Evidence-based Complementary and Alternative Medic Vol.2012 No.-

<P>KIOM-MA was recently reported as a novel herbal medicine effective for atopic dermatitis and asthma. In this study, we have demonstrated the inhibitory effect of KIOM-MA on proinflammatory mediator produced in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. KIOM-MA significantly inhibited the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) as well as nitric oxide (NO) and prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>). Consistent with the inhibitory effect on PGE<SUB>2</SUB>, KIOM-MA suppresses the LPS-induced migration of macrophages and gelatinase activity and the expression of matrix metalloprotease-9 (MMP-9) in a dose-dependent manner. Additionally, KIOM-MA showed a strong suppressive effect on the inflammatory cytokines production such as tumor necrosis factor-<I><I>α</I></I> (TNF-<I><I>α</I></I>) and interleukin-6 (IL-6). We also found that KIOM-MA inhibits the activation of nuclear factor-<I><I>κ</I></I>B (NF-<I><I>κ</I></I>B) and represses the activity of extracellular signal-regulated kinase (ERK), p38, and c-Jun NH<SUB>2</SUB>-terminal kinase (JNK) mitogen-activated protein kinases (MAPKs). Taken together, we elucidated the mechanism of anti-inflammatory effect of KIOM-MA using RAW 264.7 cells stimulated by LPS.</P>

Measurement of Insoluble Mineral Particles in a Saturated Atmosphere

Chang-Jin Ma,Sung-Boo Choi 한국대기환경학회 2008 한국대기환경학회지 Vol.24 No.E1

This study was undertaken to measure the properties of individual mineral particles in an artificially saturated atmosphere at a vertical extinct mine with 430 m height. By synchrotron radiation X-ray fluorescence (SRXRF) microprobe analysis, it was possible to determine the elemental composition of residual insoluble particles on individual cloud droplet replicas formed on the Collodion film. The XRF visualized elemental maps enabled us not only to presume the chemical mixing state of particles retained in cloud droplet, but also to estimate their source. Details about the individual mineral particles captured by artificial cloud droplets should be helpful to understand about the removal characteristics of dust particles such as interaction with clouds. Nearly all individual particles captured in cloud droplets are strongly enriched in Fe. Mass of Fe is ranged between 41 fg and 360 fg with average 112 fg. There is a good agreement between single particle analysis by SR-XRF and bulk particle analysis by PIXE.

Physicochemical Characteristics of Single Asian Dust Storm Particles

Chang Jin Ma,Mikio Kasahara,Kyung Chul Hwang,Kum Chan Choi,Seong Boo Choi,Jeong Joo Lee 한국대기환경학회 2000 한국대기환경학회지 Vol.16 No.E

Micro-PIXE as a Technique for Multi-elemental Detection and Localization in Various Atmospheric Environmental Samples

Chang-Jin Ma,Sung-Boo Choi 한국대기환경학회 2008 한국대기환경학회지 Vol.24 No.E1

Microbeam PIXE, often called micro-PIXE, is one of powerful tools for analyzing a wide range of elements for various samples. Moreover, it has important applications of interest to the atmospheric science. In the present study, a qualitative elemental imagination for various atmospheric environmental species was attempted using micro-PIXE. Especially, in combination with a novel individual droplet collection method and the micro-PIXE analytical technique, the chemical specification of various individual atmospheric samples could be carried out. Here, we briefly introduce the results of an application of micro-PIXE to the study of atmospheric environment. The detailed spatial resolution of multiple elements for various samples like individual ambient particles, individual raindrops, individual fog droplets, and individual snow crystals could be successfully achieved by scanning 2.6 MeV H? micro beam (1~2 ㎛) accelerated by 3 MeV single-end accelerator.

Energy Policy And Education in Japan

Chang-Jin Ma 한국대기환경학회 2008 한국대기환경학회 학술대회논문집 Vol.- No.-