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CGNS Data Format을 지원하는 CFD 전/후처리장치의 개발
김사량,방선희,원찬식,허남건 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-
In the present study, a pre/post-processor for CFD program is developed and the CGNS library is used to exchange grid data between different CFD programs. The CGNS library is useful to store, retrieve and exchange CFD Data. It can be easily implemented in C, C++, Fortran77 and Fortran90 applications. The developed pre/post-processor is build with Visual C++ and can be run on Microsoft Windows platforms. OpenGL library is used to manipulate graphic view which consists of many vertices and cell data.
제왕절개술 환자에서 수술전 투여한 ketamine의 혈청 interleukin-6 및 수술후 통증에 대한 효과
김진수,김유재,안기량,김천숙,김일호,한찬수 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2
The inflammatory reaction to tissue damage during surgery may induce central sensitization followed by hyperalgesia. Previous studies suggest that central sensitization is related to N-methyl-D-aspartate (NMDA) receptor activation, which can be blocked with NMDA antagonist, ketamine. Thus, we compared the effect of preoperative intravenous and epidural low doses of ketamine with placebo on serum interleukin-6 (IL-6) level and postoperative pain. ASA class I and II women scheduled for C-sections received intravenous ketamine 0.15mg/kg(group 2) or placebo(group 1), or epidural ketamine(0.15 mg/kg) before the operation. IL-6 levels were measured before and during the operation, and 8, 24, and 48 hrs after the operation. Visual Analogue Scales(VAS) and Verbal Ration Scales(VRS) were measured at 8, 24, and 48 hrs after the operation. Serum IL-6 levels at 8, 24, and 48 hrs after the operation were significantly lower in the intravenous ketamine and epidural ketamine groups than in the control group. VAS at 8 hrs and 48 hrs after the operation were significantly lower in the epidural ketamine group. VAS at 8 hrs and 48 hrs after the operation were significantly lower in the epidural ketamine group than in the control and intravenous ketamine groups. In conclusion, in the preoperative intravenous and epidural administration of low doses(0.15mg/kg) of ketamine, both are effective in reducing postoperative IL-6 levels. Epidural Ketamine is more effective than intravenous ketamine in postoperative pain control.
박찬량 국민대학교 2003 기초과학연구소 논문집 Vol.22 No.-
266㎚ 광분해로부터 생성된 들뜬 전자생태의 산소원자(O(¹D₂))와 H₂로부터 생성된 OH의 내부에너지 분포를 레이저유발 형광법을 이용하여 연구하였다. O(¹D₂)와 H₂의 반응은 매우 들뜬 회전 및 진동상태의 OH를 생성하였다. 또한 생성된 OH는 ∏(A′)Δ 레벨에 대한 선호도를 나타내었으며 이는 OH 생성물의 회전평면이 반응 중간체인 H₂O의 분자평면과 일치함을 의미한다. The distributions of the internal energies of nascent OH produced from the reaction of O(¹D₂) with H₂ was investigated using laser induced fluorescence technique. O(¹D₂) was produced from the photolysis of O₃ at 266nm. Reaction of O(¹D₂) with H₂ yields highly vibrationally and rotationally excited OH displaying the propencity for ∏(A’) A sublevel production characteristic of reactions in which the rotational plane of the OH product coincides with the plane of a triatomic intermediate complex.
Clausena anisata-mediated protection against lipopolysaccharide-induced acute lung injury in mice
JEON, CHAN-MI,SHIN, IN-SIK,SHIN, NA-RAE,HONG, JU-MI,KWON, OK-KYOUNG,KIM, JUNG-HEE,OH, SEI-RYANG,BACH, TRAN-THE,HAI, DO-VAN,QUANG, BUI-HONG,CHOI, SANG-HO,LEE, JOONGKU,MYUNG, PYUNG-KEUN,AHN, KYUNG-SEOP Spandidos Publications 2016 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.37 No.4
<P>Clausena anisata (Willd.) Hook.f. ex Benth. (CA), which is widely used in traditional medicine, reportedly exerts antitumor, anti-inflammatory and other important therapeutic effects. The aim of the present study was to investigate the potential therapeutic effects of CA in a mouse model of lipopolysaccharide (LPS)-induced acute lung injury (ALI) and in LPS-stimulated RAW 264.7 cells. Male C57BL/6 mice were administered treatments for 3 days by oral gavage. On day 3, the mice were instilled intranasally with LPS or PBS followed 3 h later by oral CA (30 mg/kg) or vehicle administration. In vitro, CA decreased nitric oxide (NO) production and pro-inflammatory cytokines, such as interleukin (IL)-6 and prostaglandin E2 (PGE(2)), in LPS-stimulated RAW 264.7 cells. CA also reduced the expression of pro-inflammatory mediators, such as cyclooxygenase-2. In vivo, CA administration significantly reduced inflammatory cell numbers in the bronchoalveolar lavage fluid (BALF) and suppressed pro-inflammatory cytokine levels, including tumor necrosis factor-alpha (TNF-alpha), IL-6, and IL-1 beta, as well as reactive oxygen species production in the BALF. CA also effectively reduced airway inflammation in mouse lung tissue of an LPS-induced ALI mouse model, in addition to decreasing inhibitor kappa B (I kappa B) and nuclear factor-kappa B (NF-kappa B) p65 phosphorylation. Taken together, the findings demonstrated that CA inhibited inflammatory responses in a mouse model of LPS-induced ALI and in LPS-stimulated RAW 264.7 cells. Thus, CA is a potential candidate for development as an adjunctive treatment for inflammatory disorders, such as ALI.</P>
외부 및 내부 확산을 적용한 인도네시아 석탄촤의 연소 반응율 분석
황찬원 ( Chan Won Hwang ),김량균 ( Ryang Gyoon Kim ),류광일 ( Kwang Il Ryu ),오택림 ( Ze Lin Wu ),전충환 ( Chung Hwan Jeon ) 한국화학공학회 2014 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.52 No.1
본 연구의 목적은 국내 화력발전소에서 사용중인 인도네시아 석탄촤의 연소반응율을 연구하는 것이다. 석탄촤의 반응율은 External, Internal effectiveness factor를 고려하여 입자 내부 및 외부확산을 정량적으로 정리하였으며, Random pore model을 사용하여 탄소변환율에 따른 입자내부비표면적의 변화를 반영하였다. 가열 및 측정이 가능한 WHR(Wire Heating Reactor)를 활용하여 반응시간을 측정함으로써 석탄촤의 반응율을 도출하였고 BET(Brunauer-Emmett-Teller) 및 TGA(Thermo-Gravimetric Analysis) 장비를 활용하여 석탄촤의 물리적인 특성인 내부비표면적과 Random pore model 의 구조변수(ψ)를 측정하였다. 석탄 종에 따른 활성화에너지 및 빈도인자를 도출하기 위해 아역청탄인 BARAMULTI, ENERGYMAN, AGM탄을 사용하였다. 본 연구 결과에서 External, Internal effectiveness factors를 통해 확산에 따른 kinetics를 비교한 결과 외부 확산 보다 내부 확산의 영향이 지배적임을 확인하였다. 최종적으로 내부 및 외부 확산에 대한 영향을 고려한 3종의 석탄촤 Intrinsic kinetics의 활성화에너지는 110~118 kJ/mol의 값을 보였다. The experiment was designed to compare the char combustion kinetics of pulverized Indonesia coals commonly utilized in Korea power plants. The reaction rate of coal char has been formulated using the external and internal effectiveness factors to describe the diffusion effect quantitatively. The Random Pore Model (RPM) was used for applying internal specific surface area as a function of carbon conversion ratio. Reaction rate was obtained from reaction time using the Wire Heating Reactor (WHR) which can heat and measure the char particle temperature at the same time. BET and TGA were used to obtain physical properties such as internal specific surface area and structural parameter. Three kinds of Indonesia Sub-bituminous coals "BARAMULTI, ENERGYMAN, AGM" were used in order to derive the activation energy and pre-exponential factor. The results of this study showed that the effect of internal diffusion than that of external diffusion is the dominant as comparison of kinetics was reflected in external and internal effectiveness factors. For three kinds of coal char, finally, activation energy of intrinsic kinetics indicates 110~118 kJ/mol.