Effects of 5-HT₄ selective receptor agonist, mosapride citrate on electrocardiogram in dogs

Chae, Ji Sang,Ahn, Jin Ok,Coh, Ye Rin,Park, Chong Woo,Youn, Hwa Young The Korean Society of Veterinary Science 2012 大韓獸醫學會誌 Vol.52 No.3

Mosapride stimulated dietary motility was introduced because of the arrhythmogenic effect of cisapride. Cisapride, 5-HT receptor agonist, induces prolongation of QT interval. Additionally, this condition can raise the possibility of acute, "malignant" arrhythmias such as torsade de pointes. It is hard to find any reports about effects of mosapride on cardiac parameters in dogs. By confirming electrocardiogram (ECG) parameters, the surface extremity leads ECG that was obtained from the four-limb electrodes and which was recorded by an ECG recorder after administration of mosapride 3 mg/kg PO b.i.d, and mosapride 3 mg/kg with itraconazole 5 mg/kg PO b.i.d, respectively. QT interval was shortened on the days of 3, 5, and post-day 1 in both mosapride 3 mg/kg administrated group and mosapride with itraconazole group. Heart rate increased significantly. QTc was slightly prolonged in mosapride administration group and mosapride with itraconazole group. However, all dogs of QTc were in normal variation (150~250 msec). Besides, the dogs showed no side effects reported in human medicine during the administration with these drugs. Although mosapride can increase the heart rate, this study suggest that mosapride may be useful for the dogs with disorders of gastrointestinal motility because of no fatal arrhythmogenic effect inspite of administration with itraconazole in dogs.

VRacing: An First Person Narrative VR Simulator to Measuring User Experience in Autonomous Vehicle

( Chae Rin Im ),( Ji In Lee ),( Hye Soo Yoo ),( Ji Yoon Sung ),( Jin Woo Kim ) 한국감성과학회 2015 추계학술대회 Vol.2015 No.-

The concept of driving has been re-defined within the evolution that it has evolved to the self-driving technology. By emerging this new paradigm of driving, researchers need to reconsider changing the primary task while driving the car. Also, many researchers have emphasized the understanding of interaction between human and autonomous vehicle in the field of affective science and engineering. However, a major problem with this research domain is lack of research instrument based on autonomous driving. The existing research of traditional driving used experiment methodology with various simulators to conduct psychology, affection, and user experience (UX) of driver. In this paper, we propose VRacing . a first person driving simulator that considers the context of autonomous vehicle in Virtual Reality environment. To achieve our research goal, we first developed five scenarios which are built within the simulator system from prior researches covering from the driver-assisted systems to autonomous driving. And we ascertain the interface and the features based on a Driver Assistance System. Finally, we implemented VRacing with Unity 5.1 and VR device (Samsung Gear VR).

냉방에너지서비스 측면에서 통합수요관리 정책추진 효과분석

이우남(Woo-Nam Lee),박종배(Jong-Bae Park),신중린(Joong-Rin Shin),조기선(Ki-Seon Cho),김형중(Hyeong-Jung Kim),채명석(Myung-Suk Chae) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

본 논문은 난방에너지부문에 통합수요관리정책을 추진할 경우의 효과를 분석하기 위해서 난방기술별 비교우위 및 난방방식간의 전환효과를 분석하였다. 냉방공급방식으로는 전기냉방, 가스냉방, 빙축열 냉방을 채택하였으며, 동일한 냉방서비스 공급에 대한 1차에너지소비량, 이산화탄소배출량, 그리고 연료비용을 비교분석하였다. 또한, 에너지원별 에너지가격정책에 따른 가격왜곡현상의 유무에 따른 영향을 시나리오에 기초하여 분석하였다. 본 연구의 시나리오 분석을 통해, 전기냉방수요의 20%를 가스냉방수요로 전환할 경우에 연간 3,141억원의 사회적 편익이 발생할 수 있음을 확인하였다.

SNS를 이용한 가상화폐 거래 시스템 구축

채희주(Chae Hee-joo),이희재(Lee Hee-Jae),최하영(Choe Ha-young),신아엘(Sin A-el),이유림(Lee Yu-lim),김시우(Kim Sea-Woo),박서린(Seo-Rin Park),김주은(Ju-en Kim),김수린(Su-Rin Kim) 한국정보기술학회 2015 Proceedings of KIIT Conference Vol.2015 No.6

본 논문에서는 가상화폐인 비트코인의 활용방안을 고안 및 가격 비교 사이트 형태의 신설 거래 시스템을 제안한다. 가상화폐인 비트코인은 세계가 주목하고 있으나 현재로서는 활용 방안이 제공되고 있지 않을 뿐만 아니라 사이버 화폐 자체에 대한 부정적인 시각과 회의와 비평만이 있었다. 그러나 본 과제에서는 그러한 회의와 비평을 다른 각도로 접근하여 부정적인 시야로 비춰지는 비트코인의 발전 가능성을 높이 평가했으며, 비트코인 자체로 거래하는 것과 홈트레이딩 시스템을 이용한 시스템 모듈로 새로운 경제시장 구축을 도울 수 있다는 것에 초점을 두며, 쿠차와 비슷한 모듈로 새로운 오픈 플랫폼 형식의 사이트를 고안했다. This paper builds the cyber currency ? bit coin exchange system. Our system searches global countries’ bit coin exchange sites and suggests best buying and selling sites. This system operates similar to COOCHA which searches social commerce products and list prices. Our system can expand to the other cyber currency exchange systems. This enables the global cyber exchange platform eventually.

모바일 소셜 네트워크 게임의 제약과 지원 기능이 사용자의 만족에 미치는 영향

임채린(Chae-Rin IM),신영수(Young-soo SHIN),김진우(Jin-woo KIM),이인성(In-seong LEE) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.7

피쳐폰 시대부터 최근 소셜 네트워크 게임(SNG)의 광풍에 이르기까지 모바일 게임은 모바일 폰의 킬러콘텐츠로써, 큰 시장 규모와 매출을 자랑하고 있다. 게임 분야의 연구 관점에서 보았을 때, 모바일 게임은 플레이 기기의 스펙부터 플레이 환경까지 사용자에게 제약이 많이 주어지므로, 사용자 만족도에 부정적일 것이라는 예측을 할 수 있다. 그러나 대다수의 모바일 게임 사용자는 게임 경험에 굉장히 만족하고 있다. 이에 따라, 제약이라는 개념에 주목하였다. 또한 제약과 지원이라는 개념을 동시에 독립 변수로 설정하고, 이러한 요인이 사용자의 몰입과 만족에 어떠한 영향을 미치는지 설문조사 방법론을 통해 검증하고자 하였다. 분석 결과, 모바일 게임에서는 제약이 몰입에 긍정적인 영향을 미치는 것으로 나타났으며, 제약을 통해 불편함을 느끼는 것이 아니라 만족감을 얻을 수 있음을 확인하였다. 이를 통해 향후 모바일 게임의 UX 디자인 과정에서 해당 연구들의 결과를 활용할 수 있으리라 기대한다. From the era of feature phone to the current smart phone which bloomed Social Network Games(SNGs), mobile games have held the top position as killer contents of mobile market. Mobile game has many constraints such as specification of device, network status, and external environment. Based on common perspective of game research, these factors have negative influences on flow of user. Even with these opinions, most mobile gamers have felt satisfaction. To explain this phenomenon, our research focuses on the constraints. Referring to theoretical concepts, we attempt to clarify the relationship between game features and flow through survey methodology. Our finding shows that the constraints have a positive effect on flow even though it disaccords with previous studies. Therefore, we argue that users of mobile game have sense of satisfaction not a cognitive overload as discomforts.

Progression-Free Survival: An Important Prognostic Marker for Long-Term Survival of Small Cell Lung Cancer

( Myoung Rin Park ),( Yeon Hee Park ),( Jae Woo Choi ),( Dong Il Park ),( Chae Uk Chung ),( Jae Young Moon ),( Hee Sun Park ),( Sung Soo Jung ),( Ju Ock Kim ),( Sun Young Kim ),( Jeong Eun Lee ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5

Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients` survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods: A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox`s analyses were performed to identify the independent factors. Results: The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25-6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59-6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98-41.73; p<0.001) were independent prognostic markers for poor survival rates. Conclusion: In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.

통합수요관리를 통한 난방에너지 이용합리화 방안

이우남(Woo-Nam Lee),박종배(Jong-Bae Park),신중린(Joong-Rin Shin),조기선(Ki-Seon Cho),김형중(Hyeong-Jung Kim),채명석(Myung-Suk Chae) 대한전기학회 2009 대한전기학회 학술대회 논문집 Vol.2009 No.7

본 논문은 최근 고유가에 따른 전기난방 수요의 급증 현상이 에너지이용효율 측면에서 바람직한 방향인지 난방방식별 효율성을 객관적 기준에서 분석하였다. 난방방식으로는 전기난방, 가스난방, 유류난방 방식을 채택하였으며, 동일한 난방서비스 공급을 위한 1차에너지소비량, 이산화탄소배출량, 그리고 연료비용을 비교분석하였다. 또한, 에너지원별 에너지가격정책에 따른 가격왜곡현상의 유무에 따른 영향을 시나리오에 기초하여 분석하였다. 본 연구의 시나리오 분석을 통해, 전기 난방 특히 전열난방방식(전열난방수요의 20%)을 가스난방으로 전환할 경우에 연간 7,214억원의 사회적 편익이 발생할 수 있음을 확인하였다.

실변수 TABU탐색기법을 이용한 최적조류계산

정창우(Chang-Woo Jung),이명환(Myung-Hwan Lee),신중린(Joong-Rin Shin),채명석(Myung-Suk Chae) 대한전기학회 2001 대한전기학회 학술대회 논문집 Vol.2001 No.7

정상인 및 아토피 피부염 환자의 건성 피부에서 Sodium Lauryl Sulphate로 유도된 자극성 피부 반응에 대한 Lactic Acid 와 Sodium Pyrrolidone Carboxylic Acid 도포의 효과

최성우,우혜진,김형옥,이하린,채구석 대한피부과학회 2000 대한피부과학회지 Vol.38 No.1

Background:Natural moisturizing factors such as sodium pyrrolidone carboxylic acid and lactic acid may play an important role in increasing the moisture retention of isolated stratum corneum and reducing the incidence of dry and flaky skin in vivo. Although the precise mechanism of surfactant irritancy is not fully understood, it has been suggested that barrier dysfunction of stratum corneum by surfactants results in skin changes such as scaling, erythema, and even fissuring. Objective:We evaluated the effect of sodium pyrrolidone carboxylic acid(NaPCA) and lactic acid(LA) with several non-invasive measuring methods in the irritated skin reaction induced by sodium lauryl sulphate (SLS) in normal persons and atopic dermatitis patients. Methods:After skin irritation for 24 hours with patch test of 1% SLS on five volar sites of right forearm, we applied nothing(A), 3% LA+3% NaPCA(B), 3% LA(C), 3% NaPCA(D), and vehicle(E) twice a day respectively. Visual score, transepidermal water loss(TEWL), water holding capacity(WHC), and erythema index were measured at 30 min, 24hr, 48hr and 72hr after patch removal. Results: 1. After 72hr, the visual scores of B and C were significantly lower than that of A(control) in atopic dermatitis patients, and that of C in normal persons was significantly lower than that of A, D, and E. 2. TEWL values of B and C in both the normal (after 72hr) and atopic dermatitis group (after 48hr and 72hr) were significantly lower than that of A. 3. WHC values of B, C, D in both the normal and atopic dermatitis group were significantly higher than that of A after 48hr and 72hr. 4. After 72hr, erythema indices by Mexameter of B, C, and D in both the normal and atopic dermatitis group were significantly lower than that of A and values of C were significantly lower than that of E. In the atopic dermatitis group, values of D were also significantly lower than that of E. 5. The mean visual score was significantly correlated with TEWL value and erythema index of Mexameter (r=0.58, r=0.64) and the TEWL value was significantly correlated with erythema index of Mexameter (r=0.64). Conclusion:These results suggest that topical application of a moisturizing factor might improve the surfactant-induced disruption of permeability barrier with improvement of the water holding capacity of the stratum corneum.

Progression-Free Survival: An Important Prognostic Marker for Long-Term Survival of Small Cell Lung Cancer

Park, Myoung-Rin,Park, Yeon-Hee,Choi, Jae-Woo,Park, Dong-Il,Chung, Chae-Uk,Moon, Jae-Young,Park, Hee-Sun,Jung, Sung-Soo,Kim, Ju-Ock,Kim, Sun-Young,Lee, Jeong-Eun The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5

Background: Small cell lung cancer (SCLC) is an extremely aggressive tumor with a poor clinical course. Although many efforts have been made to improve patients' survival rates, patients who survive longer than 2 years after chemotherapy are still very rare. We examined the baseline characteristics of patients with long-term survival rates in order to identify the prognostic factors for overall survivals. Methods: A total of 242 patients with cytologically or histologically diagnosed SCLC were enrolled into this study. The patients were categorized into long- and short-term survival groups by using a survival cut-off of 2 years after diagnosis. Cox's analyses were performed to identify the independent factors. Results: The mean patient age was 65.66 years, and 85.5% were males; among the patients, 61 of them (25.2%) survived longer than 2 years. In the multivariate analyses, CRP (hazard ratio [HR], 2.75; 95% confidence interval [CI], 1.25-6.06; p=0.012), TNM staging (HR, 3.29; 95% CI, 1.59-6.80; p=0.001), and progression-free survival (PFS) (HR, 11.14; 95% CI, 2.98-41.73; p<0.001) were independent prognostic markers for poor survival rates. Conclusion: In addition to other well-known prognostic factors, this study discovered relationships between the long-term survival rates and serum CRP levels, TNM staging, and PFS. In situations with unfavorable conditions, the PFS would be particularly helpful for managing SCLC patients.