환자용 기분기록지 개발 및 타당도 연구

차보석,최정은,장재승,김정현,하태현,유희정,최승원,하규섭 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives The aim of this study was to report the developmental process of the patient mood chart (named the Patient Mood Chart, PMC), and to test its validity and utility. Methods One hundred twenty nine subjects with bipolar disorder, as diagnosed using DSM-IV Criteria, completed the PMC. A trained clinician administered the Hamilton Depression Rating Scale (HDRS) the Montgomery Asberg Depression Rating Scale (MADRS), the Inventory of Depressive Symptomatology (IDS), the Young Mania Rating Scale (YMRS) and the Global Assessment of Functioning (GAF). Mood ratings on the PMC were compared with clinician-rated measures taken at initial visits and 6-month follow-ups. To examine the utility of the PMC, a patient questionnaire-type survey was done Results Depressive symptom ratings on the PMC were highly correlated with the HAMD MADRS and IDS scores. Manic symptom ratings on the PMC were correlated with the YMRS scores. Similarly a strong correlation was found between mood chart scores and the GAF scores. Most patients Considered the PMC to be useful and helpful. Conclusion These findings support the validity and utility of the PMC. The PMC can be used for Prospective assessment of symptom changes, treatment response, and long-term course for subjects with bipolar disorder.

한국 토종닭 집단의 혈통구조 및 유효집단크기 추정

차재범(Jaebeom Cha),박병호(Byoungho Park),박미나(Mina Park),강하연(Hayoun Kang),김용민(Yongmin Kim),김종대(Chongdae Kim),허강녕(Kangnyeong Heo),추효준(Hyojun Choo),강보석(Boseok Kang) 한국가금학회 2017 韓國家禽學會誌 Vol.44 No.2

본 연구에서는 가금연구소에서 집단의 혈통 구조 및 근친수준을 평가하기 위하여 근교계수와 유효집단크기를 추정하였으며, 추정한 근교계수의 신뢰 정도를 제시하기 위하여 혈통의 품질로써 1) 아비 · 어미를 모두 아는 개체의 비율과 2) 근교계수가 0이 아닌 개체의 비율을 태어난 부화 년도와 계통에 따라 제시하였다. 아비 · 어미를 모두 아는 개체의 비율에서 대부분 계통이 1∼2년 사이에 거의 100%에 도달하였으며, 근교계수가 0이 아닌 개체의 비율에서 기초집단인 0세대부터 5∼6년 사이에 비율이 100%에 가깝게 도달하는 것을 보면 가금연구소 혈통기록 시스템이 잘 이루어졌으며, 이 논문에서 추정한 근교계수가 신뢰할 수 있음을 나타낸다. 각 계통의 평균 근교계수에서는 20세대 동안 7.6∼10.9%의 근교계수 상승도를 보였다. 세대당 가장 높은 근교계수 상승도를 보인 계통은 S계통으로 10세대 동안 8.2%의 근교계수 상승도를 보였으며, 평균 번식에 참여한 아비 · 어미의 수가 다른 계통에 비해 낮은 것이 원인인 것으로 사료된다. 평균 근교계수 변화량(ΔF)으로 추정한 유효집단크기를 보면 모든 계통에서 평균 근교계수 변화량이 0.39∼0.85%로 1% 이하로 관리되는 것을 보이며, 따라서 유효집단크기도 모든 계통에서 50 이상의 값을 보였으며, 현 교배 관리에서 토종닭 집단이 단시간에 근친퇴화나 집단의 멸종으로부터의 위험으로부터 안전하다고 사료된다. 그리고 유효집단크기를 유지하기 위하여, 즉 유전적 다양성을 유지하기 위하여, 적정 수의 아비 · 어미가 번식에 참여해야 된다고 사료된다. The purpose of this study was to estimate the inbreeding level and effective population size of Korean indigenous chickens. In the study, two variables were considered to evaluate the pedigree completeness: (1) the proportion (%) of animals with complete pedigree, and (2) the proportion of animals with inbreeding coefficients greater than zero. In the proportion of animals having complete pedigree, all strains reached almost 100% completeness in 1∼2 years. In the proportion of animals with inbreeding coefficients greater than zero, all strains reached almost 100% completeness in 5∼6 years. We considered that the pedigree recoding system is well managed and that the inbreeding coefficient is a reliable measure. Over the past 20 years, the increase of inbreeding coefficients in Korean indigenous chicken strains has been 7.6∼10.9%. The S strain showed the most rapid increase of inbreeding coefficient of 8.2% in 10 years. The reason for this rapid increase is considered to be associated with the fact that the numbers of sires and dams involved in reproduction was 115 and 91, respectively, which are lower than those of the other strains. According to average rates of increase in inbreeding coefficients (ΔF), all strains have ΔF values of 0.39∼ 0.85%, which is lower than 1%, and the effective population size is above 50. The results showed that inbreeding levels were within the acceptable range and that Korean indigenous chicken population scan be regarded as safe from the threat of extinction.

농촌지역 주민들에서 만성 의학적 질환이 자살사고에 미치는 영향

장지훈(Jihoon Jang),차보석(Boseok Cha),이동윤(Dongyun Lee),강경희(Gyeong Hui Kang),이선숙(Sun Sook Lee),홍미향(Mi Hyang Hong),강미옥(Mi Ok Kang),김봉조(Bong-Jo Kim),이철순(Cheol-Soon Lee),이소진(So-Jin Lee),서지영(Jiyeong Seo),안인영(In 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.3

Objectives:This study attempted to investigate the effects of chronic medical diseases on suicidal ideation in a rural population, focusing on differences between adults and elderly individuals. Methods:We conducted a community-based, cross-sectional study on 682 subjects residing in rural areas. Participants aged 18–79 years were interviewed at home to assess the presence of current or past chronic medical diseases(lifetime). All participants completed the Center for Epidemiologic Studies Depression scale, Beck Scale for Suicide Ideation, Beck Anxiety Inventory, Alcohol Use Disorder Identification Test, and Barratt Impulsiveness Scale-11. Multiple logistic regression analysis was conducted to analyze the influences of chronic medical diseases on suicidal ideation in the “adult group” and “elderly group.” Results:In the unadjusted model, cardiovascular diseases(odds ratio : OR, 11.86; 95% confidence interval : 95% CI, 3.07-45.83), arthritis(OR, 3.72; 95% CI, 1.55-8.95), and cerebrovascular diseases(OR, 9.47 : 95% CI, 2.64-34.00) were significantly associated with increased suicidal ideation among adults. Furthermore, the association between cardiovascular diseases and increased suicidal ideation remained significant(OR, 12.53 : 95% CI, 1.51-104.17) after adjusting for sociodemographic factors, depression, anxiety, impulsivity, and problematic alcohol use. In elderly group, arthritis was the only significant risk factor for increased suicidal ideation in both unadjusted and adjusted models(OR, 2.80; 95% CI, 1.13-6.94 and OR, 3.71; 95% CI, 1.05-13.08, respectively). Conclusion:Chronic medical diseases that were associated with suicidal ideation differed by age group. This study suggests that primary-care physicians need to carefully assess suicidal ideation in adult patients with cardiovascular diseases and elderly patients with arthritis.

시장·군수·구청장에 의한 입원을 한 정신과 환자의 인구학적 및 임상적 특성

신윤미(Youn Mi Shin),차보석(Boseok Cha),고효정(Hyo Jung Ko) 대한사회정신의학회 2010 사회정신의학 Vol.15 No.2

연구목적: 본 연구는 시장·군수·구청장에 의한 입원을 하였던 환자들의 사회인구학적, 임상적 특성을 알아보고자 하였다. 방 법: 시장·군수·구청장에 의한 입원을 하였던 138명 환자들의 3년간 의무기록 자료를 분석하였다. 연구대상군을 두 개 그룹으로 나누었다. 3개월 이내로 입원을 하였던 단기재원 환자군, 3개월 이상 입원한 장기재원 환자군. 두 군간에 인구학적, 임상적 변인을 비교하였다. 장기재원을 예측할 수 있는 임상적 변인들을 조사하였다. 그리고, 퇴원 이후 치료중단율과 재입원 형태도 조사하였다. 결 과: 99명(72%) 환자들이 단기재원 환자군에 속했으며, 39명(28%)이 장기재원 환자군에 속했다. 장기 재원을 예측할 수 있는 의미있는 변인들로는 의료보호 1종, 실직상태 및 입원기간 중 2가지 항정신병약물 사용이었다. 시장·군수·구청장에 의한 입원 환자들은 퇴원후 외래치료 중단율이 높았다. 절반 이상의 환자들(53.3%)이 퇴원 직후 바로 치료가 중단되었으며, 6개월째 누적 치료 중단율은 86.1%였다. 재입원시 가장 흔한 입원 형태는 자의입원(60%)이었다. 결 론: 이번 연구는 의료보장형태 및 질병의 심각도가 장기 재원과 관련됨을 시사한다. 시장·군수·구청장에 의한 입원을 하였던 환자들이 높은 치료중단 위험성을 갖고 있다는 것을 고려하여, 이를 줄이기 위한 전략들이 필요하겠다. Objectives:The aim of this study was to examine demographic and clinical characteristics in patients hospitalized by the order of local authorities. Methods:Three years of clinical data from the medical records of 138 patients hospitalized by the order of local authorities were analyzed. Subjects were divided into 2 groups:length of stay less than 3 months(Short-term hospitalization, SH), and more than 3 months(Long-term hospitalization, LH). Demographic and clinical variables were compared between the two groups. We investigated the clinical variables that could predict LH. We also examined the dropout rate and readmission pattern after hospital discharge. Results:Ninty nine patients(72%) belonged to SH group, and 39(28%) to LH group. The significant clinical variables that could predict a longer length of stay were medicaid type I, unemployment, and use of two antipsy-chotics during admission. Dropout rates were high during outpatient follow-up. Slightly more than half of pa-tients (53.3%) did not attend first follow-up outpatient clinic immediately after discharge. At 6 month after discharge, cumulative dropout rates were 86.1%. The most common pattern of readmission was voluntary hospitalization(60%). Conclusion:This study suggests that type of medical security and severity of disorder might be associated with a longer length of stay. Given that patients hospitalized by the order of local authorities have a high risk for dropout, strategies for decreasing dropout are needed.

High Performance of Low Band Gap Polymer-Based Ambipolar Transistor Using Single-Layer Graphene Electrodes

Choi, Jong Yong,Kang, Woonggi,Kang, Boseok,Cha, Wonsuk,Son, Seon Kyoung,Yoon, Youngwoon,Kim, Hyunjung,Kang, Youngjong,Ko, Min Jae,Son, Hae Jung,Cho, Kilwon,Cho, Jeong Ho,Kim, BongSoo American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.10

<P>Bottom-contact bottom-gate organic field-effect transistors (OFETs) are fabricated using a low band gap pDTTDPP-DT polymer as a channel material and single-layer graphene (SLG) or Au source/drain electrodes. The SLG-based ambipolar OFETs significantly outperform the Au-based ambipolar OFETs, and thermal annealing effectively improves the carrier mobilities of the pDTTDPP-DT films. The difference is attributed to the following facts: (i) the thermally annealed pDTTDPP-DT chains on the SLG assume more crystalline features with an edge-on orientation as compared to the polymer chains on the Au, (ii) the morphological features of the thermally annealed pDTTDPP-DT films on the SLG electrodes are closer to the features of those on the gate dielectric layer, and (iii) the SLG electrode provides a flatter, more hydrophobic surface that is favorable for the polymer crystallization than the Au. In addition, the preferred carrier transport in each electrode-based OFET is associated with the HOMO/LUMO alignment relative to the Fermi level of the employed electrode. All of these experimental results consistently explain why the carrier mobilities of the SLG-based OFET are more than 10 times higher than those of the Au-based OTFT. This work demonstrates the strong dependence of ambipolar carrier transport on the source/drain electrode and annealing temperature.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-10/acsami.5b00747/production/images/medium/am-2015-00747f_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b00747'>ACS Electronic Supporting Info</A></P>

Association between morningness and resilience in Korean college students

Lee, So-Jin,Park, Chul-Soo,Kim, Bong-Jo,Lee, Cheol-Soon,Cha, Boseok,Lee, Yu Jin,Soh, Minah,Park, Jin Ah,Young, Park So,Song, Eun Hye Informa UK (Taylor Francis) 2016 Chronobiology international Vol.33 No.10

<P>Circadian typology and sleep quality may be essential factors associated with the promotion of resilience. However, previous studies investigating the association between circadian typology and resilience did not analyze the effects of sleep quality on resilience. Thus, the present study evaluated the association between circadian typology and resilience in Korean college students after controlling for sleep quality. Additionally, this study investigated several sleep-related variables, including sleep duration, social jetlag and sunlight exposure during the daytime, to examine the modifiable behavioral features of morningness and also investigated whether the findings regarding morningness-related modifiable habits were associated with resilience. This study included 1094 participants (947 males and 147 females) between 19 and 29 years of age (22.8 +/- 1.9 years) who completed the 10-item Korean version of the Connor-Davidson Resilience Scale (CD-RISC-10), the Korean version of the Morningness-Eveningness Questionnaire (MEQ), the Pittsburgh Sleep Quality Index (PSQI), the Korean version of the Hospital Anxiety and Depression Scale (HADS) and a survey about social jetlag that determined misalignments between weekday and weekend times of awakening and activity duration under conditions of sunlight between 10: 00 and 15: 00. A multiple linear regression analysis revealed that sleep duration, mean daily sunlight exposure between 10: 00 and 15: 00 and age were positive predictors of morningness, whereas social jetlag was a negative predictor of morningness. Of these morningness-related modifiable behavioral features, mean daily sunlight exposure between 10: 00 and 15: 00 significantly predicted greater resilience. An additional multiple linear regression analysis revealed that morningness was a positive predictor of resilience after controlling for age, sex, depression, anxiety and sleep quality. These results support the idea that morningness and better sleep quality are associated with greater resilience. Morningness was also associated with longer sleep duration, longer sunlight exposure during the daytime and less social jetlag, whereas longer daily sunlight exposure between 10: 00 and 15: 00 was associated with greater resilience. Future longitudinal studies are needed to examine whether manipulations of morningness-related modifiable behavioral features can rearrange chronotype and promote resilience.</P>

IEEE 802.15.4a채널환경하에서의 저간섭 Chaotic OOK 무선통신기술의 BER 성능분석에 관한 연구

정재호(Jaeho Jeong),박구만(Gooman Park),전태현(Taehyun Jeon),서보석(Boseok Seo),곽경섭(Kyungsup Kwak),장영민(Yeongmin Jang),최상열(Sangyule Choi),차재상(Jaesang Cha) 한국방송·미디어공학회 2007 방송공학회논문지 Vol.12 No.2

Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study

ChulHyun Cho,YongMin Ahn,SeJoo Kim,TaeHyun Ha,HongJin Jeon,Boseok Cha,Eunsoo Moon,DongYeon Park,JiHyun Baek,HeeJu Kang,Vin Ryu,Hyonggin An,HeonJeong Lee 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1

The Mood Disorder Cohort Research Consortium (MDCRC) study is designed as a naturalistic observational prospective cohort study for early-onset mood disorders (major depressive disorders, bipolar disorders type 1 and 2) in South Korea. The study subjects consist of two populations: 1) patients with mood disorders under 25 years old and 2) patients with mood disorders within 2 years of treatment under 35 years old. After successful screening, the subjects are evaluated using baseline assessments and serial follow-up assessments at 3-month intervals. Between the follow-up assessments, subjects are dictated to check their own daily mood status before bedtime using the eMood chart application or a paper mood diary. At the regular visits every 3 months, inter-visit assessments are evaluated based on daily mood charts and interviews with patients. In addition to the daily mood chart, sleep quality, inter-visit major and minor mood episodes, stressful life events, and medical usage pattern with medical expenses are also assessed. Genomic DNA from blood is obtained for genomic analyses. From the MDCRC study, the clinical course, prognosis, and related factors of early-onset mood disorders can be clarified. The MDCRC is also able to facilitate translational research for mood disorders and provide a resource for the convergence study of mood disorders.

Association Between Suicide and Drinking Habits in Adolescents

Ji Won Lee,Bong-Jo Kim,Cheol-Soon Lee,Boseok Cha,So-Jin Lee,Dongyun Lee,Jiyeong Seo,Young-Ji Lee,Youn-Jung Lee,Eunji Lim,Jae-Won Choi 대한소아청소년정신의학회 2021 소아청소년정신의학 Vol.32 No.4

Objectives: Adolescent suicide is a serious social problem. Adolescent alcohol use is one of the most important risk factors for adolescent suicide. This study aimed to identify the relationship between drinking habits and suicide among Korean adolescents. Methods: Data from the 14th and 15th Korean Youth Risk Behavior Web-based Survey, conducted in 2018 and 2019, were used for analysis. Multiple logistic regression analysis was used to identify the relationship between drinking habits—including the age of drinking initiation, frequency of drinking, average drinking amount, frequency of drunkenness—and suicidal ideation, plans, and attempts. Results: Even after adjusting for age, sex, school grade, academic achievement, socioeconomic status, depression, stress, and drinking habits, the frequencies of drinking and drunkenness increased the risk of suicide attempts. Suicide attempts were associated with the frequency of drinking in girls and middle school students, and with the frequency of drunkenness in boys and high school students. Conclusion: This study identified associations between drinking habits (the age of drinking initiation, frequency of drinking, average amount of drinking, frequency of drunkenness) and suicidal behavior in adolescents. Our findings suggest that to prevent adolescent suicide, it might be necessary to investigate drinking habits, including the frequencies of drinking and drunkenness. Moreover, considering the differences in sex and school grade, it is important to include the individual group characteristics when evaluating drinking habits.

Mediating Effect of Depressive Symptoms on the Relationship between Adult Attention Deficit Hyperactivity Disorder and Quality of Life

JiYeong Seo,CheolSoon Lee,ChulSoo Park,BongJo Kim,BoSeok Cha,SoJin Lee,InYoung Ahn 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2

Objective-The aim of this study was to investigate whether depressive symptoms affect the relationship between adult attention deficit hyperactivity disorder (ADHD) and the quality of life (QOL) in Korean soldiers. Methods-We evaluated past and present symptoms of adult ADHD (the Korean Adult Attention-Deficit/Hyperactivity Disorder Scale and the Wender Utah Rating Scale), depression (the Center for Epidemiological Studies Depression Scale) and QOL (the Korean version of the SmithKline Beecham ‘Quality of Life’ scale) in 131 soldiers during mental health screenings performed by a local mental health center. A structured equation model using AMOS 19.0 was used to evaluate the mediating effect of depression. Results-In our first model (without depressive symptoms), adult ADHD significantly affected QOL (standardized regression weight=-0.51, p<0.01). After depressive symptoms were added to this model, the direct effect of adult ADHD on QOL was not significant (standardized regression weight=0.10, p=0.43). Regarding the indirect effect, adult ADHD significantly affected depression (standardized regression weight=0.78, p<0.01), and depression also affected QOL (standardized regression weight=-0.79, p<0.01). Conclusion-Through structural equation modeling, the complete mediation model for the influence of depressive symptoms on ADHD and QOL was confirmed. These findings indicated that it might be important to consider comorbidities, such as depression, when adult ADHD is being evaluated.