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Rubieli Carla Frezza Zeferino,Vinicius Aleixo Angonese Piaia,Vinícius Tres Orso,Vítor Machado Pinheiro,Micheli Zanetti,Gustavo Lopes Colpani,Natan Padoin,Cíntia Soares,Márcio Antônio Fiori,Humberto Gr 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
This work aims to synthesize neryl acetate from the nerol esterification reaction with acetic anhydridethrough heterogeneous catalysis using the ion exchange resin Lewatit GF 101. The reaction was monitoredby gas chromatography and the neryl acetate chemical structure was confirmed by mass spectrometryand nuclear magnetic resonance spectroscopy. The variables effect on the neryl acetate synthesiswas evaluated from an experimental design analysis. The reaction showed the highest combined valuesfor nerol conversion (98.11%) and neryl acetate selectivity (86.10%) at 30 min within optimal experimentalconditions of temperature at 40 C, catalyst content at 7% wt, molar ratio at 1:4 (nerol: acetic anhydride),agitation speed at 250 rpm and nerol content at 3 mmol. The complete nerol conversion wasachieved at 40 min with 82.34% selectivity. The reaction rate was controlled only by the nerol decay,an expected behavior due to the excess of acetic anhydride used. In addition, the value obtained forthe main reaction kinetic constant found by a pseudo-homogeneous model was 6 times greater than thatof the parallel reaction. The catalyst reuse was investigated and after 3 cycles a high conversion (96.68%)and selectivity (83.78%) were observed indicating a low loss of the catalytic activity.
( Franciane Cabral Pinheiro ),( Vandreza Cardoso Bortolotto ),( Stifani Machado Araujo ),( Marcia Rosula Poetini ),( Carla Pohl Sehn ),( Jose S. S. Neto ),( Gilson Zeni ),( Marina Prigol ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.7
This study aimed to evaluate the antimicrobial activity of 2-phenylethynyl-butyltellurium (PEBT) in Escherichia coli and the relation to its pro-oxidant effect. For this, we carried out the disk diffusion test, minimum inhibitory concentration (MIC) assay, and survival curve analysis. We also measured the level of extracellular reactive oxygen species (ROS), activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and level of nonprotein thiols (NPSH). PEBT at 1.28 and 0.128 mg/disk exhibited antimicrobial capability in the disk diffusion test, with an MIC value of 1.92 mg/ml, whereas PEBT at 0.96, 1.92, and 3.84 mg/ml inhibited bacterial growth after a 9-h exposure. PEBT at 3.84, 1.92, and 0.96 mg/ml increased extracellular ROS production, decreased the intracellular NPSH level, and reduced the SOD and CAT activities. Glutathione or ascorbic acid in the medium protected the bacterial cells from the antimicrobial effect of PEBT. In conclusion, PEBT exhibited antimicrobial activity against E. coli, involving the generation of ROS, oxidation of NPSH, and reduction of the antioxidant defenses in the bacterial cells.
Cardiovascular Effect of Diosgenin in Ovariectomized Rats
Ilmara Cecilia Pinheiro de Silva Morais,Iris Jordaˆnia Luz Moura,Carla Kelly Barroso Sabino,Lucas Antonio Duarte Nicolau,Fabiana de Moura Souza,Jose´ Couras da Silva-Filho,Rita de Ca´ssia Meneses Oliv 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.3
Diosgenin is a phytoestrogen and a constituent of Dioscorea. It has several biological effects, and some of them are anti-inflammatory, antidiabetic, antitumor, and vasodilatory. The present study investigated both the vasorelaxing and antioxidant mechanisms of diosgenin in isolated rat aortic rings. Female rats weighing 200–220 g were subjected to sham or OVX operations at 8 weeks of age. Ovariectomy was performed for menopause induction after anesthesia. Diosgenin (10−9 M–3 × 10−4 M) produced a concentration-dependent relaxation in aortic rings precontracted with phenylephrine (1 μM), exhibiting Emax value of 55.34% ± 7.7% (in endothelium-intact rings) and Emax value of 30.30% ± 5.7% (in endothelium-denuded rings). In the endothelium-intact rings, the vasorelaxing effect of diosgenin was reduced by NG-nitro-l-arginine methyl ester (L-NAME) (100 μM), atropine (1 μM), indomethacin (10 μM), 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ) (10 μM), 4-aminopyridine (1 mM), tetraethylammonium (3 mM), glibenclamide (10 μM), apamin (10 μM), and Tiron (1 μM). Diosgenin (10−5 M) inhibited the contractions induced by cumulative addition of phenylephrine (10−9–10−5 M). The 28-days treatment with diosgenin (50 mg/kg, v.o.) did not imply changes in the myeloperoxidase parameter, but increased significantly, levels of glutathione, superoxide dismutase, and nitric oxide, as well as reduced the concentration of malondialdehyde related to lipid peroxidation. Our results suggest that diosgenin induced relaxation in aortic rings via an endothelium-dependent pathway, which involves the EDRF, the opening of potassium channels and antioxidant action.
Nuno Martins,Sérgio Dominique-Ferreira,Carla Pinheiro 한국마케팅과학회 2022 마케팅과학연구 Vol.32 No.3
Contemporary architecture has an increasing importance in tourism. The marketing implications of digital or mobile content in this niche tourism space has not been previously studied. With this project we aim to build a mobile app to cater to this market and show that it can positively impact tourism in Portugal. A two-step multidimensional approach was applied to achieve this goal. The first step was based on benchmarking, as well as interviews with two architects. The second step was based on visual identity factors, prototyping, and usability tests. We found that it was possible to develop an intuitive app that positively adjusted to the needs and preferences of future users. Improvements to the platform should include new metrics, blog links, and augmented reality.