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Xing, Zhi-Cai,Chae, Won-Pyo,Huh, Man-Woo,Park, Lee-Soon,Park, Soo-Young,Kwak, Giseop,Yoon, Keun-Byoung,Kang, Inn-Kyu American Scientific Publishers 2011 Journal of nanoscience and nanotechnology Vol.11 No.1
<P>Electrospinning has recently emerged as a leading technique for the formation of nanofibrous structures made of organic and inorganic components. In this study, nanofibrous scaffolds were prepared by electrospining a bend solution of poly(L-lactide-co-glycolide) (PLGA) and silver nanoparticles in 1,1,1,3,3,3,-hexafluoro-2-propanol (HFIP). The resulting fibers ranged from 420 to 590 nm in diameter. To evaluate the possibility of using silver-containing PLGA as a tissue engineering scaffold, experiments on cell viability and antibacterial activity were carried out. As a result, PLGA nanofibrous scaffolds having silver nanoparticles of more than 0.5 wt% showed antibacterial effect against Staphylococcus aureus and Klebsiella pneumonia. Furthermore, silver-containing PLGA nanofibrous scaffolds showed viability, indicating their possible application in the field of tissue engineering.</P>
Fabrication of Biodegradable Polyester Nanocomposites by Electrospinning for Tissue Engineering
Xing, Zhi-Cai,Han, Seung-Jin,Shin, Yong-Suk,Kang, Inn-Kyu Hindawi Publishing Corporation 2011 Journal of nanomaterials Vol.2011 No.-
<P>Recently, nanocomposites have emerged as an efficient strategy to upgrade the structural and functional properties of synthetic polymers. Polyesters have attracted wide attention because of their biodegradability and biocompatibility. A logic consequence has been the introduction of natural extracellular matrix (ECM) molecules, organic or inorganic nanostructures to biodegradable polymers to produce nanocomposites with enhanced properties. Consequently, the improvement of the interfacial adhesion between biodegradable polymers and natural ECM molecules or nanostructures has become the key technique in the fabrication of nanocomposites. Electrospinning has been employed extensively in the design and development of tissue engineering scaffolds to generate nanofibrous substrates of synthetic biodegradable polymers and to simulate the cellular microenvironment. In this paper, several types of biodegradable polyester nanocomposites were prepared by electrospinning, with the aim of being used as tissue engineering scaffolds. The combination of biodegradable nanofibrous polymers and natural ECM molecules or nanostructures opens new paradigms for tissue engineering applications.</P>
Xing, Zhi-Cai,Meng, Wan,Yuan, Jiang,Moon, Sungmo,Jeong, Yongsoo,Kang, Inn-Kyu Hindawi Limited 2012 Journal of nanomaterials Vol.2012 No.-
<P>Flavonoids, such as quercetin, have been reported to exhibit a wide range of biological activities related to their antioxidant capacity. The aim of this study was to investigate the protective effect of quercetin on cell adhesion, and the viability and proliferation of KB epithelial cells. Quercetin- (1, 5 wt%)-containing poly (l-lactide-co-glycolide) (PLGA) nanofibrous scaffolds (PLGA/Q 1, PLGA/Q 5) were prepared by electrospinning technique and their antibacterial properties were examined. Two types of bacteria strains,<I>Staphylococcus aureus</I>(SA) and<I>Klebsiella pneumoniae</I>(KP), were used to evaluate the antibacterial properties of the scaffolds. The results showed that the quercetin-containing PLGA nanofibrous scaffolds exhibited significant antibacterial effects against the two bacterial strains. KB epithelial cells were also used to evaluate the cytocompatibility of the scaffolds. From the results, it was found that the PLGA nanofibrous scaffolds with 1 wt% of quercetin had good cell compatibility. It is considered that the PLGA nanofibrous scaffolds with 1 wt% quercetin have potential to be used in tissue engineering.</P>
Xing-cai Zhou,Jinguan Lin 한국통계학회 2013 Journal of the Korean Statistical Society Vol.42 No.2
In this paper, empirical likelihood inference in mixtures of semiparametric varying coefficient errors-in-variables (EV) models for longitudinal data with nonignorable dropout is investigated. The empirical log-likelihood ratio statistic for the fixed-effects parameters and the mean parameters of random effects are proposed. The proposed statistic at the true parameters is proven to be asymptotically χ2q+r , where q and r are the dimensions of the fixed and random effects respectively, and the corresponding confidence regions for the parameters of interest are then constructed. We also obtain the maximum empirical likelihood estimator of the parameters, and prove that it is asymptotically normal under some suitable conditions. Simulation studies are undertaken to assess the finite sample performance of the proposed method.
Inhibitory Lignans against NFAT Transcription Factor from Acanthopanax koreanum
Xing Fu Cai,Im Seon Lee,Nguyen Tien Dat,Guanghai Shen,강종성,Dong Hyun Kim,Young Ho Kim 대한약학회 2004 Archives of Pharmacal Research Vol.27 No.7
Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 ± 2.5 mM). However, the activities of 1 (IC50: > 500 mM) and 2 (IC50: 136.1 ± 9.4 mM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
Xing, Zhi-Cai,Han, Seung-Jin,Shin, Yong-Suk,Koo, Tae-Hyung,Moon, Sungmo,Jeong, Yongsoo,Kang, Inn-Kyu Informa UK (TaylorFrancis) 2013 Journal of biomaterials science, Polymer edition Vol.24 No.1
<P>Hydroxyapatite (HA)-containing polymers have been proposed for improving the biological properties of bone cements. Poly(methyl methacrylate) (PMMA) has long been used to secure orthopedic implants to skeletal bones. The aim of this study was to determine whether the incorporation of HA nanoparticles into the PMMA nanofibrous scaffolds enhances the biological functions of osteoblasts. The number of osteoblasts adhered and proliferated on the PMMA/HA nanofibrous scaffolds was significantly larger than that on the PMMA alone. The cytoskeletal organization and alkaline phosphatase (ALP) activity of the osteoblasts on the PMMA/HA nanofibrous scaffolds were clearly higher than that on the PMMA control. The amount of calcium ions released from 20 wt% HA-containing PMMA nanofibrous scaffolds (PMMA/HA20) was much higher than that released from 10 wt% HA-containing PMMA nanofibrous scaffolds (PMMA/HA10) (HA, 10 wt%). These findings suggested that osteoblast differentiation was accelerated by the incorporation of HA into the PMMA nanofibrous scaffolds. Therefore, the incorporation of HA into the PMMA nanofibrous scaffolds could be a useful method. This can be used for providing PMMA scaffolds with enhanced osteogenic properties.</P>
Cai, Xing-Fu,Shen, Guanghai,Dat, Nguyen-Tien,Kang, Ok-Hwa,Lee, Young-Mi,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9
Five known kaurane type diterpenoids, 16$\alpha$H, 17-isovaleryloxy-ent-kauran-19-oic acid (1), 16$\alpha$-hydroxy-17-isovaleryloxy-ent-kauran-19-oic acid (2), paniculoside-IV (3), 16$\alpha$-hydroxy-ent-kauran-19-oic acid (4), and ent-kaur-16-en-19-oic acid (5) were isolated from the root of Acanthopanax koreanum by repeated column chromatography and reversed phase preparative HPLC. The structures of these compounds were established from physicochemical and spectral data. Among the isolated compounds 16$\alpha$H, 17-isovaleryloxy-ent-kauran-19-oic acid (1) showed potent inhibitory activity ($IC_50$ value, 16.2 $\mu$ M) on TNF-$\alpha$ secretion from HMC-1, a trypsin-stimulated human leukemic mast cell line.
Phytochemical Constituents from Acanthopanax divaricatus var. albeofructus
Cai, Xing Fu,Shen, Guanghai,Dat, Nguyen Tien,Lee, Eun Joo,Kim, Young Ho 충남대학교 약학대학 의약품개발연구소 2005 藥學論文集 Vol.20 No.-
Five known compounds were isolated from the methanolic extract of the roots of Acanthopanax divaricatus var. albeofructus through repeated silica gel and YMC gel column chromatography. Their chemical structures were elucidated as farnesol (1), linoleic acid (2), stigmasterol (3), (-)-sesamin (4), and falcarindiol (5) by spectroscopic analysis.
Triterpenoids from Acanthopanax koreanum Root and Their Inhibitory Activities on NFAT Transcription
Cai, Xing-Fu,Lee, Im-Seon,Shen, Guanghai,Dat, Nguyen-Tien,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.8
Two triterpenoids (1,4) and two triterpenoid glycosides (2,3) were isolated from the root of Acanthopanax koreanum (Araliaceae). Their structures were identified as impressic acid (1), acankoreoside A (2), 3-epi-betulinic acid 28-O-[(${\alpha}-L-rhamnopyranosyl(1{\rightarrow}4)-{\beta}-D-glucopyrano-syl(1{\rightarrow}6)]-{\beta}-D-glucopyranosyl]$ ester (3), and ursolic acid (4) by physicochemical and spectro-scopic methods. Of these compounds, impressic acid (1) exhibited a potent inhibitory activity against NFAT transcription factor ($IC_{50}:{\;}12.65{\;}{\mu\textrm{m}}$).