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Bilicki, M.,Hoekstra, H.,Brown, M. J. I.,Amaro, V.,Blake, C.,Cavuoti, S.,de Jong, J. T. A.,Georgiou, C.,Hildebrandt, H.,Wolf, C.,Amon, A.,Brescia, M.,Brough, S.,Costa-Duarte, M. V.,Erben, T.,Glazebroo EDP Sciences 2018 Astronomy and astrophysics Vol.616 No.-
<P>We present a machine-learning photometric redshift (ML photo-<I>z</I>) analysis of the Kilo-Degree Survey Data Release 3 (KiDS DR3), using two neural-network based techniques: ANNz2 and MLPQNA. Despite limited coverage of spectroscopic training sets, these ML codes provide photo-<I>z</I>s of quality comparable to, if not better than, those from the Bayesian Photometric Redshift (BPZ) code, at least up to <I>z</I>phot ≲ 0.9 and <I>r</I> ≲ 23.5. At the bright end of <I>r</I> ≲ 20, where very complete spectroscopic data overlapping with KiDS are available, the performance of the ML photo-<I>z</I>s clearly surpasses that of BPZ, currently the primary photo-<I>z</I> method for KiDS. Using the Galaxy And Mass Assembly (GAMA) spectroscopic survey as calibration, we furthermore study how photo-<I>z</I>s improve for bright sources when photometric parameters additional to magnitudes are included in the photo-<I>z</I> derivation, as well as when VIKING and WISE infrared (IR) bands are added. While the fiducial four-band <I>ugri</I> setup gives a photo-<I>z</I> bias 〈<I>δz</I>/(1 + <I>z</I>)〉 = −2 × 10<SUP>−4</SUP> and scatter <I>σδz/(1+z)</I> < 0.022 at mean 〈<I>z</I>〉 = 0.23, combining magnitudes, colours, and galaxy sizes reduces the scatter by ~7% and the bias by an order of magnitude. Once the <I>ugri</I> and IR magnitudes are joined into 12-band photometry spanning up to 12 <I>μ</I>m, the scatter decreases by more than 10% over the fiducial case. Finally, using the 12 bands together with optical colours and linear sizes gives 〈<I>δz</I>/(1 + <I>z</I>)〉 < 4 × 10<SUP>−5</SUP> and <I>σ</I><I>δz</I>/(1+<I>z</I>) < 0.019. This paper also serves as a reference for two public photo-<I>z</I> catalogues accompanying KiDS DR3, both obtained using the ANNz2 code. The first one, of general purpose, includes all the 39 million KiDS sources with four-band <I>ugri</I> measurements in DR3. The second dataset, optimised for low-redshift studies such as galaxy-galaxy lensing, is limited to <I>r</I> ≲ 20, and provides photo-<I>z</I>s of much better quality than in the full-depth case thanks to incorporating optical magnitudes, colours, and sizes in the GAMA-calibrated photo-<I>z</I> derivation.</P>
Jan C. Purrucker,Kirsten Haas,Marcel Wolf,Timolaos Rizos,Shujah Khan,Peter Kraft,Sven Poli,Rainer Dziewas,Johannes Meyne,Frederick Palm,Sebastian Jander,Markus Möhlenbruch,Peter U. Heuschmann,Roland V 대한뇌졸중학회 2017 Journal of stroke Vol.19 No.1
Background and Purpose To evaluate the frequency and outcome of haemorrhagic transformation (HT) after ischaemic stroke in patients treated with non-vitamin K antagonist oral anticoagulants (NOACs). Methods Patients with stroke on treatment with a NOAC were prospectively enrolled in this multicentre observational study between February 2012 and 2015. Brain imaging at admission and follow-up imaging until day 7 were reviewed for HT. Functional outcome was assessed by the modified Rankin scale (mRS) before the index event, at discharge, and at 3-months. Results 231 patients without recanalisation therapy (no-RT), and 32 patients with RT were eligible for analysis. Any HT was present at admission in 9/231 no-RT patients (3.9%, 95% CI 2.0 to 7.3) and in none of the patients with RT. In patients with follow-up imaging (no-RT, n=129, and RT, n=32), HT was present in 14.0% (no-RT; 95% CI, 8.9 to 21.1), and 40.6% (RT, 95% CI, 25.5 to 57.8), respectively. After adjustment for stroke severity, this difference between the no-RT and RT groups became non-significant. Symptomatic ICH was observed in 1 patient per group. HT was not associated with unfavourable outcome (mRS 3-6) at 3-months in multivariable analysis. Resumption of OAC after stroke was delayed in patients with HT compared to those without (15 d [IQR, 5–26] vs. 1 d [0–4], P<0.001). Conclusions The frequency and severity of HT after stroke on NOAC appears similar to previous reports for vitamin K antagonists and no anticoagulation. Whether asymptomatic HT should delay resumption of preventive anticoagulation requires further investigation.
Marketing Mix Modeling for the Tourism Industry: A Best Practices Approach
Michael J. Wolfe, Sr.,John C. Crotts 한국관광학회 2011 International Journal of Tourism Sciences Vol.11 No.1
The intent of this paper is to introduce marketing managers and tourism researchers to an analytic tool used to optimize the allocation of a firm’s marketing budget in such a way that provides the greatest likelihood of producing the strongest return-on-investment. Marketing mix modeling combines advanced econometrics with marketing science to objectively measure the relative productivity of a complete set of marketing programs or initiatives to produce transient tourism sales. Discussed and demonstrated in this paper are the steps in performing such an analysis, how to avoid its major pitfalls, and the benefits that can be derived from the analysis. Extensions of the marketing mix method to include the effects of the social media and product driven strategies are briefly discussed.
Advanced technologies for intuitive control and sensation of prosthetics
Erik J. Wolf,Theresa H. Cruz,Alfred A. Emondi,Nicholas B. Langhals,Stephanie Naufel,Grace C. Y. Peng,Brian W. Schulz,Michael Wolfson 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
The Department of Defense, Department of Veterans Aff airs and National Institutes of Health have invested signifi cantlyin advancing prosthetic technologies over the past 25 years, with the overall intent to improve the function, participationand quality of life of Service Members, Veterans, and all United States Citizens living with limb loss. These investmentshave contributed to substantial advancements in the control and sensory perception of prosthetic devices over the past decade. While control of motorized prosthetic devices through the use of electromyography has been widely available sincethe 1980s, this technology is not intuitive. Additionally, these systems do not provide stimulation for sensory perception. Recent research has made signifi cant advancement not only in the intuitive use of electromyography for control but also inthe ability to provide relevant meaningful perceptions through various stimulation approaches. While much of this previouswork has traditionally focused on those with upper extremity amputation, new developments include advanced bidirectionalneuroprostheses that are applicable to both the upper and lower limb amputation. The goal of this review is to examine thestate-of-the-science in the areas of intuitive control and sensation of prosthetic devices and to discuss areas of explorationfor the future. Current research and development eff orts in external systems, implanted systems, surgical approaches, andregenerative approaches will be explored.
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
Blin, Kai,Wolf, Thomas,Chevrette, Marc G.,Lu, Xiaowen,Schwalen, Christopher J.,Kautsar, Satria A.,Suarez ,Duran, Hernando G.,de ,los ,Santos, Emmanuel ,L. ,C.,Kim, Hyun Uk,Nave, Ma Oxford University Press 2017 Nucleic acids research Vol.45 No.w1
<P><B>Abstract</B></P><P>Many antibiotics, chemotherapeutics, crop protection agents and food preservatives originate from molecules produced by bacteria, fungi or plants. In recent years, genome mining methodologies have been widely adopted to identify and characterize the biosynthetic gene clusters encoding the production of such compounds. Since 2011, the ‘antibiotics and secondary metabolite analysis shell—antiSMASH’ has assisted researchers in efficiently performing this, both as a web server and a standalone tool. Here, we present the thoroughly updated antiSMASH version 4, which adds several novel features, including prediction of gene cluster boundaries using the ClusterFinder method or the newly integrated CASSIS algorithm, improved substrate specificity prediction for non-ribosomal peptide synthetase adenylation domains based on the new SANDPUMA algorithm, improved predictions for terpene and ribosomally synthesized and post-translationally modified peptides cluster products, reporting of sequence similarity to proteins encoded in experimentally characterized gene clusters on a per-protein basis and a domain-level alignment tool for comparative analysis of <I>trans</I>-AT polyketide synthase assembly line architectures. Additionally, several usability features have been updated and improved. Together, these improvements make antiSMASH up-to-date with the latest developments in natural product research and will further facilitate computational genome mining for the discovery of novel bioactive molecules.</P>