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윤천호,안병준,전학제,C. H. Yune,B. J. Ahn,Hakze Chon 대한화학회 1981 대한화학회지 Vol.25 No.1
양이온 교환 및 알루미늄 추출시킨 모더나이트와 제올라이트 Y 촉매에서 m-크실렌의 반응이 마이크로펄스방법으로 연구되었다. H-모더나이트 촉매에서 전처리온도가 높아지거나 Si/Al비가 증가할 때 동종간 주고 받기반응생성물이 크게 증가했다. $Ba^{2+}-, Mg^{2+}- $이온교환한 모더나이트촉매에서 양이온교환정도가 증가할에따라 트리메틸벤젠의 생성량이 급격히 감소했다. m-크실렌의 동종간 주고 받기반응에서는 모더나이트의 산성도의 영향과 아울러 촉매 유효세공의 크기에 따른 형상 선택성을 보여준다. Reactions of m-xylene were studied in a fixed-bed type micropulse reactor over cation-exchanged dealuminated mordenite and zeolite Y catalysts. Over H-mordenite catalysts higher catalyst pretreatment temperature as well as dealumination resulted in the increase of the formation of disproportionation product. $Ba^{2+}- and Mg^{2+}-$exchanged mordenite catalysts showed the shape selectivity in the disproportionation reaction of m-xylene, that is, the formation of trimethylbenzene decreasing sharply as the degree of cation exchange increased.
Hwang, S.,Cho, G.S.,Ryu, S.,Kim, H.J.,Song, H.Y.,Yune, T.Y.,Ju, C.,Kim, W.K. Elsevier Sequoia 2016 Journal of Ethnopharmacology Vol.186 No.-
Ethnopharmacological relevance: Anti-inflammatory therapy has been intensively investigated as a potential strategy for treatment of cerebral stroke. However, despite many positive outcomes reported in animal studies, anti-inflammatory treatments have not proven successful in humans as yet. Although immunomodulatory activity and safety of Cordyceps species (Chinese caterpillar fungi) have been proven in clinical trials and traditional Asian prescriptions for inflammatory diseases, its anti-ischemic effect remains elusive. Aim of the study: In the present study, therefore, we investigated the potential therapeutic efficacy of WIB801C, the standardized extract of Cordyceps militaris, for treatment of cerebral ischemic stroke. Materials and methods: The anti-chemotactic activity of WIB801C was assayed in cultured rat microglia/macrophages. Sprague-Dawley rats were subjected to ischemic stroke via either transient (1.5-h tMCAO and subsequent 24-h reperfusion) or permanent middle cerebral artery occlusion (pMCAO for 24-h without reperfusion). WIB801C was orally administered twice at 3- and 8-h (50mg/kg each) after the onset of MCAO. Infarct volume, edema, blood brain barrier and white matter damages, neurological deficits, and long-term survival rates were investigated. The infiltration of inflammatory cells into ischemic lesions was assayed by immunostaining. Results: WIB801C significantly decreased migration of cultured microglia/macrophages. This anti-chemotactic activity of WIB-801C was not mediated via adenosine A3 receptors, although cordycepin, the major ingredient of WIB801C, is known as an adenosine receptor agonist. Post-ischemic treatment with WIB801C significantly reduced the infiltration of ED-1-and MPO-positive inflammatory cells into ischemic lesions in tMCAO rats. WIB801C-treated rats exhibited significantly decreased infarct volume and cerebral edema, less white matter and blood-brain barrier damages, and improved neurological deficits. WIB801C also improved survival rates over 34 days after ischemia onset. A significant reduction in infarct volume and neurobehavioral deficits by WIB801C was also observed in rats subjected to pMCAO. Conclusions: In summary, post-ischemic treatment of WIB801C reduced infiltration of inflammatory cells into ischemic lesions via inhibition of chemotaxis, which confers long-lasting histological and neurological protection in ischemic brain. WIB801C may be a promising anti-ischemic drug candidate with clinically relevant therapeutic time window and safety.
Control of magnetic anisotropy by ion-beam-mixing method under external magnetic field
Yune, J.-H.,Kim, H. B.,Kim, S. H.,Whang, C. N.,Chae, K. H. WILEY-VCH Verlag 2004 Physica status solidi. A, Applied research Vol.201 No.8
<P>Manipulation of magnetic anisotropy in ferromagnetic thin films was tried with ion-beam-mixing technique. Co/Pt multilayered films were deposited on Si(100) by electron beam evaporation and mixed with an energetic Ar<SUP>+</SUP> ion-beam under external magnetic field which was parallel to the sample surface. The magnetic easy axis was observed from the ion-beam-mixed samples along the direction of applied external magnetic field. When the ion dose was less than a critical dose, a small peak was measured along the magnetic hard axis. The small peak disappeared after ion-beam-mixing with a dose higher than the critical one. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)</P>
Neuroprotective effect of <i>Scutellaria?baicalensis</i> on spinal cord injury in rats
Yune, Tae Y.,Lee, Jee Y.,Cui, Chun M.,Kim, Ho C.,Oh, Tae H. Blackwell Publishing Ltd 2009 Journal of Neurochemistry Vol.110 No.4
<P><B>Abstract</B></P><P>Inflammation has been known to play an important role in the pathogenesis after spinal cord injury (SCI). Microglia are activated after injury and produce a variety of proinflammatory factors such as tumor necrosis factor‐α, interleukin‐1β, cyclooxygenase‐2, and reactive oxygen species leading to apoptosis of neurons and oligodendrocytes. In this study, we examined the neuroprotective effects of total ethanol extract of <I>Scutellaria?baicalensis</I> (EESB)<I>,</I> after SCI. Using primary microglial cultures, EESB treatment significantly inhibited lipopolysaccharide‐induced expression of such inflammatory mediators as tumor necrosis factor‐α, IL‐1β, IL‐6, cyclooxygenase‐2, and inducible nitric oxide synthase. Furthermore, reactive oxygen species and nitric oxide production were significantly attenuated by EESB treatment. For <I>in vivo</I> study, rats that had received a moderate spinal cord contusion injury at T9 received EESB orally at a dose of 100 mg/kg. EESB inhibited expression of proinflammatory factors and protein carbonylation and nitration after SCI. EESB also inhibited microglial activation at 4 h after injury. Furthermore, EESB significantly inhibited apoptotic cell death of neurons and oligodendrocytes and improved functional recovery after SCI. Lesion cavity and myelin loss were also reduced following EESB treatment. Thus, our data suggest that EESB significantly improve functional recovery by inhibiting inflammation and oxidative stress after injury.</P>
Kim, H.,Lee, S. W.,Yune, C. Y.,Kim, G. Springer Science + Business Media 2014 Journal of mountain science Vol.11 No.3
This paper describes a geographic information system (GIS)-based method for observing changes in topography caused by the initiation, transport, and deposition of debris flows using high-resolution light detection and ranging (LiDAR) digital elevation models (DEMs) obtained before and after the debris flow events. The paper also describes a method for estimating the volume of debris flows using the differences between the LiDAR DEMs. The relative and absolute positioning accuracies of the LiDAR DEMs were evaluated using a real-time precise global navigation satellite system (GNSS) positioning method. In addition, longitudinal and cross-sectional profiles of the study area were constructed to determine the topographic changes caused by the debris flows. The volume of the debris flows was estimated based on the difference between the LiDAR DEMs. The accuracies of the relative and absolute positioning of the two LiDAR DEMs were determined to be +/- 10 cm and +/- 11 cm RMSE, respectively, which demonstrates the efficiency of the method for determining topographic changes at an scale equivalent to that of field investigations. Based on the topographic changes, the volume of the debris flows in the study area was estimated to be 3747 m(3), which is comparable with the volume estimated based on the data from field investigations.