Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法

徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.

Pyrantel Pamoate (Combantrin)에 依한 蛔蟲 및 鉤蟲感染의 集團治療

徐丙卨,朴定圭,趙昇烈,姜信榮,魚光本,康世喆,李源宰,李正雨,黃邱一 中央醫學社 1972 中央醫學 Vol.23 No.6

The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea. Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study. Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively. No side effects and no problem in drug administration were demonstrated. It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

간디스토마 감염토끼의 소화기관에 대한 β-Glucuronidase의 활성치에 관한 연구

박병규(Byong Kyoo Park),송수복(Soo Bok Song),한재금(Jae Kum Hahn) 대한기생충학열대의학회 1986 The Korean Journal of Parasitology Vol.24 No.2

하천수질 평가를 위한 종합수질지표 개발

강병준 ( Byong Jun Kang ),유순유 ( Soon Yoo Yoo ),박규홍 ( Kyoo Hong Park ) 한국물환경학회 ( 구 한국수질보전학회 ) 2012 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2012 No.-

와이블 모형의 모수 추정을 이용한 하수관거 적정 수명 분포 예측

강병준 ( Byong Jun Kang ),유순유 ( Soon Yu Yoo ),박규홍 ( Kyoo Hong Park ) 한국물환경학회(구 한국수질보전학회) 2015 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2015 No.-

JORDAN DERIVATIONS ON NONCOMMUTATIVE BANACH ALGEBRAS

PARK, KYOO-HONG,KIM, BYONG-DO,BYUN SANGHUN 서원대학교 기초과학연구소 2001 基礎科學硏究論叢 Vol.15 No.-

In this paper we shall give a slight generalization of J. Vukman's Theorem. And show from the result that the image of a continuous linear Jordan derivation on a noncommutative Banach algebra A is contained in the radical under the condition [D(χ), χ]E(χ) ∈ rad(A) for all χ ∈ A. And we show some properties of the derivationts on noncommutative Banach algebras. AMS Mathematics Subject Classification : 46H40.46J10,47B47 Key words and phrases : torsion free ring, derivation, Jordan derivation, prime ring, semisimple, noncommutative Banach algebra.

악안면부에 발생한 임파관종에 관한 고찰

김규식(Kyoo Sik Kim),민병일(Byong Il Min),남일우(Il Woo Nam),김영균(Yong Gyun Kim),김병린(Byeong Rin Kim) 대한구강악안면외과학회 1988 대한구강악안면외과학회지 Vol.14 No.1

This is a retrospective study on lymphangioma of jaw bone and soft tissue. This is based on pathologic reports and clinical charts of 10 patients treated as inpatient and outpatient at Dept. of Oral and Maxillofacial Surgery, College of Dentistry, Seoul National University between 1980 and 1987. The results obtained are as follows. 1. Age distribution of patient ranged from birth to 19 years of age. 2. The ratio of men to women was 50:50. 3. The most common location of lymphangioma was buccal cheek mucosa (40%), tongue (30%) and gingiva (20%) were next in decreasing order. 4. The most frequent misdiagnosis of lymphangioma was hemangioma (50%). 5. On microscopic view, simple lymphangioma was 70%, cavernous lymphangioma was 20% and hemangiolymphangioma was 10%. 6. The mean duration from patient s fiist recognition of lesion to visiting doctor was 7.2 years. The most chief complaint was multiple small. pebble -like masses (40%). 7. Recurrence: 2 cases (20%).

상수 처리 : 다중 주파수 초음파 조사 조건에서 H2O2의 발생

강병준 ( Byong Jun Kang ),이민주 ( Min Ju Lee ),박규홍 ( Kyoo Hong Park ),오재일 ( Je Ill Oh ) 한국물환경학회 ( 구 한국수질보전학회 ) 2009 공동 추계학술발표회 Vol.2009 No.-

Duchenne형 근이양증에서 PCR을 응용한 Dystrophin 유전자 변이 분석

한승규(Seung-Kyoo Han),김종욱(Jong-Wook Kim),손병관(Byong-Kwan Son),채종희(Jong-Hee Chae),황용승(Yong-Seung Hwang) 대한소아신경학회 2000 대한소아신경학회지 Vol.8 No.2

목적 : Duchenne형 근인양증에서 나타나는 돌연변이는 유전자 결실 65%, 중복 5%, 그리고 점돌연변이, 다형성, 뉴클레오타이드 소변이 등의 미세병변 30%로 알려져 있다. 유전자 결실은 multiplex PCR이나 Southern blot을 이용하여 검출할 수 있으나, 미세병변은 검출을 위한 여러 연구가 시도되고 있지만 아직 뚜렷한 정론이 내려져 있지 않다. 이에 저자들은 환자의 말초 혈액을 채취하여 게놈 DNA를 분리한 후, PCR과 관련된 분자 진단법을 이용하여 유전자 변이 분석을 하였다. 방법 : 서울대학교 어린이병원 소아과에서 근육 조직 검사에 의하여 Duchenne형 근이양증으로 확진된 환자 중 외래 추적 관찰이 가능한 환자 5례와 그 환자의 모친 혹은 자매 7례 즉 총 12례를 대상으로 하였다. 이들로 부터 말초 혈액을 채취하여 게놈 DNA를 분리하였다. 총 28쌍의 시발체를 이용하여 multiplex PCR을 시행하였다. Exon 중복을 분석하기 위하여 multiplex PCR과 겔밀도측정법을 시행하여 부모와 다음 세대간의 띠강도를 비교하였다. 결실이 발견되지 않은 군은exon 각각에 대한 SSCP 분석과 직접 염기 서열분석을 하였다. 결과 : 혈액 1mL로 부터 게놈 DNA 12-2O㎍을 추출할 수 있었으며 크기는 5kb 이상이었다. 게놈 DNA를 이용하여 muitiplex PCR을 수행하였고 최고 9개의 PCR 산물을 얻을 수 있었다. 유전자 변이는 5례의 환자 중 4례에서 관찰되었다. 결실은 2례에서 관찰되었으며, 위치는 각각 exon 45, 47-53, 그리고 exon 47-49, 53이었다. 중복은 1례에서 관찰되었으며, exon 43에 위치하고 있었다. 결실이나 중복이 관찰되지 않았던 1례에서 미세병변이 관찰되었으며, exon 43의 A 염기 결실과 Intron 49의 C→G transversion 변이가 관찰되었다. 결론 : 저자들은 침습적 기법을 필요로 하는 근육 조직이 아닌 가장 손쉽게 얻을 수 있는 말초 혈액을 채취한 후, PCR, SSCP, 겔 밀도측정법, 직접 염기 서열 분석법 등의 방법을 체계적으로 이용하여 Duchenne형 근이양증에서 나타나는 여러 종류의 유전자 변이를 분석할 수 있었으며, 좀더 많은 증례를 대상으로 한 연구가 필요하리라 사료된다. Purpose: Large rearrangements in the dystrophin gene is detected in about 65-70% of patients by multiplex PCR or Southern blot, although detection of point mutations and microlesions is currently in progress. The purpose of this study is to carry out mutation analysis of the dystrophin gene by application of PCR-related molecular diagnostic methods in Duchenne muscular dystrophy(DMD). Methods: Five patients diagnosed as a DMD by muscle biopsy, and their first-degree relatives and mothers were enrolled in this study. The genomic DNA was extracted from the peripheral blood lymphocyte. We used a total of 28 pairs of primers including Beggs´ and Chamberlain´s primers. The multiplex PCR was performed in 4 groups; 5´Rxn2, 3´Rxn2, Rxn2, and CRxn2. For exon duplication analysis, multiplex PCR and gel densitometry were carried out by comparing the band intensities among individual bands. For groups with no detectable deletion, single strand conformation polymorphism(SSCP) analysis and direct DNA sequencing method were performed with individual PCR of candidate exons. Results: About 12-20μg of genomic DNA was extracted from 1mL of blood, and the size of DNA was over 50kb. Up to 9 PCR products were made from multiplex PCR using the genomic DNA. Among 5 families with DMD, No. 6 had about 240kb DNA deletion from exon 45 and 47-53, and No. 11 had about 130kb deletion from exon 47-49 and 53. No. 1 showed duplication of exon 43 when the multiplex PCR products were analyzed by a densitometer. When the deletion/duplication negative No. 3 was analyzed by SSCP method, exon 43 and 49 showed abnormal band patterns. The abnormal band pattern of exon 43 was caused by deletion mutation of A residue, which resulted in pretermination of dystrophin synthesis, meanwhile exon 49 showed transversion mutation of C→G at intron 49. Conclusion: Based on the results of this study, the methods of multiplex PCR, SSCP and direct sequencing of PCR products made it possible to analyze several types of mutation of DMD.