Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

Dimethylnitrosamine 유발 급성 간 손상 흰쥐에서 ^(99m)Tc-Lactosylated Serum Albumin을 이용한 간 기능의 평가

정신영,이재태,서명랑,유정아,배진호,안병철,황재석,정재민,하정희,이규보 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.6

목적: ^(99m)Tc-lactosylated serum albumin (^(99m)Tc-LSA)은 간세포에 특이적으로 결합하는 간수용체 영상용 방사성의약품으로 새로이 합성되었다. 간섬유화를 유발하는 dimethylnitrosamine (DMN)을 투여한 간 손상 휜쥐 모델에서 ^(99m)Tc-LSa의 역동학적인 간섭취를 조사하고 간효소치의 변화와 조직학적 소견을 비교하여, LSA의 간섭취가 간기능의 변화를 반영하는지를 연구하였다. 대상 및 방법: SD계 흰쥐에 DMN를 27 mg/kg으로 복강 내 주사하여 급성 간손상을 유도하고 대조군과 비교하였다. DMN을 주사한 흰쥐를 3일(DMN-3), 8일(DMN-8), 21일(DMN-21)에 ^(99m)Tc=LSA (1,665 mg/kg) 29 MBq를 정맥 주사하여, 30분 동안 동적 영상을 획득하고 간과 신장부위에 관심영역을 설정하여 간과 심장부위의 시간방사능 곡선을 얻었다. 간기능 평가를 위해 시간방사능 곡선을 이용하여 간섭취지수와 혈중제거지수를 구하였고 곡선 최적화를 시행하였다. DMN 투여군과 대조군의 간효소치의 변화와 간조직의 광학현미경 소견을 비교하였다. 결과: 대조군에서는 ^(99m)Tc-LSA가 빠르게 간에 섭취되고 혈중에서 제거되었으나 DMN을 처리한 군에서는 간섭취가 낮았다. 간섭취지수의 비교에서 대조군에 비해 DMN 처리군에서 유의하게 간섭취지수가 낮았다(DMN-3: 0.842, DMN-8: 0.898, DMN-21: 0.91, 대조군: 0.96, p<0.05). 혈중제거지수의 비교에서도 대조군에 비해 DMN 처리군에서 혈중제거지수가 유의하게 높았다(DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, 대조군: 0.473, p<0.05). 비선형 회귀분석에서 R_(2) 값은 0.9이상으로 좋은 일치를 보였고, 대조군에ㅓ K값이 DMN처리군에 비해 크고(DMN-3: 0.28, DMN-8: 0.41, DMN-21: 0.46, 대조군: 0.97, p<0.05), T_(1/2)값은 작았다(DMN-3: 2.5, DMN-8: 1.7, DMN-21: 1.5, 대조군: 0.7, p<0.05). 간효소치의 변화는 DMN-3군에서는 대조군에 비해 상승하였으나 DMN-8, DMN-21군에서는 간효소치의 상승이 관찰되지 않았다. 간조직 소견의 경우 DMN-3군에서 중심정맥 주위에 괴사가 관찰되었으나 DMN-8군, DMN-21군에서는 미약한 정도의 염증세포 침윤만이 관찰되었다. 결론: ^(99m)Tc-LSA 간신티그래피의 간섭취 정도는 간손상과 반비례하였으며 간섭취의 변화는 조직학적 손상이 심한 정도와 간손상후 회복되는 과정을 반영하여 주었다. ^(99m)Tc-LSA 간신티그래피가 간손상을 평가하고 간손상후 회복되는 과정을 추적하는 간수용체 영상용 방사성 의약품으로 사용될 수 있을 것으로 생각된다. Objects: ^(99m)Tc-lactosylated human serum albumin(LSA) is a newly synthesized radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically presented on the hepatocyte membrane. Hepatic uptake and blood clearance of LSA were evaluated in rat with acute hepatic injury induced by dimethylnitrosamine(DMN) and results were compared with corresponding findings of liver enzyme profile and these of histologic changes. Materials and Methods: DMN (27 mg/kg) was injected intraperitoneally in Sprague-Dawley rat to induce acute hepatic injury. At 3(DMN-3), 8(DMN-8), and 21(DMN-21) days after injection of DMN, LSA injected intravenously, and dynamic images of the liver and heart were recorded for 30 minutes. Time-activity curves of the heart and liver were generated from regions of interest drawn over liver and heart area. Degree of hepatic uptake and blood clearance of LSA were evaluated with visual interpretation and semiquantitative analysis using parameters (receptor index : LHL3 and index of blood clearance : HH3), analysis of time-activity curve was also performed with curve fitting using Prism program. Results: Visual assessment of LSA images revealed decreased hepatic uptake in DMN treated rat, compared to control group. In semiquantitative analysis, LHL3 was significantly lower in DMN treated rat group than control rat group (DMN-3:0.842, DMN-8: 0.898, DMN-21: 0.91, Control: 0.96, p<0.05), whereas HH3 was significantly higher than control rat group (DMN-3: 0.731, DMN-8: 0.654, DMN-21: 0.604, Control: 0.473, p<0.05). AST and ALT were significantly higher in DMN-3 group than those of control group. Centrilobular necrosis and infiltration of inflammatory cells were most prominent in DMN-3 group, and were decreased over time. Conclusion: The degree of hepatic uptake of LSA was inversely correlated with liver transaminase and degree of histologic liver injury in rat with acute hepatic injury.

응급실에서 시행된 기관내 삽관의 현황

김병철,강보승,송형곤,이정훈,송근정,정연권 대한응급의학회 1999 대한응급의학회지 Vol.10 No.4

Background : The purpose of this study was to analyze the endotracheal intubation cases performed in the emergency department. Methods : We investigated retrospectively 326 cases of endotracheal intubation performed in the emergency department of a tertiary care center form April 1, 1998 to March 31, 1999. We focused on operators, medications used, its success rate and immediate complications, and the relationship between its success rate and medications. Results : Of 326 consecutive intubations, 193 patients(59.2%) were done by emergency medicine residents or attending physician. While 320 patients(98.2%) were successfully intubated, 6 patients could not be intubated and 2 patients underwent tracheostomy. Of 50 cases of intubations(15.3%) attempted with paralyzing agents, 48 cases were done with succinylcholine and 46 cases underwent by emergency physicians. Intubations with neuromuscular paralysis resulted in high success rates at the first attempt. Of 55 immediate adverse events were encountered in 47 patients(desaturation=17, bronchial intubation=15, hypotension=8, bradycardia=4, cardiac arrest=2, others=5). Conclusion : At this institution, paralyzing agents were used infrequently, but almost all of them were used by emergency physicians.

초등학생 학교 밖 문식 활동 빈도의 종단적 변화 유형 사례 연구

민병곤 ( Min Byeong-gon ),백정이 ( Baik Jeong-yi ) 한국독서학회 2016 독서연구 Vol.0 No.40

본 연구는 정혜승 외(2016)에서 제시된 학교 밖 문식 활동 빈도의 종단적 변화를 바탕으로 하여 학교 밖 문식 활동 빈도가 하향세인 ``전형``, 상향세인 ``특이``, 높은 상태로 유지되는 ``우수``, 낮은 상태로 유지되는 ``미흡``의 네 유형으로 변화 유형을 나누었다. 그리고 종단적 변화의 예측 변인인 학생의 문식태도, 학생의 문식 활동의 어려움, 교사 지도의 세 측면에서 각 유형에 해당하는 학생 1명씩을 선정하여 면담 내용을 분석하였다. 높은 초기값을 가지지만 이것이 하락하는 유자송 학생과 유지되는 오혜림 학생을 비교하고, 낮은 초기값을 가지지만 이것이 유지되는 천정우 학생과 상승하는 손정은 학생을 대비함으로써 이들의 변화에 주목하여 학생들의 학교 밖 문식 활동을 활성화하기 위한 연구에 시사점을 제시하고자 하였다. 본 탐색적 사례 연구를 통한 시사점은 자발성 정도, 문식 태도 하위 요인, 문식 활동 인식 수준, 인식과 실천 간의 관계, 문식 활동 정도 판단 기준, 잠재 성장 모형에서의 초기값 설정의 6가지로 논의되었다. This study is based on the longitudinal changes in out-of-school literacy practices of elementary students and its predictors which took a latent growth curve modeling approach, appeared in Chung et al.(2016). There are 4 types of changes: ‘prototypical’ which shows downward tendency fit to the pattern of ordinary students, ‘peculiar’ which shows upward tendency, ‘superior’, and ‘inferior’. Then interviews of individual students of 4 types are analyzed into 3 parts, students’ literacy attitudes, perceived difficulties of literacy practices, and teachers’ instruction, which are predictors of the change rate. Yu, Ji-Song(prototypical) and O, Hye-Lim(superior), whose initial status are high, are compared with each other, and Cheon, Jeong-U(inferior) and Son, Jeong-Eun(peculiar), whose initial status are low, are compared with each other to reveal what made the changes. Discussions on the degrees of vulnerability, subcomponents of literacy attitude, literacy practices perception levels, the relationship between perception and practices, the standard of amount of literacy practices, and decision of initial status of LGM are provided as implications for further studies.

A Novel Approach for Mining High-Utility Sequential Patterns in Sequence Databases Chowdhury Farhan Ahmed, Syed Khairuzzaman Tanbeer, and Byeong-Soo Jeong, ETRI Journal, vol.32, no.5, Oct. 2010, pp.676-686.

아메드파한,Syed Khairuzzaman Tanbeer,Byeong-Soo Jeong 한국전자통신연구원 2010 ETRI Journal Vol.32 No.5

Mining sequential patterns is an important research issue in data mining and knowledge discovery with broad applications. However, the existing sequential pattern mining approaches consider only binary frequency values of items in sequences and equal importance/significance values of distinct items. Therefore, they are not applicable to actually represent many real-world scenarios. In this paper, we propose a novel framework for mining high- utility sequential patterns for more real-life applicable information extraction from sequence databases with non-binary frequency values of items in sequences and different importance/significance values for distinct items. Moreover, for mining high-utility sequential patterns, we propose two new algorithms: UtilityLevel is a high-utility sequential pattern mining with a level-wise candidate generation approach, and UtilitySpan is a high-utility sequential pattern mining with a pattern growth approach. Extensive performance analyses show that our algorithms are very efficient and scalable for mining high-utility sequential patterns.

잔디포장에서 Pendimethalin의 처리시기에 따른 잡초방제 효과

정병룡 대구대학교 과학기술연구소 1999 科學技術硏究 Vol.5 No.5

Pendimethalin is a selective dinitroaniline herbicide, which is widely used for controlling annual and biennial weeds. It has been general that the application timing of pendimethalin was early Spring, when weeds started to germinate or regrow. The objective of this study was to evaluate the possibility that the early Spring application timing could be altered into Fall season for control of over-wintering weed species as well as annual weeds by persistence of pendimethalin in turf soil. Different amounts of pendimethalin were applied 1) at late Fall (Nov. 21, 1997) when the turf was at the dormancy and 2) early Spring (Mar. 6, 1998) when the weeds began to germinate. The pendimethalin residues in turf soil were assayed along with the developmental trend of weeds. Good correlation was obtained between the chemical and biological assay, suggesting that pendimethalin could be applied in late Fall rather than early Spring to control biennial weeds together with annual weeds.

호염세균으로부터 추출한 카로테노이드 색소의 안정성

정영기,최병대 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

A carotenoid pigment, which was a determinant for food quality, was extracted from a marine halophilic bacteria. The stability of the pigment extract was investigated for a food additive. The optimum temperature for stability was 20℃. The pigment degradation was significantly affected by solvent polarity, however, stable in salvent methanol and ethanol. The pigment degradation was highly sensitive to light and UV exposure.

한국 관광연구에 있어 사회학적 접근의 현황과 과제

정병웅 도립 강원전문대학 2000 道立 江原專門大學 論文集 Vol.3 No.-

It could say that tourism science is standing in the position of the times which can do duty as a goose laying a gold egg to the efforts. It has a potential as a leading studies in the 21st century. For the organization of the studies, It should apply and expand through the setting spurs to the study with up and down. In order to do that, It necessarily needs application and support from existing studies such as other least developed social science. Among the others, The tourism science urgently needs the sociological prospect and application that is pure studies with strong self-examination and methodology. It has an important meaning with the fact that the tourism phenomenon is a kind of a social phenomenon. Though a sociological research has done by this time, At this time of starting the new century, It is convinced that inspecting these roles and questions will be a working of the proper time for the spring of the tourism science and the establishment of identity. Especially, In the Korean society of the point of time that tourism is being acknowledged widely, that could be very significant working.

버섯 중독 환자에서의 ^(99m)Tc-galactosyl human serum albumin (GSA) scintigraphy 소견 : 간초음파 소견과의 비교 Comparison with Liver Ultrasonography

정신영,이재태,배진호,천경아,안병철,강영모,정재민,이규보 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.4

광대버섯과 같은 독버섯 중독시 간세포에 독성을 나타내어 간 기능의 이상을 유발할 수 있다. 저자들은 개나리광대버섯을 섭취한 3명의 환자에서 간 기능을 평가하기 위하여 간세포에 선택적으로 섭취되어 간기능을 평가하는데 사용되어지고 있는 99mTc-galactosyl human serum albumin (Tc-GSA)을 이용한 간 스캔을 시행하였고 간 초음파 검사와 비교하여 보았다. Tc-GSA 185MBq (3mg of GSA)을 정맥주사후 30분동안 동적 영상과 간과 심장 부위의 시간 방사능 곡선을 얻었다. 간기능의 정도를 평가하기 위하여 Tc-GSA의 간섭취 정도와 혈중 정체정도를 시각적인 평가와 간과 심장 부위의 시간 방사능 곡선을 이용한 반정량적인 평가를 시행하여 간섭취지수와 혈중제거지수를 구하였다. 시각적인 평가에서 2명의 환자에서 Tc-GSA의 경미한 정도의 간섭취 감소와 혈중 정체를 보였고 1명에서는 중등도의 간섭취 감소와 혈중 정체를 보였다. 반정량적인 평가에서는 2명의 환자에서 경미한 정도의 간섭취지수의 감소와 혈중제거지수의 증가를 보였고 1명에서 중등도의 간섭취지수의 감소와 혈중제거지수의 증가가 관찰되었다. 간초음파상에서는 1명의 환자는 지방침윤이 관찰되었으며 1명의 환자에서는 미약한 정도의 지방간이 관찰되어 급성 간기능 장애를 적절히 반영하지 못하였다. 본 증례를 통해 저자들은 간초음파 검사가 특이한 소견을 나타내지 못하여 간세포에 영향을 주는 독소나 약물 중독시에 간 영상화에는 Tc-GSA 간스캔이 유용하게 사용될 수 있을 것으로 추측할 수 있었다. ^(99m)Tc-galactosyl human serum albumin (Tc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors, which are specifically present in the hepatocyte membrane. Because these receptors are decreased in hepatic parenchymal damage, the degree of Tc-GSA accumulation in the liver correlates with findings of liver function test. Hepatic images were performed with Tc-GSA in patients with acute hepatic dysfunction by Amantia Subjunquillea poisoning, and compared with these of liver ultrasonography (USG). Tc-GSA (185 MBq, 3 mg of GSA) was injected intravenously, and dynamic images were recorded for 30minutes. Time-activity curves for the heart and liver were generated from regions of interest for the whole liver and precordium. Degree of hepatic uptake and clearance rate of Tc-GSA were generated by visual interpretation and semiquantitative analysis parameters (receptor index :LHL15 and index of blood clearance :HH15). Visual assessment of GSA scintigraphy revealed mildly decreased liver uptake in all of subjects. The mean LHL15 and HH15 were 0.886 and 0.621, graded as mild dysfunction in 2, and mild to moderate dysfunction in 1 subject. In contrast, liver USG showed no remarkable changes of hepatic parenchyme. Tc-GSA scintigraphy was considered as a useful imaging modality in the assessment of the hepatic dysfunction.

訓民正音硏究 : 制字解 中心으로

丁炳瑀 圓光大學校大學院 1981 學位論叢 Vol.6-1 No.-

This thesis is a study on the formulative and organizational principles of Hunminjeongeum derived from the Jaejahae. In formulating the writing system of Hunminjeongeum, the Chinese phonology, the interacting principles of Yin and Yang, the thought of Iching exerted absolute influence. Yet those principles and thought were not blindly applied, but they were creatively assimilated, producing unique originality. Characteristics of Hunminjeongeum can be cited as follows: 1. As written expression of spoken sounds, Hunminjeongeum is a scientific amalgamation of human speech organs and the great law of the Cosmos; 2. Segments of human speech sounds were based on ternary system, being divided into the initial, middle, final sounds; 3. Letters formulated as practical symbols of human speech sounds are facile to learn and comparatively few in number, thus taking on universality and perpetuality. Upon these facts derived, Hunminjeongum is duely regarded as the most brilliant and supreme product of human intelligence in the history of human writing.