Novel transport materials for high-performance fluorescent and phosphorescent OLEDs

Bohm, E.,Anemian, R.,Busing, A.,Fortte, R.,Heil, H.,Kaiser, J.,Krober, J.,Leu, S.,Mujica-Fernaud, T.,Parham, A.,Pflumm, C.,Voges, F. The Korean Infomation Display Society 2011 Journal of information display Vol.12 No.3

To improve the performance of blue fluorescent and green phosphorescent organic light-emitting diode devices, Merck developed novel green phosphorescent host and electron-transporting materials. The newly developed electron-transporting material improves the external quantum efficiency of blue fluorescent devices up to 8.7%, with an excellent lifetime. In combination with the newly developed host materials, the efficiency of green phosphorescent devices can be improved by a factor of 1.7, and the lifetime by a factor of 7.

ICT for Development in Uganda: Adoption of SDN and NFV Hybrid Technology for the Uganda Government Data center

Businge K. John Baptist(부싱기 K. 존 뱁티스트),Yun Seon Kim(김윤선) 연세대학교 빈곤문제국제개발연구원 2018 地域發展硏究 Vol.27 No.3

UNIFORM N-DICHOTOMY FOR EVOLUTIONARY PROCESS IN BANACH SPACES

Buse, C.,Seo, Y.C.,Nam, Y.M. The Youngnam Mathematical Society 2000 East Asian mathematical journal Vol.16 No.2

We study some properties of N-dichotomy for evolutionary process and generalize the theory of the uniform N-equistability using these properties.

A REFINEMENT OF GRÜSS TYPE INEQUALITY FOR THE BOCHNER INTEGRAL OF VECTOR-VALUED FUNCTIONS IN HILBERT SPACES AND APPLICATIONS

Buse Constantin,Cerone Pietro,Dragomir Sever Silvestru,Roumeliotis John Korean Mathematical Society 2006 대한수학회지 Vol.43 No.5

A refinement of $Gr\ddot{u}ss$ type inequality for the Bochner integral of vector-valued functions in real or complex Hilbert spaces is given. Related results are obtained. Application for finite Fourier transforms of vector-valued functions and some particular inequalities are provided.

Experimental investigation of the uplift capacity of group anchor plates embedded in sand

Emirler, Buse,Tolun, Mustafa,Laman, Mustafa Techno-Press 2016 Geomechanics & engineering Vol.11 No.5

In this study, the uplift capacity of anchor plates embedded in sand was investigated by conducting model tests. Square shaped anchors were used in the tests and parameters such as relative density of sand, embedment ratio (H/B), spacing ratio between anchors (S/B) and anchor configuration affecting the uplift capacity were investigated. Breakout factor and group efficiency which are dimensionless parameters were used to show the results. A series of finite element analyses and analytical solutions were additionally performed to ascertain the validity of the findings from the laboratory model tests and to supplement the results of the model tests. It can be concluded that the embedment depth in dense sand soil condition is the most important parameter with respect to the other parameters as to influencing the uplift capacity of group anchors.

Effect of Integrin Binding Peptide on Vascularization of Scaffold-Free Microtissue Spheroids

Yaralı Ziyşan Buse,Onak Günnur,Karaman Ozan 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.5

Background: Three-dimensional (3D) biomimetic models via various approaches can be used by therapeutic applications of tissue engineering. Creating an optimal vascular microenvironment in 3D model that mimics the extracellular matrix (ECM) and providing an adequate blood supply for the survival of cell transplants are major challenge that need to be overcome in tissue regeneration. However, currently available scaffolds-depended approaches fail to mimic essential functions of natural ECM. Scaffold-free microtissues (SFMs) can successfully overcome some of the major challenges caused by scaffold biomaterials such as low cell viability and high cost. Methods: Herein, we investigated the effect of soluble integrin binding peptide of arginine-glycine-aspartic acid (RGD) on vascularization of SFM spheroids of human umbilical vein endothelial cells. In vitro-fabricated microtissue spheroids were constructed and cultivated in 0 mM, 1 mM, 2 mM, and 4 mM of RGD peptide. The dimensions and viability of SFMs were measured. Results: Maximum dimension and cell viability observed in 2 mM RGD containing SFM. Vascular gene expression of 2 mM RGD containing SFM were higher than other groups, while 4 mM RGD containing SFM expressed minimum vascularization related genes. Immunofluorescent staining results indicating that platelet/endothelial cell adhesion molecule and vascular endothelial growth factor protein expression of 2 mM RGD containing SFM was higher compared to other groups. Conclusion: Collectively, these findings demonstrate that SFM spheroids can be successfully vascularized in determined concentration of RGD peptide containing media. Also, soluble RGD incorporated SFMs can be used as an optimal environment for successful prevascularization strategies.

Effects of an Integrated Exercise Program Including “Functional” Inspiratory Muscle Training in Geriatric Individuals with and without Chronic Obstructive Pulmonary Disease

Ismail Ozsoy,Buse Ozcan Kahraman,Gulsah Ozsoy,Nursen Ilcin,Nil Tekin,Sema Savci 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.1

Background: Inspiratory muscle training (IMT) is a commonly used exercise method for both patients with chronic obstructive pulmonary disease (COPD) and the older adult population. In addition to their primary function, respiratory muscles play an active role in core stabilization. However, no IMT program includes both of these functions (i.e., core stabilization and postural control functions as well as respiration). This study investigated the effects of a newly integrated exercise program, termed “functional IMT,” in geriatric individuals with and without COPD. Methods: This prospective and experimental study included 45 geriatric individuals with COPD (n=22) and without COPD (n=23). The training program consisted of 4 weeks of conventional IMT followed by 4 weeks of functional IMT. Respiratory muscle strength, symptoms, exercise capacity, balance, postural control, physical activity, and quality of life were evaluated. Results: After training, respiratory muscle strength, symptoms, exercise capacity, balance, postural control, and quality of life improved in both groups (p<0.05). In addition, physical activity was increased in the COPD group (p<0.05). We observed no statistically significant difference in outcomes between the two groups before and after treatment (p>0.05). Conclusion: The gains were similar in both groups. Functional IMT, which is an integrated approach that includes all respiratory muscle functions, is a safe, effective, and innovative method for use in geriatric individuals with and without COPD.

Screening-Level Assays for Potentially Human-Infectious Environmental Legionella spp.

Helen Y. Buse,Abby Brehm,Jorge W. Santo Domingo,Nicholas J. Ashbolt 한국미생물학회 2011 The journal of microbiology Vol.49 No.2

In spite of the fact that various Legionella species are isolated from nonclinical water settings, there is no standard method to determine whether environmental legionellae may be infectious to humans. Here we provide a screening-level approach based on an in vivo murine (A/J mouse) model and three in vitro proliferation assays using Acanthamoeba polyphaga, and THP-1 human and J774 murine macrophage cell lines to identify potentially human-infectious legionellae. As an initial demonstration the infectivity potential of three clinical (Legionella pneumophila, L. longbeacheae, and L. micdadei) and three environmental (L. dumoffii, L. maceachernii, and L. sainthelensi) legionellae were evaluated. A/J mice were intranasally infected and by 6 h post infection (p.i.), there were significant bacterial titers in the lungs. L. pneumophila,L. dumoffii, and L. micdadei densities were higher than L. longbeacheae, L. maceacherni, and L. sainthelensi at 24 h p.i. However, only L. pneumophila and L. micdadei persisted in the lungs after 48 h, indicating that the other isolates were rapidly cleared. Results from the in vitro assays showed that only L. pneumophila significantly multiplied within A. polyphaga, THP-1 and J774 cells after 72 h, but lysis of any of the in vitro hosts also flagged the strains for potential concern (e.g. L. dumoffii and L. micdadei). The results demonstrate the value of using multiple approaches to assess the potential level of pathogenicity of Legionella strains isolated from different environmental matrices.

Impact of the COVID-19 pandemic on diabetic ketoacidosis management in the pediatric intensive care unit

Kahveci Fevzi,Ocak Buse Önen,Gün Emrah,Gurbanov Anar,Uçmak Hacer,Aslan Ayşen Durak,Ceran Ayşegül,Özen Hasan,Balaban Burak,Botan Edin,Şıklar Zeynep,Berberoğlu Merih,Kendirli Tanıl 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.3

Background: Diabetic ketoacidosis (DKA) is a common endocrine emergency in pediatric patients. Early presentation to health facilities, diagnosis, and good management in the pediatric intensive care unit (PICU) are crucial for better outcomes in children with DKA. Methods: This was a single-center, retrospective cohort study conducted between February 2015 and January 2022. Patients with DKA were divided into two groups according to pandemic status and diabetes diagnosis. Both groups were examined in two subcategories (pandemic status: pre-pandemic vs. pandemic; and diabetes diagnosis status: previously diagnosed vs. newly diagnosed).Results: The study enrolled 59 patients, and their mean age was 11±5 years. Forty (68%) had newly diagnosed type 1 diabetes mellitus (T1DM), and 61% received follow-up in the pre-pandemic period. Blood glucose, blood ketone, potassium, phosphorus, creatinine, and alanine transaminase levels were significantly higher in the new-onset T1DM group compared with the previously diagnosed group (P=0.01, P=0.02, P=0.01, P=0.039, and p=0.001, respectively). In patients with newly diagnosed T1DM, length of PICU stays were longer than in those with previously diagnosed T1DM (28.5±8.9 vs. 17.3±6.7 hours, p<0.005). The pandemic group was compared with pre-pandemic group, there was a statistically significant difference in laboratory parameters of pH, HCO3, and lactate and also Pediatric Risk Of Mortality (PRISM) III score. All patients survived, and there were no neurologic sequelae. Conclusion: Patients admitted during the pandemic period were admitted with more severe DKA and had higher PRISM III scores. During the pandemic period, there was an increase in the incidence of DKA in the participating center compared to that before the pandemic. Although the reason for this is not fully known, it could be public health presentations were not effective during the coronavirus disease 2019 (COVID-19) period.

Effects of cyanocobalamin and its combination with morphine on neuropathic rats and the relationship between these effects and thrombospondin-4 expression

Neslihan Düzenli,Sibel Ülker,Gülgün Şengül,Buse Kayhan,Aytül Önal 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1

Background: Thrombospondin-4 (TSP4) upregulates in the spinal cord following peripheral nerve injury and contributes to the development of neuropathic pain (NP). We investigated the effects of cyanocobalamin alone or in combination with morphine on pain and the relationship between these effects and spinal TSP4 expression in neuropathic rats. Methods: NP was induced by chronic constriction injury (CCI) of the sciatic nerve. Cyanocobalamin (5 and 10 mg/kg/day) was administered 15 days before CCI and then for 4 and 14 postoperative days. Morphine (2.5 and 5 mg/kg/day) was administered only post-CCI. Combination treatment included cyanocobalamin and morphine, 10 and 5 mg/kg/day, respectively. All drugs were administered intraperitoneally. Nociceptive thresholds were detected by esthesiometer, analgesia meter, and plantar test, and TSP4 expression was assessed by western blotting and fluorescence immunohistochemistry. Results: CCI decreased nociceptive thresholds in all tests and induced TSP4 expression on the 4th postoperative day. The decrease in nociceptive thresholds persisted except for the plantar test, and the increased TSP4 expression reversed on the 14th postoperative day. Cyanocobalamin and low-dose morphine alone did not produce any antinociceptive effects. High-dose morphine improved the decreased nociceptive thresholds in the esthesiometer when administered alone but combined with cyanocobalamin in all tests. Cyanocobalamin and morphine significantly induced TSP4 expression when administered alone in both doses for 4 or 14 days. However, this increase was less when the two drugs are combined. Conclusions: The combination of cyanocobalamin and morphine is more effective in antinociception and partially decreased the induced TSP4 expression compared to the use of either drug alone.