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      • KCI등재

        Numerical and experimental analysis of a 3D printed Savonius rotor with built-in extension plate

        Burcin Deda Altan,Volkan Kovan,Gurkan Altan 한국풍공학회 2018 Wind and Structures, An International Journal (WAS Vol.27 No.1

        In this study, the enhancement of the conventional Savonius wind rotor performance with extension plate has been investigated experimentally and numerically. Experimental models used in the study have been produced with 3D (three dimensional) printing, which is one of the rapid prototyping techniques. Experiments of produced Savonius wind rotor models have been carried out in a wind tunnel. CFD (Computational Fluid Dynamics) analyses have been performed under the same experimental conditions to ensure that experiments and numerical analyses are supported to each other. An additional extension plate has been used in order to enhance the performance of the conventional Savonius wind rotor with a gap distance between blades. It can be called modified Savonius rotor or Savonius rotor with built-in extension plate. Thus, the performance of the rotor has been enhanced without using additional equipment other than the rotor itself. Numerical and experimental analyses of Savonius wind rotor models with extension plate have been carried out under predetermined boundary conditions. It has been found that the power coefficient of the modified Savonius rotor is increased about 15% according to the conventional Savonius rotor.

      • SCIESCOPUS

        Numerical and experimental analysis of a 3D printed Savonius rotor with built-in extension plate

        Altan, Burcin Deda,Kovan, Volkan,Altan, Gurkan Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.1

        In this study, the enhancement of the conventional Savonius wind rotor performance with extension plate has been investigated experimentally and numerically. Experimental models used in the study have been produced with 3D (three dimensional) printing, which is one of the rapid prototyping techniques. Experiments of produced Savonius wind rotor models have been carried out in a wind tunnel. CFD (Computational Fluid Dynamics) analyses have been performed under the same experimental conditions to ensure that experiments and numerical analyses are supported to each other. An additional extension plate has been used in order to enhance the performance of the conventional Savonius wind rotor with a gap distance between blades. It can be called modified Savonius rotor or Savonius rotor with built-in extension plate. Thus, the performance of the rotor has been enhanced without using additional equipment other than the rotor itself. Numerical and experimental analyses of Savonius wind rotor models with extension plate have been carried out under predetermined boundary conditions. It has been found that the power coefficient of the modified Savonius rotor is increased about 15% according to the conventional Savonius rotor.

      • SCIESCOPUSKCI등재

        The effect of two artificial salivas on the adhesion of Candida albicans to heat-polymerized acrylic resin

        Oncul, Burcin,Karakis, Duygu,Al, Funda Dogruman The Korean Academy of Prosthodonitics 2015 The Journal of Advanced Prosthodontics Vol.7 No.2

        PURPOSE. Xerostomia can diminish the quality of life, leads to changes in normal chemical composition of saliva and oral microbiata, and increases the risk for opportunistic infections, such as Candida albicans. Various artificial salivas have been considered for patients with xerostomia. However, the knowledge on the antifungal and antiadhesive activity of artificial saliva substitutes is limited. The aim of the present study was to evaluate influence of two artificial salivas on the adhesion of Candida albicans to the polymethylmethacrylate disc specimens. MATERIALS AND METHODS. Two commercial artificial salivas (Saliva Orthana and Biotene Oral Balance Gel) were selected. 45 polymethylmethacrylate disc specimens were prepared and randomly allocated into 3 groups; Saliva Orthana, Biotene-Oral Balance gel and distilled water. Specimens were stored in the artificial saliva or in the sterile distilled water for 60 minutes at $37^{\circ}C$. Then they were exposed to yeast suspensions including Candida albicans. Yeast cells were counted using ${\times}40$ magnification under a light microscope and data were analysed. RESULTS. Analysis of data indicated statistically significant difference in adhesion of Candida albicans among all experimental groups (P=.000). Findings indicated that Saliva Orthana had higher adhesion scores than the Biotene Oral Balance gel and distilled water (P<.05). CONCLUSION. In comparison of Saliva Orthana, the use of Biotene Oral Balance Gel including lysozyme, lactoferrin and peroxidase may be an appropriate treatment method to prevent of adhesion of Candida albicans and related infections in patients with xerostomia.

      • KCI등재

        Seismic Assessment of a Historical Masonry Mosque by Experimental Tests and Finite Element Analyses

        Ferit Cakir,Burcin S. Seker,Ahmet Durmus,Adem Dogangun,Habib Uysal 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.1

        The mosques are the most important pieces of Islamic culture in terms of their architectural and structural properties. Although,thousands of these mosques are still being used all over the world, many historical mosques are at risk in terms of seismic events. This study mainly focuses on historical Lala Pasha Mosque, which is located in the city center of Erzurum, Turkey. The main purposeof this study is to assess the structural behaviors and to investigate the architectural features and components of the mosque. Thestudy was carried out in two main steps. Firstly, compression and three-point bending tests on the construction materials wereconducted to determine the mechanical properties of the materials. In the second step, a three-dimensional finite element model of themosque was developed and structural responses for the model were investigated by means of static and dynamic analyses. The resultsof the analyses show that the most critical parts of the mosque are the dome, pulley, and the supports of the main arch structures thatcarry the main dome. Additionally, the dynamic analyses prove that the most critical parts of the mosque are the sub-sections of themain columns, the window edges, and small domes.

      • KCI등재후보
      • Can Recurrence and Progression be Predicted by HYAL-1 Expression in Primary T1 Bladder Cancer?

        Mammadov, Elnur,Aslan, Guven,Tuna, Burcin,Bozkurt, Ozan,Yorukoglu, Kutsal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

        Background: Molecular prognostic markers have been under investigation for the last decade and no validated marker to date has been proven to be used in daily clinical practice for urinary bladder cancers. The aim of the present study is to evaluate the significance of HYAL-1 expression in prediction of recurrence and progression in pT1 urothelial carcinomas. Materials and Methods: Eighty-nine urothelial carcinoma cases staged as T1 according to 2004 WHO classification were studied. Representative sections from every case were stained immunohistochemically for HYAL-1 and scored between 0 and +3, according to staining density, and graded as low and high for the scores 0-1 and 2-3, respectively. Results: Of the 89 pT1 bladder cancer patients, HYAL-1 expression was high in 92.1% (82 patients; 72 patients +3 and 10 patients +2) and low in 7.9% (only 7 patients; 6 patients +1 and 1 patient 0) of the cases. Of the 89 patients, 38 (42.7%) had recurrence and 22 (24.7%) showed progression. HYAL-1 staining did not show significant characteristics for tumor grade, accompanying CIS, multiplicity, tumor size, age and sex. HYAL-1 expression did not have any prognostic value in estimating recurrence or progression. Conclusions: HYAL-1 expression was found to be high, but did not have any prognostic importance in T1 bladder urothelial carcinomas.

      • Prognostic Significance of Nestin Expression in pT1 High-Grade Bladder Urothelial Carcinoma Patients Treated with Intravesical BCG

        Sen, Volkan,Bozkurt, Ozan,Demir, Omer,Tuna, Burcin,Yorukoglu, Kutsal,Ellidokuz, Hulya,Mungan, Ugur Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24

        Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.

      • KCI등재

        The effect of two artificial salivas on the adhesion of Candida albicans to heat-polymerized acrylic resin

        Funda Dogruman Al,Duygu Karakis,Burcin Oncul 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.2

        PURPOSE Xerostomia can diminish the quality of life, leads to changes in normal chemical composition of saliva and oral microbiata, and increases the risk for opportunistic infections, such as Candida albicans. Various artificial salivas have been considered for patients with xerostomia. However, the knowledge on the antifungal and antiadhesive activity of artificial saliva substitutes is limited. The aim of the present study was to evaluate influence of two artificial salivas on the adhesion of Candida albicans to the polymethylmethacrylate disc specimens. MATERIALS AND METHODS Two commercial artificial salivas (Saliva Orthana and Biotene Oral Balance Gel) were selected. 45 polymethylmethacrylate disc specimens were prepared and randomly allocated into 3 groups; Saliva Orthana, Biotene-Oral Balance gel and distilled water. Specimens were stored in the artificial saliva or in the sterile distilled water for 60 minutes at 37℃. Then they were exposed to yeast suspensions including Candida albicans. Yeast cells were counted using ×40 magnification under a light microscope and data were analysed. RESULTS Analysis of data indicated statistically significant difference in adhesion of Candida albicans among all experimental groups (P=.000). Findings indicated that Saliva Orthana had higher adhesion scores than the Biotene Oral Balance gel and distilled water (P<.05). CONCLUSION In comparison of Saliva Orthana, the use of Biotene Oral Balance Gel including lysozyme, lactoferrin and peroxidase may be an appropriate treatment method to prevent of adhesion of Candida albicans and related infections in patients with xerostomia.

      • KCI등재

        An Outbreak of Tularemia in Western Black Sea Region of Turkey

        Saban Gurcan,Muserref Tatman-Otkun,Metin Otkun,Osman Kursat Arikan,Burcin Ozer 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.1

        The aim of this study was to investigate the source and the size of a tularemia outbreak in a village located in a non-endemic area. Five patients from the same village were admitted to hospital with the same complaints all within one week of September 2001. Tularemia was suspected and a diagnosis was made after physical and anamnesis examinations. The village was visited the same week that the patients were admitted to the hospital, in the January and April 2002. The villagers were examined and screened serologically by microagglutination method and the water sources were investigated bacteriologically. A total of 14 people were found to be infected from the outbreak and the oropharyngeal form was the only clinical presentation. Antibody titers ranged between 1:80 and 1:640. The patients responded well to the aminoglycoside plus tetracycline therapy. Examination of the pipewater and three springs revealed that all the water sources were contaminated by coliforms, however, Francisella tularensis could not be isolated in glucose-cystine medium. Antibody levels stayed stable or decreased seven months after. Tularemia had not been reported in this area before, so the first patients were misdiagnosed. In conclusion tularemia should be considered in differential diagnosis of patients with fever, sore throat and cervical lymphadenopaties.

      • KCI등재

        An Overview of Deep Learning Algorithms and Their Applications in Neuropsychiatry

        Gokhan Guney,Busra Ozgode Yigin,Necdet Guven,Yasemin Hosgoren Alici,Burcin Colak,Gamze Erzin,Gorkem Saygili 대한정신약물학회 2021 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.19 No.2

        Deep learning (DL) algorithms have achieved important successes in data analysis tasks, thanks to their capability of revealing complex patterns in data. With the advance of new sensors, data storage, and processing hardware, DL algo-rithms start dominating various fields including neuropsychiatry. There are many types of DL algorithms for different data types from survey data to functional magnetic resonance imaging scans. Because of limitations in diagnosing, esti-mating prognosis and treatment response of neuropsychiatric disorders; DL algorithms are becoming promising approaches. In this review, we aim to summarize the most common DL algorithms and their applications in neuro-psychiatry and also provide an overview to guide the researchers in choosing the proper DL architecture for their research.

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