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소범식(Bum-Sik So),박동환(Dong-Hwan Park),송태성(Tae-Seong Song),정희진(Hee-Jin Jeong),고태조(Tae-Jo Ko) 한국기계가공학회 2008 한국기계가공학회 춘추계학술대회 논문집 Vol.2008 No.-
In this study, new effective offset algorithm using convex/concave curves for closed 2-dimensional shape is presented. The computation to check an intersection point among all elements is dominant in the offset calculation, and it makes significant computing time according to increase of number of elements. In the proposed algorithm, an intersection point for generation of offset loop is searched by checking of convex/concave curves of the loop instead of all elements. Therefore the proposed simple algorithm for offset loop requires significantly reduced computational cost.
MCNP Simulation Based Optimization of Prussian Blue for Cesium Removal
So On Park,Byung Sik Lee,Su Jung Min,Bum Kyoung Seo,Chang hyun Roh,Sang Bum Hong 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
The nuclear fuel that melted during the Fukushima nuclear accident in 2011 is still being cooled by water. In this process, contaminated water containing radioactive substances such as cesium and strontium is generated. The total amount of radioactive pollutants released by the natural environment due to the nuclear accident in Fukushima in 2011 is estimated to be 900 PBq, of which 10 to 37 PBq for cesium. Radioactive cesium (137Cs) is a potassium analog that exists in the water in the form of cations with similar daytime behavior and a small hydration radius and is recognized as a radioactive nuclide that has the greatest impact on the environment due to its long half-life (about 30 years), high solubility and diffusion coefficient, and gamma-ray emission. In this study, alginate beads were designed using Prussian blue, known as a material that selectively adsorbs cesium for removal and detection of cesium. To confirm the adsorption performance of the produced Prussian blue, immersion experiments were conducted using Cs standard solution, and MCNP simulations were performed by modeling 1L reservoir to conduct experiments using radioactive Cs in the future. An adsorption experiment was conducted with water containing standard cesium solution using alginate beads impregnated with Prussian blue. The adsorption experiment tested how much cesium of the same concentration was adsorbed over time. As a result, it was found that Prussian blue beads removed about 80% of cesium within 10-15 minutes. In addition, MCNP simulation was performed using a 1 L reservoir and a 3inch NaI detector to optimize the amount of Prussian blue. The results of comparing the efficiency according to the Prussian volume was shown. It showed that our designed system holds great promise for the cleanup and detection of radioactive cesium contaminated seawater around nuclear plants and/or after nuclear accidents. Thus, this work is expected to provide insights into the fundamental MCNP simulation based optimization of Prussian blue for cesium removal and this work based MCNP simulation will pave the way for various practical applications.
( So Young Park ),( Sang Min Lee ),( Jong Wook Shin ),( Byoung Whui Choi ),( Hojoong Kim ),( Jae Seung Lee ),( Sang Do Lee ),( Sung Soo Park ),( Hwa Sik Moon ),( Yong Bum Park ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2
Background/Aims: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is diff icult for numerous reasons and is related with a poor prognosis. In Korea, the incidence of CTEPH and its clinical features are unknown. Thus, in this study, we evaluated the clinical characteristics and outcomes of CTEPH in a Korean cohort. Methods: This study included South Korean patients diagnosed with CTEPH between September 2008 and October 2011. Baseline characteristics, treatments and outcomes were analyzed. Results: A total of 134 patients were included in this study with 76 females (56.7%). Their median age was 58.3 ± 15.9 years and dyspnea (112 patients, 83.5%) was the most common presenting symptom. Sixty-three patients (47%) had a history of acute pulmonary embolism or deep vein thrombosis, and six (4.5%) had pulmonary tuberculosis. In total, 28 patients (21%) underwent pulmonary thromboendarterectomy (PTE), and 99 patients had medical therapy. During the study period, 18 patients (13.4%) died. In a multivariate analysis, higher hemoglobin (relative risk [RR], 1.516; 95% confidence interval [CI], 1.053 to 2.184; p = 0.025) and lower total cholesterol levels (RR, 0.982; 95% CI, 0.965 to 0.999; p = 0.037) were associated with increased mortality. Conclusions: This was the first national cohort study of Korean patients with CTEPH. Accurate diagnosis, characterization and distributions of CTEPH are imperative for prompt treatment in patients, particularly those undergoing PTE.
( So Young Joo ),( Young A Song ),( Young Lan Park ),( Eun Myung ),( Cho Yun Chung ),( Kang Jin Park ),( Sung Bum Cho ),( Wan Sik Lee ),( Hyun Soo Kim ),( Jong Sun Rew ),( Nack Sung Kim ),( Young Eun 대한소화기학회 2012 Gut and Liver Vol.6 No.2
Background/Aims: Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has anti-inflammatory and anti-oxidative properties. The aim of the current study was to characterize the impact of EGCG on lipopolysaccharide (LPS)-induced innate signaling in bone marrow-derived macrophages (BMMs) isolated from ICR mice. Methods: The effect of EGCG on LPS-induced pro-infl ammatory gene expression and nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling was examined using reverse transcription-polymerase chain reaction, Western blotting, immunofl uorescence, and the electrophoretic mobility shift assay. Results: EGCG inhibited accumulation of LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA in BMMs. EGCG blocked LPS-induced IκBα degradation and RelA nuclear translocation. EGCG blocked the DNA-binding activity of NF-κB. LPS-induced phosphorylation of ERK1/2, JNK, and p38 was inhibited by EGCG. U0126 (an inhibitor of MEK- 1/2) suppressed the LPS-induced IL-12p40, IL-6, MCP-1, ICAM-1, and VCAM-1 mRNA accumulation in BMMs. Conclusions: These results indicate that EGCG may prevent LPSinduced pro-infl ammatory gene expression through blocking NF-κB and MAPK signaling pathways in BMMs. (Gut Liver 2012;6:188-196)