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Han Sungpil,Choi Hee Youn,Kim Yo Han,Choi SeungChan,Kim Seokuee,Nam Ji Yeon,Kim Bongtae,Song Geun Seog,Lim Hyeong-Seok,Bae Kyun-Seop 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1
Background/Aims: Tegoprazan, a novel potassium-competitive acid blocker, is expected to overcome the limitations of proton pump inhibitors and effectively control nocturnal acid breakthrough. To evaluate the pharmacodynamics of tegoprazan versus dexlansoprazole regarding nocturnal acid breakthrough in healthy subjects. Methods: In a randomized, open-label, single-dose, balanced incomplete block crossover study, 24 healthy male volunteers were enrolled and randomized to receive oral tegoprazan (50, 100, or 200 mg) or dexlansoprazole (60 mg) during each of two administration periods, separated by a 7- to 10-day washout period. Blood samples were collected for pharmacokinetic parameter analysis; gastric monitoring was performed for pharmacodynamic parameter evaluation. Results: All 24 subjects completed the study. Average maximum plasma concentration, area under the plasma concentration–time curve, and mean time with gastric pH >4 and pH >6 for tegoprazan demonstrated dose-dependent incremental increases. All the tegoprazan groups reached mean pH ≥4 within 2 hours, whereas the dexlansoprazole group required 7 hours after drug administration. Based on pharmacodynamic parameters up to 12 hours after evening dosing, 50, 100, and 200 mg of tegoprazan presented a stronger acid-suppressive effect than 60 mg of dexlansoprazole. Moreover, the dexlansoprazole group presented a comparable acid-suppressive effect with the tegoprazan groups 12 hours after dosing. Conclusions: All the tegoprazan groups demonstrated a significantly faster onset of gastric pH increase and longer holding times above pH >4 and pH >6 up to 12 hours after evening dosing than the dexlansoprazole group.
Error analysis of the phase-shifting technique when applied to shadow moiré
Han, Changwoon,Han, Bongtae The Optical Society 2006 Applied Optics Vol.45 No.6
<P>An exact solution for the intensity distribution of shadow moiré fringes produced by a broad spectrum light is presented. A mathematical study quantifies errors in fractional fringe orders determined by the phase-shifting technique, and its validity is corroborated experimentally. The errors vary cyclically as the distance between the reference grating and the specimen increases. The amplitude of the maximum error is approximately 0.017 fringe, which defines the theoretical limit of resolution enhancement offered by the phase-shifting technique.</P>
KIM, Bongtae,LEE, Kichan,HAN, Kiwon,KIM, Duyeol,HA, Yooncheol,KIM, Chung Hyun,OH, Yeonsu,KANG, Ikjae,LEE, Jeehoon,CHAE, Chanhee Japanese Society of Veterinary Science 2010 The Journal of veterinary medical science Vol.72 No.9
<P>The aim of this study was to develop <I>in situ</I> hybridization for detection of <I>Mycoplasma hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from pigs with polyserositis. <I>M. hyorhinis</I> was isolated from the spleen (2 pigs) and pericardium (1 pig). <I>M. hyorhinis</I> DNA was detected 16 out of 20 pigs with polyserositis. <I>In situ</I> hybridization produced a distinct positive signal for the <I>M. hyorhinis</I> p37 gene in inflammatory cells in the polyserositis. <I>In situ</I> hybridization developed in the present study present diagnostic tools capable of detection of <I>M. hyorhinis</I> in formalin-fixed, paraffin-wax-embedded tissues from the naturally infected pigs.</P>
KIM, Bongtae,AHN, Kyoung Kyu,HA, Yooncheol,LEE, Yong Hoon,KIM, Duyeol,LIM, Jeong Han,KIM, Sung-Hoon,KIM, Mi-Young,CHO, Kyung-Dong,LEE, Bog-Hieu,CHAE, Chanhee Japanese Society of Veterinary Science 2009 The Journal of veterinary medical science Vol.71 No.5
<P>The relationship between tumor necrosis factor (TNF)-α level, body temperature, and pulmonary lesion score was determined in 3-week-old pigs inoculated intranasally with swine influenza virus (SIV) subtype H1N2. The expression of TNF-α was measured in bronchoalveolar lavage (BAL) fluids by enzyme-linked immunosorbent assay and lung tissues by immunohistochemistry. In BAL fluid, TNF-α concentration was maximal at 1 days post-inoculation (dpi), declined markedly by 3 dpi (<I>P</I><0.05) and steady thereafter. Mean rectal temperatures were above 40°C for the infected groups at 1 dpi and declined markedly by 3 dpi. The body temperatures were correlated with the levels of TNF-α in BAL fluids from pigs experimentally infected with SIV (<I>r</I><SUB>s</SUB>=0.9754, <I>P</I><0.05). The pulmonary lesion scores were correlated with the means of positive cells by immunohistochemistry for TNF- α (<I>r</I><SUB>s</SUB>=0.9949, <I>P</I><0.001). The results suggest that the expression of TNF-α protein plays an important role in induction of pulmonary lesion and clinical sign such as fever in SIV infection.</P>
Four Point Bending Test for Adhesion Testing of Packaging Strictures: A Review
Mahan, Kenny,Han, Bongtae The Korean Microelectronics and Packaging Society 2014 마이크로전자 및 패키징학회지 Vol.21 No.4
To establish the reliability of a packaging structures, adhesion testing of key interfaces is a critical task. Due to the material mismatch, the interface may be prone to delamination failure due to conditions during the manufacturing of the product or just from the day-to-day use. To assess the reliability of the interface adhesion strength testing can be performed during the design phase of the product. One test method of interest is the four-point bending (4PB) adhesion strength test method. This test method has been implemented in a variety of situations to evaluate the adhesion strength of interfaces in bimaterial structures to the interfaces within thin film multilayer stacks. This article presents a review of the 4PB adhesion strength testing method and key implementations of the technique in regards to semiconductor packaging.
모아레 간섭계를 이용한 CBGA 패키지의 비선형 열변형 해석
주진원(Jinwon Joo),한봉태(Bongtae Han),조승민(Seungmin Cho) 대한기계학회 2002 대한기계학회 춘추학술대회 Vol.2002 No.8
Thermo-mechanical behavior of a ceramic ball grid array (CBGA) package assembly are characterized by high sensitive moire interferometry. Moire fringe patterns are recorded and analyzed at various temperatures. Thermal-history dependent analyses of global and local deformations are presented. A significant non-linear global behavior is documented due to stress relaxation at high temperature. Analysis of the solder interconnections reveals that inelastic deformation accumulates at eutectic solder fillets only at high temperatures.
Seo, Hyeon-Seok,Han, Bongtae,Kim, Youn-Jea American Scientific Publishers 2012 Journal of nanoscience and nanotechnology Vol.12 No.6
<P>A new type of electrokinetic micromixer with a ring-type channel is introduced for fast mixing. The proposed mixer takes two fluids from different inlets and combines them in a ring-type mixing chamber. The fluids enter two different inlets (inner radius: 25 microm and outer radius: 50 microm), respectively. The total channel length is 500 microm, and four microelectrodes are positioned on the outer wall of the mixing chamber. The electric potentials on the four microelectrodes are sinusoidal with time, having various maximum values of voltage, zeta potential and frequency. Also, in order to compare the mixing performance with different obstacle configurations, we performed a numerical analysis using a commercial code, COMSOL. The concentration of the dissolved substances in the working fluid and the flow and electric fields in the channel were investigated and the results were graphically depicted for various flow and electric conditions.</P>
Hyunseok Oh,Hsiu-Ping Wei,Bongtae Han,Youn, Byeng D. IEEE 2016 IEEE transactions on components, packaging, and ma Vol.6 No.2
<P>We propose a novel methodology for calibrating the physics-based lifetime models of the electronic packages using the eigenvector dimension-reduction (EDR) method and a censored data analysis. The methodology enables to overcome two challenges that are encountered in typical electronic packaging applications: 1) the minimum computational cost without sacrificing the prediction accuracy and 2) the proper handling of the censored data. The EDR method is first employed for uncertainty propagation for the computational efficiency when multiple unknown variables are to be used in nonlinear damage models. Next, the likelihood function is modified to handle the failure data as well as the censored data in the likelihood analysis, and thus establishes the correlation between the model response and the experimental result. Finally, through an unconstrained optimization process, a calibrated parameter set of statistical distributions for unknown input variables is obtained while maximizing the modified likelihood. The proposed statistical calibration approach is implemented for solder joint fatigue reliability. The results confirm the claimed computational effectiveness for an accurate physics-based lifetime model.</P>