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( Da Wei Chen ),( Zhen Quan Yang ),( Xia Chen ),( Yu Jun Huang ),( Bo Xing Yin ),( Fei Xiang Guo ),( Hai Qing Zhao ),( Jia Di Huang ),( Yun Wu ),( Rui Xia Gu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
Accumulating evidence indicates that lactic acid bacteria could improve host physiology and lipid metabolism. To investigate the effect of the gut microbiota on host lipid metabolism, a hyperlipidemic rat model was established by feeding rats a high-fat diet for 28 days, and the gut microbiota of the rats was analyzed using real-time PCR before and after administration of Lactobacillus rhamnosus hsryfm 1301 and its fermented milk for 28 days. The findings showed that the Lactobacillus spp., Bifidobacterium spp., Bacteroides spp., and Enterococcus spp. content in the hyperlipidemic rats gut was increased significantly (p < 0.05), while the Clostridium leptum and Enterobacter spp. content was decreased significantly after intervening with L. rhamnosus hrsyfm 1301 and its fermented milk for 28 days (p < 0.05). Furthermore, the lipid levels of the serum and the liver were decreased significantly (p < 0.05) and the fecal water content was increased significantly (p < 0.05) in the hyperlipidemic rats after the intervention, and hepatocyte fatty degeneration of liver tissues was also prevented. A positive correlation was observed between the Clostridium leptum content and the level of serum cholesterol, triglycerides, low-density lipoprotein, and high-density lipoprotein, and a negative correlation was observed between the Enterobacter spp. content and the Lactobacillus spp. and Bifidobacterium spp. content in the hyperlipidemic rats gut. These results suggest that the gut microbiota and lipid metabolism of hyperlipidemic rats could be improved by supplementation with L. rhamnosus hsryfm 1301 and its fermented milk.
Mitochondrial DNA Levels in Blood and Tissue Samples from Breast Cancer Patients of Different Stages
Xia, Peng,Wang, Hui-Juan,Geng, Ting-Ting,Xun, Xiao-Jie,Zhou, Wen-Jing,Jin, Tian-Bo,Chen, Chao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Aims: Alterations in mitochondrial DNA (mtDNA) have been implicated in carcinogenesis and tumor progression. We here evaluated the diagnostic and prognostic potential of mtDNA as a biomarker for breast cancer. Methods: Using multiplex real-time polymerase chain reaction, nuclear DNA (nDNA) and mtDNA levels in serum, buffy coat, tumor, and tumor-adjacent tissue samples from 50 breast cancer patients were determined and assessed for associations with clinicopathological features. To evaluate mtDNA as a biomarker for distinguishing between the four sample types, we created receiver operating characteristic (ROC) curves. Results: The mtDNA levels in buffy coat were significantly lower than in other sample types. Relative to tumor-adjacent tissue, reduced levels of mtDNA were identified in buffy coat and tumor tissue but not in serum. According to ROC curve analysis, mtDNA levels could be used to distinguish between buffy coat and tumor-adjacent tissue samples with good sensitivity (77%) and specificity (83%). Moreover, mtDNA levels in serum and tumor tissue were positively associated with cancer TMN stage. Conclusions: The mtDNA levels in blood samples may represent a promising, non-invasive biomarker in breast cancer patients. Additional, large-scale validation studies are required to establish the potential use of mtDNA levels in the early diagnosis and monitoring of breast cancer.
Guoqing Xia,Caiyun Liu,Bo Zhao,Xinghua Chen,Xingchao Shao 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.11
This paper investigates finite-time output feedback control for ship dynamic positioning assisted mooring system with external disturbances and without velocity measurement. Firstly, a finite-time observer is designed to estimate the velocity of the positioning ship and the external disturbances. Secondly, based on the proposed observer, a finite-time control law is introduced to bring the ship to the desired position and heading. Furthermore, the stability of the overall closed-loop system is proved by using matrix inequality, homogeneous and Lyapunov stability theory. Finally, the effectiveness of the proposed positioning control is verified by numerical simulations.
Resilient Filtering for Delayed Markov Jump Neural Networks via Event-triggered Strategy
Weifeng Xia,Yongmin Li,Zuxin Li,Shuxin Du,Bo Li,Wenbin Chen 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.10
This paper deals with the event triggered filtering problem for a class of delayed discrete-time Markov jump neural networks, where a resilient filter with parameter uncertainties is adopted. The aim of this paper is to design a suitable filter which ensures that the filtering error system is stochastically stable and satisfies a prescribed mixed passivity and H∞ performance. Sufficient conditions for solvability of such a problem are developed. Basedon the obtained conditions, an explicit expression of the desired resilient filter is proposed. Finally, an example is presented to show the usefulness of the proposed scheme.
Geographic Distribution and Epidemiology of Lung Cancer During 2011 in Zhejiang Province of China
Lin, Xia-Lu,Chen, Yan,Gong, Wei-Wei,Wu, Zhao-Fan,Zou, Bao-Bo,Zhao, Jin-Shun,Gu, Hua,Jiang, Jian-Min Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Background: To explore etiology for providing scientific clues for the prevention of lung cancer. Materials and Methods: Data for lung cancer incidence and meteorological geographic factors from 25 counties in Zhejiang province of China during 2011 were studied. Stepwise multiple regression and correlation analysis were performed to analyze the geographic distribution and epidemiology of lung cancer. Results: 8,291 new cases (5,998 in males and 2,293 females) of lung cancer during 2011 in Zhejiang province were reported in the 25 studied counties. Reported and standardized incidence rates for lung cancer were 58.0 and 47.0 per 100,000 population, respectively. The incidence of lung cancer increased with age. Geographic distribution analysis shows that the standardized incidence rates of lung cancer in northeastern Zhejiang province were higher than in the southwestern part, such as in Nanhu, Fuyang, Wuxing and Yuyao counties, where the rates were more than 50 per 100,000 population. In the southwestern Zhejiang province, for instance, in Yueqing, Xianju and Jiande counties, the standardized incidence rates of lung cancer were lower than 37 per 100,000 population. Spearman correlation tests showed that forest coverage rate, air quality index (AQI), and annual precipitation level are associated with the incidence of lung cancer. Conclusions: Lung cancer in Zhejiang province shows obvious regional differences. High incidence appears associated with low forest coverage rate, poor air quality and low annual precipitation. Therefore, increasing the forest coverage rate and controlling air pollution may play an important role in lung cancer prevention.
Xin Chen,Dan Sheng,Honghui Xia,Weilin Xu,Bo Deng,Genyang Cao 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12
In this study, a combined dyeing method by integrating the advantages of both carrier dyeing and hot-pressingdyeing was utilized for the dyeing of meta-aramid. A rapid dyeing with increased mechanical properties of the fibers wasachieved for the meta-aramid fiber. A so-called particle flow mechanism involving both N,N-dimethylacetamide (DMAc)and dye molecules was proposed to explain the accelerating effect of this unique dyeing method. The mechanical propertiesand thermodynamic stability of the fiber after hot-pressing were both increased. XRD results showed increasedcorresponding fiber crystallinity. TEM showed that the disperse dyes were well dispersed in DMAc. Cross-sectional opticalphotographs of dyed fibers revealed that the dyes were successfully carried into the interior of the fiber under the synergiceffect of temperature and pressure. Combined with hot-pressing dyeing, the dyeing cycle for the meta-aramid could begreatly shortened and the amounts of dyes and carriers could be significantly reduced.
Mao-pu Xia,Hai-bo Li,Nan Jiang,Jun-lin Chen,Jia-wen Zhou 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1
Rockfall is a major geological disaster that frequently occurs on rock slopes in alpine and gorge regions and poses a significant threat to life and property in areas exposed to rockfall hazards. In this study, a methodology is presented for comprehensive rockfall hazard analysis, including data acquisition, source identification, numerical simulation, quantitative assessment and mitigation evaluation. A high-precision and high-resolution digital terrain model (DTM) is generated based on the point cloud data obtained by terrestrial laser scanning (TLS) and is utilized for rockfall simulation and automatic identification of structural planes. The model parameters are calibrated by three-dimensional (3D) back analysis, and the rockfall motion is simulated based on a probabilistic model and an energy dissipation model. Rockfall mitigation under passive protection is evaluated according to the rockfall interception ratio (RIR), hazard reduction rate (HRR) and statistics of the rockfall characteristics and hazards within the rockfall threat area. Under the influence of construction excavation, the diversion tunnel inlet slope of Jinchuan Hydropower Station has suffered from a series of rockfall events and potential overall instability, which has become a great threat to the construction personnel, equipment and vehicles below the slope. Thus, the presented methodology is applied to thoroughly study the example case of the rockfall events at the inlet slope of the diversion tunnel of Jinchuan Hydropower Station. The advantages, limitations and notes of each link of the presented methodology are discussed, and the suggestion of strengthening the cracked area with integral active support is proposed.
NA HAO,BO JIANG,PENG SUN,CHUANCHAO LI,Lili Liu,XIA LI,LU CHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.7
Immunoglobulin A nephropathy (IgAN) has been recognized as the most prevalent form ofglomerulonephritis with various histologic and clinical phenotypes in the world. The Gal-de¯cientIgA1 with terminally exposed GalNAc residue(s) plays a key role in the pathogenesis of thedisease. In this study, a novel colorimetric biosensor based on Helix aspersa agglutinin (HAA)absorbed on polydiacetylene (PCDA) nanovesicles for N-acetylgalactosamine (GalNAC) mo-lecular as core framework of Gal-de¯cient IgA1 recognition was investigated using the higha±nity between lectin HAA and GalNAC. The PCDA nanovesicles were prepared via UVcrosslinking. The size, morphology and elastic property of the nanovesicles were tested. Theoptimal concentration of HAA for the recognition of GalNAC via naked eyes observation was3 mM and the critical concentration of GalNAC for the sensitive color transition was 2 ? g/mL. This novel method has many advantages such as low prices, intuitive, real-time and easy to carryout and great potential in Gal-de¯cient IgA1 detection.