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Kinoshita, Yoshihiro,Chen, Junwen,Rapee, Ronald M.,Bö,gels, Susan,Schneier, Franklin R.,Choy, Yujuan,Kwon, Jung-Hye,Liu, Xinghua,Schramm, Elisabeth,Chavira, Denise A.,Nakano, Yumi,Watanabe, Norio Lippincott Williams Wilkins, Inc. 2008 Journal of nervous and mental disease Vol.196 No.4
Conviction subtype Taijin-Kyofu (c-TK) is a subgroup of mental disorder characterized by conviction and strong fear of offending others in social situations. Although the concept of c-TK overlaps with that of social anxiety disorder (SAD), patients with c-TK often may not be diagnosed as such within the current Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV criteria. We propose the Nagoya-Osaka criteria to amend this situation. This study examined the cross-cultural interrater reliability of the proposed criteria. Eighteen case vignettes of patients with a variety of complaints focused around social anxieties were collected from 6 different countries, and diagnosed by 13 independent raters from various nationalities according to the original DSM-IV and the expanded criteria. The average agreement ratio for the most frequent diagnostic category in each case was 61.5% with DSM-IV and 87.6% with the modified DSM-IV with Nagoya-Osaka criteria (p < 0.001). These findings indicate that the Nagoya-Osaka criteria for SAD can improve interrater reliability of SAD.
Analysis and Verification of the Stability for PV Series-Connected Power Optimizer System
Yutai Fu,Jizhi Qi,Yonghao Li,Xinghua Zhang,Min Chen 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Photovoltaic (PV) energy generation gets more and more attention in the last decades. Among many structures of PV system, series-connected power optimizer (SCPO) system is regarded as a promising one. However, the cross-coupling effect introduced by the series-connected structure cannot be avoided, which would weaken the stability of the system, resulting in failure of operation of the system. Therefore, it is significant to analysis the stability of the series-connected system and suppress the effect by improving the closed-loop control strategy and compensation design. In this paper, the small-signal ac model consisting of three optimizers is derived and the criterions of stability and compensation design are proposed. Computer simulation and hardware experiment are used to verify the validity of the proposed theories.
Guoqing Xia,Caiyun Liu,Bo Zhao,Xinghua Chen,Xingchao Shao 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.11
This paper investigates finite-time output feedback control for ship dynamic positioning assisted mooring system with external disturbances and without velocity measurement. Firstly, a finite-time observer is designed to estimate the velocity of the positioning ship and the external disturbances. Secondly, based on the proposed observer, a finite-time control law is introduced to bring the ship to the desired position and heading. Furthermore, the stability of the overall closed-loop system is proved by using matrix inequality, homogeneous and Lyapunov stability theory. Finally, the effectiveness of the proposed positioning control is verified by numerical simulations.
Zhan Wenzhi,Luo Wei,Zhang Yulong,Xiang Keheng,Chen Xiaomei,Shen Shuirong,Huang Chuqing,Xu Tingting,Ding Wenbin,Chen Yuehan,Lin Mingtong,Pan Xinghua,Lai Kefang 대한천식알레르기학회 2024 Allergy, Asthma & Immunology Research Vol.16 No.1
Purpose: Eosinophilic asthma (EA) and non-asthmatic eosinophilic bronchitis (EB) share similar eosinophilic airway inflammation. Unlike EA, EB did not present airway hyperresponsiveness or airflow obstruction. We aimed to compare the mechanism underlying the different manifestations between EA and EB via sputum transcriptomics analysis. Methods: Induced-sputum cells from newly physician-diagnosed EA, EB patients, and healthy controls (HCs) were collected for RNA sequencing. Results: Bulk RNA sequencing was performed using sputum cells from patients with EA (n = 18), EB (n = 15) and HCs (n = 28). Principal component analysis revealed similar gene expression patterns in EA and EB. The most differentially expressed genes in EB compared with HC were also shared by EA, including IL4, IL5 IL13, CLC, CPA3, and DNASE1L3. However, gene set enrichment analysis showed that the signatures regulating macrophage activation were enriched in EA compared to EB. Sputum cells were profiled using single-cell RNA sequencing. FABP4+ macrophages, SPP1+ macrophages, FCN1+ macrophages, dendritic cells, T cells, B cells, mast cells, and epithelial cells were identified based on gene expression profiling. Analysis of cell-cell communication revealed that interactions between FCN1+ macrophages and other cells were higher in EA than in EB. A wealth of transforming growth factor beta (TGF-β) and vascular endothelial growth factor (VEGF) interactions between FCN1+ macrophages and other cells have been shown in EA. The gene expression levels of EREG, TGFBI, and VEGFA in FCN1+ macrophages of EA were significantly higher than those of EB. Furthermore, signatures associated with the response to TGF-β, cellular response to VEGF stimulus and developmental cell growth were enriched in FCN1+ macrophages of EA compared to those of EB. Conclusions: FCN1+ macrophage activation associated with airway remodeling processes was upregulated in EA compared to that in EB, which may contribute to airway hyperresponsiveness and airflow obstruction.