http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kap-Suk Kang,Leonard F. Bjeldanes 한국식품영양과학회 1998 Preventive Nutrition and Food Science Vol.3 No.2
Inhibitory effect of indole oligomers induced from indole-3-carbinol (I3C) on the growth of breast cancer cells was studied. We generated the reaction mixtures (RXM) at ambient temperature by treating a stirred aqueous solution of I3C (typically 0.25 ml at a concentration of 12μmol/ml) with hydrochloric acid (typically 28μl of a 1 mmol/ml solution). RXM was fractionated by the column chromatography. The fractions with similar UV -pattern were further fractionated by HPLC and 3,3'-diindoylmethane (DIM) and other indole oligomers were identified. I3C, RXM, and its derived indole compounds were added to MCF-7 cells and cultured in the presence of 10^(-7)M estradiol for 7 days. The growth-inhibitory effect of I3C and DIM on the growth of MCF-7 cell was very strong. The synthetic DIM also revealed antiproliferative effect on MCF-7 cell. The fractions containing high DIM content (77%), were most effective in inhibiting MCF-7 cell growth induced by estradiol. With these results, we suggest that I3C and DIM might have anticarcinogenic effect on the breast cancer.