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신호정,Stefan Bister,이상준 한국생산관리학회 2022 韓國生産管理學會誌 Vol.33 No.4
This study aims to find empirical evidence of the contribution of information technology (IT) adoption in enhancing transportation safety. We analyze train accidents that occurred in European countries between 1980 and 2014. The findings indicate that the adoption of IT leads to a lower number of accidents, thus improving safety. Specifically, countries with a high level of IT adoption for their track networks show fewer serious accidents than those with low IT adoption. However, serious accidents have not decreased over time, indicating a limited positive effect of IT adoption. In addition, serious accidents such as rolling stocks and people at crossings continue to occur. The results indicate that improvement in transportation safety leveraged by intangible IT must accompany the quality assurance of physical systems and activities in basic transportation services.
Inhibitor of MYC identified in a Kröhnke pyridine library
Hart, Jonathan R.,Garner, Amanda L.,Yu, Jing,Ito, Yoshihiro,Sun, Minghao,Ueno, Lynn,Rhee, Jin-Kyu,Baksh, Michael M.,Stefan, Eduard,Hartl, Markus,Bister, Klaus,Vogt, Peter K.,Janda, Kim D. National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.34
<P>In a fluorescence polarization screen for the MYC–MAX interaction, we have identified a novel small-molecule inhibitor of MYC, KJ-Pyr-9, from a Kröhnke pyridine library. The <I>K</I><SUB>d</SUB> of KJ-Pyr-9 for MYC in vitro is 6.5 ± 1.0 nM, as determined by backscattering interferometry; KJ-Pyr-9 also interferes with MYC–MAX complex formation in the cell, as shown in a protein fragment complementation assay. KJ-Pyr-9 specifically inhibits MYC-induced oncogenic transformation in cell culture; it has no or only weak effects on the oncogenic activity of several unrelated oncoproteins. KJ-Pyr-9 preferentially interferes with the proliferation of MYC-overexpressing human and avian cells and specifically reduces the MYC-driven transcriptional signature. In vivo, KJ-Pyr-9 effectively blocks the growth of a xenotransplant of MYC-amplified human cancer cells.</P>