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RISS 인기검색어
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- 저자 : Biondi, Barbara (검색결과 4 건)
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Quality Over Volume: Modeling Centralization of Gastric Cancer Resections in Italy
Lorenzon Laura,Biondi Alberto,Agnes Annamaria,Scrima Ottavio,Persiani Roberto,D’Ugo Domenico 대한위암학회 2022 Journal of gastric cancer Vol.22 No.1
Background: The correlation between hospital volume and postoperative outcomes has led to the centralization of complex procedures in several countries. However, the results reported in relation to gastric cancer (GC) are contradictory. This study aimed to analyze GC surgical volumes and 30-day postoperative mortality in Italy and to provide a simulation for modeling centralization of GC resections based on district case volumes. Methods: A national registry was used to identify all GC resections, record mortality rates, and track the national in-border GC resection health travel. Hospitals were grouped according to caseload. Centralization of all GC procedures performed within the same district was modeled. The outcome measures were a minimal volume of 25 GC resections/ year and the 30-day postoperative mortality. Results: In 2018, 5,873 GC resections were performed in 498 Italian hospitals (mean resections per hospital per year: 11.8); the postoperative mortality rate (5.51%) was tracked from 2016–2018. GC resection health travel ranged from 2% to 50.5%, with a significant (P<0.001) difference between northern and central/southern Italy. The mean mortality rate was 7.7% in hospitals performing one to 3 GC resections per year, compared with 4.7% in those with >17 GC resections/year (P≤0.01). Most Italian districts achieved 25 procedures/year after centralization; however, 66.3% of GC cases in southern Italy vs. 42.2% in central and 52.7% in the northern regions (P<0.001) required reallocation. Conclusion: Postoperative mortality after GC resection correlated with hospital volume. Despite health travel, most Italian districts can reach a high-volume threshold, but discrepancies in mortality rates are alarming.Trial RegistrationResearch Registry Identifierresearchregistry6869
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Trichogin GA IV: an antibacterial and protease-resistant peptide
De Zotti, Marta,Biondi, Barbara,Formaggio, Fernando,Toniolo, Claudio,Stella, Lorenzo,Park, Yoonkyung,Hahm, Kyung-Soo John Wiley Sons, Ltd. 2009 Journal of Peptide Science Vol.15 No.9
<P>The antibacterial and hemolytic activities of the amphiphilic helical, membrane-active, lipopeptaibol trichogin GA IV and its [Leu<SUP>11</SUP>-OMe] analogue were compared to those of the partially helical or non-helical 8-meric or 4-meric, C-terminal short sequences, respectively. The study on trichogin GA IV was extended to several methicillin-resistant Staphylococcus aureus strains. Using a large set of enzymes, we also evaluated the resistance to proteolysis of all of the four peptides. Copyright © 2009 European Peptide Society and John Wiley & Sons, Ltd.</P>
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Trichogin GA IV: A versatile template for the synthesis of novel peptaibiotics
Zotti, Marta De,Biondi, Barbara,Peggion, Cristina,Formaggio, Fernando,Park, Yoonkyung,Hahm, Kyung-Soo,Toniolo, Claudio The Royal Society of Chemistry 2012 Organic & biomolecular chemistry Vol.10 No.6
<P>Trichogin GA IV, isolated from the fungus <I>Trichoderma longibrachiatum</I>, is the prototype of lipopeptaibols, the sub-class of short-length peptaibiotics exhibiting membrane-modifying properties. This peptaibol is predominantly folded in a mixed 3<SUB>10</SUB>-/α- helical conformation with a clear, albeit modest, amphiphilic character, which is likely to be responsible for its capability to perturb bacterial membranes and to induce cell death. In previous papers, we reported on the interesting biological properties of trichogin GA IV, namely its good activity against Gram positive bacteria, in particular methicillin-resistant <I>S. aureus</I> strains, its stability towards proteolytic degradation, and its low hemolytic activity. Aiming at broadening the antimicrobial activity spectrum by increasing the peptide helical amphiphilicity, in this work we synthesized, by solution and solid-phase methodologies, purified and fully characterized a set of trichogin GA IV analogs in which the four Gly residues at positions 2, 5, 6, 9, lying in the poorly hydrophilic face of the helical structure, are substituted by one (position 2, 5, 6 or 9), two (positions 5 and 6), three (positions 2, 5, and 9), and four (positions 2, 5, 6, and 9) Lys residues. The conformational preferences of the Lys-containing analogs were assessed by FT-IR absorption, CD and 2D-NMR techniques in aqueous, organic, and membrane-mimetic environments. Interestingly, it turns out that the presence of charged residues induces a transition of the helical conformation adopted by the peptaibols (from 3<SUB>10</SUB>- to α-helix) as a function of pH in a reversible process. The role played in the analogs by the markedly increased amphiphilicity was further tested by fluorescence leakage experiments in model membranes, protease resistance, antibacterial and antifungal activities, cytotoxicity, and hemolysis. Taken together, our biological results provide evidence that some of the least substituted among these analogs are good candidates for the development of new membrane-active antimicrobial agents.</P> <P>Graphic Abstract</P><P>One or more Gly-to-Lys replacements on the hydrophilic face of the peptide-template trichogin GA IV modulate its biological properties and promote a pH-mediated, reversible, 3<SUB>10</SUB>- to α-helix transition. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1ob06178j'> </P>
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A Novel DPP Based Polymer HTL for PbS CQD-SCs
천형진,김홍일,백세웅,류승언,이승진,최민재,최경원,Margherita Biondi,Sjoerd Hoogland,F. Pelayo Garcia de Arquer,권순기,박태호,Edward H. Sargent,김윤희 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
DPP-based polymers are widely used in organic photovoltaics (OPV) and organic field-effect transistors (OFET) as the p-type materials. DPP with bithiophene (π-bridge) has already been proven to have excellent charge transport properties owing to an attractive S···O electrostatic interaction that induces π–π stacking. Therefore, we were performed Stille coupling reaction to combine these D–A building blocks to form the desired HTL. PD2FCT-29DPP (D1–A1–D1–A2) is a D–A alternating copolymer from the DPP (A2) and CPDT (D1) with fluorinated BT (A1). PD2FCT-29DPP-based devices achieve an FF of 70.0% and a PCE of 14.0%.
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