Catheter-Directed Thrombolysis with a Continuous Infusion of Low-Dose Urokinase for Non-Acute Deep Venous Thrombosis of the Lower Extremity

Binbin Gao,Jingyong Zhang,Xuejun Wu,Zonglin Han,Hua Zhou,Dianning Dong,Xing Jin 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.1

Objective: We wanted to evaluate the feasibility of catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for treating non-acute (less than 14 days) deep venous thrombosis of the lower extremity. Materials and Methods: The clinical data of 110 patients who were treated by catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for lower extremity deep venous thrombosis was analysed. Adjunctive angioplasty or/and stenting was performed for the residual stenosis. Venous recanalization was graded by pre- and posttreatment venography. Follow-up was performed by clinical evaluation and Doppler ultrasound. Results: A total of 112 limbs with deep venous thrombosis with a mean symptom duration of 22.7 days (range: 15-38 days) were treated with a urokinase infusion (mean: 3.5 million IU) for a mean of 196 hours. After thrombolysis, stent placement was performed in 25 iliac vein lesions and percutaneous angioplasty (PTA) alone was done in fi ve iliac veins. Clinically signifi cant recanalization was achieved in 81% (90 of 112) of the treated limbs; complete recanalization was achieved in 28% (31 of 112) and partial recanalization was achieved in 53% (59 of 112). Minor bleeding occurred in 14 (13%) patients, but none of the patients suffered from major bleeding or symptomatic pulmonary embolism. During followup (mean: 15.2 months, range: 3-24 months), the veins were patent in 74 (67%) limbs. Thirty seven limbs (32%) showed progression of the stenosis with luminal narrowing more than 50%, including three with rethrombosis, while one revealed an asymptomatic iliac vein occlusion; 25 limbs (22%) developed mild post-thrombotic syndrome, and none had severe post-thrombotic syndrome. Valvular refl ux occurred in 24 (21%) limbs. Conclusion: Catheter-directed thrombolysis with a continuous infusion of low-dose urokinase combined with adjunctive iliac vein stenting is safe and effective for removal of the clot burden and for restoration of the venous fl ow in patients with non-acute lower extremity deep venous thrombosis. Objective: We wanted to evaluate the feasibility of catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for treating non-acute (less than 14 days) deep venous thrombosis of the lower extremity. Materials and Methods: The clinical data of 110 patients who were treated by catheter-directed thrombolysis with a continuous infusion of low-dose urokinase for lower extremity deep venous thrombosis was analysed. Adjunctive angioplasty or/and stenting was performed for the residual stenosis. Venous recanalization was graded by pre- and posttreatment venography. Follow-up was performed by clinical evaluation and Doppler ultrasound. Results: A total of 112 limbs with deep venous thrombosis with a mean symptom duration of 22.7 days (range: 15-38 days) were treated with a urokinase infusion (mean: 3.5 million IU) for a mean of 196 hours. After thrombolysis, stent placement was performed in 25 iliac vein lesions and percutaneous angioplasty (PTA) alone was done in fi ve iliac veins. Clinically signifi cant recanalization was achieved in 81% (90 of 112) of the treated limbs; complete recanalization was achieved in 28% (31 of 112) and partial recanalization was achieved in 53% (59 of 112). Minor bleeding occurred in 14 (13%) patients, but none of the patients suffered from major bleeding or symptomatic pulmonary embolism. During followup (mean: 15.2 months, range: 3-24 months), the veins were patent in 74 (67%) limbs. Thirty seven limbs (32%) showed progression of the stenosis with luminal narrowing more than 50%, including three with rethrombosis, while one revealed an asymptomatic iliac vein occlusion; 25 limbs (22%) developed mild post-thrombotic syndrome, and none had severe post-thrombotic syndrome. Valvular refl ux occurred in 24 (21%) limbs. Conclusion: Catheter-directed thrombolysis with a continuous infusion of low-dose urokinase combined with adjunctive iliac vein stenting is safe and effective for removal of the clot burden and for restoration of the venous fl ow in patients with non-acute lower extremity deep venous thrombosis.

Reliability of mortar filling layer void length in in-service ballastless track-bridge system of HSR

Binbin He,Sheng Wen,Yulin Feng,Lizhong Jiang,Wangbao Zhou 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.1

To study the evaluation standard and control limit of mortar filling layer void length, in this paper, the train submodel was developed by MATLAB and the track-bridge sub-model considering the mortar filling layer void was established by ANSYS. The two sub-models were assembled into a train-track-bridge coupling dynamic model through the wheel-rail contact relationship, and the validity was corroborated by the coupling dynamic model with the literature model. Considering the randomness of fastening stiffness, mortar elastic modulus, length of mortar filling layer void, and pier settlement, the test points were designed by the Box-Behnken method based on Design-Expert software. The coupled dynamic model was calculated, and the support vector regression (SVR) nonlinear mapping model of the wheel-rail system was established. The learning, prediction, and verification were carried out. Finally, the reliable probability of the amplification coefficient distribution of the response index of the train and structure in different ranges was obtained based on the SVR nonlinear mapping model and Latin hypercube sampling method. The limit of the length of the mortar filling layer void was, thus, obtained. The results show that the SVR nonlinear mapping model developed in this paper has a high fitting accuracy of 0.993, and the computational efficiency is significantly improved by 99.86%. It can be used to calculate the dynamic response of the wheel-rail system. The length of the mortar filling layer void significantly affects the wheel-rail vertical force, wheel weight load reduction ratio, rail vertical displacement, and track plate vertical displacement. The dynamic response of the track structure has a more significant effect on the limit value of the length of the mortar filling layer void than the dynamic response of the vehicle, and the rail vertical displacement is the most obvious. At 250 km/h – 350 km/h train running speed, the limit values of grade Ⅰ, Ⅱ, and Ⅲ of the lengths of the mortar filling layer void are 3.932 m, 4.337 m, and 4.766 m, respectively. The results can provide some reference for the long-term service performance reliability of the ballastless track-bridge system of HRS.

Reliability of electric power grids under tornadoes

Wei Liu,Binbin Zhou,Qianxiang Wu,Huiquan Miao 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.4

Strong wind disasters, especially tornadoes with high damage scales, constantly cause huge damage to electric power grids (EPGs). In this paper, a concept is presented to quantify the connectivity reliability of EPGs under tornadoes. First, a tornado wind field is established using a modified Rankine vortex model, which is a representative 2D tornado wind field model. Second, fragility models of grid components, including transmission substations, transmission support structures, distribution poles, distribution conductors, and local circuits, are introduced. Third, a Monte Carlo simulation is presented to evaluate the connectivity reliability of EPGs under tornadoes. Finally, the connectivity reliability is verified under different scales and propagation angles of tornadoes by taking an actual EPG in China as a case study. Results show that the connectivity reliability directly correlates with the maximum wind speed and the propagation angle of the tornado, and the EPG experiences severe damage when the tornado exceeds the Enhanced Fujita 3 scale.

Analysis on natural vibration characteristics of steel-concrete composite truss beam

Lizhong Jiang,Yulin Feng,Wangbao Zhou,Binbin He 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.1

In order to study the natural vibration characteristics of steel-concrete composite truss beam (SCCTB), the influence of multiple factors such as interface slip, shear deformation and moment of inertia are considered. Afterwards, based on the Hamilton principle the vibration control differential equation and natural boundary conditions of SCCTB are deduced. By solving SCCTB differential equations of vibration control, an analytical calculation method is proposed for analyzing the natural vibration characteristics of SCCTB. The natural frequencies of SCCTBs with different degrees of shear connection and effective lengths are calculated by using the analytical method, and the results are compared against those obtained from ANSYS finite element numerical calculation method. The results show that the analytical method considering the influence factors such as interface slip, shear deformation and moment of inertia are in good agreement with those obtained from ANSYS finite element numerical calculation method. This evidences the correctness of the analytical method and show that the method proposed exhibits improvement over the previously developed theories for the natural vibration characteristics of SCCTB. Finally, based on the analytical method, the influence factors of SCCTB natural vibration characteristics are analyzed. The results indicate that the influence of interface slip stiffness on SCCTB's natural frequency is more than 10% and therefore cannot be neglected. Moreover, shear deformation has an effect of more than 35% on SCCTB’s natural frequency and the effect cannot be ignored either in this case too.

A Novel Coverage Holes Discovery Algorithm Based on Voronoi Diagram in Wireless Sensor Networks

Guoyong Dai,Hexin Lv,Luyi Chen,Binbin Zhou,Ping Xu 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.3

Coverage is a key and fundamental problem in wireless sensor networks. To provide high quality of service, high coverage ratio of sensor nodes in monitored area should be assured. Coverage holes may lead to routing failure and degrade the quality of service. A novel coverage hole discovery algorithm, VCHDA, is proposed for wireless sensor networks in this paper. The proposed algorithm is based on the well-known Voronoi diagram. It can recognize coverage holes and label the border nodes of coverage holes effectively. Simulations are conducted and the results show that the proposed algorithm is effective and with high accuracy.

Vibration characteristic analysis of high-speed railway simply supported beam bridge-track structure system

Lizhong Jiang,Yulin Feng,Wangbao Zhou,Binbin He 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.6

Based on the energy-variational principle, a coupling vibration analysis model of high-speed railway simply supported beam bridge-track structure system (HSRBTS) was established by considering the effect of shear deformation. The vibration differential equation and natural boundary conditions of HSRBTS were derived by considering the interlayer slip effect. Then, an analytic calculation method for the natural vibration frequency of this system was obtained. By taking two simply supported beam bridges of high-speed railway of 24 m and 32 m in span as examples, ANSYS and MIDAS finite-element numerical calculation methods were compared with the analytic method established in this paper. The calculation results show that two of them agree well with each other, validating the analytic method reported in this paper. The analytic method established in this study was used to evaluate the natural vibration characteristics of HSRBTS under different interlayer stiffness and length of rails at different subgrade sections. The results show that the vertical interlayer compressive stiffness had a great influence on the high-order natural vibration frequency of HSRBTS, and the effect of longitudinal interlayer slip stiffness on the natural vibration frequency of HSRBTS could be ignored. Under different vertical interlayer stiffness conditions, the subgrade section of HSRBTS has a critical rail length, and the critical length of rail at subgrade section decreases with the increase in vertical interlayer compressive stiffness.

Treatment of wastewater containing linear alkylbenzene sulfonate by bacterial-microalgal biological turntable

Renjie Tu,Wenbiao Jin,Song-fang Han,Binbin Ding,Shu-hong Gao,Xu Zhou,Shao-feng Li,Xiaochi Feng,Qing Wang,Qinhui Yang,Yu Yuwen 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5

Linear alkylbenzene sulfonate (LAS), which is widely used as detergent, is a common toxic pollutant in wastewater. Generally, biodegradation process is applied to remove LAS. However, the efficiency of traditional wastewater treatment cannot meet the growing demand. In this study, an improved biological turntable with a symbiotic system of bacteria and microalgae was primarily used to enhance the biodegradation efficiency of LAS from wastewater. The symbiotic system of bacteria and microalgae was mainly composed of Scenedesmus dimorphus and three LAS-degrading bacteria Plesiomonas sp. (L3, L7) and Pseudomonas sp. (H6). The average removal rate of LAS was up to 94.6%. The LAS concentration of the effluent of the system decreased by 81.7% after the bacterial-microalgae inoculation (the inoculation temperature was 25 oC; microalgae were inoculated at a concentration of 10% only at the start of the system; bacteria were continuously inoculated at 1‰ concentration). After bacterial-microalgae inoculation, the average effluent concentration of CODCr in the tertiary reaction tank was 24.3mg/L, the average membrane effluent concentration was 15.8mg/L, and the average removal rate was 90.5%. Compared with the control group without inoculation, the concentration of CODCr in the tertiary reaction tank and membrane effluent decreased by 55.7% and 46.4%. The denaturing gradient electrophoresis (DGGE) pattern analysis of the systemic flora showed that there were two dominant species of high LAS degrading bacteria. They were identified to belong to Plesiomonas sp. and Pseudomonas sp., respectively.