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RISS 인기검색어
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- 저자 : Bibi Maryam (검색결과 2 건)
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Maryam Hashemi,Fatemeh Kalalinia,Mobina Razi,Fatemeh Moameri,Bibi Sedigheh Fazly Bazzaz,Mehrdad Iranshahi,Jebrail Movaffagh 한국고분자학회 2022 Macromolecular Research Vol.30 No.8
Some species of the Berberidaceae family and natural biopolymer chitosan have good effects on wound healing. In this research, a new formulation of chitosan hydrogel containing alcoholic root extract of Berberis integerrima (Chi-BIE) was designed and evaluated for the treatment of full-thickness skin wounds in an animal model. Alcoholic extract of Berberis integerrima root (BIE) was prepared, and its total amount of berberine was determined using UV/visible spectroscopy. Chitosan gel containing 10 and 20% BIE was prepared, and their extract release profile was assayed. The antimicrobial activity of Chi-BIE was investigated by the minimum inhibitory concentration assay. Finally, the efficiency of Chi-BIE formulations on the full-thickness wound healing was physically and histologically evaluated in an animal model. BIE was successfully loaded into the chitosan hydrogel and showed a burst release of extract during the first 4 h (60%) followed by a sustained release. Formulation of BIE in chitosan hydrogel could increase the antimicrobial activity of chitosan and BIE alone against Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilius, Escherichia coli, and Candida albicans. Chi-20% BIE indicated more antimicrobial activity compared to Chi-10%BIE. Formulation of BIE in chitosan hydrogel could increase the wound healing effects of chitosan and BIE alone. Chi-20% BIE had a faster restorative effect than other treatment groups due to more formation of epithelial tissue and faster maturation of bud tissue. Based on the results of this study, the chitosan hydrogel containing BIE is proposed as a suitable dressing for wound-healing.
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Electrochemical sensing of H2O2 using cobalt oxide modified TiO2 nanotubes
Ullah Rahim,Rasheed Muhammad Asim,Abbas Shafqat,Rehman Khalil-ul,Shah Attaullah,Ullah Karim,Khan Yaqoob,Bibi Maryam,Ahmad Mashkoor,Ali Ghafar 한국물리학회 2022 Current Applied Physics Vol.38 No.-
Cobalt oxide (Co3O4) modified anatase titanium dioxide nanotubes (ATNTs) have been investigated for the electrochemical sensing of hydrogen peroxide (H2O2). ATNTs have been synthesized by a two-step anodization process. ATNTs were then modified with Co3O4 employing chemical bath deposition method. The structure and morphology of ATNTs and their modification with Co3O4 has been confirmed by X-ray diffraction by scanning electron microscopy. H2O2 sensing has been studied in 0.1 M PBS solution, by cyclic voltammetry and amperometry. Variation in the peak positions and current densities was observed with addition of H2O2 for Co3O4 modified ATNTs. Sensitivity and limit of detection improved with modification of ATNTs with Co3O4 with precursor concentration up to 0.8 M. However, at higher precursor concentrations sensitivity and limit of detection toward H2O2 deteriorated. Co3O4 Modified ATNTS using 0.8 M precursor concentration are comparatively more suitable for H2O2 sensing applications due to the optimum formation of Co3O4/ATNTs heterojunctions.
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