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전통적인 경영전략모형에 대한 비판과 미래의 성공기업을 위한 새로운 경영전략모형에 관한 연구
소영일(Young Il So) 한국산학경영학회 1993 산학경영연구 Vol.6 No.-
The main purpose of this study is to suggest the new strategic management model for the future successful company. The new model consists of the following structure. First, to identify the object dimension. The upper object is to satisfy the customers needs. And the lower object is to satisfy the workers needs. Second, to identify the external enviromental problems dimensions. There are five dimensions. They are ethical responsinilities, government-business alliances, collaboration amongst competitors, innovative invester-company relations, and globalization of enterprise. Third, to identify the internal enviromental problems dimensions. There are two dimensions. They are new organizational forms and integrated subcultures. Fourth, to find the solution for the above dimensions. The solution is as follow. All the managers and workers must have business reengineering minds and apply the complexity management. And the company should construct the strategic information systems.
소영(Young So),이강욱(Kang Wook Lee),이헌영(Heon Young Lee),이원우(Won Woo Lee) 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.3
N/A Purpose: We studied clinical aspects and courses of patients with pulmonary radioactivity on liver scintigraphy and speculated the mechanism of pulmonary uptake of radiocolloids. Materials and Merhods:Forty-nine patients with pulmonary radioactivity were classified into 5 disease froups-liver disease, infection, cancer, ischemic necrosis of liver, etc.- and their presence or absence of chronic liver disease (CLD), Child-Pugh class, serum levels of AST and ALT, results of follow-up liver scintigraphy and clincal course were checked. Results: Of total 49 patients 25 had CLD: there were 23 liver disease patients, 16 infection patients, 7 advanced cancer patients, 2 ischemic necrosis of liver patients, and 1 hemolytic anemia patient. Reversible rise of serum levels of AST and ALT was observed in all patients with liver drsease and ischemic necrosis of liver;on one-way ANOVA,these rise were statistically significanrt (p<0.01). Serum level of ALT of liver disease group patients without CLD was significantly higher than that of infecrion group patients without CLD (p<0.05). Among 17 patients who underwent follow-up liver scintigraphy, 13 showed no pumonary radioactivty. Total 12 patients died during follow-up and most of them were terminal cancer patients or CLD patients of Child-pugh class C. Conclusion: pulmonary radioactivity of radiocolloid liver scintlgraphy could be attrivuted to the mobilization of reticuloendothelial system (RES) cells by the activation of RES cells in severe infection and terminal cancer, and also by the extensive liver destruction in liver diseases. (Korean J Nucl Med 2002;36;185-94)
소영(Young So),이동수(Dong Soo Lee),현인영(In Yong Hyun),강원준(Won Jun Kang),이원우(Won Woo Lee),정준기(June Key Chung),김성권(Suhng Gwon Kim),이명철(Myung Chul Lee),이정상(Jung Sang Lee),고창순(Chang Soon Koh) 대한내과학회 1997 대한내과학회지 Vol.53 No.2
N/A Objectives: It is suggested that frequency of low turnover bone disease is much higher in diabetic renal osteodystrophy. We tried to find out whether bone scan images show less 99mTc-MDP uptake in diabetic renal ostwdystrophy. Methods: We compared bone scan images of renal failure patients with and without diabetes. The number of patients studied was 134 (43 patients had diabetes and 91 patients did not). Two experienced nuclear physicians read Tc-99m-MDP bone scan twice separately and gave the score either 1 or 0 on 6 areas; axial skeleton, long bone, skull & mandible, periarticular areas, costochondral junction and sternum. The means of summed scores were compared using Students t-test. To exclude the effects of sex, age and serum creatinine concentration, we analysed these factors together with the effect of diabetes using analysis of covariance. We also interpreted on bone scan images, as classical renal osteodystrophy, renal failure and normal. Results: The intra- and interobserver variations were very low. Patients of diabetes group showed significantly lower mean of summed score(2.0±0.95) compared to patients of non-DM group(3.3±1.2). Analysis of covariance revealed that lower score of diabetes group was independent of sex, age and serum creatinine level. of diabetes group, 2 nuclear physicians interpreted bone scans as classical renal osteodystrophy in 60% and 56%, However, they interpreted bone scans of non-DM group in 80%, 88%(between-observer k: 0.74). Chi-square test showed that this difference was statistically significant (p<0.05). Conclusion: Bone scan image of diabetic renal osteodystrophy showed less 99mTc-MDP uptake, which meant low osteoblastic activity. This influence of diabetes upon bone uptake was significant after considering other confounding factors.
신 이식 직후 신장 스캔 소견과 이식신 장기 생존의 관계
소영(Young So),이강욱(Kang Wook Lee),신영태(Young Tai Shin),안문상(Moon Sang Ahn),배진선(Jin Sun Bae),설종구(Chong Koo Sul),정인목(In Mok Jung) 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.4
N/A Purpose: We investigated the possibility of early postoperative Tc-99m DTPA scintigraphy in predicting long-term renal transplant survival. Materials and Methods: 64 living donor (LD) grafts were divided into two groups according to the graft function on early post-operative renal scintigraphy. Survival analysis was performed using Kaplan-Meier method and Cox proportional hazard model. Chi-square test was performed to evaluate the difference in the frequency of acute rejection. Results: Cumulative renal transplant survival was decreased in 11 patients with abnormal renal scintigraphy, but it was not statistically significant. Decreased graft function on early post-operative renal scintigraphy was not a predictor of long-term graft survival. The frequency of acute rejection was higher in abnormal scintigraphy group, and the difference was statistically significant. Conclusion: Decreased graft function on early post-operative renal scintigraphy has no direct effect on long-term renal transplant survival in LD transplantation. But it may have an indirect effect through increasing the frequency of acute rejection. (Korean J Nucl Med 200135-251-257)
PET/CT 영상의 부분체적효과와 장기의 움직임으로 인해 감소된 SUV의 보정을 위한 회복계수의 비교
김영재(Youngjae Kim),박훈희(Hoon-Hee Park),이주영(Joo-Young Lee),소영(Young So),이정우(Jeong-Woo Lee) 대한방사선과학회(구 대한방사선기술학회) 2022 방사선기술과학 Vol.45 No.3
In this study, a recovery coefficient (RC) calculation was conducted that can correct the underestimation of the standardized uptake value (SUV) due to the partial volume effect (PVE) through phantom measurements and formulas. The experiment was conducted using a dynamic phantom capable of implement cranio-caudal movement at a respiratory rate of 15 times per minute along with the measured phantom experiment of the stopped state, and the RC of the moving state is calculated and compared. Ingenuity TF (Philips Healthcare, Netherland) was used as a positron emission tomography/ computed tomography (PET/CT) device. PET-CT Phantom (Biodex Medical System, USA) was used as a phantom for measurement. A phantom image in a stationary state was acquired, and a moving phantom image was acquired using the AZ-733V Respiratory Phantom (Anzai Medical Co, Japan) capable of breathing movement in the cranio-caudal direction under the same acquisition parameters. For RC calculation, the sphere maximum radioactivity concentration and the background mean radioactivity concentration of the acquired images were measured, and the initially determined sphere and background radioactivity concentrations were calculated. The calculated RC was 0.08 to 0.72. The size of sphere smaller, it was confirmed that the RC reduced. And the RC in the moving state reduced than in the stationary state. As a result of this study, the change of the RC was confirmed according to the size of spheres and the phantom moving. Using the RC derived by implement movement of breathing with the respiratory phantom, it is possible to considering correction of underestimated SUV by the partial volume effect of PET images and the patient movements.
아급성 뇌경색 환자에서 99mTC - HMPAO 및 99mTc - ECD 뇌 SPECT 증례보고
고창순(Chang Soon Koh),이명철(Myung Chul Lee),이동수(Dong Soo Lee),소영(Young So),윤병우(Byung Woo Yoon),안병철(Byeong Cheol Ahn),정준기(June Key Jung) 대한핵의학회 1996 핵의학 분자영상 Vol.30 No.4
For brain perfusion SPECT imaging, Tc-99m-HMPAO and Tc-99m-ECD are commonly used. Although these two tracers usually show similar distribution, it is well known that discrepant finding might be noted between Tc-99m-HMPAO and Tc-99m-ECD imaging in some conditions. Luxury perfusion(perfusion/metabolism mismatch) is one of the examples and could be observed in subacute cerebral infarction. We report a case of subacute cerebral infarction that revealed luxury perfusion. Increased perfusion was found in Tc-99m-HMPAO SPECT and perfusion defect was found in Tc-99m-ECD SPECT. We found 1arge area of mismatch with a consecutive acquisition-subtraction method. Crossed cerebellar diaschisis was observed in both SPECT images.
수술 후 암 재발 판정에 있어서 전신 F - 18 FDG - PET의 유용성
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),강원준(Won Jun Kang),정재민(Jae Min Jeong),소영(Young So),곽철은(Cheol Eun Kwark),강순범(Soon Beum Kang),정희원(Hee Won Jung),김광현(Kwang Hyu 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.3
N/A he purpose of this study was to evaluate the usefulness of whole body F-18 FDG PET scan for deceting postoperative recurrence of cancer. One hundred four cancer patients after operation were enrolled(l4 brain tumor, 15 head and neck cancer, 23 gynecologic cancer). Besides conventional images(CI) including CT and MRI, F-18 FDG PET scan was obtained on ECAT EXACT 47 scanner(Siemens-CTI), beginning 60 minutes after injection of 370MBq(10mCi) of F-18 FDG. Regional scan was also obtained with emission image. Transmission images using Ge-68 were carried out for attenuation correction in both whole body and regional images. Findings of PET and CI were confirmed by pathology or clinical follow up. The sensitivity and specificity of PET for detecting recurrence were 94% and 92%, respectively. Contrarily, the sensitivity and specific it of CI were 78% and 68% CI results were negative and PET results were positive in 11 cases. The biopsy or clinical follow-up of those cases confirmed recurrence of tumor. False negative cases of CI were frequent in patients with gynecologic cancers. Also we measured the Serum concentration of tumor markers in patients with gynecologic cancer(CA125), thyroid cancer(thyroglobulin), and colorectal cancer(CEA). The sensitivity and specificity of tumor markers were 71% and 84%, respectively. We conclude that F-18 FDG PET can be used valuably in detecting recurrent foci of a wide variety of malignancy compared to conventional diagnositic methods.
국산 항 백혈병 항체 ( 항 CALLA , 항 JL - 1 ) 의 동위원소 표지 및 면역학적 특성에 관한 연구
고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),박성회(Seong Hoe Park),정재민(Jae Min Jeong),소영(Young So) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A Recently murine monoclonal antibodies have studied actively for radioimmuno-scintigraphy and radioinamunotherapy, especially on patients with leukemia and lymphoma. In this research, we studied radiolabeling and immunologic characteristics of two in-house anti-leukemic monoclonal antibodies(anti-CALLA & anti-J1-l antibodies) to make the basis tor their clinical application. Each antibody was radiolabeled successfully with 99mTc by pretargeting transchelation method and with 125I by Iodogen method. We also studied cell binding assay, Scatchard analysis and modulation phenomenon. 125I showed 90% labeling efficiency for each anti-body which was satisfactory, but 99mTc showed labeling efficiency below 70%, for which we need better labeling method, In cell binding assay, the immunoreactivity(IR) was low for 99mTc-labeled antibodies. Scatchard analysis showed satisfactory data for both binding affinity. The affinity constant and antibody binding sites per cell are around 109M-1 and 104, respectively. There was no modulation phenomenon in cases of 125I or 99mTc labeled antibodies. We expect that two anti-leukemic monoclonal antibodies may be useful in diagnosis and therapy for leukemia and lymphoma patients.