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RISS 인기검색어
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- 저자 : Bai-Gang Huang (검색결과 4 건)
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Bai Weizhe,Zhu Tianchuan,Zuo Jiebin,Li Yang,Huang Xi,Li Gang 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.7
BACKGROUND: Myocardial infarction (MI) leads to cardiomyocyte death, poor cardiac remodeling, and heart failure, making it a major cause of mortality and morbidity. To restore cardiac pumping function, induction of cardiomyocyte regeneration has become a focus of academic interest. The Hippo pathway is known to regulate cardiomyocyte proliferation and heart size, and its inactivation allows adult cardiomyocytes to re-enter the cell cycle. METHODS: In this study, we investigated whether exosomes from adipose-derived stem cells (ADSCs) could effectively transfer siRNA for the Hippo pathway regulator Salvador (SAV) into cardiomyocytes to induce cardiomyocyte regeneration in a mouse model of MI. RESULTS: Our results showed that exosomes loaded with SAV-siRNA effectively transferred siRNA into cardiomyocytes and induced cardiomyocyte re-entry into the cell cycle, while retaining the previously demonstrated therapeutic efficacy of ADSC-derived exosomes to improve post-infarction cardiac function through anti-fibrotic, pro-angiogenic, and other effects. CONCLUSIONS: Our findings suggest that siRNA delivery via ADSC-derived exosomes may be a promising approach for the treatment of MI.
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Xiao-bo Wang,Hui-yuan Gao,Bai-ling Hou,Jian Huang,Rong-gang Xi,Li-jun Wu 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
Nanoparticle realgar powders (NRP) inhibited U937 cell growth in a time and dose-dependent manner. U937 cells treated with NRP showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation. Caspase family inhibitor (z-VAD-fmk), caspase-8, -9 inhibitor (z-IETD-fmk, Ac-LEHD-CHO, respectively) and caspase-3 inhibitor (z- DEVD-fmk) partially prevented NRP -induced apoptosis. Moreover, the classical substrates of caspase-3, poly-ADP ribose polymerase (PARP) was degraded after U937 cells treatment with NRP. In addition, NRP increased the ratio of Bax/Bcl-2 protein expression. Although p38 inhibitor (SB203580) and ERK inhibitor (PD98059) failed to block cell death, JNK inhibitor (SP600125) had marked inhibitory effects on NRP -induced apoptosis. Furthermore, the phosphorylation of JNK was up-regulated, suggesting that JNK was responsible for NRP -induced apoptosis in U937 cells. These results suggested that the caspase, mitochondria and MAPK signal pathways were involved in NRP-induced U937 apoptosis.
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Wei-Wei Ding,Zao-jian Zou,Jing-Ping Wu,Bai-Gang Huang 대한조선학회 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
Bragg reflection of water waves by three kinds of surface-piercing fixed structures with rectangular, cosinoidal and triangular shapes is studied. Boundary element method is used to analyze the wave scattering by these structures based on the linear wave theory. Results of reflection and transmission coefficients are validated by comparing with those available in literature. These structures with proper configurations are proved to be effective in attenuating waves by using Bragg reflection, and the triangular structures are found to be the best choices among the structures with same width and same area. Systematic calculations are then carried out for the triangular structures by varying the number, the draft, the width, the gap and the combination of width and gap of the structures to analyze their influences on the characteristics of Bragg reflection. The results are of reference values for design of the structures to attenuate waves based on the Bragg reflection.
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Ding, Wei-Wei,Zou, Zao-Jian,Wu, Jing-Ping,Huang, Bai-Gang The Society of Naval Architects of Korea 2019 International Journal of Naval Architecture and Oc Vol.11 No.2
Bragg reflection of water waves by three kinds of surface-piercing fixed structures with rectangular, cosinoidal and triangular shapes is studied. Boundary element method is used to analyze the wave scattering by these structures based on the linear wave theory. Results of reflection and transmission coefficients are validated by comparing with those available in literature. These structures with proper configurations are proved to be effective in attenuating waves by using Bragg reflection, and the triangular structures are found to be the best choices among the structures with same width and same area. Systematic calculations are then carried out for the triangular structures by varying the number, the draft, the width, the gap and the combination of width and gap of the structures to analyze their influences on the characteristics of Bragg reflection. The results are of reference values for design of the structures to attenuate waves based on the Bragg reflection.
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