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- 저자 : Baharudin Abdullah (검색결과 3 건)
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Ruziana Baharudin,Nur Suhaila Idris,Juliawati Muhammad,Wan Noor Hasbee Wan Abdullah 대한가정의학회 2022 Korean Journal of Family Medicine Vol.43 No.2
Systemic lupus erythematosus (SLE) is a connective tissue disease of unknown etiology that predominantly affects women of childbearing age. We report a case of male systemic lupus erythematous with antinuclear antibodies and typical clinical presentations of multiple skin lesions, polyarticular joint pain, fatigue, anorexia, and hair loss. Full evaluations were used to establish a diagnosis of SLE. The lower prevalence of SLE among males and antinuclear antibody-negative patients poses a great challenge for diagnosis. Therefore, as primary care doctors, we need to have a high suspicion of systemic lupus erythematous even in male and antinuclear antibody-negative patients. Thus, early treatment may help patients improve their quality of life.
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Bathma Dhevi Susibalan,Baharudin Abdullah,Norhafiza Mat Lazim,Azidah Abdul Kadir 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.3
Allergic rhinitis is a prevailing chronic infl ammatory respiratory disorder that aff ects 10–30% of the population globally. Channa striatus (Channa) is a snakehead, freshwater fi sh that has been used traditionally to enhance wound healing and relief post-operative pain. This study evaluates the effi cacy of oral Channa extract on allergic rhinitis subjects on total nasal symptom score and serum immunoglobulin E (Ig E). A randomized, double-blind, placebo-controlled trial was conducted by comparing the oral Channa extract 500 mg/day and placebo among allergic rhinitis subjects for a 6-week intervention period. Subjects aged 18–50 years old, diagnosed with allergic rhinitis based on total symptoms score, naso-endoscopy fi ndings, and positive skin prick test were included in this trial. All subjects were treated with antihistamine (levocetrizine) and local corticosteroid nasal spray (fl uticasone furoate nasal spray). Laboratory-based blood tests were used as safety measures. A total of 70 subjects were randomized. Channa group showed signifi cant improvement in nasal blockage ( p < 0.05), nasal itchiness ( p < 0.05), eye itchiness ( p < 0.05) and general symptoms ( p < 0.05) compared to the placebo groups. Serum Ig E were signifi cantly lowered in Channa group compared to placebo ( p < 0.001). No signifi cant diff erences were found between the groups in terms of nasal discharge, sneezing, palate itchiness, and smell score. No serious adverse events were reported. In conclusion, Channa has a benefi cial role in improving nasal symptoms and reduction in serum Ig E in allergic rhinitis subjects.
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Distribution of HPV Genotypes in Cervical Cancer in Multiethnic Malaysia
Raub, Sayyidi Hamzi Abdul,Isa, Nurismah Md.,Zailani, Hatta Ahmad,Omar, Baharudin,Abdullah, Mohamad Farouk,Amin, Wan Anna Mohd,Noor, Rushdan Md.,Ayub, Mukarramah Che,Abidin, Zainal,Kassim, Fauziah,Vick Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Background: Cervical cancer is the third commonest type of cancer among women in Malaysia. Our aim was to determine the distribution of human papilloma virus (HPV) genotypes in cervical cancer in our multi-ethnic population. Materials and Methods: This was a multicentre study with a total of 280 cases of cervical cancer from 4 referral centres in Malaysia, studied using real-time polymerase chain reaction (qPCR) detection of 12 high risk-HPV genotypes. Results: Overall HPV was detected in 92.5% of cases, in 95.9% of squamous cell carcinomas and 84.3%of adenocarcinomas. The five most prevalent high-risk HPV genotypes were HPV 16 (68.2%), 18 (40%), 58 (10.7%), 33 (10.4%) and 52 (10.4%). Multiple HPV infections were more prevalent (55.7%) than single HPV infections (36.8%). The percentage of HPV positive cases in Chinese, Malays and Indians were 95.5%, 91.9% and 80.0%, respectively. HPV 16 and 18 genotypes were the commonest in all ethnic groups. We found that the percentage of HPV 16 infection was significantly higher in Chinese (75.9%) compared to Malays (63.7%) and Indians (52.0%) (p<0.05), while HPV 18 was significantly higher in Malays (52.6%) compared to Chinese (25.0%) and Indians (28%) (p<0.05). Meanwhile, HPV 33 (17.9%) and 52 (15.2%) were also more commonly detected in the Chinese (p<0.05). Conclusions: This study showed that the distribution of HPV genotype in Malaysia is similar to other Asian countries. Importantly, we found that different ethnic groups in Malaysia have different HPV genotype infection rates, which is a point to consider during the implementation of HPV vaccination.
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