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Harsha, Sree,Al-Khars, Mohammed,Al-Hassan, Mohammed,Kumar, N. Prem,Nair, Anroop B.,Attimarad, Mahesh,Al-Dhubiab, Bandar E. 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
For cancer therapy, microspheres can be used to increase effectiveness while decreasing side effects of treatments. We prepared gelatin microspheres containing carboplatin (GCPtM) for treating lung cancer. We prepared gelatin microspheres of carboplatin (GCPtM) for use in treating lung cancer. Microspheres were prepared using a Buchi B-90 nano spray-drier. Surface morphology was found to be shriveled to nearly spherical, with an average size of $14.7{\mu}m$. Drug loading and percentage yield were found to be $72{\pm}0.4$ and $88{\pm}0.2%$, respectively. In vitro release studies indicated that diffusion followed the Peppas model, with 99.3 % of total carboplatin released from GCPtM after 12 h, while for the pure drug this value was 92.4 % in 0.5 h. Liquification was observed during stability studies at $37^{\circ}C$ with an relative humidity of 75 %. Plasma concentration profile was described using a two-compartment model after intravenous injection of GCPtM. Carboplatin containing microspheres distributed in the lung, spleen, liver, and blood were found to be primarily distributed in the lungs. We used a powder technology (spray-dryer) method in this study to significantly reduce the overall production time and desired particle size, without using organic solvents; additionally, this method is economically feasible. Thus, microsphere may be an effective method for successfully delivering carboplatin to the lungs.
Sree Harsha,Mohammed Al-Khars,Mohammed Al-Hassan,N. Prem Kumar,Anroop B. Nair,Mahesh Attimarad,Bandar E. Al-Dhubiab 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
For cancer therapy, microspheres can be usedto increase effectiveness while decreasing side effects oftreatments. We prepared gelatin microspheres containingcarboplatin (GCPtM) for treating lung cancer. We preparedgelatin microspheres of carboplatin (GCPtM) for use intreating lung cancer. Microspheres were prepared using aBuchi B-90 nano spray-drier. Surface morphology wasfound to be shriveled to nearly spherical, with an averagesize of 14.7 lm. Drug loading and percentage yield werefound to be 72 ± 0.4 and 88 ± 0.2 %, respectively. In vitro release studies indicated that diffusion followed thePeppas model, with 99.3 % of total carboplatin releasedfrom GCPtM after 12 h, while for the pure drug this valuewas 92.4 % in 0.5 h. Liquification was observed duringstability studies at 37 C with an relative humidity of75 %. Plasma concentration profile was described using atwo-compartment model after intravenous injection ofGCPtM. Carboplatin containing microspheres distributedin the lung, spleen, liver, and blood were found to be primarilydistributed in the lungs. We used a powder technology(spray-dryer) method in this study to significantlyreduce the overall production time and desired particlesize, without using organic solvents; additionally, thismethod is economically feasible. Thus, microsphere maybe an effective method for successfully delivering carboplatinto the lungs.
Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement
Xia, Shuai,Wang, Li-Ying,Sun, Heng-Zhi,Yue, Huan,Wang, Xiu-Hua,Tan, Jia-Lian,Wang, Yin,Hou, Di,He, Xiao-Yan,Mun, Ki-Cheol,Kumar, B. Prem,Zuo, Hua,Shin, Dong-Soo Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.
Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement
Shuai Xia,Li-Ying Wang,Heng-Zhi Sun,Huan Yue,Xiu-Hua Wang,Jia-Lian Tan,Yin Wang,Di Hou,Xiao-Yan He,Ki-Cheol Mun,B. Prem kumar,Hua Zuo,신동수 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.2
An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of Nazaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.