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RISS 인기검색어
- 검색키워드
- 저자 : Anroop B. Nair (검색결과 4 건)
- 무료
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Brassica oleracea Extracts Prevent Hyperglycemia in Type 2 Diabetes Mellitus
Sumeet Gupta,Satish Burman,Anroop B. Nair,Samrat Chauhan,Debabrata Sircar,Partha Roy,Meenakshi Dhanwat,Debrupa Lahiri,Dinesh Mehta,Rina Das,Hany Ezzat Khalil 한국식품영양과학회 2022 Preventive Nutrition and Food Science Vol.27 No.1
This study investigated the protective effect of extracts from flowers of Brassica oleracea L. var. italica Plenck on type 2 diabetes mellitus and its associated disorders. Three different doses of each extract (petroleum ether, ethanol, and aqueous) were administered orally for 42 days. Biochemical parameters, behavioral studies, and histological studies were measured at different periods. Mortality was found to be nil up to 2,000 mg/kg. Statistically significant (P<0.001) improvement in serum glucose level was observed in the groups receiving 400 mg/kg of petroleum ether, aqueous, or ethanol extracts compared with the negative control group. Insulin level was decreased by aqueous extracts, whereas lipid profiles were improved by aqueous and ethanol extracts. A reduction in transfer latency was observed in treatments of all three extract types. Ethanol extract treatment (400 mg/kg) showed maximum percentage inhibition in a lipid peroxidation assay. Additionally, the aqueous and ethanol extract treatments markedly reduced tumor necrosis factor-α, interleukin-6, and glycosylated hemoglobin levels. Histological results showed that high doses of extracts alleviated the damages induced by type 2 diabetes mellitus in various organs and bones. Based on the results of this study, it can be concluded that B. oleracea has the potential to alleviate type 2 diabetes mellitus.
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Harsha, Sree,Al-Khars, Mohammed,Al-Hassan, Mohammed,Kumar, N. Prem,Nair, Anroop B.,Attimarad, Mahesh,Al-Dhubiab, Bandar E. 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
For cancer therapy, microspheres can be used to increase effectiveness while decreasing side effects of treatments. We prepared gelatin microspheres containing carboplatin (GCPtM) for treating lung cancer. We prepared gelatin microspheres of carboplatin (GCPtM) for use in treating lung cancer. Microspheres were prepared using a Buchi B-90 nano spray-drier. Surface morphology was found to be shriveled to nearly spherical, with an average size of $14.7{\mu}m$. Drug loading and percentage yield were found to be $72{\pm}0.4$ and $88{\pm}0.2%$, respectively. In vitro release studies indicated that diffusion followed the Peppas model, with 99.3 % of total carboplatin released from GCPtM after 12 h, while for the pure drug this value was 92.4 % in 0.5 h. Liquification was observed during stability studies at $37^{\circ}C$ with an relative humidity of 75 %. Plasma concentration profile was described using a two-compartment model after intravenous injection of GCPtM. Carboplatin containing microspheres distributed in the lung, spleen, liver, and blood were found to be primarily distributed in the lungs. We used a powder technology (spray-dryer) method in this study to significantly reduce the overall production time and desired particle size, without using organic solvents; additionally, this method is economically feasible. Thus, microsphere may be an effective method for successfully delivering carboplatin to the lungs.
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Sree Harsha,Mohammed Al-Khars,Mohammed Al-Hassan,N. Prem Kumar,Anroop B. Nair,Mahesh Attimarad,Bandar E. Al-Dhubiab 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3
For cancer therapy, microspheres can be usedto increase effectiveness while decreasing side effects oftreatments. We prepared gelatin microspheres containingcarboplatin (GCPtM) for treating lung cancer. We preparedgelatin microspheres of carboplatin (GCPtM) for use intreating lung cancer. Microspheres were prepared using aBuchi B-90 nano spray-drier. Surface morphology wasfound to be shriveled to nearly spherical, with an averagesize of 14.7 lm. Drug loading and percentage yield werefound to be 72 ± 0.4 and 88 ± 0.2 %, respectively. In vitro release studies indicated that diffusion followed thePeppas model, with 99.3 % of total carboplatin releasedfrom GCPtM after 12 h, while for the pure drug this valuewas 92.4 % in 0.5 h. Liquification was observed duringstability studies at 37 C with an relative humidity of75 %. Plasma concentration profile was described using atwo-compartment model after intravenous injection ofGCPtM. Carboplatin containing microspheres distributedin the lung, spleen, liver, and blood were found to be primarilydistributed in the lungs. We used a powder technology(spray-dryer) method in this study to significantlyreduce the overall production time and desired particlesize, without using organic solvents; additionally, thismethod is economically feasible. Thus, microsphere maybe an effective method for successfully delivering carboplatinto the lungs.
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Emerging role of nanosuspensions in drug delivery systems
Shery Jacob,Anroop B. Nair,Jigar Shah 한국생체재료학회 2020 생체재료학회지 Vol.24 No.1
Rapid advancement in drug discovery process is leading to a number of potential new drug candidates having excellent drug efficacy but limited aqueous solubility. By virtue of the submicron particle size and distinct physicochemical properties, nanosuspension has the potential ability to tackle many formulation and drug delivery issues typically associated with poorly water and lipid soluble drugs. Conventional size reduction equipment such as media mill and high-pressure homogenizers and formulation approaches such as precipitation, emulsion-solvent evaporation, solvent diffusion and microemulsion techniques can be successfully implemented to prepare and scale-up nanosuspensions. Maintaining the stability in solution as well as in solid state, resuspendability without aggregation are the key factors to be considered for the successful production and scale-up of nanosuspensions. Due to the considerable enhancement of bioavailability, adaptability for surface modification and mucoadhesion for drug targeting have significantly expanded the scope of this novel formulation strategy. The application of nanosuspensions in different drug delivery systems such as oral, ocular, brain, topical, buccal, nasal and transdermal routes are currently undergoing extensive research. Oral drug delivery of nanosuspension with receptor mediated endocytosis has the promising ability to resolve most permeability limited absorption and hepatic first-pass metabolism related issues adversely affecting bioavailability. Advancement of enabling technologies such as nanosuspension can solve many formulation challenges currently faced among protein and peptide-based pharmaceuticals.
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