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Lee, Ayoung,Yoo, Hye Jin,Kim, Minkyung,Kim, Minjoo,Choi, Jong-Hun,Lee, Chulyoung,Lee, Jong Ho Elsevier 2019 Journal of Functional Foods Vol.53 No.-
<P><B>Abstract</B></P> <P>We assessed the effects of medium-chain diacylglycerol (MCDG) oil on postprandial triglycerides (TGs) and plasma fatty acids through a clinical trial (NCT03415568; clinicaltrials.gov). Meal tolerance tests using muffins containing 15 g of MCDG oil (MCDG muffins, test) or long-chain triacylglycerol (LCT) oil (LCT muffins, control) were conducted. Blood samples were collected under fasting conditions (0 h) and at 2, 3, 4, and 6 h after muffin ingestion. Compared to LCT muffin consumption, serum TG and chylomicron-TG levels were significantly lower at 3 and 4 h and at 4 h, respectively. The area under the curve for serum TG and chylomicron-TG decreased approximately 13% after MCDG muffin consumption although the decreases were not statistically significant (borderline significance: TG AUC; <I>p</I> = 0.052, Chylomicron-TG; <I>p</I> = 0.081). Postprandial fatty acid levels (palmitic acid, stearic acid, and linoleic acid) were also decreased after MCDG muffin intake. These results suggest potential benefits of MCDG oil in postprandial lipid control.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MCDG oil is advantageous to control postprandial lipid response in healthy adults. </LI> <LI> Compared to LCT, postprandial serum/chylomicron-TG decreased after MCDG intake. </LI> <LI> In addition to TGs, postprandial plasma fatty acids also reduced after MCDG intake. </LI> <LI> Metabolic characteristics of MCDG in the digestive tract may exhibit these changes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
이지수(Jisu Lee),장아영(Ayoung Jang),권지은(Ji Eun Gwon),이승우(Seung Woo Lee),이상오(Sang Oh Lee),이재웅(Jaewoong Lee) 한국염색가공학회 2023 韓國染色加工學會誌 Vol.35 No.4
Meta-aramid and polyamic acid were separated and the manufactured films were analyzed for their integration and logarithmic properties. The miscibility of meta-aramid and polyamic acid was analyzed by Fourier transform infrared spectroscop and scanning electron microscopy. Using calorimetric analysis and differential scanning calorimetry, the storage of meta-aramid and polyamic acid, indicated on the right side of the column, was analyzed. It was confirmed that the initial thermal resistance occurs because the polyamic acid is accounted for in the meta-aramid, and the glass transition temperature and persistence phenomenon are explained.
Lee, Soo-Yeon,Go, Ga-Yeon,Vuong, Tuan Anh,Kim, Jee Won,Lee, Sullim,Jo, Ayoung,An, Jun Min,Kim, Su-Nam,Seo, Dong-Wan,Kim, Jin-Seok,Kim, Yong Kee,Kang, Jong-Sun,Lee, Sang-Jin,Bae, Gyu-Un The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.1
Background: Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not yet been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy. Methods: BG-treated C2C12 myoblasts were differentiated, followed by immunoblotting for myogenic regulators, immunostaining for a muscle marker, myosin heavy chain or immunoprecipitation analysis for myogenic transcription factors. Results: BG treatment of C2C12 cells resulted in the activation of Akt, thereby enhancing hetero-dimerization of MyoD and E proteins, which in turn promoted muscle-specific gene expression and myoblast differentiation. BG-treated myoblasts formed larger multinucleated myotubes with increased diameter and thickness, accompanied by enhanced Akt/mTOR/p70S6K activation. Furthermore, the BG treatment of human rhabdomyosarcoma cells restored myogenic differentiation. Conclusion: BG enhances myoblast differentiation and myotube hypertrophy by activating Akt/mTOR/p70S6k axis. Thus, our study demonstrates that BG has promising potential to treat or prevent muscle loss related to aging or other pathological conditions, such as diabetes.
Lee, Hong Kyung,Kim, Ki Hun,Kim, Hyung Sook,Kim, Ji Sung,Lee, Jae Hee,Ji, Ayoung,Kim, Kyung Suk,Lee, Tae Yong,Chang, In Young,Bae, Sang-Cheol,Hong, Jin Tae,Kim, Youngsoo,Han, Sang-Bae Hindawi 2018 Stem cells international Vol.2018 No.-
<P>The combination of immunosuppressants and mesenchymal stem cells (MSCs) is a promising therapeutic strategy for systemic lupus erythematosus, since this approach reduces doses of immunosuppressants while maintaining the same therapeutic outcome. However, it is unavoidable for MSCs to be exposed to immunosuppressants. Here, we examined the combination effect of prednisone (PD) or mycophenolate mofetil (MMF) and MSCs. We showed that PD or MMF in combination with MSCs showed better therapeutic effect than single therapy in lupus-prone MRL.<I>Fas</I><SUP>lpr</SUP> mice, as assessed by using the following readouts: prolongation of survival, decrease in anti-dsDNA and total IgG levels in serum, decrease in cytokine gene expression in spleen cells, and decrease in inflammatory cell infiltration into the kidney. <I>In vitro</I>, immunosuppressants and MSCs inhibited T cell proliferation in a synergistic manner. However, immunosuppressants did not affect MSC viability and functions such as TGF-<I>β</I>1 and PGE<SUB>2</SUB> production, migration, and immunosuppressive capacity. In summary, our study demonstrates that a combination of immunosuppressants and MSCs is a good strategy to reduce the side effects of PD and MMF without the loss of therapeutic outcome.</P>
Optimization of Experimental Parameters to Suppress Nozzle Clogging in Inkjet Printing
Lee, Ayoung,Sudau, Kai,Ahn, Kyung Hyun,Lee, Seung Jong,Willenbacher, Norbert American Chemical Society 2012 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.51 No.40
<P>Stable drop jettability is mandatory for a successful, technical scale inkjet printing, and accordingly, this aspect has attracted much attention in fundamental and applied research. Previous studies were mainly focused on Newtonian fluids or polymer solutions. Here, we have investigated the drop jetting for zinc oxide (ZnO) particulate suspensions. Generally, the inverse Ohnesorge number <I>Z</I> = Oh<SUP>–1</SUP>, which relates viscous forces to inertia and surface tension, is sufficient to predict the jettability of single phase fluids. For the inkjet printer setup used here, jetting was possible for Newtonian fluids with 2.5 < <I>Z</I> < 26, but in the identical <I>Z</I>-range, nonjetting and nozzle clogging occurred for certain suspensions. A so-called ring-slit device, which allows for simultaneous formation and detection of aggregates in strongly converging flow fields, and single particle detecting techniques, which allow for an accurate determination of the number and size of micrometer-sized aggregates in suspensions of nanoparticles, were used to study this phenomenon. Nozzle clogging is induced by heterocoagulation of micrometer-sized aggregates and ZnO nanoparticles in the elongational flow field at the nozzle exit. Clogging may occur even if the size of these aggregates is well below the nozzle diameter and their concentration is on the order of only a few hundred parts per million (ppm). Accordingly, increased colloidal stability of nanoparticles and reduced aggregate concentration result in better drop jettability. Also, a nozzle design resulting in a shorter exposure time of the ink to elongational flow and an increased flow velocity helps to avoid nozzle clogging.</P>
Dielectric Characterization of Pigment Inks for Electrohydrodynamic Jet Printing
Lee, Ayoung,Watanabe, Hiroshi,Matsumiya, Yumi,Choi, Kyung-Hyun,Ahn, Kyung Hyun,Lee, Seung Jong American Chemical Society 2014 INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH - Vol.53 No.44
<P>This article presents a characterization method that could be useful for evaluating the performance of ink in electrohydrodynamic jet printing. The ink contains pigment particles and polymer (stabilizer for pigments) and has a low viscosity and a low elasticity. Depending on the medium (hydrocarbon for oil-based inks and glycol ether for polar solvent-based inks) and the type of pigment (exhibiting different colors), vast differences were found in the dielectric properties even when the viscosities of the inks were almost identical. These differences between the two series of inks were related to differences in the ion concentration <I>n</I> and ion mobility μ estimated from an analysis of the complex dielectric constant ε* (= ε′ – iε″) on the basis of Macdonald theory. These differences between the polar solvent- and oil-based inks are discussed in relation to the performances of the inks in electrohydrodynamic inkjet printing.</P>
Endoscopic Resection of Undifferentiated-type Early Gastric Cancer
Lee, Ayoung,Chung, Hyunsoo The Korean Gastric Cancer Association 2020 Journal of gastric cancer Vol.20 No.4
Early detection of gastric cancer is crucial because the survival rate can be improved through curative treatment. Although surgery and gastrectomy with lymph node dissection remain as the gold standard for curative treatment, early gastric cancer (EGC) with negligible risk of lymph node metastasis can be treated with endoscopic resection (ER), such as endoscopic submucosal dissection. Among gastric cancers, undifferentiated-type cancer is distinguished from differentiated-type cancer in various aspects in terms of clinical features and pathophysiology. The undifferentiated-type cancer is also known to be associated with an aggressive behavior and a poor prognosis. Therefore, the indication of ER for undifferentiated EGC is limited compared with differentiated-type. Recent studies have reported that ER for undifferentiated EGC is safe and shows favorable short- and long-term outcomes. However, it is necessary to understand the details of the research results and to selectively accept them. In this review, we aimed to evaluate the current practice guidelines and the short-term and long-term outcomes of ER for undifferentiated type EGC.
Lee, Young Ju,Lee, Ayoung,Yoo, Hye Jin,Kim, Minkyung,Noh, Geon Min,Lee, Jong Ho Elsevier 2018 Journal of Functional Foods Vol.48 No.-
<P><B>Abstract</B></P> <P>The aim of this study was to investigate the impact of consuming <I>Weissella cibaria</I> (<I>W. cibaria</I>) JW15 on natural killer (NK) cell activity, cytokines and immunoglobulins (Igs). This randomized, double-blinded, placebo-controlled study enrolled 100 nondiabetic participants. For eight weeks, the probiotic group consumed capsules containing 1 × 10<SUP>10</SUP> colony forming units (cfu) of <I>W. cibaria</I> JW15 daily, whereas the placebo group consumed the same capsules without a probiotic. NK cell activity at effector cell (E; peripheral blood mononuclear cells, PBMCs):target cell (T; K562 cells) ratios of 10:1, 5:1, 2.5:1, or 1.25:1 was significantly increased in the probiotic group compared to the placebo group at 8 weeks after baseline. The probiotic group had significantly greater increases in NK cell activity than the placebo group under all assay conditions. Daily consumption of the <I>W. cibaria</I> JW15 probiotic effectively enhanced immune functions by increasing NK cell activity (Clinicaltrials.gov; NCT03209635).</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>