Association between vitamin D and urinary tract infection in children

Mahyar, Abolfazl,Ayazi, Parviz,Safari, Sara,Dalirani, Reza,Javadi, Amir,Esmaeily, Shiva The Korean Pediatric Society 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.3

Purpose: The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children. Methods: In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups. Results: Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The $mean{\pm}standard$ deviation of age in the case and control groups were $53.2{\pm}35.6$ and $36.1{\pm}60.2months$, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group ($20.4{\pm}8.6ng/mL$ vs. $16.9{\pm}7.4ng/mL$, P=0.01) Conclusion: This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.

Serum levels of interleukin-6 and interleukin-8 as diagnostic markers of acute pyelonephritis in children

Mahyar, Abolfazl,Ayazi, Parviz,Maleki, Mohammad Reza,Daneshi-Kohan, Mohammad Mahdi,Sarokhani, Hamid Reza,Hashemi, Hassan Jahani,Talebi-Bakhshayesh, Mousa The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.5

Purpose: Early diagnosis and treatment of acute pyelonephritis in children is of special importance in order to prevent serious complications. This study was conducted to determine the diagnostic value of serum interleukin (IL)-6 and IL-8 in children with acute pyelonephritis. Methods: Eighty-seven patients between 1 month to 12 years old with urinary tract infection (UTI) were divided into 2 groups based on the result of 99m-technetium dimercapto-succinic acid renal scan: acute pyelonephritis (n=37) and lower UTI (n=50) groups. White blood cell (WBC) count, neutrophil (Neutl) count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) concentration, platelet count, and serum IL-6 and IL-8 concentrations of both groups were measured and compared. Results: There was a significant difference between two groups regarding WBC count, Neutl count, ESR, and CRP concentration (P<0.05). In addition, the difference between the two groups regarding serum IL-6 and IL-8 concentrations was not significant (IL-6, 60 and 35.4 pg/mL and IL-8, 404 and 617 pg/mL, respectively). The sensitivity and specificity of serum IL-6 and IL-8 for diagnosis of acute pyelonephritis were 73%, 42% and 78%, 32%, respectively. Sensitivity, specificity, negative and positive predictive values of serum IL-6 and IL-8 were less than those of acute phase serum reactants such as CRP. Conclusion: This study showed that there was no significant difference between acute pyelonephritis and lower UTI groups regarding serum IL-6 and IL-8 levels. Therefore, despite confirming results of previous studies, it seems that IL-6 and IL-8 are not suitable markers for differentiating between acute pyelonephritis and lower UTI.

Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?

Mahyar, Abolfazl,Ayazi, Parviz,Orangpour, Reza,Daneshi-Kohan, Mohammad Mahdi,Sarokhani, Mohammad Reza,Javadi, Amir,Habibi, Morteza,Talebi-Bakhshayesh, Mousa The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.10

Purpose: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remains unclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrile seizures. The present study was conducted to identify potential links between serum interleukin-1beta (IL-$1{\beta}$), tumor necrosis factor-alpha (TNF-${\alpha}$), and febrile seizures. Methods: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type), and 46 controls with comparable age, sex, and severity of temperature were enrolled. Results: The median concentrations of serum IL-$1{\beta}$ in the simple, complex febrile seizure, and control groups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrations of TNF-${\alpha}$ in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL, respectively (P=0.001). Furthermore, there were significant differences between the case groups in serum IL-$1{\beta}$ and TNF-${\alpha}$ levels (P<0.05). Conclusion: Unlike previous studies, our study does not support the hypothesis that increased IL-$1{\beta}$ and TNF-${\alpha}$ production is involved in the pathogenesis of febrile seizures.

Are Clinical, Laboratory, and Imaging Markers Suitable Predictors of Vesicoureteral Reflux in Children With Their First Febrile Urinary Tract Infection?

Abolfazl Mahyar,Parviz Ayazi,Shiva Mavadati,Sonia Oveisi,Morteza Habibi,Shiva Esmaeily 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.8

Purpose: This study was conducted to determine the predictive value of clinical, laboratory,and imaging variables for the diagnosis of vesicoureteral reflux in children withtheir first febrile urinary tract infection. Materials and Methods: One hundred fifty-three children with their first febrile urinarytract infection were divided into two groups according to the results of voiding cystourethrography:60 children with vesicoureteral reflux and 93 children without. Thesensitivity, specificity, positive and negative predictive value, likelihood ratio (positiveand negative), and accuracy of the clinical, laboratory, and imaging variables for thediagnosis of vesicoureteral reflux were determined. Results: Of the 153 children with febrile urinary tract infection, 60 patients (39.2%)had vesicoureteral reflux. There were significant differences between the two groupsregarding fever>38oC, suprapubic pain, C-reactive protein quantitative level, numberof red blood cells in the urine, and results of renal ultrasound and dimercaptosuccinicacid renal scanning (p<0.05). There were significant positive correlations between fever>38.2oC and dimercaptosuccinic acid renal scanning and vesicoureteral reflux. Also, there were significant positive correlations between the erythrocyte sedimentationrate, positive urinary nitrite test, hyaline cast, and renal ultrasound andhigh-grade vesicoureteral reflux. Conclusions: This study revealed fever>38.2oC and dimercaptosuccinic acid renalscanning as the best predictive markers for vesicoureteral reflux in children with theirfirst febrile urinary tract infection. In addition, erythrocyte sedimentation rate, positiveurinary nitrite test, hyaline cast, and renal ultrasound are the best predictivemarkers for high-grade vesicoureteral reflux.

Association between vitamin D and urinary tract infection in children

Abolfazl Mahyar,Parviz Ayazi,Sara Safari,Reza Dalirani,Amir Javadi,Shiva Esmaeily 대한소아청소년과학회 2018 Clinical and Experimental Pediatrics (CEP) Vol.61 No.3

Purpose: The present study aimed to determine the relationship between serum 25-hydroxyvitamin D (25(OH)D) level and Urinary tract infections (UTIs) in children. Methods: In this case-control study, 70 children with UTI (case group) were compared with 70 healthy children (control group) in terms of serum 25(OH)D levels. The children were between 1 month and 12 years of age. Serum 25(OH)D levels were measured using enzyme-linked immunosorbent assay (ELISA). The results were analyzed and compared between both groups. Results: Among 70 children with UTI (case group), 5 children (7.2%) were male and 65 (92.8%) were female. Among the healthy children (control group), 9 (12.8%) and 61 children (87.2%) were male and female, respectively (P=0.39). The mean±standard deviation of age in the case and control groups were 53.2±35.6 and 36.1±60.2 months, respectively (P=0.24). The mean level of serum 25(OH)D in the case group was significantly higher than that of the control group (20.4±8.6 ng/mL vs. 16.9±7.4 ng/mL, P= 0.01) Conclusion: This study showed that there was a relationship between serum 25(OH)D levels and UTI in children. It seems that 25(OH)D plays a role in the pathogenesis of UTI.

Serum levels of interleukin-6 and interleukin-8 as diagnostic markers of acute pyelonephritis in children

Abolfazl Mahyar,Parviz Ayazi,Mohammad Reza Maleki,Mohammad Mahdi Daneshi-Kohan,Hamid Reza Sarokhani,Hassan Jahani Hashemi,Mousa Talebi-Bakhshayesh 대한소아청소년과학회 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.5

Purpose: Early diagnosis and treatment of acute pyelonephritis in children is of special importance in order to prevent serious complications. This study was conducted to determine the diagnostic value of serum interleukin (IL)-6 and IL-8 in children with acute pyelonephritis. Methods: Eighty-seven patients between 1 month to 12 years old with urinary tract infection (UTI)were divided into 2 groups based on the result of 99m-technetium dimercapto-succinic acid renal scan:acute pyelonephritis (n=37) and lower UTI (n=50) groups. White blood cell (WBC) count, neutrophil (Neutl)count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) concentration, platelet count,and serum IL-6 and IL-8 concentrations of both groups were measured and compared . Results: There was a significant difference between two groups regarding WBC count, Neutl count,ESR, and CRP concentration (P<0.05). In addition, the difference between the two groups regarding serum IL-6 and IL-8 concentrations was not significant (IL-6, 60 and 35.4 pg/mL and IL-8, 404 and 617 pg/mL, respectively). The sensitivity and specificity of serum IL-6 and IL-8 for diagnosis of acute pyelonephritis were 73%, 42% and 78%, 32%, respectively. Sensitivity, specificity, negative and positive predictive values of serum IL-6 and IL-8 were less than those of acute phase serum reactants such as CRP. Conclusion: This study showed that there was no significant difference between acute pyelonephritis and lower UTI groups regarding serum IL-6 and IL-8 levels. Therefore, despite confirming results of previous studies, it seems that IL-6 and IL-8 are not suitable markers for differentiating between acute pyelonephritis and lower UTI.

The Effect of Adding Honey to Zinc in the Treatment of Diarrhea in Children

Abolfazl Mahyar,Parviz Ayazi,Mohammad Reza Shaftaroni,Sonia Oveisi,Reza Dalirani,Shiva Esmaeili 대한가정의학회 2022 Korean Journal of Family Medicine Vol.43 No.3

Background: Honey has been used in medicine since ancient times. Limited reports are available to indicate its antibacterial, antiviral, and antidiarrheal properties. This study aimed to determine the effect of honey on acute di-arrhea in children.Methods: This randomized clinical trial included 80 children with acute diarrhea. Forty children received honey and zinc gluconate (trial group) and 40 received only zinc gluconate (control group). After treatment, vomiting/di-arrhea duration, the recovery time, and the duration of hospitalization were compared between the groups.Results: Among the 40 children in the trial group, 19 were male and 21 were female. In the control group, 25 chil-dren were male and 15 female (P=0.26). After initiating treatment, the duration of diarrhea, recovery time, and the duration of hospitalization was significantly shorter in the trial group than in the control group (P<0.05).Conclusion: This study showed that honey with zinc gluconate reduces the duration of diarrhea, accelerates the re-covery time, and shortens the duration of hospitalization.

Serum interleukin-1beta and tumor necrosis factor-alpha in febrile seizures: is there a link?

Abolfazl Mahyar,Parviz Ayazi,Reza Orangpour,Mohammad Mahdi Daneshi-Kohan,Mohammad Reza Sarokhani,Amir Javadi,Mousa Talebi-Bakhshayesh 대한소아청소년과학회 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.10

Purpose: Febrile seizures are induced by fever and are the most common type of seizures in children. Although numerous studies have been performed on febrile seizures, their pathophysiology remainsunclear. Recent studies have shown that cytokines may play a role in the pathogenesis of febrileseizures. The present study was conducted to identify potential links between serum interleukin-1beta(IL-1β), tumor necrosis factor-alpha (TNF-α), and febrile seizures. Methods: Ninety-two patients with simple or complex febrile seizures (46 patients per seizure type),and 46 controls with comparable age, sex, and severity of temperature were enrolled. Results: The median concentrations of serum IL-1β in the simple, complex febrile seizure, and controlgroups were 0.05, 0.1, and 0.67 pg/mL, respectively (P=0.001). Moreover, the median concentrationsof TNF-α in the simple, complex febrile seizure, and control groups were 2.5, 1, and 61.5 pg/mL,respectively (P=0.001). Furthermore, there were significant differences between the case groups inserum IL-1β and TNF-α levels (P<0.05). Conclusion: Unlike previous studies, our study does not support the hypothesis that increased IL-1βand TNF-α production is involved in the pathogenesis of febrile seizures.

Fatigue Reduction in Tubular Web Connections in Semi-deep Beams

Amir Nadi,Aboozar Saleh,Amir Ayazi 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.4

In this paper, the experimental and numerical results of a new type of Reduced Beam Section (RBS) connection called (abbreviated of Holed Tubular Web), are investigated. The HTW-RBS connection is a kind of accordion-web RBS connection by which contribution of the web to the fl exural capacity of the beam would be reduced. In HTW-RBS connection, a steel tube is used instead of part of the beam web to place the plastic hinge in the expected location and also holes are created on the beam web. Similar to the corrugated webs, HTW-RBS connection has also adequate shear capacity but has little contribution to the fl exural stiff ness and capacity. Specimens of semi-deep beams with HTW-RBS connections are prepared and tested under cyclic loading. Results of proposed connection (HTW-RBS), indicated that the fatigue caused by stress concentration at the connection of the tube and beam is decreased and no fracture and cracking occurred at this area. Holes as second fuse actuated After the tube (primary fuse) and the length of plastic hinge is increased. Specimens provide at least 7% story drift, without any signifi cant strength loss, which is more than current requirements for qualifying connections in special moment frames. Finally, the HTW-RBS specimen is simulated by fi nite element software and the results are compatible with the experimental results.