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- 저자 : Atiye Seda Yar (검색결과 3 건)
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Atiye Seda Yar,Sevda Menevse,Irem Dogan,Ebru Alp,Volkan Ergin,Ahmet Cumaoglu,Aysel Aricioglu,Abdullah Ekmekci,Adnan Menevse 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Changes in vascular endothelial growth factor (VEGF), angiotensin-converting enzyme (ACE), matrix metalloproteinase (MMP)-9, and endothelial nitric oxide synthase (eNOS) mRNA expression profiles and oxidative stress in the eye tissue microenviroment may have important roles in ocular neovascularization and permeability in proliferative diabetic retinopathy. The present study investigated the effects of resveratrol (RSV) treatment on the mRNA expression profile of VEGF, ACE, MMP-9, and eNOS, which are associated with vascular neovascularization, and glutathione, protein carbonyl,and nitrite–nitrate levels, which are markers of oxidative stress in eyes of diabetic rats. Twenty-four Wistar albino male rats were divided into four groups. After diabetes induction with streptozotocin (10 mg/kg/day) RSV was administered to the RSV and diabetes mellitus (DM) + RSV groups for 4 weeks. The mRNA levels were measured by quantitative real-time polymerase chain reaction assay, and biochemical estimations were determined with spectrophotometric assays in eye homogenates. The mRNA expression levels of VEGF, ACE, and MMP-9 were increased in the DM group compared with the control group, and RSV treatment decreased their mRNA levels. Expression of eNOS mRNA was increased in the RSV and DM groups and decreased in the DM+ RSV group. Nitrite–nitrate levels and protein carbonyl content were increased and glutathione levels were decreased in the DM group compared with controls. Consequently, these data suggest that RSV suppressed the expression of eNOS, which is actively involved in the inflammation and healing process in chronic diabetes. Although oxidative stress was increased in eye tissue from diabetic rats, mRNA levels of VEGF, MMP-9, and ACE genes associated with vascular remodeling did not change in diabetic eyes.
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Prostaglandin F receptor expression in intrauterine tissues of pregnant rats
Elvan Anadol,Halit Kanca,Atiye Seda Yar,Fatma Helvacioğlu,Sevda Menevşe,Engin Ҫalgüner,Deniz Erdoğan 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.1
In this investigation, we studied the expression andlocalization of rat prostaglandin F (FP) receptor in uterinetissues of rats on gestational Days 10, 15, 18, 20, 21, 21.5 andpostpartal Days 1 and 3 using Western blotting analysis,real-time PCR, and immunohistochemistry. A high level ofimmunoreactivity was observed on gestational Days 20, 21,and 21.5 with the most significant signals found on Day 20. FP receptor protein was expressed starting on gestationalDay 15, and a fluctuating unsteady increase was observeduntil delivery. Uterine FP receptor mRNA levels were lowbetween Days 10 and 18 of gestation (p < 0.05). Thetranscript level increased significantly on Day 20 andpeaked on Day 21.5 just before labor (p < 0.05). There wasa positive correlation between FP receptor mRNAexpression and serum estradiol levels (rs = 0.78; p < 0.01)along with serum estradiol/progesterone ratios (rs = 0.79; p < 0.01). In summary, we observed an increase FP receptorexpression in rat uterus with advancing gestation, a markedelevation of expression at term, and a concominant decreaseduring the postpartum period. These findings indicate a rolefor uterine FP receptors in the mediation of uterinecontractility at term.
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Çağrı Yayla,Kaan Okyay,Asife Şahinarslan,Akın Yılmaz,Atiye Seda Yar Sağlam,Azmi Eyiol,Hasan Ata Bolayır,Burak Sezenöz,Sevda Menevşe,Atiye Çengel 대한심장학회 2016 Korean Circulation Journal Vol.46 No.5
Background and Objectives: Genetic predisposition is an important risk factor for coronary artery disease (CAD). In this study, we aimed to evaluate the impact of rs10757274 and rs2383206 polymorphisms in chromosome 9p21 on presence and severity of CAD in a Turkish population. Subjects and Methods: A total of 646 patients who underwent coronary angiography were included in this study. Coronary vessel score and Gensini score were calculated to assess the angiographic severity of CAD. Alleles of AA, AG, and GG were determined for rs10757274 (polymorphism-1) and rs2383206 (polymorphism-2) polymorphisms located in chromosome 9p21 from the blood samples. Results: There was a significant difference between the alleles in polymorphism-1 in the presence of coronary artery disease (38.9% in AA, 48.0% in GG and 56.4% in AG, p=0.017). However, there was no difference between the alleles in polymorphism-2. According to vessel scores, there was a significant difference between the alleles in polymorphism-1 (AA 0.71±1.04, GG 0.88±1.07, AG 1.06±1.12, p=0.018). In polymorphism-2, vessel scores did not show a difference between the alleles. In polymorphism-1, there was a significant difference in Gensini score (p=0.041). Gensini scores did not differ between the alleles in polymorphism-2 (p>0.05 for all). In multivariate analyses, none of the alleles was an independent factor for presence of CAD. Conclusion: The presence of rs10757274 polymorphism including AG allele in chromosome 9p21 was related to CAD. However, this relationship was not independent of other cardiovascular risk factors.
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