Poster Session : PS 0080 ; Cardiology : Vascular Dysfunction in Newly Diagnosed Pre-Diabetic Hypertensive Patients

( Mirela Anghel ),( Elena Radu Sultanescu ),( Mihai Sandulescu ),( Anca Ioana Anghel ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Introduction: Hypertension is one of the most important causes of premature death worldwide. Pre-diabetic state, mainly impaired glucose tolerance (IGT), is a risk factor for coronary artery disease (CAD) and sudden death. Aortic function (AD-aortic distensibility) plays a signifi cant prognostic role for cardiovascular (CV) events. The resistive index (RI) refl ects local wall extensibility and the related vascular resistance. Methods: We enrolled 285 consecutive newly diagnosed hypertensive pre-diabetic (IGT) patients without CAD (according to ESC and EASD). All patients were evaluated by lab tests, ambulatory blood pressure monitoring, carotid Doppler ultrasound (RI), Doppler echocardiography (AD), ECG stress test for non-cardiac or atypical chest symptom, rest ECG and/or cardiac echo abnormalities. We analyzed the association between AD, RI, BP, abnormal exercise ECG, several clinical parameters and cardiac events during a mean follow-up period of 4.5 ± 0.3 years. Results: The mean age of the population was 47.5 ± 14.6 years. Abnormal stress ECG showing inducible ischemia was noticed in 21% pts. Univariate analysis has shown the following parameters signifi cant associated with abnormal exercise testing: age (p<0.01), family history of premature CV events (p<0.02), SBP (p<0.02), dyslipidaemia (p<0.02), AD (p<0.03), carotid RI (p<0.04), and plasma glucose (p<0.04). Multi-adjusted analysis revealed that LDL cholesterol (p<0.01), SBP (p<0.02), higher values ofRI (p<0.02) and lower values of AD (p<0.03) were signifi cant independent predictors of abnormal ECG exercise test. Multivariate Cox proportional analysis revealed that abnormal stress ECG (HR=2.4, 95%CI: 1.5 - 6.1, p=0.032) and post-load glucose (2- hPG) (HR=2.7, 95%CI: 0.8 - 6.5, p=0.039) were good predictors of the cardiac events. Conclusion: Two simple, effective markers of vascular dysfunction - aortic distensibility and resistive index can be extremely useful in every day clinical practice in the initial risk evaluation of newly diagnosed pre-diabetic hypertensive patients without known previous CAD.

Urban housing redevelopment trends in Downtown San Diego, California

Mihai Anghel,Young-Sik Kim,Albert Garcia 국토지리학회 2004 국토지리학회지 Vol.38 No.1

Starting in the late 1990s San Diego’s downtown area has seen a very aggressive revitalization andredevelopment campaign. Spearheaded mainly by city government, investment bankers, and private developers, this newurban center redevelopment involves the rehabilitation of older buildings, renovations, reallocation of space, demolition ofexisting structures, and rerouting of public resources. This paper briefly overviews these new developments in downtownSan Diego from 2000 to 2003 and evaluates the efficacy of four different subareas of downtown using some GIStechniques, in terms of the location of the new developments, and how they interact [with]in regards to: publictransportation, land use zoning, number of units per building, type of buildings, and location of services. Downtownconstruction in San Diego has dramatically altered the socio-economic dynamics as well as the landscape of San Diego’sdowntown area.

BCC Tantalum의 변형 메커니즘

이승현(Seunghyeon Lee),조한솔(Hansohl Cho),C. A. Bronkhorst,V. Anghel,D. W. Brown 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.7

Systematic Review and Comparative Meta-Analysis of Outcomes Following Pedicled Muscle versus Fasciocutaneous Flap Coverage for Complex Periprosthetic Wounds in Patients with Total Knee Arthroplasty

Economides, James M.,DeFazio, Michael V.,Golshani, Kayvon,Cinque, Mark,Anghel, Ersilia L.,Attinger, Christopher E.,Evans, Karen Kim Korean Society of Plastic and Reconstructive Surge 2017 Archives of Plastic Surgery Vol.44 No.2

Background In cases of total knee arthroplasty (TKA) threatened by potential hardware exposure, flap-based reconstruction is indicated to provide durable coverage. Historically, muscle flaps were favored as they provide vascular tissue to an infected wound bed. However, data comparing the performance of muscle versus fasciocutaneous flaps are limited and reflect a lack of consensus regarding the optimal management of these wounds. The aim of this study was to compare the outcomes of muscle versus fasciocutaneous flaps following the salvage of compromised TKA. Methods A systematic search and meta-analysis were performed to identify patients with TKA who underwent either pedicled muscle or fasciocutaneous flap coverage of periprosthetic knee defects. Studies evaluating implant/limb salvage rates, ambulatory function, complications, and donor-site morbidity were included in the comparative analysis. Results A total of 18 articles, corresponding to 172 flaps (119 muscle flaps and 53 fasciocutaneous flaps) were reviewed. Rates of implant salvage (88.8% vs. 90.1%, P=0.05) and limb salvage (89.8% vs. 100%, P=0.14) were comparable in each cohort. While overall complication rates were similar (47.3% vs. 44%, P=0.78), the rates of persistent infection (16.4% vs. 0%, P=0.14) and recurrent infection (9.1% vs. 4%, P=0.94) tended to be higher in the muscle flap cohort. Notably, functional outcomes and ambulation rates were sparingly reported. Conclusions Rates of limb and prosthetic salvage were comparable following muscle or fasciocutaneous flap coverage of compromised TKA. The functional morbidity associated with muscle flap harvest, however, may support the use of fasciocutaneous flaps for coverage of these defects, particularly in young patients and/or high-performance athletes.

Systematic Review and Comparative Meta-Analysis of Outcomes Following Pedicled Muscle versus Fasciocutaneous Flap Coverage for Complex Periprosthetic Wounds in Patients with Total Knee Arthroplasty

James M. Economides,Michael V. DeFazio,Kayvon Golshani,Mark Cinque,Ersilia L. Anghel,Christopher E Attinger,Karen Kim Evans 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.2

Background In cases of total knee arthroplasty (TKA) threatened by potential hardware exposure, flap-based reconstruction is indicated to provide durable coverage. Historically, muscle flaps were favored as they provide vascular tissue to an infected wound bed. However, data comparing the performance of muscle versus fasciocutaneous flaps are limited and reflect a lack of consensus regarding the optimal management of these wounds. The aim of this study was to compare the outcomes of muscle versus fasciocutaneous flaps following the salvage of compromised TKA. Methods A systematic search and meta-analysis were performed to identify patients with TKA who underwent either pedicled muscle or fasciocutaneous flap coverage of periprosthetic knee defects. Studies evaluating implant/limb salvage rates, ambulatory function, complications, and donor-site morbidity were included in the comparative analysis. Results A total of 18 articles, corresponding to 172 flaps (119 muscle flaps and 53 fasciocutaneous flaps) were reviewed. Rates of implant salvage (88.8% vs. 90.1%, P=0.05) and limb salvage (89.8% vs. 100%, P=0.14) were comparable in each cohort. While overall complication rates were similar (47.3% vs. 44%, P=0.78), the rates of persistent infection (16.4% vs. 0%, P=0.14) and recurrent infection (9.1% vs. 4%, P=0.94) tended to be higher in the muscle flap cohort. Notably, functional outcomes and ambulation rates were sparingly reported. Conclusions Rates of limb and prosthetic salvage were comparable following muscle or fasciocutaneous flap coverage of compromised TKA. The functional morbidity associated with muscle flap harvest, however, may support the use of fasciocutaneous flaps for coverage of these defects, particularly in young patients and/or high-performance athletes.

Circulating Plasma Micro RNAs in Patients with Major Depressive Disorder Treated with Antidepressants: A Pilot Study

Virgil Radu Enatescu,Ion Papava,Ileana Enatescu,Mirela Antonescu,Andrei Anghel,Edward Seclaman,Ioan Ovidiu Sirbu,Catalin Marian 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.5

ObjectiveaaSignificant progress was made in the understanding etiopathogenic factors related to MDD, including through research on the role of micro RNAs (miRs). We investigated plasma miRs as potential markers for MDD in patients treated with antidepressants. MethodsaaAt the initiation and at the end of twelve weeks of treatment, blood samples were collected and a structured diagnostic interview and a standardized depression rating scale for the presence and severity of major depression were done. The average decrease in HAMD score was 76.89%. Plasma miR expression profiling was performed by real time PCR. The lists of up-regulated (cut-off=2) and down-regulated miRs were imported into the miRWalk2.0 algorithm and used for target predictions. KEGG database pathways analysis was used to retrieve the pathways significantly targeted by at least two of the miRs. ResultsaaOf the 222 miRs detected in plasma samples of MDD patients, 40 were differentially expressed after treatment. Twenty-three miRs were significantly overexpressed with fold changes between 1.85 and 25.42, and 17 miRs were significantly downregulated with fold changes from 0.28 to 0.68. Pathway analysis revealed a list of 29 pathways for up-regulated miRs, and 20 pathways for down-regulated miRs. Six dysregulated miRs are common to all the top five pathways (Wnt signaling, Cancer, Endocytosis, Axon guidance, MAPK signaling): miR-146a-5p, miR-146b-5p, miR-221-3p, miR-24-3p, miR-26a-5p. ConclusionaaOverall, our miRWalk analysis of changes in plasma microRNAs after treatment of patients with major depression might open a new avenue for the understanding of Escitalopram mode of action and for its side effects.