http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Implications of strong intergalactic magnetic fields for ultrahigh-energy cosmic-ray astronomy
Alves Batista, Rafael,Shin, Min-Su,Devriendt, Julien,Semikoz, Dmitri,Sigl, Guenter American Physical Society 2017 Physical review. D Vol.96 No.2
<P>We study the propagation of ultrahigh-energy cosmic rays in the magnetized cosmic web. We focus on the particular case of highly magnetized voids (B similar to nG), using the upper bounds from the Planck satellite. The cosmic web was obtained from purely magnetohydrodynamical cosmological simulations of structure formation considering different power spectra for the seed magnetic field in order to account for theoretical uncertainties. We investigate the impact of these uncertainties on the propagation of cosmic rays, showing that they can affect the measured spectrum and composition by up to. similar or equal to 80% and. similar or equal to 5%, respectively. In our scenarios, even if magnetic fields in voids are strong, deflections of 50 EeV protons from sources closer than similar to 50 Mpc are less than 15 degrees in approximately 10-50% of the sky, depending on the distribution of sources and magnetic power spectrum. Therefore, UHECR astronomy might be possible in a significant portion of the sky depending on the primordial magnetic power spectrum, provided that protons constitute a sizeable fraction of the observed UHECR flux.</P>
Bruno Augusto Alves Martins,Marcelo de Melo Andrade Coura,Romulo Medeiros de Almeida,Natascha Mourão Moreira,João Batista de Sousa,Paulo Gonçalves de Oliveira 대한대장항문학회 2017 Annals of Coloproctolgy Vol.33 No.3
Transanal endoscopic microsurgery is considered a safe, appropriate, and minimally invasive approach, and complications after endoscopic microsurgery are rare. We report a case of sepsis and pneumoretroperitoneum after resection of a rectal lateral spreading tumor. The patient presented with rectal mucous discharge. Colonoscopy revealed a rectal lateral spreading tumor. The patient underwent an endoscopic transanal resection of the lesion. He presented with sepsis of the abdominal focus, and imaging tests revealed pneumoretroperitoneum. A new surgical intervention was performed with a loop colostomy. Despite the existence of other reports on pneumoretroperitoneum after transanal endoscopic microsurgery, what draws attention to this case is the association with sepsis.
Batista Letícia Aparecida Silva,dos Reis-Prado Alexandre Henrique,Chaves Hebertt Gonzaga dos Santos,de Arantes Lara Cancella,Morgan Luís Fernando Santos Alves,André Carolina Bosso,Suzuki Thaís Yumi,Be 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.4
Objectives: This study aimed to investigate the effectiveness of different topical/systemic agents in reducing the damage caused by bleaching gel to pulp tissue or cells. Materials and Methods: Electronic searches were performed in July 2023. In vivo and in vitro studies evaluating the effects of different topical or systemic agents on pulp inflammation or cytotoxicity after exposure to bleaching agents were included. The risk of bias was assessed. Results: Out of 1,112 articles, 27 were included. Nine animal studies evaluated remineralizing/anti-inflammatories agents in rat molars subjected to bleaching with 35%– 38% hydrogen peroxide (HP). Five of these studies demonstrated a significant reduction in inflammation caused by HP when combined with bioglass or MI Paste Plus (GC America), or following KF-desensitizing or Otosporin treatment (n = 3). However, orally administered drugs did not reduce pulp inflammation (n = 4). Cytotoxicity (n = 17) was primarily assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on human dental pulp cells and mouse dental papilla Cell-23 cells. Certain substances, including sodium ascorbate, butein, manganese chloride, and peroxidase, were found to reduce cytotoxicity, particularly when applied prior to bleaching. The risk of bias was high in animal studies and low in laboratory studies. Conclusions: Few in vivo studies have evaluated agents to reduce the damage caused by bleaching gel to pulp tissue. Within the limitations of these studies, it was found that topical agents were effective in reducing pulp inflammation in animals and cytotoxicity. Further analyses with human pulp are required to substantiate these findings.
Larissa Morais Ribeiro da Silva,Jorgiane da Silva Severino Lima,Franscisco Ernani Alves Magalhaes,Adriana Rolim Campos,Jose Ismael Feitosa de Araujo,Francisco Lucas Alves Batista,Sandra Maria Barbosa 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.2
Studies involving foods associated with pain reversal and anti-inflammatory effects using zebrafish are rarely reported in the literature. This study aimed to evaluate the effect of graviola (Annona muricata L.) fruit bar (GFB) and GFB added with acerola (Malpighia glabra L) seed extract (ASE) on acute nociception and abdominal inflammation in adult zebrafish (Danio rerio). Acute nociception was induced by formalin, capsaicin, cinnamaldehyde, acidic saline, glutamate (cutaneous models), and hypertonic saline (corneal model), and inflammation was induced by carrageenan. Both GFB and ASE exhibited antinociceptive effect modulated by the nitrergic system, guanylate cyclase, and transient receptor potential ankyrin 1 and acid-sensing ion channels. The antinociceptive effect of GFB also appears to be modulated by the opioid system and glutamatergic receptors (N-methyl-D-aspartate receptor). Only ASE presented corneal antinociceptive effect. Both samples showed anti-inflammatory effect, being more significant the effect of GFB. The addition of acerola by-product extract in GFB results in a product with greater biological potential.
José Maria Renata,Ortega Jéssica da Silva,Baran Jordana Batista Correia,Lüders Débora,Gonçalves Claudia Giglio de Oliveira,Zeigelboim Bianca Simone,Taveira Karinna Veríssimo Meira,Polanski José Fernan 대한청각학회 2024 Journal of Audiology & Otology Vol.28 No.2
Background and Objectives: Chloroquine and its analog hydroxychloroquine are derivatives of 4-aminoquinoline and are regularly used in the treatment of malaria and autoimmune diseases. Among the side effects of these drugs, alterations associated with the auditory system are frequently mentioned. Thus, the aim of this systematic review is to systematically review publications on hearing disorders and chloroquine or hydroxychloroquine use.Materials and Methods: Inclusion criteria were observational or interventional studies on audiological assessment in participants who were using chloroquine or hydroxychloroquine. The methodological quality was independently assessed by two reviewers using the Meta-Analysis of Statistics: assessment and review Instrument. The certainty of the evidence was assessed using the GRADE tool.Results: A total of 1,372 non-duplicate papers were screened, out of which 17 were included in the final qualitative synthesis, and 5 studies in the meta-analysis. The odds ratio for the two subgroups evaluated did not show significance with no heterogeneity between the effects observed between the different diseases (I<sup>2</sup>=0%) and obtaining the global estimate of 0.76 (95% confidence interval [CI]=0.41–1.39; <i>p</i>>0.05). Despite the inclusion of papers with different disease samples, the heterogeneity observed in the analysis was low (I<sup>2</sup>= 0%) and prediction interval (95% PI=0.32–1.80; p>0.05) remained close to that estimated by the CI (95% CI=0.41–1.39; <i>p</i>>0.05). The certainty of the evidence assessed by the GRADE tool was considered very low due to the risk of bias, indirect evidence, and imprecision.Conclusions: The findings of this study suggest that the use of chloroquine/hydroxychloroquine is not associated with hearing disorders.
Ana Beatriz Albino de Almeida,Anderson Luiz-Ferreira,Maı´ra Cola,Luciana Di Pietro Magri,Leonia Maria Batista,Joseilson Alves de Paiva,Jose´ Roberto Trigo,Alba R.M. Souza-Brito 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.4
Arctium lappa L. has been used in folk medicine as a diuretic, depurative, and digestive stimulant and in dermatological conditions. The mechanisms involved in the anti-ulcerogenic activity of the sesquiterpene onopordopicrin (ONP)-enriched fraction (termed the ONP fraction), obtained from A. lappa leaves, were studied. The gastroprotective mechanism of the ONP fraction was evaluated in experimental in vivo models in rodents, mimicking this disease in humans. ONP fraction (50mg/kg, p.o.) significantly inhibited the mucosal injury induced by ethanol/HCl solution (75%), indomethacin/bethanecol (68.9%), and stress (58.3%). When the ONP fraction was investigated in pylorus ligature, it did not induce alteration in the gastric volume but did modify the pH and total acid concentration of gastric juice. ONP fraction significantly increased serum somatostatin levels (82.1 – 4.1 vs. control group 12.7 – 4 pmol/L) and decreased serum gastrin levels (62.6 – 6.04 vs. control group 361.5 – 8.2 lU/mL). Mucus production was not significantly altered by the ONP fraction. Gastroprotection by the ONP fraction was completely inhibited by N-ethylmaleimide treatment and did not modify the effect in the animals pretreated with l-NG-nitroarginine methyl ester. These results suggest an antisecretory mechanism involved with the antiulcerogenic effect of the ONP fraction. However, only endogenous sulfhydryls play an important role in gastroprotection of the ONP fraction.
Aab, A.,Abreu, P.,Aglietta, M.,Ahn, E. J.,Al Samarai, I.,Albuquerque, I. F. M.,Allekotte, I.,Allen, J.,Allison, P.,Almela, A.,Castillo, J. Alvarez,Alvarez-Muñ,iz, J.,Batista, R. Alves,Ambrosio, IOP Publishing 2014 The Astrophysical journal Vol.794 No.2
<P>Spherical harmonic moments are well-suited for capturing anisotropy at any scale in the flux of cosmic rays. An unambiguous measurement of the full set of spherical harmonic coefficients requires full-sky coverage. This can be achieved by combining data from observatories located in both the northern and southern hemispheres. To this end, a joint analysis using data recorded at the Telescope Array and the Pierre Auger Observatory above 10(19) eV is presented in this work. The resulting multipolar expansion of the flux of cosmic rays allows us to perform a series of anisotropy searches, and in particular to report on the angular power spectrum of cosmic rays above 10(19) eV. No significant deviation from isotropic expectations is found throughout the analyses performed. Upper limits on the amplitudes of the dipole and quadrupole moments are derived as a function of the direction in the sky, varying between 7% and 13% for the dipole and between 7% and 10% for a symmetric quadrupole.</P>