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RISS 인기검색어
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- 저자 : Alexander Zimmermann (검색결과 4 건)
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Alexander Mischnik,Marlies Trampe,Stefan Zimmermann 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.2
This erratum is being published to correct the printing error on pages 82 and 88 of the article entitled ‘Evaluation of the Impact of Automated Specimen Inoculation, Using Previ Isola, on the Quality of and Technical Time for Stool Cultures’ by Alexander Mischnik, Marlies Trampe, and Stefan Zimmermann in Ann Lab Med 2015;35:82-8, DOI 10.3343/alm.2015.35.1.82 as follows.
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Alexander Mischnik,Stefan Zimmermann,Marlies Trampe 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.1
Background: This study was designed as a quasi-experiment to evaluate automatic inoculation of fecal specimens, using the automated specimen inoculator Previ Isola (bioMérieux, France). Methods: We evaluated the quality of cultures, recovery rates of enteropathogenic bacteria (Salmonella, Shigella, Campylobacter, and Yersinia species), and cost-effectiveness in terms of technical time. The Previ Isola recovery rates for the two-year period from August 2009 to July 2011 were compared with historical manual inoculation data of the previous two years (August 2007 to July 2009). The regional (Baden-Württemberg) and nationwide (Germany) trends of recovery rates for this four-year period were referred. Results: A total of 5,884 fecal specimens were collected over the study period. Most positive cultures were for Salmonella, followed by Campylobacter. Compared with the historical data, the numbers of Campylobacter-positive specimens for a year between August and July were increased significantly, from 19 in 2007-2008 and 10 in 2008-2009 to 32 in 2009-2010 (P=0.002) and 32 in 2010-2011 (P=0.003), respectively. During the study period, the official data for our region and nationwide did not show this increase in the recovery rate of Campylobacter. For Salmonella, Shigella, and Yersinia, no significant changes were observed. Compared with manual inoculation, the mean hands-on time with Previ Isola inoculation was significantly shortened, from 37:30 min to 8:42 min per 15 fecal specimens. Conclusions: Inoculation by Previ Isola improves the quality of routine culture of fecal specimens, with better sensitivity for Campylobacter and less hands-on time.
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I'll Be a Bit Late -- Packet Reordering in Mobile Networks
Lennart Schulte,Alexander Zimmermann,Puneeth Nanjundaswamy,Lars Eggert,Jukka Manner 한국통신학회 2017 Journal of communications and networks Vol.19 No.6
Data transfer in mobile networks has increased significantlyover the past years, and the capacity of these networkshas grown accordingly. Due to their different set of characteristicscompared to wired networks, they have also received attentionfrom end-to-end developers on transport and application level. However, there exists no research on packet reordering in modernmobile networks, and how a transport layer should be designed tocope with it. In this paper we discuss how to measure packet reorderingin mobile networks with the help of transmission controlprotocol (TCP). Our analysis in Finnish mobile networks showsthat reordering characteristics depend heavily on the operator, butis present in all tested networks, and negatively impacts TCP whennot handled. We find that both number of reorderings in a connectionand the extent of the reordering is influenced by the sendingrate. Additionally, we present the framework for a reorderingprevention algorithm which takes into account the findings by automaticallyadapting to the current sending rate.
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U6 is unsuitable for normalization of serum miRNA levels in patients with sepsis or liver fibrosis
Fabian Benz,Christoph Roderburg,David Vargas Cardenas,Mihael Vucur,Jeremie Gautheron,Alexander Koch,Henning Zimmermann,Jorn Janssen,Lukas Nieuwenhuijsen,Mark Luedde,Norbert Frey,Frank Tacke,Christian 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.9
MicroRNA (miRNA) levels in serum have recently emerged as potential novel biomarkers for various diseases. miRNAs are routinely measured by standard quantitative real-time PCR (qPCR); however, the high sensitivity of qPCR demands appropriate normalization to correct for nonbiological variation. Presently, RNU6B (U6) is used for data normalization of circulating miRNAs in many studies. However, it was suggested that serum levels of U6 themselves might differ between individuals. Therefore, no consensus has been reached on the best normalization strategy in ‘circulating miRNA’. We analyzed U6 levels as well as levels of spiked-in SV40-RNA in sera of 44 healthy volunteers, 203 intensive care unit patients and 64 patients with liver fibrosis. Levels of U6 demonstrated a high variability in sera of healthy donors, patients with critical illness and liver fibrosis. This high variability could also be confirmed in sera of mice after the cecal ligation and puncture procedure. Most importantly, levels of circulating U6 were significantly upregulated in sera of patients with critical illness and sepsis compared with controls and correlated with established markers of inflammation. In patients with liver fibrosis, U6 levels were significantly downregulated. In contrast, levels of spiked-in SV40 displayed a significantly higher stability both in human cohorts (healthy, critical illness,liver fibrosis) and in mice. Thus, we conclude that U6 levels in the serum are dysregulated in a disease-specific manner. Therefore, U6 should not be used for data normalization of circulating miRNAs in inflammatory diseases and previous studies using this approach should be interpreted with caution. Further studies are warranted to identify specific regulatory processes of U6 levels in sepsis and liver fibrosis.
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