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Alexander Mischnik,Marlies Trampe,Stefan Zimmermann 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.2
This erratum is being published to correct the printing error on pages 82 and 88 of the article entitled ‘Evaluation of the Impact of Automated Specimen Inoculation, Using Previ Isola, on the Quality of and Technical Time for Stool Cultures’ by Alexander Mischnik, Marlies Trampe, and Stefan Zimmermann in Ann Lab Med 2015;35:82-8, DOI 10.3343/alm.2015.35.1.82 as follows.
Skyrmions, Antiskyrmions, Bobbers: New Particles for Information technology
Stefan Blugel,Juba Bouaziz,Sergii Grytsiuk,Jan-Phillip Hanke,Markus Hoffmann,Hongying Jia,Gideon P. Muller,Bernd Zimmermann,Gustav Bihlmayer,Samir Lounis,Nikolai S. Kiselev,Yuriy Mokrousov 한국자기학회 2019 한국자기학회 학술연구발표회 논문개요집 Vol.29 No.2
Kleinbeck, Stefan,Schaper, Michael,Juran, Stephanie A.,Kiesswetter, Ernst,Blaszkewicz, Meinolf,Golka, Klaus,Zimmermann, Anna,Bruning, Thomas,Van Thriel, Christoph Occupational Safety and Health Research Institute 2011 Safety and health at work Vol.2 No.4
Objectives: Though sulfur dioxide (SO2) is used widely at workplaces, itseffects on humans are not known. Thresholds are reportedwithout reference to gender or age and occupational exposure limits are basedon effects on lung functioning, although localized effects in the upper airways can be expected. This study's aim is to determine thresholds with respect to age and gender and suggests a new approach to risk assessment using breathing reflexes presumably triggered by trigeminal receptors in the upper airways. Methods: Odor thresholds were determined by the ascending method of limits in groups stratified by age and gender. Subjects rated intensities of different olfactory and trigeminal perceptions at different concentrations of $SO_2$. During the presentation of the concentrations, breathing movements were measured by respiratory inductive plethysmography. Results: Neither age nor gender effects were observed for odor threshold. Only ratings of nasal irritation were influenced bygender. A benchmark dose analysis on relative respiratory depth revealed a 10%-deviation from baseline at about 25.27 mg/$m^3$. Conclusion: The proposed new approach to risk assessment appearsto be sustainable. We discuss whether a 10%-deviation of breathingdepth is relevant.
Alexander Mischnik,Stefan Zimmermann,Marlies Trampe 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.1
Background: This study was designed as a quasi-experiment to evaluate automatic inoculation of fecal specimens, using the automated specimen inoculator Previ Isola (bioMérieux, France). Methods: We evaluated the quality of cultures, recovery rates of enteropathogenic bacteria (Salmonella, Shigella, Campylobacter, and Yersinia species), and cost-effectiveness in terms of technical time. The Previ Isola recovery rates for the two-year period from August 2009 to July 2011 were compared with historical manual inoculation data of the previous two years (August 2007 to July 2009). The regional (Baden-Württemberg) and nationwide (Germany) trends of recovery rates for this four-year period were referred. Results: A total of 5,884 fecal specimens were collected over the study period. Most positive cultures were for Salmonella, followed by Campylobacter. Compared with the historical data, the numbers of Campylobacter-positive specimens for a year between August and July were increased significantly, from 19 in 2007-2008 and 10 in 2008-2009 to 32 in 2009-2010 (P=0.002) and 32 in 2010-2011 (P=0.003), respectively. During the study period, the official data for our region and nationwide did not show this increase in the recovery rate of Campylobacter. For Salmonella, Shigella, and Yersinia, no significant changes were observed. Compared with manual inoculation, the mean hands-on time with Previ Isola inoculation was significantly shortened, from 37:30 min to 8:42 min per 15 fecal specimens. Conclusions: Inoculation by Previ Isola improves the quality of routine culture of fecal specimens, with better sensitivity for Campylobacter and less hands-on time.
Irene Burckhardt,Katharina Last,,Stefan Zimmermann, 대한진단검사의학회 2019 Annals of Laboratory Medicine Vol.39 No.1
Background: The transition from manual processing of patient samples to automated workflows in medical microbiology is challenging. Although automation enables microbiologists to evaluate all samples following the same incubation period, the essential incubation times have yet to be determined. We defined essential incubation times for detecting methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant gram-negative bacteria (MDRGN), and vancomycin-resistant enterococci (VRE). Methods: We monitored the growth kinetics of MRSA, MDRGN, and VRE between two and 48 hours on chromogenic media to establish the time points of first growth, single colony appearance, and typical morphology for 102, 104, 106, and 108 colony forming units/mL. Subsequently, we imaged plates inoculated with 778 patient samples after 20, 24, and 36 hours. Results: The first growth, single colony appearance, and typical morphology time points were inoculum-dependent. First growth appeared after 6–18 hours, 4–18 hours, and 8– 48 hours for MRSA, MDRGN, and VRE, respectively, and single colonies appeared at 12– 18 hours, 6–20 hours, and 12–48 hours, respectively. Typical morphology was visible at 14–22 hours and 12–48 hours for MRSA and VRE, but was not determined for MDRGN. By examining patient samples, ≥98% of MRSA and MDRGN were visible 20 hours after the start of incubation. Following 24 hours of incubation, only 79.5% of VRE were clearly visible on the respective plates. Conclusions: An incubation time of 20 hours is sufficient for detecting MRSA and MDRGN. VRE growth is much slower and requires additional imaging after 36 hours.
A 25-Gb/s Monolithic Optical Receiver With Improved Sensitivity and Energy Efficiency
Hyun-Yong Jung,Jeong-Min Lee,Lischke, Stefan,Knoll, Dieter,Zimmermann, Lars,Woo-Young Choi IEEE 2017 IEEE photonics technology letters Vol.29 No.17
<P>A high-performance integrated optical receiver is realized in photonic BiCMOS technology. The receiver includes waveguide type Ge photodetector (PD), transimpedance amplifier, single-to-differential converter, postamplifier, and output buffer, all of which are monolithically implemented on a Si wafer. It achieves bit-error rate (BER) of 10(-12) for 25-Gb/s 2(31) - 1 PRBS at the incident optical power of -10 dBm with energy efficiency of 1.5 pJ/b. In addition, with the help of the accurate Ge-PD circuit model, the simulated optical receiver eye diagrams and BER performances accurately predict the measured results.</P>