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Alberto Broatch,Manuel Lujan,Santiago Ruiz,Pablo Olmeda 한국자동차공학회 2008 International journal of automotive technology Vol.9 No.2
Most of hydrocarbon (HC) and carbon monoxide (CO) emissions from automotive DI Diesel engines are produced during the engine warm-up period and are primarily caused by difficulties in obtaining stable and efficient combustion under these conditions. Furthermore, the contribution of engine starting to these emissions is not negligible; since this operating condition is highly unfavorable for the combustion progress. Additionally, the catalytic converter is ineffective due to the low engine temperature. In conjunction with adequate engine settings (fuel injection and fresh air control), either the glow plugs or the intake air heater are activated during a portion of the engine warm-up period, so that a nominal engine temperatures is reached faster, and the impact of these difficulties is minimized. Measurement of gaseous pollutants during engine warm-up is currently possible with detectors used in standard exhaust gas analyzers (EGA), which have response times well-suited for sampling at such transient conditions. However, these devices are not suitable for the measurement of exhaust emissions produced during extremely short time intervals, such as engine starting. Herein, we present a methodology for the measurement of the cumulative pollutant emissions during the starting phase of passenger car DI Diesel engines, with the goal of overcoming this limitation by taking advantage of standard detectors. In the proposed method, a warm canister is filled with an exhaust gas sample at constant volumetric flow, during a time period that depends on the engine starting time; the gas concentration in the canister is later evaluated with a standard EGA. When compared with direct pollutant measurements performed with a state-of-art EGA, the proposed procedure was found to be more sensitive to combustion changes and provided more reliable data.
Alvarado-Ruiz, Liliana,Martinez-Silva, Maria Guadalupe,Torres-Reyes, Luis Alberto,Pina-Sanchez, Patricia,Ortiz-Lazareno, Pablo,Bravo-Cuellar, Alejandro,Aguilar-Lemarroy, Adriana,Jave-Suarez, Luis Feli Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
HOX transcription factors are evolutionarily conserved in many different species and are involved in important cellular processes such as morphogenesis, differentiation, and proliferation. They have also recently been implicated in carcinogenesis, but their precise role in cancer, especially in cervical cancer (CC), remains unclear. In this work, using microarray assays followed by the quantitative polymerase chain reaction (qPCR), we found that the expression of 25 HOX genes was downregulated in CC derived cell lines compared with non-tumorigenic keratinocytes. In particular, the expression of HOXA9 was observed as down-modulated in CC-derived cell lines. The expression of HOXA9 has not been previously reported in CC, or in normal keratinocytes of the cervix. We found that normal CC from women without cervical lesions express HOXA9; in contrast, CC cell lines and samples of biopsies from women with CC showed significantly diminished HOXA9 expression. Furthermore, we found that methylation at the first exon of HOXA9 could play an important role in modulating the expression of this gene. Exogenous restoration of HOXA9 expression in CC cell lines decreased cell proliferation and migration, and induced an epithelial-like phenotype. Interestingly, the silencing of human papilloma virus (HPV) E6 and E7 oncogenes induced expression of HOXA9. In conclusion, controlling HOXA9 expression appears to be a necessary step during CC development. Further studies are needed to delineate the role of HOXA9 during malignant progression and to afford more insights into the relationship between downmodulation of HOXA9 and viral HPV oncoprotein expression during cercical cancer development.
Percutaneous Microwave Ablation of Desmoid Fibromatosis
Martínez-Martínez Alberto,García-Espinosa Jade,Láinez Ramos-Bossini Antonio Jesús,Ruiz Santiago Fernando 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6
Objective: To demonstrate the feasibility of percutaneous microwave ablation in desmoid fibromatosis with respect to tumor volume control and improvement in the quality of life. Materials and Methods: Twelve microwave ablations were performed in 9 patients with a histological diagnosis of desmoid fibromatosis between January 2010 and January 2019. The study population included 6 female and 3 male, with an age range of 21–76 years (mean = 46.6 years; standard deviation [SD] = 19.3 years). The mean major axis of the tumors was 10.9 cm (SD = 5.2 cm) and mean lesion volume was 212.7 cm3 (SD = 213 cm3). Their anatomical distribution was as follows: 3 lesions in the thigh, 2 in the gluteus, 2 in the leg and 2 in the periscapular region. We evaluated the reduction in tumor volume and improvement in the quality of life based on the Eastern Cooperative Oncology Group (ECOG) scale. Results: An average tumor volume reduction of 70.4% (SD = 24.9) was achieved, while the quality of life (ECOG scale) improved in 88.9% of patients. Conclusion: Percutaneous microwave ablation may potentially be a safe, effective, and promising technique for controlling tumor volume and improving the quality of life in patients with desmoid fibromatosis.
A Hybrid SA-GA Method for Finding the Maximum Number of Switching Gates in a Combinational Circuit
Ichiro R. Ruiz Obregon,Alberto Palacios Pawlovsky 대한전자공학회 2008 ITC-CSCC :International Technical Conference on Ci Vol.2008 No.7
This work shows the results obtained with the combined application of simulating annealing (SA) and genetic algorithms (GA) in the generation of inputs pairs that cause the maximum number of switching gates in combinational circuits. We found that a combination of SA and GA produces better results than those obtained using only one of them.
Gutierrez-Vargas, Gildardo,Ruiz, Alberto,Lopez-Morelos, Victor H.,Kim, Jin-Yeon,Gonzalez-Sanchez, Jorge,Medina-Flores, Ariosto Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9
One of the consequences of the 475 ℃ embrittlement of duplex stainless steels is the reduction of the resistance to localized corrosion. Therefore, the detection of this type of embrittlement before the material exhibits significant loss in toughness, and corrosion resistance is important to ensure the structural integrity of critical components under corrosion threats. In this research, conductivity measurements are performed using the alternating current potential drop (ACPD) technique with using a portable four-point probe as a nondestructive evaluation (NDE) method for detecting the embrittlement in a 2507 (UNS S32750) super duplex stainless steel (SDSS) aged at 475 ℃ from as-received condition to 300 h. The electric conductivity results were compared against two electrochemical tests namely double loop electrochemical potentiokinetic reactivation (DL-EPR) and critical pitting temperature (CPT). Mechanical tests and the microstructure characterized using scanning electron microscopy (SEM) imaging are conducted to track the progress of embrittlement. It is shown that the electric conductivity correlates with the changes in impact energy, microhardness, and CPT corrosion tests result demonstrating the feasibility of the four-point probe as a possible field-deployable method for evaluating the 475 ℃ embrittlement of 2507 SDSS.
Evaluation of thermal embrittlement in 2507 super duplex stainless steel using thermoelectric power
Gildardo Gutierrez-Vargas,Alberto Ruiz,김진연,Víctor H. Lopez-Morelos,Ricardo R. Ambriz 한국원자력학회 2019 Nuclear Engineering and Technology Vol.51 No.7
This research investigates the feasibility of using the thermoelectric power to monitor the thermal embrittlement in 2507 super duplex stainless steel (SDSS) exposed to a temperature between 280 °C and 500 °C. It is well known that the precipitation of Cr-rich α′ phase as a result of the spinodal decomposition is the major cause of the embrittlement and the loss of corrosion resistance in this material. The specimens are thermally aged at 475 °C for different holding times. A series of mechanical testing including the tensile test, Vickers microhardness measurement, and Charpy impact test are conducted to determine the property changes with holding time due to the embrittlement. The mechanical strengths and ferrite hardness exhibit very similar trends. Scanning electron microscopy images of impact-fractured surfaces reveal a ductile to brittle transition in the fracture mode as direct evidence of the embrittlement. It is shown that the thermoelectric power is highly sensitive to the thermal embrittlement and has an excellent linear correlation with the ferrite hardness. This paper, therefore, demonstrates that the thermoelectric power is an excellent nondestructive evaluation technique for detecting and evaluating the 475 °C embrittlement of field 2507 SDSS structures.
Mikel Prieto,Mikel Gastaca,Patricia Ruiz,Alberto Ventoso,Ibone Palomares,Arkaitz Perfecto,Andres Valdivieso 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.4
Surgery is the only treatment for biliary tract cancer with long term survival. Unfortunately, most patients are diagnosed at stage IV with distant metastases. In these circumstances, life expectancy is less than one year due to aggressive tumour biology and a lack of effective systemic therapies. HER2 overexpression or amplification is predominantly seen in extrahepatic cholangiocarcinoma and gallbladder cancer (10-18%) and rarely in intrahepatic cholangiocarcinoma (1%). Trastuzumab is a monoclonal antibody that targets HER-2. We present a clinical case with a stage IV gallbladder cancer (liver and interaortocaval lymph node metastases), which presented progression during first-line chemotherapy treatment, which prompted a change in therapy to study the Her 2/Neu mutation which showed an intense positive overexpression. A combination of HER2/Neu-directed therapy (Trastuzumab) with second-line chemotherapy, was able to achieve a long term complete radiological, metabolic, and biochemical response. A curative intention surgery was performed and the patient is alive and recurrence-free at five years. To the best of our knowledge, we present a case which is the first report of a patient with a Stage IV gallbladder cancer who achieved a five-year survival without recurrence after a conversion therapy combining chemotherapy plus Trastuzumab and radical salvage surgery.
A case of COVID-19 immediately after liver transplantation: Not only bad news
Mikel Prieto,Mikel Gastaca,Patricia Ruiz,Alberto Ventoso,Ibone Palomares,Regino Jose Rodriguez-Alvarez,Patricia Salvador,Javier Bustamante,Andres Valdivieso 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.3
COVID-19, the illness caused by the SARS-CoV-2 virus originated in December 2019 in Wuhan, China and has caused more 3,3 million cases and more than 230,000 deaths throughout the world, with 25,000 of them only in Spain, where the first case was diagnosed on January 31st, 2020. As COVID-19 is a “new” disease, we still do not have data on prognosis or treatment in transplant patients or on how to manage immunosuppression in this complex scenario. We present a case of COVID-19 diagnosed during the early postoperative period in a recipient whose liver transplantation was performed on late March during the lockdown in Spain, with donor and recipient previously negative rRT-PCR to SARS-CoV-2. In the first post-operative week the patient suffered COVID-19 pneumonia that was treated with immunosuppression minimization, oral Hydroxycloroquine and Azithromycin with favorable outcome. The patient was discharged on POD 21 without complications. To date, few early post-liver transplantation SARS-CoV-2 infected recipients have been published, but only one was an early postoperative infection. In our case the outcome was favorable, even though it was an early post -liver transplantation COVID-19 in a frail patient.
Salcedo, Mauricio,Pina-Sanchez, Patricia,Vallejo-Ruiz, Veronica,Monroy-Garcia, Alberto,Aguilar-Lemarroy, Adriana,Cortes-Gutierrez, Elva I.,Santos-Lopez, Gerardo,Montoya-Fuentes, Hector,Grijalva, Renan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: The aetiological relationship between human papillomavirus (HPV) infection and cervical cancer (CC) is widely accepted. Our goal was to determine the prevalence of HPV types in Mexican women attending at the Mexican Institute for Social Security from different areas of Mexico. Materials and Methods: DNAs from 2,956 cervical samples were subjected to HPV genotyping: 1,020 samples with normal cytology, 931 with low-grade squamous intraepithelial lesions (LGSIL), 481 with high grade HGSIL and 524 CC. Results: Overall HPV prevalence was 67.1%. A total of 40 HPV types were found; HPV16 was detected in 39.4% of the HPV-positive samples followed by HPV18 at 7.5%, HPV31 at 7.1%, HPV59 at 4.9%, and HPV58 at 3.2%. HPV16 presented the highest prevalence both in women with altered or normal cytology and HPV 18 presented a minor prevalence as reported worldwide. The prevalence ratio (PR) was calculated for the HPV types. The analysis of PR showed that HPV16 presents the highest association with CC, HPV 31, -33, -45, -52 and -58 also demonstrating a high association. Conclusions: The most prevalent HPV types in cervical cancer samples were -16, -18, -31, but it is important to note that we obtained a minor prevalence of HPV18 as reported worldwide, and that HPV58 and -52 also were genotypes with an important prevalence in CC samples. Determination of HPV genotypes is very important in order to evaluate the impact of vaccine introduction and future cervical cancer prevention strategies.