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Radioactive cesium removal by Prussian blue deposited iron oxide nanoparticles
( Faruque Md Hasan Al ),최은숙,김정희,김은주 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
In this study, to mitigate the side effects of Prussian Blue (PB), magnetic nanoparticle (M-NP)-based absorbents for cesium (Cs) was prepared by simple binding or photo-deposition of PB on iron oxide nanoparticles (M-PB-UV). PB-deposited magnetic nanoparticles may reduce the intake of potentially hazardous PB along with improved Cs removal capacity compare with the original form of the adsorbent.
Magnetic hyperthermia for induction of apoptosis of tumor xenograft with EGFR mutation
( Faruque Md Hasan Al ),최은숙,김정희,김은주 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
In this study, we investigate the effects of temperature distribution on the viability of cancer cells and the therapeutic potential in a xenograft model. Tumor volume of the magnetic hyperthermia group stagnated in long term observation during 28 days, whereas the untreated control group showed liner tumor growth. The intratumoral application of magnetic material was shown to be an efficient tool for the induction of hyperthermic temperature and kill the cancer cells both in vitro and in vivo conditions.
( Faruque Md Hasan Al ),최은숙,이효룡,김정희,박석호,김은주 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
In this study, leukemia cells in the bloodstream were directly removed under whole-body hyperthermia, using leukemia cell-specific MNPs. EpCAM antibody was immobilized on the surface of MNPs (EpCAMMNPs) to introduce the specificity of MNPs to leukemia cells. Magnetic hyperthermia can be used to remove leukemia cells owing to the specific binding of MNPs to target cells.
김정희,김은주,최은숙,( Hasan Al Faruque ) 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Exosomes, nano-sized extracellular vesicles, are reported to harbor signaling molecules to communicate between remote cells. Due to this reason, exosomal biomarkers have received interests as a source of early detection of cancers. To determine whether the exosomes affect tumor progression in cancer patients, we primarily identified the changes in exosomal protein contents exosomes from serum in cancer patient. We select the best exosomal biomarkers from exosomes in cancer patients. In this study, we compared the expression level of exosomal biomarkers in serum exosomes of cancer patients vs. tissue of cancer patients. Exosomal biomarkers were detected at higher levels in serum exosome from cancer patients compared to tissue. These results suggest that increased exosomal biomarkers from serum exosomes in cancer patients is associated with cancer progression.
( Eon Jeong Nam ),( Yong Min Chang ),( Jang Woo Park ),( Shi Jin Sung ),( Jung Wan Hong ),( Hasan Al Faruque ),( Jong Min Lee ),( Young Mo Kang ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Rheumatoid arthritis (RA) is a chronic infi ammatory disease in which adequate diagnosis of disease activity is particularly important for optimizing treatment outcomes. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to detect infi ammatory changes in synovial joints, and to discriminate active and inactive stages of disease. However, DCE-MRI has not been previously used to evaluate quantitative kinetic parameters, such as vascular permeability. The aim of this study was to investigate the quantitative changes in vascular permeability associated with chronic infi ammatory arthritis. Methods: Arthritis was induced in DBA/1J mice by immunization with bovine type- II collagen emulsifi ed in complete and incomplete Freund`s adjuvants. The severity of arthritis was monitored using the clinical arthritis index (CAI). R images of mice were obtained at different stages of arthritis progression, and 3 weeks after methotrexate (MTX) treatment. Immunohistochemical staining with an anti-CD31 antibody was used to assess vessel density. Results: Permeability maps on the knee joint revealed less heterogeneity during the active stage, compared to early and late stages of arthritis. Vascular permeability increased progressively until the active stage of arthritis was reached, and thereafter declined gradually. The pattern of permeability changes quantified using DCE-MRI was consistent with the vascular densities and disease activity. Furthermore, vascular permeability and densities decreased signifi cantly in a dose-dependent manner after treatment with MTX. Conclusions: Vascular permeability assessed by DCE-MRI can be used as an imaging biomarker for tracking disease progression, and for monitoring therapeutic effi cacy in infi ammatory arthritis.