Distributional Changes in Rainfall and River Flow in Sarawak, Malaysia

Zulfaqar Sa’adi,Shamsuddin Shahid,Tarmizi Ismail,정은성,Xiao-Jun Wang 한국기상학회 2017 Asia-Pacific Journal of Atmospheric Sciences Vol.53 No.4

Climate change may not change the rainfall mean, but the variability and extremes. Therefore, it is required to explore the possible distributional changes of rainfall characteristics over time. The objective of present study is to assess the distributional changes in annual and northeast monsoon rainfall (November-January) and river flow in Sarawak where small changes in rainfall or river flow variability/distribution may have severe implications on ecology and agriculture. A quantile regression-based approach was used to assess the changes of scale and location of empirical probability density function over the period 1980-2014 at 31 observational stations. The results indicate that diverse variation patterns exist at all stations for annual rainfall but mainly increasing quantile trend at the lowers, and higher quantiles for the month of January and December. The significant increase in annual rainfall is found mostly in the north and central-coastal region and monsoon month rainfalls in the interior and north of Sarawak. Trends in river flow data show that changes in rainfall distribution have affected higher quantiles of river flow in monsoon months at some of the basins and therefore more flooding. The study reveals that quantile trend can provide more information of rainfall change which may be useful for climate change mitigation and adaptation planning.

Inter-comparison on the Suitability of Rain-Based Meteorological Drought in Johor River Basin, Malaysia

Zulfaqar Sa’adi,Zulkifli Yusop,Nor Eliza Alias 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.5

Drought is identified and quantified using a variety of methods. This study aims to evaluate the performance of several rain-based meteorological droughts, namely, Rainfall Anomaly Index (RAI), Standard Precipitation Index (SPI), China-Z Index (CZI), Percent of Normal (PN), Deciles Index (DI), and Z-Score Index (ZSI) on 1-, 3-, 6-, 9-, 12-, 18-, 24-, 48-, and 72-month time scales based on monthly precipitation totals for 24 Johor River Basin (JRB) stations from 1970 to 2015. After imputation of missing data with Multiple Imputation by Chained Equations (MICE), homogeneity test for the annual time series found that 21 stations were ‘useful’, 1 station ‘doubtful’ and 2 stations ‘suspect’, meanwhile monthly time series found 17 stations ‘useful’, 1 station ‘doubtful’ and 6 stations ‘suspect’. The performance of CZI, RAI, and SPI were found to be higher compared to others based on the correlation between drought indices, average correlation of a combination of drought indices for all stations (correlation plot and heatmap), scatter plot linearity between drought indices in capturing the wet/dry conditions, and simulating the historical drought events. However, based on the ability to simulate the historical event, spatial assessment, and frequency analysis, it was found that RAI is more responsive in identifying the ‘drought prone’ area to enable a better spatial mapping of the 3- and 6-months drought condition in JRB. ‘Moderately dry’ condition is expected to be temporally and spatially widespread as North East (NE) monsoon becomes drier. Meanwhile, a condition of ‘very dry’ and ‘extremely dry’ is expected to be more prevalent in the South East area of the basin, particularly due to the drier South West (SW) monsoon period. Study results indicate that RAI can perform comparatively better than other studied indices, and because the calculations of RAI are relatively simple, they can be used as better tools to monitor the conditions of drought in JRB.

Novel Compound Heterozygous Mutations of TGM1 Gene Identified in a Turkish Collodion Baby Diagnosed with Non-Bullous Congenital Ichthyosiform Erythroderma

( Elif Keleş Gülnerman ),( Nurcan Hanedan ),( Merve Akillioglu ),( Gülsüm Kayhan ),( Esra Adişen ),( Özlem Erdem ),( İbrahim Murat Hirfanoğlu ),( Ebru Ergenekon ),( Eray Esra Önal ),( Canan Türkyilmaz 대한피부과학회 2023 Annals of Dermatology Vol.35 No.7

Autosomal recessive congenital ichthyosis (ARCI) is a group of diseases presenting as collodion baby at birth. ARCI is categorized as Harlequin ichthyosis, lamellar ichthyosis, and non-bullous congenital ichthyosiform erythroderma (NBCIE), bathing suit icthyosis (BSI) and others. We describe the case of a male newborn with NBCIE whose whole exome sequencing revealed two variants of TGM1 gene (NM_000359.3) in a compound heterozygous state: c.790C>T (p.Arg264Trp) in exon 5 and c.2060G>A (p.Arg687His) in exon 13. In the literature, the Arg264Trp variant has been reported as homozygous or compound heterozygous with other variants in patients with BSI. In contrast, the Arg687His variant has been reported only as homozygous in patients with BSI. To the best of our knowledge, this is the first case whose two compound heterozygous variants, exhibiting the NBCIE phenotype, instead of the BSI.

Novel Compound Heterozygous Mutations of TGM1 Gene Identified in a Turkish Collodion Baby Diagnosed with Non-Bullous Congenital Ichthyosiform Erythroderma

Elif Keleş Gülnerman,Nurcan Hanedan,Merve Akillioglu,Gülsüm Kayhan,Esra Adişen,Özlem Erdem,İbrahim Murat Hirfanoğlu,Ebru Ergenekon,Eray Esra Önal,Canan Türkyilmaz,Esin Koç 대한피부과학회 2023 Annals of Dermatology Vol.35 No.-

Autosomal recessive congenital ichthyosis (ARCI) is a group of diseases presenting as col- lodion baby at birth. ARCI is categorized as Harlequin ichthyosis, lamellar ichthyosis, and non-bullous congenital ichthyosiform erythroderma (NBCIE), bathing suit icthyosis (BSI) and others. We describe the case of a male newborn with NBCIE whose whole exome se- quencing revealed two variants of TGM1 gene (NM_000359.3) in a compound heterozygous state: c.790C>T (p.Arg264Trp) in exon 5 and c.2060G>A (p.Arg687His) in exon 13. In the literature, the Arg264Trp variant has been reported as homozygous or compound heterozy- gous with other variants in patients with BSI. In contrast, the Arg687His variant has been reported only as homozygous in patients with BSI. To the best of our knowledge, this is the first case whose two compound heterozygous variants, exhibiting the NBCIE phenotype, instead of the BSI.

Changes in Policy and Endoscopic Procedures during the 2019 Coronavirus Disease Outbreak: A Single Center Experience

Adi Lahat,Avidan Benjamin 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.1

Background/Aims: The coronavirus disease-19 (COVID-19) pandemic forced endoscopy units to enact major changes on dailypractice and policy. The Chaim Sheba Medical Center is a tertiary referral center located in the center of Israel, and serves cities withhigh infection rates. Our aim was to review the policies enacted during this outbreak and study their influence on the performanceof endoscopic procedures. Methods: Following the revision of work protocols, personnel were divided into two permanent and physically separate workinggroups and screening procedures were rescheduled. Relevant data including the number of endoscopic examinations, type ofprocedure performed, and patient referrals and indications were taken from a computerized database and evaluated. The studyincluded data for January–March 2018–2020, and a comparison among the data from each year was performed. Results: As of March 2020, the total number of endoscopic examinations performed reduced by 44% (p<0.0001) as compared toprevious years, gastroscopy examinations reduced by 39% (p=0.02), and lower endoscopy procedures reduced by 57% (p<0.0001). Meanwhile, the number of advanced endoscopic procedures performed remained consistent with previous years. The indicationsfor performance of gastroscopy and lower endoscopy were different in March 2020, while these remained unchanged for advancedendoscopic procedures. Conclusions: The current policy appears to serve both our initial goals: protecting personnel and patients’ safety and minimizingpotential damage from delayed endoscopic procedures. A longer term follow-up study is needed in order to fully analyze our results.

Exploring the Attitudes of English Language Learners toward Online Learning in Indonesian Higher Education

Adi Isma,Putu Wahyu Sudewi,Amrang 아시아테플 2024 The Journal of Asia TEFL Vol.21 No.1

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Glucagon-Like Peptide 1 Therapy: From Discovery to Type 2 Diabetes and Beyond

Adie Viljoen,Stephen C. Bain 대한내분비학회 2023 Endocrinology and metabolism Vol.38 No.1

The therapeutic benefits of the incretin hormone, glucagon-like peptide 1 (GLP1), for people with type 2 diabetes and/or obesity, are now firmly established. The evidence-base arising from head-to-head comparative effectiveness studies in people with type 2 diabetes, as well as the recommendations by professional guidelines suggest that GLP1 receptor agonists should replace more traditional treatment options such as sulfonylureas and dipeptidyl-peptidase 4 (DPP4) inhibitors. Furthermore, their benefits in reducing cardiovascular events in people with type 2 diabetes beyond improvements in glycaemic control has led to numerous clinical trials seeking to translate this benefit beyond type 2 diabetes. Following early trial results their therapeutic benefit is currently being tested in other conditions including fatty liver disease, kidney disease, and Alzheimer’s disease.

Economic Performance: Leading Sector, Economic Structure and Competitiveness of Export Commodities

Adi WIJAYA,Zainal ILMI,Dio Caisar DARMA 한국유통과학회 2020 Asian Journal of Business Environment (AJBE) Vol.10 No.3

Purpose: The purpose of this study is for the leading sector, a pattern of shifting structure of the economic sector, and community export competitiveness on the economy Malinau Regency. Research design, data, and methodology: The type of data used is secondary data with a quantitative approach of 2009-2018. The study data used Location Quotient (LQ), Shift Share Analysis (SSA), and Revealed Comparative Advantage (RCA) analysis tools. Results: There are 6 leading sectors: agriculture; electricity, gas, and clean water; building and construction; trade, hotels, and restaurants. That has been classified has changed the economic structure of the Malinau Regency from the secondary sector to the tertiary and primary sectors in 10 years. While, community export competitiveness of the Malinau Regency through RCA Analysis, see if the export products of coal and excavation (types A, B, C) are shown to have a higher comparative advantage with comparative advantage. This shows that only a few commodities that can provide the good performance of export. Conclusions: Analysis of economic growth in the Malinau Regency after regional autonomy shows that there has been a shift in the economic structure of the economy which is dominated by the structure of the primary sector.

Multidrug-resistant Staphylococci Found on Book Surfaces in East London Libraries

( Adi Idris ),( Ron R Cutler ) 한국미생물생명공학회(구 한국산업미생물학회) 2017 한국미생물·생명공학회지 Vol.45 No.4

There is an increase in the presence of drug-resistant staphylococci outside of the nosocomial and health-care setting. Although the presence of staphylococci has been studied in several public spaces, nothing is known on the presence of staphylococci in public libraries. Book surfaces from public libraries in the East London area, United Kingdom were swabbed and cultured and identity of the isolates determined by matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry (MS). Seven dif-ferent staphylococcal species were identified by MALDI-TOF-MS analysis. This short study provides evi-dence of the presence of multidrug-resistant staphylococci in public libraries in the East London area.

Treatment of Tardive Dyskinesia : Success Still Seems a Long Way Off

ADIS Medical Publications Korea 1976 Medical Progress Vol.3 No.7