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Supersonically sprayed thermal barrier layers using clay micro-particles
Kim, D.Y.,Lee, J.G.,Joshi, B.,Lee, J.H.,Al-Deyab, S.S.,Yoon, H.G.,Yang, D.R.,Yarin, A.,Yoon, S.S. Elsevier 2016 Applied clay science Vol.120 No.-
<P>Several clay minerals were supersonically sprayed onto flexible substrates to form highly thermally and electrically insulating materials which could be wrapped onto protected surfaces. Among these clay minerals, montmorillonite (Mt) revealed the best thermal insulating properties. (C) 2015 Elsevier B.V. All rights reserved.</P>
Phytochemical Studies of Phyllanthus debilis
K.S.Chandrashekar,D.Satyanarayana,A.B.Joshi,E.V.S.Subrahmanyam 한국생약학회 2004 Natural Product Sciences Vol.10 No.3
Two Lignans Phyllanthin and Hypophyllanthin, and a steroid b-sitosterol has been isolated from the leaves of Phyllanthus debilis and their structures were established by spectral analysis and direct comparison with authentic samples. This is the first report of occurrence of these compound from P.debilis.
Engineering a novel bilayer membrane for bone defects regeneration
Tiwari, A.P.,Joshi, M.K.,Maharjan, B.,Ko, S.W.,Kim, J.I.,Park, C.H.,Kim, C.S. North-Holland 2016 Materials letters Vol.180 No.-
We report the fabrication of a novel bilayer scaffold as a barrier membrane via modified-solvent casting and evaporation technique for the regeneration of bone defects. The blended solution of polycaprolactone (PCL) and calcium carbonate (CaCO<SUB>3</SUB>) was treated with hydrochloric acid (HCL), which resulted in the in situ formation of carbon dioxide (CO<SUB>2</SUB>) and water. This led to the phase separation between the PCL and calcium-based compounds and subsequently to the formation of a bilayer membrane. Surface morphology, surface wettability, and energy-dispersive X-ray spectroscopy (EDX) analysis confirmed the formation of a bilayered construct with a PCL-rich thin layer on the upper surface and a calcium-rich porous layer on the lower surface. From the FE-SEM images, the PC30 membrane showed a smooth upper layer with pores less than 10@?m diameter, whereas the lower layer contained many interconnected larger pores up to 1000@?m diameter in addition to the visibly identified macrovoids. The cell adhesion assay showed that both surfaces of the membrane responded well to the cells. In addition, the upper surface prevented the down-growth of the fibroblasts. The initial results suggest a new strategy for the fabrication of the bilayer membrane for regenerative medicine.
Nordstrom, U.,Beauvais, G.,Ghosh, A.,Pulikkaparambil Sasidharan, B.C.,Lundblad, M.,Fuchs, J.,Joshi, R.L.,Lipton, J.W.,Roholt, A.,Medicetty, S.,Feinstein, T.N.,Steiner, J.A.,Escobar Galvis, M.L.,Prochi Blackwell Science ; Academic Press 2015 Neurobiology of disease Vol.73 No.-
Current research on Parkinson's disease (PD) pathogenesis requires relevant animal models that mimic the gradual and progressive development of neuronal dysfunction and degeneration that characterizes the disease. Polymorphisms in engrailed 1 (En1), a homeobox transcription factor that is crucial for both the development and survival of mesencephalic dopaminergic neurons, are associated with sporadic PD. This suggests that En1 mutant mice might be a promising candidate PD model. Indeed, a mouse that lacks one En1 allele exhibits decreased mitochondrial complex I activity and progressive midbrain dopamine neuron degeneration in adulthood, both features associated with PD. We aimed to further characterize the disease-like phenotype of these En1<SUP>+/-</SUP> mice with a focus on early neurodegenerative changes that can be utilized to score efficacy of future disease modifying studies. We observed early terminal defects in the dopaminergic nigrostriatal pathway in En1<SUP>+/-</SUP> mice. Several weeks before a significant loss of dopaminergic neurons in the substantia nigra could be detected, we found that striatal terminals expressing high levels of dopaminergic neuron markers TH, VMAT2, and DAT were dystrophic and swollen. Using transmission electron microscopy, we identified electron dense bodies consistent with abnormal autophagic vacuoles in these terminal swellings. In line with these findings, we detected an up-regulation of the mTOR pathway, concurrent with a downregulation of the autophagic marker LC3B, in ventral midbrain and nigral dopaminergic neurons of the En1<SUP>+/-</SUP> mice. This supports the notion that autophagic protein degradation is reduced in the absence of one En1 allele. We imaged the nigrostriatal pathway using the CLARITY technique and observed many fragmented axons in the medial forebrain bundle of the En1<SUP>+/-</SUP> mice, consistent with axonal maintenance failure. Using in vivo electrochemistry, we found that nigrostriatal terminals in the dorsal striatum were severely deficient in dopamine release and reuptake. Our findings support a progressive retrograde degeneration of En1<SUP>+/-</SUP> nigrostriatal neurons, akin to what is suggested to occur in PD. We suggest that using the En1<SUP>+/-</SUP> mice as a model will provide further key insights into PD pathogenesis, and propose that axon terminal integrity and function can be utilized to estimate dopaminergic neuron health and efficacy of experimental PD therapies.
N. D. Sangle,A. N. Metkari,S. B. Joshi 경남대학교 기초과학연구소 2021 Nonlinear Functional Analysis and Applications Vol.26 No.5
In this paper, we have introduced a generalized class S_H^i (m, n, γ, φ, ψ; α), i ∈ {0, 1} of harmonic univalent functions in unit disc U, a sufficient coefficient condition for the normalized harmonic function in this class is obtained. It is also shown that this coefficient condition is necessary for its subclass T S_H^i (m, n, γ, φ, ψ; α). We further obtained extreme points, bounds and a covering result for the class T S_H^i (m, n, γ, φ, ψ; α). Also, show that this class is closed under convolution and convex combination. While proving our results, certain conditions related to the coefficients of φ and ψ are considered, which lead to various well-known results.
A.B.Joshi,D.Satyanarayana,K.S.Chandrashekar,E.V.S.Subrahmanyam 한국생약학회 2004 Natural Product Sciences Vol.10 No.3
From the flowers of Ervatamia coronaria four indole alkaloids have been isolated and characterized as harmine, heyneanine, voacristine and apparicine with the help of various spectral data. The alkaloids Harmine and Heyneanine are reported first time from the flowers of Ervatamia coronaria.
Yoon, H.,Kim, M.w.,Kim, H.,Kim, D.Y.,An, S.,Lee, J.G.,Joshi, B.N.,Jo, H.S.,Choi, J.,Al-Deyab, S.S.,Yarin, A.L.,Yoon, S.S. Pergamon Press ; Elsevier Science Ltd 2016 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.101 No.-
Several types of nano-textured surfaces were studied with the goal to enhance heat removal rate in a cooling device (a heat sink) with water flow-through. The nano-textured surfaces where heat removal to flowing water took place included: (i) electrospun copper-plated thorny-devil nanofibers deposited on the copper substrate, (ii) graphene oxide flakes sprayed on the copper substrate, and (iii) silver nanowires spin-coated on a separate copper substrate. Their cooling performance was monitored by measuring the difference between the outlet and inlet temperature of water flowing through the heat sink and the temperature of the nano-textured copper substrate in the heat sink. The effect of the macroscopic vortex generator (wires) on cooling of the heat sink surface was less than that of the nano-textured surfaces, which revealed that the latter provide a much larger interfacial area, rather than an extra flow mixing, to enhance heat transfer rate. Of the nano-textured surfaces the most significant cooling enhancement was achieved with silver nanowires.
Pal, Aruna,Chakravarty, A.K.,Bhattacharya, T.K.,Joshi, B.K.,Sharma, Arjava Asian Australasian Association of Animal Productio 2004 Animal Bioscience Vol.17 No.10
The present study was conducted to detect polymorphism at growth hormone gene in Karan Fries bulls. A 428 bp fragment of growth hormone gene spanning over $4^{th}$exon, $4^{th}$intron and $5^{th}$ exon was amplified and digested with AluI restriction enzyme to identify polymorphism at this locus. Karan Fries bulls were found to be polymorphic at this locus. Two genotypes LL and LV were identified in Karan Fries with higher allelic frequency for L allele. In Karan Fries males, the average birth weight, 3 months body weight and daily body weight gains of LL homozygotes were significantly higher than that of LV heterozygotes. Genetic distances of KF bulls with respect to genotype along with 3 months body weight and average daily body weight gain forms a single cluster of bulls with LL genotype, while individuals with LV genotype forms three distinct clusters indicating more influence of L allele on growth traits.