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Magnetodielectric Properties of La0.67Sr0.33MnO3 and Ba0.7Sr0.3TiO3 Thin Film Heterostructures
Arjun Tarale,Y.D. Kolekar,V.L. Mathe,S.B. Kulkarni,V.R. Reddy,Pradeep Joshi 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.4
The paper discuses synthesis and magnetodielectric properties of La0.67Sr0.33MnO3 (LSMO), Ba0.7Sr0.3TiO3 (BST),and BST/LSMO thin film heterostructures. The XRD spectra are determined for confirmation of the crystal structure of LSMO, BST and formation of a pure bi-phase composite. The paper presents variation of Cp and tanδ as a function of frequency between 100 Hz to 1 MHz and applied magnetic field up to 0.6 T. The observed variation of Cp, tanδ, magnetocapacitance and impedance spectra are analyzed in terms of a possible equivalent circuit model. The present analysis shows that the method of impedance spectra could be used to separate out the possible contributions.
Lunavat, Taral R.,Cheng, Lesley,Einarsdottir, Berglind O.,Olofsson Bagge, Roger,Veppil Muralidharan, Somsundar,Sharples, Robyn A.,Lasser, Cecilia,Gho, Yong Song,Hill, Andrew F.,Nilsson, Jonas A.,Lotva National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.29
<P>The BRAF inhibitors vemurafenib and dabrafenib can be used to treat patients with metastatic melanomas harboring BRAF(V600) mutations. Initial antitumoral responses are often seen, but drug-resistant clones with reactivation of the MEK-ERK pathway soon appear. Recently, the secretome of tumor-derived extracellular vesicles (EVs) has been ascribed important functions in cancers. To elucidate the possible functions of EVs in BRAF-mutant melanoma, we determined the RNA content of the EVs, including apoptotic bodies, microvesicles, and exosomes, released from such cancer cells after vemurafenib treatment. We found that vemurafenib significantly increased the total RNA and protein content of the released EVs and caused significant changes in the RNA profiles. RNA sequencing and quantitative PCR show that cells and EVs from vemurafenib-treated cell cultures and tumor tissues harvested from cell-derived and patient-derived xenografts harbor unique miRNAs, especially increased expression of miR-211-5p. Mechanistically, the expression of miR-211-5p as a result of BRAF inhibition was induced by increased expression of MITF that regulates the TRPM1 gene resulting in activation of the survival pathway. In addition, transfection of miR-211 in melanoma cells reduced the sensitivity to vemurafenib treatment, whereas miR-211-5p inhibition in a vemurafenib resistant cell line affected the proliferation negatively. Taken together, our results show that vemurafenib treatment induces miR-211-5p up-regulation in melanoma cells both in vitro and in vivo, as well as in subsets of EVs, suggesting that EVs may provide a tool to understand malignant melanoma progression.</P>
What Is the Evidence to Support the Use of Therapeutic Gardens for the Elderly?
Mark B. Detweiler,Taral Sharma,Jonna G. Detweiler,Pamela F. Murphy,Sandra Lane,Jack Carman,Amara S. Chudhary,Mary H. Halling,Kye Y. Kim 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.2
Horticulture therapy employs plants and gardening activities in therapeutic and rehabilitation activities and could be utilized to improve the quality of life of the worldwide aging population, possibly reducing costs for long-term, assisted living and dementia unit residents. Preliminary studies have reported the benefits of horticultural therapy and garden settings in reduction of pain, improvement in attention, lessening of stress, modulation of agitation, lowering of as needed medications, antipsychotics and reduction of falls. This is especially relevant for both the United States and the Republic of Korea since aging is occurring at an unprecedented rate, with Korea experiencing some of the world’s greatest increases in elderly populations. In support of the role of nature as a therapeutic modality in geriatrics, most of the existing studies of garden settings have utilized views of nature or indoor plants with sparse studies employing therapeutic gardens and rehabilitation greenhouses. With few controlled clinical trials demonstrating the positive or negative effects of the use of garden settings for the rehabilitation of the aging populations, a more vigorous quantitative analysis of the benefits is long overdue. This literature review presents the data supporting future studies of the effects of natural settings for the long term care and rehabilitation of the elderly having the medical and mental health problems frequently occurring with aging.