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Usman A. Malik,Naveed Riaz,Sajjad Asghar,Mehnaz Hafeez 보안공학연구지원센터(IJGDC) 2011 International Journal of Grid and Distributed Comp Vol.4 No.4

Diversity of pollinators and their role in the pollination biology of chickpea, Cicer arietinum L. (Fabaceae)

Abdul Latif,Saeed Ahmad Malik,Shafqat Saeed,Naeem Iqbal,Qamar Saeed,Khalid Ali Khan,Chen Ting,Hamed A. Ghramh 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

Chickpea (Cicer arietinum L.) is an important source of food for people worldwide. In the current study, we studied its pollination biology with special reference to floral visitors along with their visitation rate, frequency and pollen load during 2012 and 2013. We also explored the effect of floral visitors on the capsule weight, seed weight, seed numbers and seed germination. Results revealed three bees, two wasps, five flies, one moth and three butterfly species on the flowers of chickpea. Apis dorsata, A. florea, Amegilla sp. and Eristalinus aeneus were the major species with 434–474, 223–311, 69–74 and 81–136 individuals, respectively in both years. Floral visitors differed significantly in term of visitation frequency with A. florea as the most frequent visitor (9.13–9.86 visits/flower/5 min) followed by E. aeneus (5.43–5.58 visits/flower/5 min) and A. dorsata (1.72–2.31 visits/ flower/5 min) in both years. Similarly, A. florea had statistically highest visitation rate (16.85–19.99 flowers visited/min) followed by E. aeneus (9.73–10.68 flowers visited/min). A. dorsata had significantly higher pollen load on its body (84629–85,104 pollen grains) followed by A. florea (64940–65,135 pollen grains) and Amegilla sp. (64020–65,120 pollen grains). The open-pollinated flowers had significantly higher capsule weight (0.27 ± 0.01 g), seed weight (0.18 ± 0.01 g), seed numbers (1.67 ± 0.07 seeds) and seed germination (95 ± 1.38%) as compared to flowers deprived of pollinators in cages. The results suggested A. florea, A. dorsata and E. aeneus could be effective pollinators of chickpea. Hence these three species can be properly utilized on commercial scale to increase crop yield.

Prostaglandins Inhibit Cytochrome P450 4A Activity and Contribute to Endotoxin-Induced Hypotension in Rats via Nitric Oxide Production

Tunctan, Bahar,Yaghini, Fariborz A.,Estes, Anne,Malik, Kafait U. 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that endotoxemiainduced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure (MAP). By using cyclooxygenase (COX) inhibitor indomethacin, we investigated herein whether prostaglandins, via NO production, inhibit renal CYP 4A1 protein expression and CYP 4A activity and contribute to the endotoxin-induced hypotension. In conscious male Sprague-Dawley rats, endotoxin (10 mg/kg, intraperitoneal (i.p.)) reduced MAP, increased serum nitrite and bicyclo PGE2 levels, renal nitrite production and iNOS protein expression, and decreased renal CYP 4A1 protein expression and CYP 4A activity after 4 h injection. All of the endotoxin-induced changes, except for increase in renal nitrite production, were prevented by indomethacin (5 mg/kg, i.p. 1 h after endotoxin). The effects of indomethacin on the endotoxin-induced decrease in MAP, CYP 4A1 protein expression and CYP 4A activity were minimized by the CYP 4A inhibitor, aminobenzotriazole (50 mg/kg, i.p. 1 h after endotoxin). These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A.

Prostaglandins Inhibit Cytochrome P450 4A Activity and Contribute to Endotoxin-Induced Hypotension in Rats via Nitric Oxide Production

Bahar Tunctan,Fariborz A. Yaghini,Anne Estes,Kafait U. Malik 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7

Increased production of nitric oxide (NO) and prostaglandins contribute to development of hypotension during endotoxemia. We have previously demonstrated that endotoxemiainduced increase in NO production suppresses renal cytochrome P450 (CYP) 4A expression and activity, and that selective inhibition of inducible NO synthase (iNOS) with 1,3-PBIT restores renal CYP 4A protein and activity and mean arterial pressure (MAP). By using cyclooxygenase (COX) inhibitor indomethacin, we investigated herein whether prostaglandins, via NO production, inhibit renal CYP 4A1 protein expression and CYP 4A activity and contribute to the endotoxin-induced hypotension. In conscious male Sprague-Dawley rats, endotoxin (10 mg/kg, intraperitoneal (i.p.)) reduced MAP, increased serum nitrite and bicyclo PGE2 levels, renal nitrite production and iNOS protein expression, and decreased renal CYP 4A1 protein expression and CYP 4A activity after 4 h injection. All of the endotoxin-induced changes, except for increase in renal nitrite production, were prevented by indomethacin (5 mg/kg, i.p. 1 h after endotoxin). The effects of indomethacin on the endotoxin-induced decrease in MAP, CYP 4A1 protein expression and CYP 4A activity were minimized by the CYP 4A inhibitor, aminobenzotriazole (50 mg/kg, i.p. 1 h after endotoxin). These data suggest that prostaglandins produced during endotoxemia increase iNOS protein expression and NO synthesis, and decrease CYP 4A protein expression and CYP 4A activity and that inhibition of iNOS or COX restores renal CYP 4A protein level and CYP 4A activity and MAP presumably due to increased production of arachidonic acid metabolites derived from CYP 4A.

Giant strain, thermally-stable high energy storage properties and structural evolution of Bi-based lead-free piezoceramics

Malik, R.A.,Hussain, A.,Maqbool, A.,Zaman, A.,Song, T.K.,Kim, W.J.,Kim, M.H. Elsevier Sequoia 2016 Journal of Alloys and Compounds Vol.682 No.-

In this study, the mechanism of electric-field-induced phase transition in 0.96[Bi<SUB>0.5</SUB>(Na<SUB>0.84</SUB>K<SUB>0.16</SUB>)<SUB>0.5</SUB>Ti<SUB>1-x</SUB>Ta<SUB>x</SUB>O<SUB>3</SUB>]-0.04SrTiO<SUB>3</SUB>, (where 0.00 @? x @? 0.030, abbreviated as BNKTT-ST) ceramics was discussed based on crystal structure and electromechanical properties. X-ray powder diffraction (XRD) showed a phase transition from mixed rhombohedral-tetragonal to single pseudocubic when x ≥ 0.020. Large electromechanical strain of ~0.42% with a dynamic piezoelectric constant (S<SUB>max</SUB>/E<SUB>max</SUB>) of ~700 pm/V at 6 kV/mm was recorded for 2 mol. % Ta content. Interestingly, at lower field of 4 kV/mm, the S<SUB>max</SUB>/E<SUB>max</SUB> attained the highest value of ~830 pm/V. Poled, unpoled XRD analysis and electrical properties suggest that the relatively high S<SUB>max</SUB>/E<SUB>max</SUB> at x = 0.020 may be attributed to the combined effect of composition and ferroelectric (FE) to ergodic relaxor (ER) phase transition. Furthermore, the energy storage density was studied as a function of both composition and temperature to demonstrate the suitability for capacitor applications. This system also revealed improved energy storage properties. Particularly, for x = 0.020, a nearly temperature-invariant large recoverable energy density (W = 0.65 J/cm<SUP>3</SUP>) was achieved over a wide temperature range (75-150 <SUP>o</SUP>C). These properties demonstrate that the fabricated system might be a promising lead-free candidate for actuators and high temperature energy storage capacitor applications.

Peritoneal cancer index as a predictor of survival in advanced stage serous epithelial ovarian cancer: a prospective study

Alaa A. Elzarkaa,Waleed Shaalan,Doaa Elemam,Hassan Mansour,Mahmoud Melis,Eduard Malik,Amr A. Soliman 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.4

OBJECTIVE: A numerical score, the peritoneal cancer index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival. METHODS: This was a prospective observational cohort study. Patients with primary serous EOC at International Federation of Gynecology and Obstetrics (FIGO) stages IIIB or higher were included. Patients with FIGO stage IVB as well as those assigned to receive neoadjuvant treatment were excluded from the study. The PCI was obtained and registered intraoperatively. RESULTS: In the study period we recruited 96 patients with serous EOC stage IIIB-IVA. A PCI score cut-off value of 13 was calculated using a receiver operator characteristic (ROC) curve, above which worse survival is expected (area under the curve [AUC]=0.641; 95% confidence interval [CI]=0.517-0.765; sensitivity and specificity 80.6%, 45.0%, respectively; p=0.050). A multivariate analysis determined that suboptimal surgical cytoreduction was the only independent predictive factor for recurrence (odds ratio [OR]=7.548; 95% CI=1.473-38.675; p=0.015). A multivariate analysis determined that only suboptimal surgical cytoreduction (hazard ratio [HR]=2.33; 95% CI=0.616-8.795; p=0.005), but not PCI score >13 (HR=1.289; 95% CI=0.329-5.046; p=0.716), was an independent predictive factor for death. CONCLUSION: We conclude from this study that the PCI score is a reliable tool helping to assess the extent of disease in advanced serous EOC patients and may help predicting complete surgical cytoreduction but cannot qualify as a predictor of survival.

Bristle Maps: A Multivariate Abstraction Technique for Geovisualization

SungYe Kim,Maciejewski, R.,Malik, A.,Yun Jang,Ebert, D. S.,Isenberg, T. IEEE 2013 IEEE transactions on visualization and computer gr Vol.19 No.9

<P>We present Bristle Maps, a novel method for the aggregation, abstraction, and stylization of spatiotemporal data that enables multiattribute visualization, exploration, and analysis. This visualization technique supports the display of multidimensional data by providing users with a multiparameter encoding scheme within a single visual encoding paradigm. Given a set of geographically located spatiotemporal events, we approximate the data as a continuous function using kernel density estimation. The density estimation encodes the probability that an event will occur within the space over a given temporal aggregation. These probability values, for one or more set of events, are then encoded into a bristle map. A bristle map consists of a series of straight lines that extend from, and are connected to, linear map elements such as roads, train, subway lines, and so on. These lines vary in length, density, color, orientation, and transparencyâcreating the multivariate attribute encoding scheme where event magnitude, change, and uncertainty can be mapped as various bristle parameters. This approach increases the amount of information displayed in a single plot and allows for unique designs for various information schemes. We show the application of our bristle map encoding scheme using categorical spatiotemporal police reports. Our examples demonstrate the use of our technique for visualizing data magnitude, variable comparisons, and a variety of multivariate attribute combinations. To evaluate the effectiveness of our bristle map, we have conducted quantitative and qualitative evaluations in which we compare our bristle map to conventional geovisualization techniques. Our results show that bristle maps are competitive in completion time and accuracy of tasks with various levels of complexity.</P>

Patella dislocation: an online systematic video analysis of the mechanism of injury

Dewan V.,Webb M. S. L.,Prakash D.,Malik A.,Gella S.,Kipps C. 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-

Background: The mechanism of injury (MoI) for a patellar dislocation has not been fully established. The aim of this study was to use systematic video analysis to determine the MoI of a patella dislocation. Methods: A systematic search was conducted of three video sharing websites and three popular search engines to identify videos demonstrating a patellar dislocation. Videos were reviewed by three surgeons trained in systematic video analysis, who commented on the position of the lower limb and the situation in which the injury occurred. The results were reviewed to build a consensus of the MoI for each video. Statistical analysis was conducted for interobserver agreement (p < 0.05). Results: Initial search yielded 603 videos with 13 meeting the inclusion criteria. The injuries were sustained performing a sporting activity (n = 9) or whilst dancing (n = 4). The injury was predominantly sustained during a non-contact situation (n = 10). The most common mechanism was an unbalanced individual with a flexed hip sustaining a valgus force to their flexed knee with the tibia externally rotated. Conclusions: This study provides some insight into the MoI for a patellar dislocation and the findings may assist in developing injury prevention programmes and rehabilitation protocols as well as guiding future research.

A bio-medical snake optimizer system driven by logarithmic surviving global search for optimizing feature selection and its application for disorder recognition

Khurma Ruba Abu,Alhenawi Esraa,Braik Malik,Hashim Fatma A,Chhabra Amit,Castillo Pedro A 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.6

It is of paramount importance to enhance medical practices, given how important it is to protect human life. Medical therapy can be accelerated by automating patient prediction using machine learning techniques. To double the efficiency of classifiers, several preprocessing strategies must be adopted for their crucial duty in this field. Feature Selection (FS) is one tool that has been used frequently to modify data and enhance classification outcomes by lowering the dimensionality of datasets. Excluded features are those that have a poor correlation coefficient with the label class, i.e., they have no meaningful correlation with classification and do not indicate where the instance belongs. Along with the recurring features, which show a strong association with the remainder of the features. Contrarily, the model being produced during training is harmed, and the classifier is misled by their presence. This causes overfitting and increases algorithm complexity and processing time. The pattern is made clearer by FS, which also creates a broader classification model with a lower chance of overfitting in an acceptable amount of time and algorithmic complexity. To optimize the FS process, building wrappers must employ metaheuristic algorithms as search algorithms. The best solution, which reflects the best subset of features within a particular medical dataset that aids in patient diagnosis, is sought in this study using the Snake Optimizer (SO). The swarm-based approaches that SO is founded on have left it with several general flaws, like local minimum trapping, early convergence, uneven exploration and exploitation, and early convergence. By employing the cosine function to calculate the separation between the present solution and the ideal solution, the logarithm operator was paired with SO to better the exploitation process and get over these restrictions. In order to get the best overall answer, this forces the solutions to spiral downward. Additionally, SO is employed to put the evolutionary algorithms’ preservation of the best premise into practice. This is accomplished by utilizing three alternative selection systems – tournament, proportional, and linear – to improve the exploration phase. These are used in exploration to allow solutions to be found more thoroughly and in relation to a chosen solution than at random. These are Tournament Logarithmic Snake Optimizer (TLSO), Proportional Logarithmic Snake Optimizer, and Linear Order Logarithmic Snake Optimizer. A number of 22 reference medical datasets were used in experiments. The findings indicate that, among 86% of the datasets, TLSO attained the best accuracy, and among 82% of the datasets, the best feature reduction. In terms of the standard deviation, the TLSO also attained noteworthy reliability and stability. On the basis of running duration, it is, nonetheless, quite effective.

Enhanced electromechanical properties of (1-x)BiFeO₃-BaTiO₃-xLiNbO₃ ceramics by quenching process

Ahmed Malik, R.,Hussain, A.,Kwon Song, T.,Kim, W.J.,Ahmed, R.,Soo Sung, Y.,Kim, M.H. Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.suppl1

A new lead-free piezoelectric ceramics (1-x) (0.67Bi<SUB>1.05</SUB>FeO<SUB>3</SUB> - 0.33BaTiO<SUB>3</SUB>)-x LiNbO<SUB>3</SUB>, abbreviated as BFBT-LNx (x = 0.00-0.030), were fabricated by conventional mixed oxide route following by quenching process and crystal structure and electromechanical properties were discussed. X-ray diffraction pattern showed that LiNbO<SUB>3</SUB> addition into 0.67Bi<SUB>1.05</SUB>FeO<SUB>3</SUB> - 0.33BaTiO<SUB>3</SUB> system did not caused any significant change in crystal structure. However, an obvious variation in electrical properties was observed. It is revealed from electrical properties that the modification of LiNbO<SUB>3</SUB> induces a phase transition from a ferroelectric to relaxor state in the 0.67Bi<SUB>1.05</SUB>FeO<SUB>3</SUB> - 0.33BaTiO<SUB>3</SUB> system. At optimum composition (x = 0.010), enhanced field-induced strain with large dynamic piezoelectric constant S<SUB>max</SUB>/E<SUB>max</SUB> = d<SUP>*</SUP><SUB>33</SUB> = 500pm / V at a relatively low field of 3.5kV / mm with lower hysteresis loss of 40% was recorded. For this composition, a high Curie temperature T<SUB>C</SUB> ~ 390<SUP>o</SUP>C was found. These properties suggests that the synthesized system is promising for high temperature actuator applications.