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학교건물의 공기질 개선을 위한 환기시스템 적용에 관한 연구
안철린(Ahn, Chul-Lin),김좌진(Kim, Jwa-Jin),금종수(Kum, Jong-Soo),박효순(Park, Hyo-Soon) 한국교육시설학회 2004 敎育施設 Vol.11 No.2
The purpose of this study concerns the improvement of air quality in school classrooms. Polluted indoor air is improved by efficient ventilation systems. So it is important to measure the amount of ventilation needed in classrooms. First, the amount of natural ventilation were measured through a tracer gas method. And we have established a heat recovery ventilation system from 4 cases of airflow in classrooms, and we have measured the change of density. According to air quality measurements in the classrooms, the density of is well above environmental standards which are acceptable. When the amount of ventilated airflow increases, indoor air quality is improved. It is surveyed that the most suitable amount of external inducted air is 770 CMH to satisfy less than 1,000 ppm in classrooms. For improvement of air quality in classrooms, we must consider a suitable ventilation plan and installation of ventilation systems when constructing school buildings.
감마선 조사된 Apigenin의 H1975 인체 비소폐암세포에서의 Apoptosis 유발 효과
박재남(Jae-Nam Park),변의백(Eui-Baek Byun),김좌진(Jwa-Jin Kim),장범수(Beon-Su Jang),박상현(Sang-Hyun Park) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.6
본 연구는 감마선 조사에 의해 유도된 apigenin 화합물(radiolysis products)이 인체유래 다양한 암세포에 처리했을 때의 항암 효과를 알아보기 위하여 실험을 진행하였다. Apigenin을 50 kGy로 조사할 경우 유도 화합물이 생성됨을 확인할 수 있었으며, radiolysis 화합물을 분획하여 인체유래 섬유육종세포(HS68)에 대한 독성을 평가한 결과 독성이 없는 것으로 나타났다. 다양한 암세포에 항암 활성을 평가한 결과 폐암(H1975)세포주의 경우 다른 암세포에 비해 효과가 높은 것으로 나타났다. Annexin V/PI 염색을 통해 감마선 조사된 apigenin 처리구에서 apoptosis의 발현을 확인할 수 있었으며, ROS(reactive oxygen species) 평가 결과에서도 농도 의존적으로 발현을 확인할 수 있었다. 본 연구는 방사선 구조 변환 연구를 통해 방사선을 이용한 새로운 신약개발 가능성을 제시하는 기초자료로 활용될 수 있을 것으로 판단하였다. The objective of this study was to evaluate the anticancer effects of gamma-irradiated apigenin against various human cancer cells. Structural changes were analyzed by high pressure liquid chromatography. Gamma-irradiated apigenin showed a new peak distinguished from the main peak of apigenin (non-irradiated). Cytotoxic effects in human normal cells (HS68) were not observed upon gamma-irradiated and non-irradiated apigenin treatment. However, gamma- irradiated apigenin treatment significantly increased cytotoxicity against non-small lung cancer cells. For apoptosis induction activity tested by Annexin V/PI staining, gamma-irradiated apigenin showed a stronger effect than non-irradiated apigenin, and the level of reactive oxygen species was apparently elevated by gamma-irradiated apigenin treatment. These results suggest that gamma irradiation could be an effective method for development of a new physiological compound from an original compound by inducing structural changes.
영지다당체의 실험적 간경화에 대한 섬유화 억제효과에 대한 연구
김좌진,김재백,고건일,손동환 圓光大學校 藥品硏究所 1996 藥品硏究所報 Vol.11 No.1
This study was carried out to investigate the effects of the water soluble fraction and the ethanol soluble fraction of polysaccharide extracted from Ganoderma lucidum. The experimental hepatic cirrhosis was induced by bile duct ligation/scission (BDL/S) in rats. BDL/S rats in each group were dosed 5 mg/rat/day of the ethanol soluble polysaccharide extracted from Ganoderma lucidum and were dosed 0.5, 2.0, 5.0 or 10 mg/rat/day of the water soluble polysaccharide orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, hydroxyproline contents in liver, and light microscopical histology of liver. In ethanol soluble polysaccharide extracted from Ganoderma lucidum, the result obtained were as follows; Hydroxyproline and PIlIP contents in liver of 5mg/kg treated group were significantly reduced. In serum test ALT AST values were rather increased. In water soluble polysaccharide extracted from Ganoderma lucidum, the results obtained were as follows; 1) Hydroxyproline contents in liver of 2.0 and 5.0 mg/kg treated group were significantly reduced in dose dependent manner. 2) In serum test, ALT, AST, ALP values in polysaccharide group were lower than BDL/S control group. 3) The hepatic damage such as hepatocellular inflammation, bile duct proliferation and fibrosis was less severe in the livers of 2.0 and 5.0 mg/kg polysaccharide treated rats than BDL/S control groups. These results suggest water soluble polysaccharides from Ganoderma lucidum had the antifibrotic effect on liver cirrhosis induced by BDL/S.