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산양산삼 추출액의 항암효과 및 Doxorubicin에 의한 고환독성 방어효과
민병일,김호현,서일복,권기록,Min, Byung-Il,Kim, Ho-Hyun,Seo, Il-Bok,Kwon, Ki-Rok 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.1
Objectives : This research was executed to verify antitumor effect and protective effect on doxorubicin(Doxo)-induced toxicity of Cultivated Wild Ginseng(CWG) and synergic effect of CWG with Doxo in B16/F10 melanomas-bearing C57BL/6 mice. Methods : To evaluate protective effect on doxorubicin(Doxo)-induced toxicity and enhancing effect on the antitumor activity of Doxo, CWG water extract(0.5 ml) was intraperitoneally injected for 10 days, in combination with intraperitoneal injection of Doxo(4 mg/kg) on days 12, 16, 19, to mice subcutaneously inoculated with $2{\times}10^6/ml$ B16/F10 melanoma cells. In order to investigate antitumor effect of CWG, CWG water extract(0.5 ml) was intraperitoneally injected for 10 days to mice subcutaneously inoculated with $2{\times}10^6/ml$ B16/F10 melanoma cells. Results : The body weights of melanoma-bearing mice increased following B16/F10 cells inoculation. In contrast, such an increase in body weights was significantly attenuated by Doxo administration. Whereas CWG inhibits the decrease in body weights induced by Doxo. The tumor volume and tumor weights of melanomas-bearing mice dramatically increased following B16/F10 cells inoculation, In contrast, such an increase in tumor volume and tumor weights were significantly attenuated by Doxo or CWG administration. But the synergic effect of CWG with Doxo was not observed. The reduction of cellularity of seminiferous epithelia, level of spermatogonium and spermatid induced by Doxo was recovered by CWG administration. BrdU labeling index of spermatogonium was remarkably decreased in Doxo group but was no change in CWG group. Whereas the incidence and intensity of BrdU labelled spermatocytes and spermatids were increased by CWG administration than those of Doxo group. Conclusions : The obtained results suggest that CWG have antitumor effect and protective effect on doxo-induced testicular toxicity. This effect might be mediated through the supplementation of vital energy.
강자성 Fe16N₂ 화합물에서의 Fe 자기모멘트의 증가
민병일(Byung Il Min),김창석(C. S. Kim) 한국자기학회 1991 韓國磁氣學會誌 Vol.1 No.2
In order to investigate electronic and magnetic properties of Fe_(16)N₂ ferromagnet, we have performed electronic structure calculations employing the self-consistent local density functional LMTO(linearized muffin tin orbital) band method. We have obtained the ground state parameters, such as band structures, density of states, Stoner parameters, and magnetic moments. Based on these results, we have investigated microscopically the magnetic structure and the enhancement of Fe magnetic moments in this compound. Magnetic moments of 3 types of Fe(Fe Ⅰ, Fe Ⅱ and Fe Ⅲ) in Fe_(16)N₂ are 2.13, 2.50, and 2.85 μ_B, respectively. Large enhancement of Fe magnetic moment is observed in Fe Ⅱ and Fe Ⅲ, which are located rather far from N. This implies that local environment is very important in determining the Fe magnetic moments in this compound. Our value of average magnetic moment per Fe atom, 2.50 μ_B, is a bit smaller than the reported estimate, ~3.0 μ_B, from the experiment.
민병일(Byung Il Min),김종원(Jong Won Kim),정필훈(Pill Hoon Choung),박영욱(Young Wook Park) 대한구강악안면외과학회 1989 대한구강악안면외과학회지 Vol.15 No.1
전충협부결손의 재건을 위해서는 구강내결손부위와 피부측결손부위를 동시에 수복해 주어야 할 필요성이 있다. 외측협부결손부위를 피개해 주는 방법으로는 피부이식, 전두피판이나 관상유경피판, 경부회전피판, 국소흉부피판, 그리고 견갑피판 등이 있으며, 구강내결손부위의 이장을 위한 방법에도 여러가지가 있는 바 대흉근피판이 가장 널리 이용되고 있다. 저자등은 외측결손부에 경흉피판을, 구강내결손부위에 대흉근피판을 같이 이용하여 전충협부결손을 재건하여 주었다. 특히 외측결손부에 경흉피판을 이용함으로써 색감과 모양 그리고 반흔조직의 위치 등 심미적 관점에서 우수한 결과를 얻었다. 또한 광범위한 노출을 통해 수술시야를 좋게할 수 있었으며 공여부를 피부이식의 필요성 없이 일차봉합할 수 있었고 장기적으로 피판의 안정성을 기대할 수 있었다. 이에 저자등은 경흉피판과 대흉근피판을 이용하여 전충협부결손을 재건한 3증례를 문헌고찰과 함께 보고하는 바이다.
Byung Il Min(閔丙一),Young Kyun Kim(金榮均),Kyoung Won Kim(金京元) 대한구강악안면외과학회 1988 대한구강악안면외과학회지 Vol.14 No.1
Malignant melanoma in the region of the head and neck is a rare and threating disease. The primary malignant melanoma of the oral cavity represents less than 2 per cent of all malignant melanomas. The oral cavity contained half of the malignant melanomas with palate and alveolus predominating. This is the case report of the primary malignant melanoma on the palate. In the case of 52 old male patient, he was admitted to our department with the chief complaint of black discoloration and ulcerative lesion on the left palatal area. This lesion was treated by subtotal maxillectomy and prophylactic neck dissection. Postoperative biopsy revealed metastatic malignant melanomas in 2 out of 9 lymph nodes. So we thought that prophylactic regional lymph node dissection was significant.