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        신장 ; 국내 단일기관에서 시행한 췌장이식의 임상적인 결과

        한덕종 ( Duck Jong Han ),김송철 ( Song Cheol Kim ),박재범 ( Jae Berm Park ),김영훈 ( Young Hoon Kim ),박관태 ( Kwan Tae Park ),홍정자 ( Jung Ja Hong ),하희선 ( Hea Seon Ha ),정주희 ( Ju Hee Jung ),김인구 ( In Koo Kim ),박건춘 ( Ku 대한내과학회 2011 대한내과학회지 Vol.80 No.2

        목적: 췌장이식은 인슐린 의존형 당뇨병에서 1966년 미네소타대학 병원에서 처음 시행된 수술로써 인슐린을 끊을 수 있는 유일한 치료법으로 이식수술 후 합병증의 감소, 면역억제제 및 수술 후 관리의 개선으로 널리 시행되고 있다. 국내에서는 1992년 첫 췌장이식이 시행된 이래 점차 늘어가고 있지만 아직 활발히 이루어지고 있지는 못하다. 이에 저자들은 1992년 7월부터 2009년 12월까지 국내 단일기관에서 시행한 췌장이식의 임상 결과를 분석하여 보고하고자 한다. 방법: 본원에서는 1992년 7월 이후 2009년 12월까지 18년간 119명의 당뇨병 환자에서 췌장이식을 시행한바 이를 후향적으로 분석하여 췌장 이식의 임상적인 결과를 분석하였다. 결과: 이식수혜자의 당뇨병 분류로 총 119명 중 인슐린 의존형이 93명(78.2%)이었고, 16명(13.4%)에서는 Type II형 이었다. 기증자는 뇌사자가 107명(89.9%), 그리고 12명(10.1%)에서는 가족간 생체기증이었다. 당뇨합병증으로 신·췌장 동시 이식이 67명(56.3%)이었고, 42명(35.3%)에서는 췌장단독이식, 10명(8.4%)에서는 이미 신장이식을 받은 환자에서 췌장이식이 시행되었다. 수술 후 췌장 이식편생존율은 81.6%(1년), 63.4%(5년), 그리고 57.1%(10년)이었다. 면역억제제로 tacrolimus와 MMF를 사용한 1999년 이후(n=96) 췌장 이식편 생존율은 89.1%(1년), 72.9%(5년), 그리고 66.2%(10년)이었고, 환자의 생존율은 93.0%(1년), 86.0%(5년), 그리고 86%(10년)이었다. 결론: 최근 췌장이식 수술의 향상된 성적으로 삶의 질과 장기 환자 생존을 고려할 때, 췌장 이식은 당뇨병의 유형에 상관 없이 인슐린 투여가 필요한, 심각한 당뇨 합병증 또는 인슐린 투여 관련 합병증의 위험에 놓여 있는, 비비만형 당뇨병 환자들에게 효과적인 치료로 제시 될 수 있다. Background/Aims: Pancreas transplantation (PT) as the ultimate treatment for insulin-dependent diabetes has been the subject of debate clinically. Marked improvements in patient and graft survival, and decreases in postoperative morbidity have been achieved due to technical refinements, improved immunosuppressants, and better postoperative management. Here, we report our 18-year experience with PT performed at our institute. Methods: All recipients who underwent deceased donor or living donor PT between July 1992 and December 2009 were included. We reviewed the medical records, including operation records, progress, and laboratory findings during follow-up. Graft and patient survival were analyzed using the Kaplan-Meier method. Results: In total, 119 cases of pancreas transplantation were performed between July 1992 and December 2009 at our institute. Indications for pancreas transplantation were type I diabetes in 93 (78.2%) patients and type II diabetes in 16 (13.4%) patients. The transplanted pancreas was obtained from a deceased donor in 108 cases (90.8%) and a living donor in 11 cases (9.2%). Median follow-up duration was 39.3 months posttransplantation (range 0~176 months). Overall graft survival rates at 1, 5, and 10 years were 81.6%, 63.4%, and 57.1%, respectively. Following the introduction of tacrolimus as an immunosuppressant in 1999, graft survival at 1, 5, and 10 years was 89.1%, 72.9%, and 66.2%, and overall patient survival at 1, 5, and 10 years was 93.0%, 86.0%, and 86.%, respectively. Conclusions: Considering the quality of life and long-term patient survival, PT is an effective treatment strategy in non-obese diabetic patients requiring insulin regardless of the type of diabetes. (Korean J Med 2011;80:167-178)

      • SCOPUSKCI등재

        장내 출혈을 수반한 췌십이지장의 동정맥기형에서 시행한 췌장 전절제술 및 췌장도세포 자가이식

        한덕종(Duck Jong Han),김송철(Song Cheol Kim),김태희(Tae Hee Kim),위유미(Yu Mi We),조경민(Kyung Min Cho),홍정자(Jung Ja Hong) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1

        Ascaris lumbricoides, the roundworm, is recognized as one of the most prevalent human intestinal helminths in the world, but the positive rate of its egg is markedly decreased recently in Korea. Biliary ascariasis is a relatively common complication of intestinal ascaris infestation and may cause pancreatic ductal obstruction, choledocholithiasis, cholecystitis, cholangitis, hemobilia, and liver abscess. However, there has been no report on biliary ascariasis combined with both bile duct stone and liver abscess in Korea. We experienced a case of having two worms of Ascaris lumbricoides in the bile duct combined with both bile duct stones and liver abscess. The case was managed with endoscopic removal of the worms and stone and with percutaneous drainage of the liver abscess. We report the case with a review of literatures. (Korean J Gastroenterol 2001;38:61-64)

      • KCI등재
      • 뇌사자 가족의 장기기증에 대한 경험 연구

        홍정자,지성애 중앙대학교 의과대학 간호학과 간호과학연구소 2002 중앙간호논문집 Vol.6 No.1

        The purpose of this study was to understand of experience about organ donation of brain death donor families by the use of analytical theory of Benner's Interpretive Phenomenology. The object was that what kind of experience did they feel during the organ donation. This research participants were 9 brain death donors' families who had experienced that organ donation from Jan. 1999 to Jan. 2000 and hospitalized from A. hospital in seoul. The data was collected and the contents of interview were recorded while interviewing deeply with the each participants from the January to August 2000. It took one half hours to two hours while interviewing. This research data was analysed in terms of Benner's Interpretive Phenomenoloic strategy tools which named paradigm case, thematic analysis, examlar. The conclusion that gained from this study which was based on experiences about organ donation of brain death donors families. The results of the study are as follows : At fist, the experience about organ donation of brain death donors' families was shock as like falling down. During this stage, donors' families felt that being at a loss, loss of spirit. and next, the experience about organ donation of brain death donors' families was agonizing. agonizing appeared in all process that their experiences related organ donation. During this stage, they felt that as like crushing their heart, deep grief, unable to calm themselves. and next, the experience about organ donation of brain death donors' families was the fear about uncertainty. During this stage, they felt that frightening, appealed to medical staff for saving to life and next, the experience about organ donation of brain death donors' families was having a hope to recovery. During this stage, they felt that unbelievable, having a hope. and next, the experience about organ donation of brain death donor's familirs was anger. and next, the experience about organ donation of brain death donors' families was the difficulty about accepting of brain death and decision of organ donation. and next, the experience about organ donation of brain death donors' families was want to information related to brain death and donation process, being together, emotional support by hospital staffs and relatives and needing the help on the funeral process. and next, the experience about organ donation of brain death donors' families was beravement(loss of loved one's). During this stage, donors' families felt that loneliness, withdrawal of life, missing and guilty feeling.at last, the experience about organ donation of brain death donors' families was having a positive thining about organ donation. During this stage, dnors' families felt that they feel free from the guilty feeling and organ donation means Gift of life. This study itemize the experiences about organ donation of brian death donors' families by applying the analytical interpretive phenomenology of Benner. Based upon this study, the theory of benner which describes the experiences about organ donation of brain death donors' family is suitable for brain death donors' family care, cadaveric organ transplantation nursing.

      • 가정과에의 열린 교육 적용 연구 : 직소(Jigsaw) II 협동학습을 중심으로

        최목화,홍정자,이강분 한남대학교 교육연구소 1997 교육연구 Vol.5 No.2

        The purpose of this study is to investigate the concept, teaching and learning method in open education and to help to expand the use of open education in Home Economics education. To achieve this purpose, this study was reviewed meaning, principle and characteristics of open education based on the theoretical background and developed an instructional plan of the open education for Home Economics education. This plan was applied to second grade students of Ohjeong middle school in July 1997, using Jigsaw It's cooperational teaching and learning method. The results were as follows: 1) Students chose their learning tasks themselves and accomplished the student-centered, positive, spontaneous learning of small group cooperational learning. 2) Students who were involved in the same group made their plans together in order to solve their tasks. Within these groups each student then took smaller roles to accomplish the goal of the group. 3) All students were able to gain some self-confidence and make a statement about their tasks. The knowledge gained from the group work improved the ability of their presentation. 4) The experiment of heating food in various conditions allowed the students to recognize natuarally the changes that occurred in the food. They could realize the scientific cooking principle through comparison with foods which were cooked in several conditions. 5) Observing and comparing food that was cooked by the students themselves with food that was cooked by others, was very effective.

      • SCOPUSKCI등재

        Toxic Epidermal Necrolysis 의 1 예

        국홍일,홍정자 대한피부과학회 1974 大韓皮膚科學會誌 Vol.12 No.3

        A case of Toxic epidermal necrolysis in 19 th years old man is presented. This patient has been suffering from erythematous patches and bullae over entire body including vesicles, erosions, and fissures on both lips since 2 days ago after taking some drugs (analgetics, aspirin, chloramphenicol, sulfisoxazole, erythromycine.) for treatment of tonsillitis. Furthermore, it is very difficult for us to say why the disease has occured. Toxic Epidermal Necrolysis (TEN) by talking drugs or Staphylococcal Scalded Skin Syndrpme (4S) by staphylococcus aurues because staphylococcus aureus was found on bacteriai culture from his throat swab. He was treated with corticosteroid, antibiotics and fluids for 20 days with good result. Literature was briefly reviewed.

      • SCOPUSKCI등재

        Pseudoxanthoma Elasticum 의 3 예

        국홍일,홍정자,함정희 대한피부과학회 1974 大韓皮膚科學會誌 Vol.12 No.2

        Dupuytren's contracture is a idiopathic hypertrophy of palmar aponeurosis and consequent flexion deformity of distal palms and fingers. This patient is a 58-year-old man who has been suffering from diabetes mllitus since last 20 years. Skin lesion developed from one year ago. Skin lesion is a well defined, yellowish brown, nontender, firm, pea-sized nodule at distal palmar crease proximal to ring finger on both hands. On physical examination, he is within normal limit except skin lesion and flexion deformity on both hands. Skin biopsy on nodule revealed non-specific fibrosis. Literature was briefly reviewed.

      • SCOPUSKCI등재

        자매에 발생한 Alopecia totalis 의 정신역동학적 고찰

        국홍일,홍정자,함정희,우항원 대한피부과학회 1974 大韓皮膚科學會誌 Vol.12 No.2

        Alopecia totalis is a varient of alopecia areata which is a depilated, round or oval patch, which developed on scalp, eye lashes, eye brows, and beared areas. There is two sisters, elder is 7 year -3month-old, younger is 5-year 7-month-old. Hair loss began to developed on scalp (especially on forehead) 2 months and and 14 months prior to visit to our OPD. We consult the psychiatric department, and concluded that the etiology of our cases are suggested to have emotional disturbances which are ambivalent mother and fear of loss

      • SCOPUSKCI등재

        신장이식 환자의 근력, 근지구력, 유연성 및 일상생활활동의 변화

        안재현,하희선,홍정자 성인간호학회 2001 성인간호학회지 Vol.13 No.1

        The purpose of this study was to explore the change of muscle strength, muscle endurance, flexibility and activities of daily living to develop a rehabilitational program. The subjects were selected randomly among the patients who underwent kidney trans- plantations at one major transplantation hospital in Seoul, Korea. This study was carried out between November 23, 1999 and February 15, 2000. The subjects in this study consisted of 16 patients who had kidney transplantations between 1 month and 12 months ago prior to this study. They were all on steroids and did not take any physical exercise regularly. The muscle strength, muscle endurance, flexibility and activities of daily living were evaluated at 1st week and after 12 weeks. The data were analyzed with numbers, percentiles, mean, standard deviation and t-test. The results were as follows : 1.After 12 weeks, the grip strength was significantly decreased than 1st week(p =.0002). 2.After 12 weeks, the back lift strength was significantly decreased than 1st week(p =.0002). 3.After 12 weeks, the muscle endurance was increased than 1st week, but it was not significant(p=.5487) 4.After 12 weeks, the flexibility was significantly decreased than 1st week(p=.0002). 5.After 12 weeks, the activities of daily living was significantly decreased than 1st week(p=.0006). Like the above result, the kidney transplant receipients' muscle strength, flexibility and activities of daily living were reduced In order to solve this problem, the writer has found that program development to prevent the defects should be extremely required. Since now on the number of patients should expand. After the kidney transplantation, the periods of 4, 8, 12 and 16 weeks are extended. The writer proposes to examine the different phase of change in each periods.

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